Stra6 (signaling receptor and transporter of retinol STRA6) - Rat Genome Database

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Gene: Stra6 (signaling receptor and transporter of retinol STRA6) Rattus norvegicus
Analyze
Symbol: Stra6
Name: signaling receptor and transporter of retinol STRA6
RGD ID: 1307551
Description: Predicted to enable retinol transmembrane transporter activity. Involved in response to retinoic acid. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in syndromic microphthalmia 9. Orthologous to human STRA6 (signaling receptor and transporter of retinol STRA6); PARTICIPATES IN retinoic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A; 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363071; MGC114408; receptor for retinol uptake STRA6; retinol-binding protein receptor STRA6; RGD1307551; similar to retinoic acid-responsive protein; stimulated by retinoic acid 6; stimulated by retinoic acid gene 6; stimulated by retinoic acid gene 6 homolog; stimulated by retinoic acid gene 6 homolog (mouse); stimulated by retinoic acid gene 6 protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,444,757 - 67,464,719 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl867,444,742 - 67,464,720 (+)EnsemblGRCr8
mRatBN7.2858,548,899 - 58,568,861 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,549,736 - 58,568,860 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx864,079,448 - 64,099,415 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,357,008 - 62,376,974 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,221,574 - 60,241,541 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,925,364 - 62,944,438 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,925,357 - 62,944,437 (+)Ensemblrn6Rnor6.0
Rnor_5.0862,701,454 - 62,720,528 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,920,772 - 61,939,791 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera858,013,586 - 58,032,719 (+)NCBICelera
RGSC_v3.1861,939,822 - 61,958,845 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
amitrole  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
D-glucose  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
glucose  (ISO)
hydrogen sulfide  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
ochratoxin A  (EXP)
paclitaxel  (EXP)
panobinostat  (ISO)
pentane-2,3-dione  (EXP)
permethrin  (ISO)
pirinixic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome. Berner D, etal., Hum Mol Genet. 2019 Aug 1;28(15):2531-2548. doi: 10.1093/hmg/ddz075.
2. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Berry DC and Noy N, Biochim Biophys Acta. 2012 Jan;1821(1):168-76. Epub 2011 Jul 12.
3. First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype. Casey J, etal., Hum Mutat. 2011 Dec;32(12):1417-26. doi: 10.1002/humu.21590. Epub 2011 Sep 29.
4. Phenotypic spectrum of STRA6 mutations: from Matthew-Wood syndrome to non-lethal anophthalmia. Chassaing N, etal., Hum Mutat. 2009 May;30(5):E673-81. doi: 10.1002/humu.21023.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated Retinal Pigment Epithelial Cells and Diabetic Eyes. Kang MK, etal., Nutrients. 2018 Aug 8;10(8). pii: nu10081046. doi: 10.3390/nu10081046.
7. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Malechka VV, etal., Am J Pathol. 2017 Oct;187(10):2222-2231. doi: 10.1016/j.ajpath.2017.06.007. Epub 2017 Jul 19.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Pasutto F, etal., Am J Hum Genet. 2007 Mar;80(3):550-60. doi: 10.1086/512203. Epub 2007 Jan 29.
12. Novel STRA6 null mutations in the original family described with Matthew-Wood syndrome. Pasutto F, etal., Am J Med Genet A. 2018 Jan;176(1):134-138. doi: 10.1002/ajmg.a.38529. Epub 2017 Nov 23.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Szeto W, etal., Cancer Res. 2001 May 15;61(10):4197-205.
17. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
Additional References at PubMed
PMID:12477932   PMID:19500772   PMID:23105095   PMID:23839944  


Genomics

Comparative Map Data
Stra6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,444,757 - 67,464,719 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl867,444,742 - 67,464,720 (+)EnsemblGRCr8
mRatBN7.2858,548,899 - 58,568,861 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,549,736 - 58,568,860 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx864,079,448 - 64,099,415 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,357,008 - 62,376,974 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,221,574 - 60,241,541 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,925,364 - 62,944,438 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,925,357 - 62,944,437 (+)Ensemblrn6Rnor6.0
Rnor_5.0862,701,454 - 62,720,528 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,920,772 - 61,939,791 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera858,013,586 - 58,032,719 (+)NCBICelera
RGSC_v3.1861,939,822 - 61,958,845 (+)NCBI
Cytogenetic Map8q24NCBI
STRA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,179,466 - 74,212,259 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,179,466 - 74,212,267 (-)Ensemblhg38GRCh38
GRCh371574,471,807 - 74,502,046 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,258,860 - 72,282,245 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341572,258,862 - 72,282,245NCBI
Celera1551,418,988 - 51,448,552 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,265,478 - 51,295,736 (-)NCBIHuRef
CHM1_11574,590,002 - 74,620,238 (-)NCBICHM1_1
T2T-CHM13v2.01572,045,386 - 72,078,184 (-)NCBIT2T-CHM13v2.0
Stra6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,971,076 - 58,061,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,971,071 - 58,061,279 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38958,063,793 - 58,154,004 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,063,788 - 58,153,996 (+)Ensemblmm10GRCm38
MGSCv37957,976,895 - 58,001,804 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36957,927,486 - 57,952,090 (+)NCBIMGSCv36mm8
Celera955,363,368 - 55,388,212 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.63NCBI
Stra6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,580,662 - 3,602,600 (+)Ensembl
ChiLan1.0NW_0049554503,579,081 - 3,602,538 (+)NCBIChiLan1.0ChiLan1.0
STRA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,403,177 - 63,433,441 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11567,566,763 - 67,597,027 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,117,891 - 53,150,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11572,740,868 - 72,773,802 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1572,741,482 - 72,770,876 (-)EnsemblpanPan2panpan1.1
STRA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,331,834 - 37,359,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,331,832 - 37,353,529 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3037,267,455 - 37,295,072 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03037,538,888 - 37,566,524 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,538,924 - 37,560,014 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,491,016 - 37,518,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,516,933 - 37,544,523 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,772,499 - 37,800,122 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stra6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,376,111 - 115,490,544 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,224,859 - 33,245,030 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,224,174 - 33,245,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STRA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl759,318,011 - 59,347,266 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1759,317,930 - 59,347,274 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,936,184 - 63,965,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STRA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1269,275,317 - 9,311,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl269,278,303 - 9,311,475 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048132,311,962 - 132,346,794 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stra6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781389,481 - 413,728 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624781304,890 - 413,655 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Stra6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1852,011,401 - 52,030,850 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stra6
175 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:66
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000011074
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
AI059311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,556,456 - 58,556,665 (+)MAPPERmRatBN7.2
Rnor_6.0862,932,078 - 62,932,286NCBIRnor6.0
Rnor_5.0862,708,168 - 62,708,376UniSTSRnor5.0
RGSC_v3.4861,927,486 - 61,927,694UniSTSRGSC3.4
Celera858,020,303 - 58,020,511UniSTS
RH 3.4 Map8673.8UniSTS
Cytogenetic Map8q24UniSTS
BI284420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,568,272 - 58,568,449 (+)MAPPERmRatBN7.2
Rnor_6.0862,943,850 - 62,944,026NCBIRnor6.0
Rnor_5.0862,719,940 - 62,720,116UniSTSRnor5.0
RGSC_v3.4861,939,203 - 61,939,379UniSTSRGSC3.4
Celera858,032,131 - 58,032,307UniSTS
RH 3.4 Map8675.3UniSTS
Cytogenetic Map8q24UniSTS
Stra6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,568,687 - 58,568,798 (+)MAPPERmRatBN7.2
Rnor_6.0862,944,265 - 62,944,375NCBIRnor6.0
Rnor_5.0862,720,355 - 62,720,465UniSTSRnor5.0
RGSC_v3.4861,939,618 - 61,939,728UniSTSRGSC3.4
Celera858,032,546 - 58,032,656UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 61 147 60 59 28 88 28 6 308 176 4 130 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000011074   ⟹   ENSRNOP00000011074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl867,444,742 - 67,464,720 (+)Ensembl
mRatBN7.2 Ensembl858,549,736 - 58,568,860 (+)Ensembl
Rnor_6.0 Ensembl862,925,357 - 62,944,437 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090588   ⟹   ENSRNOP00000070968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl867,444,742 - 67,464,720 (+)Ensembl
mRatBN7.2 Ensembl858,549,736 - 58,568,860 (+)Ensembl
Rnor_6.0 Ensembl862,925,376 - 62,943,788 (+)Ensembl
RefSeq Acc Id: NM_001029924   ⟹   NP_001025095
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,444,757 - 67,464,719 (+)NCBI
mRatBN7.2858,548,899 - 58,568,861 (+)NCBI
Rnor_6.0862,925,364 - 62,944,438 (+)NCBI
Rnor_5.0862,701,454 - 62,720,528 (+)NCBI
RGSC_v3.4861,920,772 - 61,939,791 (+)RGD
Celera858,013,586 - 58,032,719 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001025095 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97373 (Get FASTA)   NCBI Sequence Viewer  
  EDL95664 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011074
  ENSRNOP00000011074.7
GenBank Protein Q4QR83 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001025095   ⟸   NM_001029924
- UniProtKB: Q4QR83 (UniProtKB/Swiss-Prot),   A0A8L2R3C2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070968   ⟸   ENSRNOT00000090588
Ensembl Acc Id: ENSRNOP00000011074   ⟸   ENSRNOT00000011074

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QR83-F1-model_v2 AlphaFold Q4QR83 1-670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307551 AgrOrtholog
BioCyc Gene G2FUF-30277 BioCyc
Ensembl Genes ENSRNOG00000008312 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011074 ENTREZGENE
  ENSRNOT00000011074.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7444462 IMAGE-MGC_LOAD
InterPro STRA6 UniProtKB/Swiss-Prot
KEGG Report rno:363071 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114408 IMAGE-MGC_LOAD
NCBI Gene 363071 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 180 UniProtKB/Swiss-Prot
  PTHR21444:SF16 UniProtKB/Swiss-Prot
Pfam RBP_receptor UniProtKB/Swiss-Prot
PhenoGen Stra6 PhenoGen
RatGTEx ENSRNOG00000008312 RatGTEx
UniProt A0A0H2UHG6_RAT UniProtKB/TrEMBL
  A0A8L2R3C2 ENTREZGENE, UniProtKB/TrEMBL
  A6J4Z2_RAT UniProtKB/TrEMBL
  Q4QR83 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Stra6  signaling receptor and transporter of retinol STRA6  Stra6  stimulated by retinoic acid 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-01 Stra6  stimulated by retinoic acid 6  Stra6  stimulated by retinoic acid gene 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Stra6  stimulated by retinoic acid gene 6  Stra6  stimulated by retinoic acid gene 6 homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Stra6  stimulated by retinoic acid gene 6 homolog (mouse)  RGD1307551  similar to retinoic acid-responsive protein; STRA6  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307551  similar to retinoic acid-responsive protein; STRA6  RGD1307551_predicted  similar to retinoic acid-responsive protein; STRA6 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307551_predicted  similar to retinoic acid-responsive protein; STRA6 (predicted)  LOC363071_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC363071_predicted  similar to retinoic acid-responsive protein; STRA6 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL