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Gene: Ikbke (inhibitor of nuclear factor kappa B kinase subunit epsilon) Rattus norvegicus

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Symbol:

Ikbke

Name:

inhibitor of nuclear factor kappa B kinase subunit epsilon

RGD ID:

1308352

Description:

Predicted to enable several functions, including IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to virus; positive regulation of gene expression; and positive regulation of innate immune response. Predicted to act upstream of or within type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; LOC363984

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,264,404 - 45,290,737 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	45,264,412 - 45,289,396 (-)	Ensembl				GRCr8
mRatBN7.2	13	42,712,154 - 42,738,470 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	42,712,159 - 42,737,143 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	45,320,191 - 45,345,227 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,608,323 - 46,633,354 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	43,872,035 - 43,897,029 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,031,325 - 48,056,394 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,031,410 - 48,056,394 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	53,107,093 - 53,132,162 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	44,197,625 - 44,222,609 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	43,057,856 - 43,082,833 (-)	NCBI		Celera
RGSC_v3.1	13	44,211,668 - 44,233,796 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxy-TEMPO (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

aldrin (ISO)

amlexanox (ISO)

andrographolide (ISO)

aripiprazole (ISO)

arsane (ISO)

arsenic atom (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

brilliant green (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chloroethene (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crystal violet (ISO)

cyproconazole (ISO)

daunorubicin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diallyl trisulfide (ISO)

diclofenac (ISO)

diethyl maleate (ISO)

dioxygen (EXP)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

hexadecanoic acid (ISO)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

inulin (ISO)

lipopolysaccharide (ISO)

melphalan (ISO)

motexafin gadolinium (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

poly(I:C) (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

succimer (ISO)

sucrose (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

thioacetamide (EXP)

thiram (ISO)

triadimefon (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

zinc acetate (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IBA)

cellular response to virus (ISO)

gene expression (ISO)

immune response (ISO)

interleukin-17-mediated signaling pathway (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

mRNA stabilization (ISO)

peptidyl-serine phosphorylation (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of gene expression (IEA)

positive regulation of lipid storage (ISO)

positive regulation of type I interferon production (IBA,ISO)

positive regulation of type I interferon-mediated signaling pathway (ISO)

regulation of protein-containing complex assembly (ISO)

response to interferon-beta (ISO)

response to type I interferon (ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (ISO)

mitochondrial membrane (ISO)

nucleus (ISO)

PML body (ISO)

Molecular Function

ATP binding (IEA)

identical protein binding (ISO)

IkappaB kinase activity (ISO)

K48-linked polyubiquitin modification-dependent protein binding (ISO)

K63-linked polyubiquitin modification-dependent protein binding (ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine/threonine kinase activity (IBA,IEA,ISO)

transferase activity (IEA)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

Toll-like receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10421793	PMID:10882136	PMID:12477932	PMID:12761501	PMID:16876765	PMID:20188669	PMID:23741427	PMID:24380861	PMID:24882218	PMID:27129230	PMID:30794866	PMID:34933200

Genomics

Comparative Map Data

Ikbke
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,264,404 - 45,290,737 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	45,264,412 - 45,289,396 (-)	Ensembl				GRCr8
mRatBN7.2	13	42,712,154 - 42,738,470 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	42,712,159 - 42,737,143 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	45,320,191 - 45,345,227 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,608,323 - 46,633,354 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	43,872,035 - 43,897,029 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,031,325 - 48,056,394 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,031,410 - 48,056,394 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	53,107,093 - 53,132,162 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	44,197,625 - 44,222,609 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	43,057,856 - 43,082,833 (-)	NCBI		Celera
RGSC_v3.1	13	44,211,668 - 44,233,796 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

IKBKE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	206,470,476 - 206,496,889 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	206,470,332 - 206,496,891 (+)	Ensembl			hg38	GRCh38
GRCh37	1	206,643,819 - 206,670,222 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	204,710,419 - 204,736,845 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	203,032,190 - 203,058,617	NCBI
Celera	1	179,895,028 - 179,921,668 (+)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	177,341,834 - 177,368,529 (+)	NCBI		HuRef
CHM1_1	1	207,915,782 - 207,942,429 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	205,734,655 - 205,761,052 (+)	NCBI		T2T-CHM13v2.0

Ikbke
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	131,182,337 - 131,207,339 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	131,182,080 - 131,207,344 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	131,254,600 - 131,279,601 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	131,254,343 - 131,279,606 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	133,151,179 - 133,176,140 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	133,082,148 - 133,107,109 (-)	NCBI		MGSCv36	mm8
Celera	1	133,876,834 - 133,902,322 (-)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	56.93	NCBI

Ikbke
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	42,056,014 - 42,077,701 (+)	Ensembl
ChiLan1.0	NW_004955406	42,056,014 - 42,077,701 (+)	NCBI	ChiLan1.0	ChiLan1.0

IKBKE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	42,881,624 - 42,909,446 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	42,847,151 - 42,873,352 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	182,070,565 - 182,096,797 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	186,351,807 - 186,377,970 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	186,351,807 - 186,377,971 (+)	Ensembl			panPan2	panpan1.1

IKBKE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	2,747,303 - 2,772,574 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	2,747,297 - 2,772,587 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	2,839,619 - 2,864,841 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	2,744,869 - 2,770,037 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	2,744,859 - 2,770,035 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	2,738,094 - 2,763,301 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	3,131,469 - 3,156,703 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	3,331,693 - 3,356,866 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ikbke
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	68,825,925 - 68,851,246 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	6,066,278 - 6,090,777 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	6,066,207 - 6,090,767 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IKBKE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	67,123,265 - 67,147,989 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	67,123,055 - 67,147,991 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	73,367,929 - 73,388,131 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IKBKE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	22,865,720 - 22,892,346 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	22,865,734 - 22,891,920 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	23,564,077 - 23,591,390 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ikbke
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	4,913,742 - 4,933,267 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624807	4,913,734 - 4,934,096 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ikbke
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	4,536,040 - 4,558,348 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ikbke
317 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	471
Count of miRNA genes:	229
Interacting mature miRNAs:	266
Transcripts:	ENSRNOT00000038151
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2303032	Bp328	Blood pressure QTL 328			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	43736327	47969993	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

RH130591

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	42,712,185 - 42,712,379 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	48,031,437 - 48,031,630	NCBI	Rnor6.0
Rnor_5.0	13	53,107,205 - 53,107,398	UniSTS	Rnor5.0
RGSC_v3.4	13	44,197,652 - 44,197,845	UniSTS	RGSC3.4
Celera	13	43,057,883 - 43,058,076	UniSTS
RH 3.4 Map	13	110.6	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	161	91	90	59	92	59	6	355	191	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001840783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_595427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_595428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC128751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000038151 ⟹ ENSRNOP00000030127

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	45,264,412 - 45,289,396 (-)	Ensembl
mRatBN7.2 Ensembl	13	42,712,159 - 42,737,143 (-)	Ensembl
Rnor_6.0 Ensembl	13	48,031,410 - 48,056,394 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151006 ⟹ ENSRNOP00000100304

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	45,266,730 - 45,289,396 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151581 ⟹ ENSRNOP00000112135

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	45,264,412 - 45,289,339 (-)	Ensembl

RefSeq Acc Id:

NM_001108854 ⟹ NP_001102324

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,264,412 - 45,289,396 (-)	NCBI
mRatBN7.2	13	42,712,159 - 42,737,143 (-)	NCBI
Rnor_6.0	13	48,031,410 - 48,056,394 (-)	NCBI
Rnor_5.0	13	53,107,093 - 53,132,162 (-)	NCBI
RGSC_v3.4	13	44,197,625 - 44,222,609 (-)	RGD
Celera	13	43,057,856 - 43,082,833 (-)	RGD

Sequence:

show sequence

GGAGGGGAGAAAGAGAGAAAGAGAGAGAGCGAGAGAGAGAAGTGAATCAGGAAGTATGACAGAC
CTAAGAGCCTGGGGCTGTGTATCCCACTGCTATTAGAGAGGCAGGCGAGAAACCTTCAGGCTCA
AGACCATACTCTGCCTTAGTGGATCCCGGGGGCCCATCGCTACCAGGATCTTCTAGGCACTGCT
CAGGATTGACTTCAAGGCCTGAACCCCTGAGGGTGCCACCCAGTCCCACAAGTCCGCATTCCCC
TGCAGCTGAGATGGGAGATGGGCTTGGCTCCTGGACTTGCCCCAGACAGAAAGCATAGCACAGA
CCTGCCAGGGAGAGTCTTTGCCTGATTCTAGGCCCCTTGGAGTGCAGGAGGAAGGATGCAGAGT
ACCACTAACTACCTGTGGCATACTGATGACCTGCTAGGGCAGGGGGCCACTGCCAATGTGTACA
AGGCCCGGAATAAGAAATCCGGGGAGGTGGTTGCTGTAAAGGTCTTCAACTCAGCCAGCTACCG
GCGGCCCCCTGAGGTACAAGTGAGGGAGTTCGAGGTCTTGCGGAGGCTGGATCATGAGAACATC
GTGAAGCTATTCGCAGTGGAGGAAACGGGAGGCAGCCGGCAGAAGGTGCTAGTGATGGAGTACT
GCTCCAGTGGGAGCCTGCTGAGCGTGCTGGAAGACCCTGAGAACACATTCGGCCTTCCTGAGGA
GGAGTTCCTGGTGGTACTGCGCTGTGTGGTGGCTGGCATGAACCACCTGCGGGAGAATGGCATT
GTCCACCGTGACATCAAGCCCGGGAATATCATGCGCCTGGTAGGCAAGGAGGGGCAGAGCATCT
ACAAGCTGTCTGACTTCGGGGCTGCCCGGAAGCTGGACGACGATGAGAAGTTTGTTTCTGTCTA
TGGTACAGAGGAGTACCTGCACCCTGACATGTATGAGCGGGCAGTGCTTCGCAAACCCCAGCAA
AAGGCGTTCGGGGTGACAGTGGATCTCTGGAGTATTGGGGTGACCTTGTACCACGCAGCCACCG
GTAGTCTGCCCTTCATCCCCTTTGGTGGGCCCCGGCGCAACAAGGAGATCATGTATAGGATCAC
CACAGAGAAGCCAGCTGGGGCCATTTCCGGGACTCAGAAGCAGGAAAATGGTCCCCTGGAATGG
AGCTACAGCCTCCCCATCACCTGTAGACTGTCTGTGGGGCTGCAGAGTCAGCTAGTGCCCATCC
TGGCCAACATCCTGGAGGCCGAACAGGCTAAATGCTGGGGCTTCGATCAGTTCTTTGCAGAGAC
CAGTGACATCCTGCAGCGAACTGTCATCCATGTCTTCTCCCTGCCCCAGGCGGTTTTGCATCAC
ATCTACATCCATGCCCACAACACGATTGCCATCTTTTTGGAGGCTGTATATGAACAGACCAACG
TGGCCCCCAAACACCAAGAATACTTCTTCGAGGGTCACCCTTGTGTCCTCGAGCCAAGCCTCTC
AGCCCAGCACATCGCCCACACAGCTGCCAGCAGCCCTCTAACTCTGTTCAGCATGGCCAGCGAC
ACACCCAAGGGGCTGGCCTTCAGGGACCCTGCTCTGGATGTCCCAAAGTTCGTCCCTAAGGTTG
ACCTACAGGCCGATTACAGCACCGCTAAGGGCGTGCTGGGCGCTGGTTACCAGGCCTTGTGGCT
GGCGCGGGTCCTGCTGGATGGACAGGCGTTGATGCTTCGAGGGTTACACTGGGTCCTGGTGGTG
CTTCAGAACACGTGCCAACAGACACTGGAGATCACACGGACAGCCCTCCTCTTCCTCAGTAGCA
GCCTGGGCACTGAAAGGCTCAGCAGTGGAGCTGGGATGCTTGACATCCAGGAACTAAAGGAAGC
CACGGAGCTGAGGTCCAGGCTGCAGACTTTCTCAGAGGTCCTGTCTAAGTGTTCCCACAATGTC
ACAGAAACCCAAAGGAGCCTGAGTTGTCTGGTTGGAGAGCTTTTGAAGAGCCGGGATCAGATTC
ATGAGGATAACAGAAGTATCCAGAAGATTCAGTGTTGTTTGGACAAGATGCACTTCATCTACAA
ACAGTTCAAGAAGTCTAGGATGAGGCCAGGCCTCAGCTACAATGAGGAGCAGATCCACAAGCTG
GATAAGGTAAATTTTAGTCACCTAGCCAAGAGGCTGCTGCAGGTGTTCCAGGAGGAGTGTGCAC
AGACGTATCAGGTGTCACTGGTCACACATGGCAAGCGGATGAGGCAGGTGCAGAAGGCCCAGAA
CCACCTGCACCTCATTGGCCACTCCGTGGCTACCTGTAACTCAGAAGCCCGGGGAGCCCAGGAG
AGCCTGGCCAAGATGTTTGATCAGCTCCTCCTGGACAGAGCTTCCAAACAGGGAGCTGAGGTCT
CACCACAACCTATGGCAACTCATCCCGGCCCCGATCCGAAGGACCTGGTCTTCCACATGCAGGA
ACTTTGTAATGATATGAAGCTATTGGCCTTTGATCTCCAGGACAACAACAGACTCATCGAACGG
CTACATAGAGTTCCACCAACACCAGAAGTCTGAGCCCCCTGGGGGTGCACAAGGCACTCGGAAG
CAATAGAGTCATTCATACCGTACCCCTGCACTGCAAGACCAAATTCAGGGCAAGTTCTGGTCCC
ATCTCACTAGCCTACCTCCCTCTTGGCCATTGGCCAACAAATTAGCATTACTTTGACTGCCTGT
CCTCTTGGGAAGCAGCCAGCACAGGGACTCCTGGCCATTCAGGGCAGTACCCGCAAGAGAGACC
ATGTGGCTACCTACCACTGCCTCATTGAGACACCAAGACTGTTTTTCCTCACCCAGGCCAGGAG
GTCTGAACTCAGGCGGGTCTCGGGGAGAAAAGCCTCAGTCCTCTCACACTCTGCACTTCCCAGG
ACCAGCAGGCCTCTCCTGTGGCTTCTCCAGGAGGTTGGATAAGTGGGCTTATTCTTCACCGTTT
TCCATGCTGTTTCCTGAGTCCCATCCTTGGCCGCAGGCGACCCACAAATGGCCCCTCTGTGTTT
GGTCTGGATGCACCTGCATTTGAGAAAGTGGGAAGTTGAGGCCAACGGCTGGTGCTTTAGGGAT
CCTTTGCCTTTTCTCCCTGAGGAACCCTTGATTCTGAGAAACAGCTGGTTGGTATCAAGCATAG
CCATGCCAACTGGACAGATGTTAGAACCCAGAGTCCTAAGGAGAGAGAAGGCCTGTACCTCCCT
TCAGACATGGAATAAATGTACCGCCTTTTCTGTTT

hide sequence

RefSeq Acc Id:

XM_017598875 ⟹ XP_017454364

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,264,404 - 45,290,031 (-)	NCBI
mRatBN7.2	13	42,712,154 - 42,737,765 (-)	NCBI
Rnor_6.0	13	48,031,325 - 48,056,378 (-)	NCBI

Sequence:

show sequence

GAAAGAGAGAGAGCGAGAGAGAGAAGTGAATCAGGAAGTATGACAGACCTAAGAGCCTGGGGCT
GTGTATCCCACTGCTATTAGAGAGGCAGGCGAGAAACCTTCAGGCTCAAGACCATACTCTGCCT
TAGTGGATCCCGGGGGCCCATCGCTACCAGGATCTTCTAGGCACTGCTCAGGATTGACTTCAAG
GCCTGAACCCCTGAGGGTGCCACCCAGTCCCACAAGTCCGCATTCCCCTGCAGCTGAGATGGGA
GATGGGCTTGGCTCCTGGACTTGCCCCAGACAGAAAGCATAGCACAGACCTGCCAGGGAGAGTC
TTTGCCTGATTCTAGGCCCCTTGGAGTGCAGGAGGAAGGATGCAGAGTACCACTAACTACCTGT
GGCATACTGATGACCTGCTAGGGCAGGGGGCCACTGCCAATGTGTACAAGGCCCGGAATAAGAA
ATCCGGGGAGGTGGTTGCTGTAAAGGTCTTCAACTCAGCCAGCTACCGGCGGCCCCCTGAGGTA
CAAGTGAGGGAGTTCGAGGTCTTGCGGAGGCTGGATCATGAGAACATCGTGAAGCTATTCGCAG
TGGAGGAAACGGGAGGCAGCCGGCAGAAGGTGCTAGTGATGGAGTACTGCTCCAGTGGGAGCCT
GCTGAGCGTGCTGGAAGACCCTGAGAACACATTCGGCCTTCCTGAGGAGGAGTTCCTGGTGGTA
CTGCGCTGTGTGGTGGCTGGCATGAACCACCTGCGGGAGAATGGCATTGTCCACCGTGACATCA
AGCCCGGGAATATCATGCGCCTGGTAGGCAAGGAGGGGCAGAGCATCTACAAGCTGTCTGACTT
CGGGGCTGCCCGGAAGCTGGACGACGATGAGAAGTTTGTTTCTGTCTATGGTACAGAGGAGTAC
CTGCACCCTGACATGTATGAGCGGGCAGTGCTTCGCAAACCCCAGCAAAAGGCGTTCGGGGTGA
CAGTGGATCTCTGGAGTATTGGGGTGACCTTGTACCACGCAGCCACCGGTAGTCTGCCCTTCAT
CCCCTTTGGTGGGCCCCGGCGCAACAAGGAGATCATGTATAGGATCACCACAGAGAAGCCAGCT
GGGGCCATTTCCGGGACTCAGAAGCAGGAAAATGGTCCCCTGGAATGGAGCTACAGCCTCCCCA
TCACCTGTAGACTGTCTGTGGGGCTGCAGAGTCAGCTAGTGCCCATCCTGGCCAACATCCTGGA
GGCCGAACAGGCTAAATGCTGGGGCTTCGATCAGTTCTTTGCAGAGACCAGTGACATCCTGCAG
CGAACTGTCATCCATGTCTTCTCCCTGCCCCAGGCGGTTTTGCATCACATCTACATCCATGCCC
ACAACACGATTGCCATCTTTTTGGAGGCTGTATATGAACAGACCAACGTGGCCCCCAAACACCA
AGAATACTTCTTCGAGGGTCACCCTTGTGTCCTCGAGCCAAGCCTCTCAGCCCAGCACATCGCC
CACACAGCTGCCAGCAGCCCTCTAACTCTGTTCAGCATGGCCAGCGACACACCCAAGGGGCTGG
CCTTCAGGGACCCTGCTCTGGATGTCCCAAAGTTCGTCCCTAAGGTTGACCTACAGGCCGATTA
CAGCACCGCTAAGGGCGTGCTGGGCGCTGGTTACCAGGCCTTGTGGCTGGCGCGGGTCCTGCTG
GATGGACAGGCGTTGATGCTTCGAGGGTTACACTGGGTCCTGGTGGTGCTTCAGAACACGTGCC
AACAGACACTGGAGATCACACGGACAGCCCTCCTCTTCCTCAGTAGCAGCCTGGGCACTGAAAG
GCTCAGCAGTGGAGCTGGGATGCTTGACATCCAGGAACTAAAGGAAGCCACGGAGCTGAGGTCC
AGGCTGCAGACTTTCTCAGAGGTCCTGTCTAAGTGTTCCCACAATGTCACAGAAACCCAAAGGA
GCCTGAGTTGTCTGGTTGGAGAGCTTTTGAAGAGCCGGGATCAGATTCATGAGGATAACAGAAG
TATCCAGAAGATTCAGTGTTGTTTGGACAAGATGCACTTCATCTACAAACAGTTCAAGAAGTCT
AGGATGAGGCCAGGCCTCAGCTACAATGAGGAGCAGATCCACAAGCTGGATAAGGTAAATTTTA
GTCACCTAGCCAAGAGGCTGCTGCAGGTGTTCCAGGAGGAGTGTGCACAGACGTATCAGGTGTC
ACTGGTCACACATGGCAAGCGGATGAGGCAGGTGCAGAAGGCCCAGAACCACCTGCACCTCATT
GGCCACTCCGTGGCTACCTGTAACTCAGAAGCCCGGGGAGCCCAGGAGAGCCTGGCCAAGATGT
TTGATCAGCTCCTCCTGGACAGAGCTTCCAAACAGGGAGCTGAGGTCTCACCACAACCTATGGC
AACTCATCCCGGCCCCGATCCGAAGGACCTGGTCTTCCAGCCATCCCCTGCTCCGTGGCCTCTG
CAAGTGGGCTCTGGACCAAGTAACCTGGGCCTCAGCCACCCCGTTCTTGTGCCTTGGACAGCAT
GCAGGAACTTTGTAATGATATGAAGCTATTGGCCTTTGATCTCCAGGACAACAACAGACTCATC
GAACGGCTACATAGAGTTCCACCAACACCAGAAGTCTGAGCCCCCTGGGGGTGCACAAGGCACT
CGGAAGCAATAGAGTCATTCATACCGTACCCCTGCACTGCAAGACCAAATTCAGGGCAAGTTCT
GGTCCCATCTCACTAGCCTACCTCCCTCTTGGCCATTGGCCAACAAATTAGCATTACTTTGACT
GCCTGTCCTCTTGGGAAGCAGCCAGCACAGGGACTCCTGGCCATTCAGGGCAGTACCCGCAAGA
GAGACCATGTGGCTACCTACCACTGCCTCATTGAGACACCAAGACTGTTTTTCCTCACCCAGGC
CAGGAGGTCTGAACTCAGGCGGGTCTCGGGGAGAAAAGCCTCAGTCCTCTCACACTCTGCACTT
CCCAGGACCAGCAGGCCTCTCCTGTGGCTTCTCCAGGAGGTTGGATAAGTGGGCTTATTCTTCA
CCGTTTTCCATGCTGTTTCCTGAGTCCCATCCTTGGCCGCAGGCGACCCACAAATGGCCCCTCT
GTGTTTGGTCTGGATGCACCTGCATTTGAGAAAGTGGGAAGTTGAGGCCAACGGCTGGTGCTTT
AGGGATCCTTTGCCTTTTCTCCCTGAGGAACCCTTGATTCTGAGAAACAGCTGGTTGGTATCAA
GCATAGCCATGCCAACTGGACAGATGTTAGAACCCAGAGTCCTAAGGAGAGAGAAGGCCTGTAC
CTCCCTTCAGACATGGAATAAATGTACCGCCTTTTCTGTTTTCCTACAACTACGGTACCTGACC
GGGAAGGGGTGGGGAAGCCCGGAGGTCCGGGAAAGATGTCTCCAGAGCTTTGGGAAATGGAA

hide sequence

RefSeq Acc Id:

XM_039090949 ⟹ XP_038946877

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,264,404 - 45,290,737 (-)	NCBI
mRatBN7.2	13	42,712,154 - 42,738,470 (-)	NCBI

RefSeq Acc Id:

XM_039090950 ⟹ XP_038946878

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,264,404 - 45,283,851 (-)	NCBI
mRatBN7.2	13	42,712,154 - 42,731,598 (-)	NCBI

RefSeq Acc Id:

XM_063272513 ⟹ XP_063128583

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,277,588 - 45,290,028 (-)	NCBI

RefSeq Acc Id:

XR_005492260

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,264,404 - 45,290,021 (-)	NCBI
mRatBN7.2	13	42,712,159 - 42,737,755 (-)	NCBI

RefSeq Acc Id:

XR_005492261

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,275,785 - 45,290,028 (-)	NCBI
mRatBN7.2	13	42,723,532 - 42,737,762 (-)	NCBI

RefSeq Acc Id:

XR_005492262

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,280,166 - 45,290,014 (-)	NCBI
mRatBN7.2	13	42,727,913 - 42,737,746 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102324	(Get FASTA)	NCBI Sequence Viewer
	XP_017454364	(Get FASTA)	NCBI Sequence Viewer
	XP_038946877	(Get FASTA)	NCBI Sequence Viewer
	XP_038946878	(Get FASTA)	NCBI Sequence Viewer
	XP_063128583	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09830	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000030127.4
	ENSRNOP00000100304
	ENSRNOP00000100304.1
	ENSRNOP00000112135
	ENSRNOP00000112135.1

RefSeq Acc Id:

NP_001102324 ⟸ NM_001108854

- UniProtKB:

D4A5E7 (UniProtKB/TrEMBL), A6IC17 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQSTTNYLWHTDDLLGQGATANVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLDH
ENIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLEDPENTFGLPEEEFLVVLRCVVAGMNHLRE
NGIVHRDIKPGNIMRLVGKEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRK
PQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGP
LEWSYSLPITCRLSVGLQSQLVPILANILEAEQAKCWGFDQFFAETSDILQRTVIHVFSLPQAV
LHHIYIHAHNTIAIFLEAVYEQTNVAPKHQEYFFEGHPCVLEPSLSAQHIAHTAASSPLTLFSM
ASDTPKGLAFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWV
LVVLQNTCQQTLEITRTALLFLSSSLGTERLSSGAGMLDIQELKEATELRSRLQTFSEVLSKCS
HNVTETQRSLSCLVGELLKSRDQIHEDNRSIQKIQCCLDKMHFIYKQFKKSRMRPGLSYNEEQI
HKLDKVNFSHLAKRLLQVFQEECAQTYQVSLVTHGKRMRQVQKAQNHLHLIGHSVATCNSEARG
AQESLAKMFDQLLLDRASKQGAEVSPQPMATHPGPDPKDLVFHMQELCNDMKLLAFDLQDNNRL
IERLHRVPPTPEV

hide sequence

RefSeq Acc Id:

XP_017454364 ⟸ XM_017598875

- Peptide Label:

isoform X1

- Sequence:

show sequence

MQSTTNYLWHTDDLLGQGATANVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLDH
ENIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLEDPENTFGLPEEEFLVVLRCVVAGMNHLRE
NGIVHRDIKPGNIMRLVGKEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRK
PQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGP
LEWSYSLPITCRLSVGLQSQLVPILANILEAEQAKCWGFDQFFAETSDILQRTVIHVFSLPQAV
LHHIYIHAHNTIAIFLEAVYEQTNVAPKHQEYFFEGHPCVLEPSLSAQHIAHTAASSPLTLFSM
ASDTPKGLAFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWV
LVVLQNTCQQTLEITRTALLFLSSSLGTERLSSGAGMLDIQELKEATELRSRLQTFSEVLSKCS
HNVTETQRSLSCLVGELLKSRDQIHEDNRSIQKIQCCLDKMHFIYKQFKKSRMRPGLSYNEEQI
HKLDKVNFSHLAKRLLQVFQEECAQTYQVSLVTHGKRMRQVQKAQNHLHLIGHSVATCNSEARG
AQESLAKMFDQLLLDRASKQGAEVSPQPMATHPGPDPKDLVFQPSPAPWPLQVGSGPSNLGLSH
PVLVPWTACRNFVMI

hide sequence

Ensembl Acc Id:

ENSRNOP00000030127 ⟸ ENSRNOT00000038151

RefSeq Acc Id:	XP_038946877 ⟸ XM_039090949
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038946878 ⟸ XM_039090950
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063128583 ⟸ XM_063272513
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000112135 ⟸ ENSRNOT00000151581

Ensembl Acc Id:

ENSRNOP00000100304 ⟸ ENSRNOT00000151006

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A5E7-F1-model_v2	AlphaFold	D4A5E7	1-717	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698795

Promoter ID:

EPDNEW_R9320

Type:

multiple initiation site

Name:

Ikbke_1

Description:

inhibitor of nuclear factor kappa B kinase subunit epsilon

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	48,056,350 - 48,056,410	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308352	AgrOrtholog
BioCyc Gene	G2FUF-18353	BioCyc
Ensembl Genes	ENSRNOG00000025100	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038151.5	UniProtKB/TrEMBL
	ENSRNOT00000151006	ENTREZGENE
	ENSRNOT00000151006.1	UniProtKB/TrEMBL
	ENSRNOT00000151581	ENTREZGENE
	ENSRNOT00000151581.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.420	UniProtKB/TrEMBL
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	IKK	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	TBK1_CCD1	UniProtKB/TrEMBL
	TBK1_ULD	UniProtKB/TrEMBL
KEGG Report	rno:363984	UniProtKB/TrEMBL
NCBI Gene	363984	ENTREZGENE
PANTHER	IKB KINASE	UniProtKB/TrEMBL
	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
	TBK1_CCD1	UniProtKB/TrEMBL
	TBK1_ULD	UniProtKB/TrEMBL
PhenoGen	Ikbke	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025100	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0ABK0L747_RAT	UniProtKB/TrEMBL
	A0ABK0M8N8_RAT	UniProtKB/TrEMBL
	A6IC17	ENTREZGENE, UniProtKB/TrEMBL
	D4A5E7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-02-01	Ikbke	inhibitor of nuclear factor kappa B kinase subunit epsilon	Ikbke	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-02-26	Ikbke	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	Ikbke	inhibitor of kappaB kinase epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ikbke	inhibitor of kappaB kinase epsilon	Ikbke_predicted	inhibitor of kappaB kinase epsilon (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ikbke_predicted	inhibitor of kappaB kinase epsilon (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)