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Gene: Rpp38 (ribonuclease P/MRP subunit p38) Rattus norvegicus

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Symbol:

Rpp38

Name:

ribonuclease P/MRP subunit p38

RGD ID:

1307474

Description:

Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be located in nucleolus. Predicted to be part of multimeric ribonuclease P complex. Predicted to be active in fibrillar center. Orthologous to human RPP38 (ribonuclease P/MRP subunit p38); PARTICIPATES IN tRNA maturation pathway; ribosome biogenesis pathway; RNA transport pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC291317; MGC124666; ribonuclease P protein subunit p38; ribonuclease P/MRP 38 subunit; ribonuclease P/MRP 38 subunit (human); ribonuclease P/MRP 38kDa subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPP38 (ribonuclease P/MRP subunit p38)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rpp38 (ribonuclease P/MRP 38 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rpp38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RPP38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RPP38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rpp38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPP38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RPP38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rpp38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rpp38 (ribonuclease P/MRP subunit p38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RPP38 (ribonuclease P/MRP subunit p38)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rpp38 (ribonuclease P/MRP 38 subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rpp38 (ribonuclease P/MRP 38 subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rpp38	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	79,823,237 - 79,826,908 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	79,822,980 - 79,869,245 (+)	Ensembl				GRCr8
mRatBN7.2	17	74,914,066 - 74,917,742 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	74,908,932 - 74,927,431 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	78,380,911 - 78,384,455 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	82,216,290 - 82,219,834 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	76,264,235 - 76,267,779 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	78,915,450 - 78,919,144 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	78,915,604 - 78,919,143 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	80,556,274 - 80,560,521 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	86,033,450 - 86,036,990 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	74,293,601 - 74,297,141 (+)	NCBI		Celera
RGSC_v3.1	17	86,046,905 - 86,047,736 (+)	NCBI
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

melanoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxynon-2-enal (ISO)

alpha-phellandrene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

copper(II) sulfate (ISO)

Dibutyl phosphate (ISO)

dioxygen (EXP)

endosulfan (EXP)

ethanol (ISO)

fipronil (EXP)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

manganese(II) chloride (EXP)

paracetamol (EXP,ISO)

PCB138 (EXP)

perfluorooctane-1-sulfonic acid (ISO)

picoxystrobin (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

rotenone (EXP,ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

tRNA 5'-leader removal (IBA,IEA,ISO)

Cellular Component

fibrillar center (IBA)

multimeric ribonuclease P complex (IBA,IEA,ISO)

nucleolar ribonuclease P complex (IEA)

nucleolus (IEA,ISO)

ribonuclease MRP complex (IEA)

Molecular Function

protein binding (ISO)

ribonuclease P activity (IBA,IEA,ISO)

ribonuclease P RNA binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

RNA transport pathway (IEA)

tRNA maturation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects.	Lai LB, etal., FEBS Lett. 2010 Jan 21;584(2):287-96. doi: 10.1016/j.febslet.2009.11.048. Epub .
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:10444065	PMID:12477932	PMID:30454648

Genomics

Comparative Map Data

Rpp38
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	79,823,237 - 79,826,908 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	79,822,980 - 79,869,245 (+)	Ensembl				GRCr8
mRatBN7.2	17	74,914,066 - 74,917,742 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	74,908,932 - 74,927,431 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	78,380,911 - 78,384,455 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	82,216,290 - 82,219,834 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	76,264,235 - 76,267,779 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	78,915,450 - 78,919,144 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	78,915,604 - 78,919,143 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	80,556,274 - 80,560,521 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	86,033,450 - 86,036,990 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	74,293,601 - 74,297,141 (+)	NCBI		Celera
RGSC_v3.1	17	86,046,905 - 86,047,736 (+)	NCBI
Cytogenetic Map	17	q12.3	NCBI

RPP38
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	15,097,355 - 15,104,257 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	15,097,120 - 15,139,818 (+)	Ensembl			hg38	GRCh38
GRCh37	10	15,139,354 - 15,146,256 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	15,179,188 - 15,186,262 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	10	15,067,814 - 15,074,888 (+)	NCBI		Celera
Cytogenetic Map	10	p13	NCBI
HuRef	10	15,049,413 - 15,056,395 (+)	NCBI		HuRef
CHM1_1	10	15,139,292 - 15,146,368 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	15,111,088 - 15,118,231 (+)	NCBI		T2T-CHM13v2.0

Rpp38
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	3,328,305 - 3,334,023 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	3,329,986 - 3,333,680 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	3,326,548 - 3,332,986 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	3,328,949 - 3,332,643 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	3,246,221 - 3,249,900 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	3,246,221 - 3,249,863 (-)	NCBI		MGSCv36	mm8
Celera	2	3,280,688 - 3,284,367 (-)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	1.87	NCBI

Rpp38
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	19,358,765 - 19,360,973 (-)	Ensembl
ChiLan1.0	NW_004955429	19,358,765 - 19,360,973 (-)	NCBI	ChiLan1.0	ChiLan1.0

RPP38
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	27,937,238 - 27,944,415 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	27,942,564 - 27,949,741 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	15,413,026 - 15,420,170 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	15,694,410 - 15,701,569 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	15,700,027 - 15,703,046 (+)	Ensembl			panPan2	panpan1.1

RPP38
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	21,612,114 - 21,617,371 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	21,612,200 - 21,614,485 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	18,725,394 - 18,730,634 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	21,913,363 - 21,918,600 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	21,913,380 - 21,918,563 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	19,113,947 - 19,119,188 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	19,948,839 - 19,954,079 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	20,575,433 - 20,580,672 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rpp38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	16,149,771 - 16,153,543 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936574	5,651,758 - 5,657,119 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936574	5,648,696 - 5,653,030 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPP38
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	46,717,197 - 46,725,920 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	46,720,135 - 46,725,962 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	51,454,233 - 51,459,147 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPP38
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	15,073,265 - 15,080,322 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	15,079,383 - 15,080,231 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	20,617,027 - 20,624,053 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rpp38
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624805	453,703 - 460,430 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624805	456,432 - 460,906 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rpp38
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	109,988,409 - 109,988,854 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rpp38
92 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	44
Count of miRNA genes:	42
Interacting mature miRNAs:	44
Transcripts:	ENSRNOT00000057855
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	70613502	86062352	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63697147	82818564	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	64569820	86954580	Rat

Markers in Region

D17Got93

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	74,913,451 - 74,913,656 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	78,914,854 - 78,915,058	NCBI	Rnor6.0
Rnor_5.0	17	80,555,659 - 80,555,863	UniSTS	Rnor5.0
RGSC_v3.4	17	86,032,699 - 86,032,904	RGD	RGSC3.4
RGSC_v3.4	17	86,032,700 - 86,032,904	UniSTS	RGSC3.4
Celera	17	74,292,851 - 74,293,055	UniSTS
RGSC_v3.1	17	86,043,533 - 86,043,737	RGD
RH 3.4 Map	17	765.5	UniSTS
RH 3.4 Map	17	765.5	RGD
RH 2.0 Map	17	666.8	RGD
Cytogenetic Map	17	q12.3	UniSTS

RH127990

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	74,917,529 - 74,917,721 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	78,918,932 - 78,919,123	NCBI	Rnor6.0
Rnor_5.0	17	80,559,737 - 80,559,928	UniSTS	Rnor5.0
RGSC_v3.4	17	86,036,778 - 86,036,969	UniSTS	RGSC3.4
Celera	17	74,296,929 - 74,297,120	UniSTS
RH 3.4 Map	17	761.4	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

RH137116

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	79,827,048 - 79,827,230 (+)	Marker Load Pipeline
mRatBN7.2	17	74,917,882 - 74,918,064 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	78,919,285 - 78,919,466	NCBI	Rnor6.0
Rnor_5.0	17	80,560,090 - 80,560,271	UniSTS	Rnor5.0
RGSC_v3.4	17	86,037,131 - 86,037,312	UniSTS	RGSC3.4
Celera	17	74,297,282 - 74,297,463	UniSTS
RH 3.4 Map	17	761.3	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	85	59	6	349	185	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000057855 ⟹ ENSRNOP00000054664

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	78,915,604 - 78,919,143 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094577 ⟹ ENSRNOP00000080403

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	74,908,932 - 74,920,677 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097249 ⟹ ENSRNOP00000076703

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,143 - 79,831,501 (+)	Ensembl
mRatBN7.2 Ensembl	17	74,908,932 - 74,920,677 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104375 ⟹ ENSRNOP00000088393

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,143 - 79,830,813 (+)	Ensembl
mRatBN7.2 Ensembl	17	74,912,734 - 74,920,677 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113691 ⟹ ENSRNOP00000089727

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,130 - 79,827,822 (+)	Ensembl
mRatBN7.2 Ensembl	17	74,908,932 - 74,927,431 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133039 ⟹ ENSRNOP00000112622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,261 - 79,869,245 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133712 ⟹ ENSRNOP00000111340

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,368 - 79,826,907 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151742 ⟹ ENSRNOP00000104525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,822,980 - 79,850,642 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000152366 ⟹ ENSRNOP00000102450

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,121 - 79,862,627 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000162891 ⟹ ENSRNOP00000112286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,823,248 - 79,852,244 (+)	Ensembl

RefSeq Acc Id:

NM_001033063 ⟹ NP_001028235

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	79,823,368 - 79,826,908 (+)	NCBI
mRatBN7.2	17	74,914,202 - 74,917,742 (+)	NCBI
Rnor_6.0	17	78,915,604 - 78,919,144 (+)	NCBI
Rnor_5.0	17	80,556,274 - 80,560,521 (+)	NCBI
RGSC_v3.4	17	86,033,450 - 86,036,990 (+)	RGD
Celera	17	74,293,601 - 74,297,141 (+)	RGD

Sequence:

show sequence

CGCGCGCAGCAGGCACACGTGGAGCGGGCGCCGTGGTCCCCGGTGGTGGCGGAGTTGCCGCCGC
AGTGAATCGATCTGTCACGTGGTCTCCGCGGGGCGCTTCTGCACAGCATCTCTGTCCCGAGCGA
TACTGAACTTTAATACTCTTCTGGGATACCTCGCAGCCCGCTTCCTTCGGAAGGAATTCTTTTA
GAAAGCGGTTGTTACGGTCATTTCCTCCAGAGAGACTTCTTTTCCTGACCCTCTCAACTAAGGT
CGCTAACTGTCTGTTCCTCAAGGGTTTTCAAGATGGCTGCAGCTCCTCAGGCACCAAAGAGGGG
ATCTATTCGGAAGACTAGACCTCTGGTTGTAAAGACATCACTGAACAACCCCTATGTCATTTCC
TGGAGCAGCTTGGAGAGAGAAGACATGCACTTTATCCTACAGACGCTGGAGGACAAGTTTAAGT
CGATCGGACTTCAGAAAATTGAAGATAAGAAGAAAAGGAAAGCAAAGCAGAGAGGCGGGCTTGT
TGGGACCAGTGAGGAGCCGCAAGAGCCCCATGGGGGTGTGCGGGTGTCAGGGTGGACCCCTGTG
CACACCAGGAAGCAGCTGGCCATCGGGGTTAATGAGGTCACCCGGGCTCTGGAGAGGAATGAAC
TGCTCCTGGTTCTAGTGTGTAAGTCAGTCAAGCCCGCCATCATCACCTCACACTTGATTCAGCT
GAGTTTAAGCAGAACCGTTCCTGCCTGTCAGGTACCTCAGCTCAGCGAGAGAATTGCTCCAGTC
ATTGGCTTAAAATGTGTGCTAGCCTTGGGCTTCAGAAAGAACACCATGGACTTTGCTGATGAAG
TAGAAGCCATCATTCCCAGGGTGCCCAGCTTAAATGTGCCCTGGCTTCCAGACGGAACCCAAGG
TCTCACAGACAGTTTGGAGACGGAGTCTTTGGAAAGCCAGGACAAAGAGGTTTTGGACACTTCA
TTTGATGACCTTACAAGACTTAAGAGGAAGCTTGCTGAAGGTGGACAAGCTCCAGCTGCAACAC
TACAACCCCTGAAAATAAAGAGACTCGTTCCTAACCCGAGTAAGATAAGGAAACCACCCAAGAG
TAAAAACCCCTCAAAGTAGTTCTGTGTGACCCTGCCACTTCGTGCAAGTATGTGGTCTAAATAA
GCGTTGACACAAATAAAGCCAGGTGTGCTGCATATGCTCTTAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006254268 ⟹ XP_006254330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	79,823,237 - 79,826,898 (+)	NCBI
mRatBN7.2	17	74,914,066 - 74,917,742 (+)	NCBI
Rnor_6.0	17	78,915,450 - 78,919,144 (+)	NCBI
Rnor_5.0	17	80,556,274 - 80,560,521 (+)	NCBI

Sequence:

show sequence

GACCGTACGCCTGCGCAGTGCTGCTCCAGAGCTCGGTCCCAGGCTGAGGGATTTTACGCAGGGA
CCACTCTCGGTAGCCAAACTACGGCTGACGTTCCTTACTAGGAGTGACGTAATGCAGAGCGGCA
GGTAGGCGGAGCTCGTGTTCTGCGCACGCGCGCAGCAGGCGCACGTGGAGCGGGCGCCGTGGTC
CCCGGTGGTGGCGGAGTTGCCGCCGCAGTGAATCGATCTGTCACGTGGTCTCCGCGGGGCGCTT
CTGCACAGGGTTTTCAAGATGGCTGCAGCTCCTCAGGCACCAAAGAGGGGATCTATTCGGAAGA
CTAGACCTCTGGTTGTAAAGACATCACTGAACAACCCCTATGTCATTTCCTGGAGCAGCTTGGA
GAGAGAAGACATGCACTTTATCCTACAGACGCTGGAGGACAAGTTTAAGTCGATCGGACTTCAG
AAAATTGAAGATAAGAAGAAAAGGAAAGCAAAGCAGAGAGGCGGGCTTGTTGGGACCAGTGAGG
AGCCGCAAGAGCCCCATGGGGGTGTGCGGGTGTCAGGGTGGACCCCTGTGCACACCAGGAAGCA
GCTGGCCATCGGGGTTAATGAGGTCACCCGGGCTCTGGAGAGGAATGAACTGCTCCTGGTTCTA
GTGTGTAAGTCAGTCAAGCCCGCCATCATCACCTCACACTTGATTCAGCTGAGTTTAAGCAGAA
CCGTTCCTGCCTGTCAGGTACCTCAGCTCAGCGAGAGAATTGCTCCAGTCATTGGCTTAAAATG
TGTGCTAGCCTTGGGCTTCAGAAAGAACACCATGGACTTTGCTGATGAAGTAGAAGCCATCATT
CCCAGGGTGCCCAGCTTAAATGTGCCCTGGCTTCCAGACGGAACCCAAGGTCTCACAGACAGTT
TGGAGACGGAGTCTTTGGAAAGCCAGGACAAAGAGGTTTTGGACACTTCATTTGATGACCTTAC
AAGACTTAAGAGGAAGCTTGCTGAAGGTGGACAAGCTCCAGCTGCAACACTACAACCCCTGAAA
ATAAAGAGACTCGTTCCTAACCCGAGTAAGATAAGGAAACCACCCAAGAGTAAAAACCCCTCAA
AGTAGTTCTGTGTGACCCTGCCACTTCGTGCAAGTATGTGGTCTAAATAAGCGTTGACACAAAT
AAAGCCAGGTGTGCTGCATATGCTCTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001028235	(Get FASTA)	NCBI Sequence Viewer
	XP_006254330	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00624	(Get FASTA)	NCBI Sequence Viewer
	EDL78701	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076703.1
	ENSRNOP00000088393.1
	ENSRNOP00000089727.2
	ENSRNOP00000102450.1
	ENSRNOP00000104525.1
	ENSRNOP00000111340
	ENSRNOP00000111340.1
	ENSRNOP00000112286.1
	ENSRNOP00000112622.1

RefSeq Acc Id:

NP_001028235 ⟸ NM_001033063

- UniProtKB:

Q497C2 (UniProtKB/TrEMBL), A6JM24 (UniProtKB/TrEMBL), A0A8I5YBF8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAAPQAPKRGSIRKTRPLVVKTSLNNPYVISWSSLEREDMHFILQTLEDKFKSIGLQKIEDKK
KRKAKQRGGLVGTSEEPQEPHGGVRVSGWTPVHTRKQLAIGVNEVTRALERNELLLVLVCKSVK
PAIITSHLIQLSLSRTVPACQVPQLSERIAPVIGLKCVLALGFRKNTMDFADEVEAIIPRVPSL
NVPWLPDGTQGLTDSLETESLESQDKEVLDTSFDDLTRLKRKLAEGGQAPAATLQPLKIKRLVP
NPSKIRKPPKSKNPSK

hide sequence

RefSeq Acc Id:	XP_006254330 ⟸ XM_006254268
- Peptide Label:	isoform X1
- UniProtKB:	Q497C2 (UniProtKB/TrEMBL), A6JM24 (UniProtKB/TrEMBL), A0A8I5YBF8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAPQAPKRGSIRKTRPLVVKTSLNNPYVISWSSLEREDMHFILQTLEDKFKSIGLQKIEDKK KRKAKQRGGLVGTSEEPQEPHGGVRVSGWTPVHTRKQLAIGVNEVTRALERNELLLVLVCKSVK PAIITSHLIQLSLSRTVPACQVPQLSERIAPVIGLKCVLALGFRKNTMDFADEVEAIIPRVPSL NVPWLPDGTQGLTDSLETESLESQDKEVLDTSFDDLTRLKRKLAEGGQAPAATLQPLKIKRLVP NPSKIRKPPKSKNPSK hide sequence

Ensembl Acc Id:

ENSRNOP00000054664 ⟸ ENSRNOT00000057855

Ensembl Acc Id:

ENSRNOP00000089727 ⟸ ENSRNOT00000113691

Ensembl Acc Id:

ENSRNOP00000080403 ⟸ ENSRNOT00000094577

Ensembl Acc Id:

ENSRNOP00000076703 ⟸ ENSRNOT00000097249

Ensembl Acc Id:

ENSRNOP00000088393 ⟸ ENSRNOT00000104375

Ensembl Acc Id:

ENSRNOP00000102450 ⟸ ENSRNOT00000152366

Ensembl Acc Id:

ENSRNOP00000112286 ⟸ ENSRNOT00000162891

Ensembl Acc Id:

ENSRNOP00000104525 ⟸ ENSRNOT00000151742

Ensembl Acc Id:

ENSRNOP00000112622 ⟸ ENSRNOT00000133039

Ensembl Acc Id:

ENSRNOP00000111340 ⟸ ENSRNOT00000133712

Protein Domains

Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q497C2-F1-model_v2	AlphaFold	Q497C2	1-272	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700587

Promoter ID:

EPDNEW_R11111

Type:

initiation region

Name:

Rpp38_1

Description:

ribonuclease P/MRP subunit p38

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	78,915,592 - 78,915,652	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307474	AgrOrtholog
BioCyc Gene	G2FUF-8640	BioCyc
Ensembl Genes	ENSRNOG00000038025	Ensembl
	ENSRNOG00000063181	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000097249.2	UniProtKB/TrEMBL
	ENSRNOT00000104375.2	UniProtKB/TrEMBL
	ENSRNOT00000113691.2	UniProtKB/TrEMBL
	ENSRNOT00000133039.1	UniProtKB/TrEMBL
	ENSRNOT00000133712	ENTREZGENE
	ENSRNOT00000133712.1	UniProtKB/TrEMBL
	ENSRNOT00000151742.1	UniProtKB/TrEMBL
	ENSRNOT00000152366.1	UniProtKB/TrEMBL
	ENSRNOT00000162891.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1330.30	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7929545	IMAGE-MGC_LOAD
InterPro	L30e-like	UniProtKB/TrEMBL
	Ribosomal_L7Ae/L30e/S12e/Gad45	UniProtKB/TrEMBL
	Rpp38	UniProtKB/TrEMBL
KEGG Report	rno:291317	UniProtKB/TrEMBL
MGC_CLONE	MGC:124666	IMAGE-MGC_LOAD
NCBI Gene	291317	ENTREZGENE
PANTHER	PTHR46948	UniProtKB/TrEMBL
	RIBONUCLEASE P PROTEIN SUBUNIT P38	UniProtKB/TrEMBL
Pfam	Ribosomal_L7Ae	UniProtKB/TrEMBL
PhenoGen	Rpp38	PhenoGen
RatGTEx	ENSRNOG00000038025	RatGTEx
	ENSRNOG00000063181	RatGTEx
Superfamily-SCOP	SSF55315	UniProtKB/TrEMBL
UniProt	A0A8I5YBF8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ACC6_RAT	UniProtKB/TrEMBL
	A6JM24	ENTREZGENE
	Q497C2	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A6JM24	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-27	Rpp38	ribonuclease P/MRP subunit p38	Rpp38	ribonuclease P/MRP 38 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-02-04	Rpp38	ribonuclease P/MRP 38 subunit	Rpp38	ribonuclease P/MRP 38 subunit (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Rpp38	ribonuclease P/MRP 38 subunit (human)		ribonuclease P/MRP 38kDa subunit	Name updated	1299863	APPROVED
2005-12-06	Rpp38	ribonuclease P/MRP 38kDa subunit	Rpp38_predicted	ribonuclease P/MRP 38kDa subunit (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rpp38_predicted	ribonuclease P/MRP 38kDa subunit (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)