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Gene: Mthfs (methenyltetrahydrofolate synthetase) Rattus norvegicus

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Symbol:

Mthfs

Name:

methenyltetrahydrofolate synthetase

RGD ID:

1306876

Description:

Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in dicarboxylic acid metabolic process; folic acid-containing compound biosynthetic process; and tetrahydrofolate interconversion. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

5, 10-methenyltetrahydrofolate synthetase; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; LOC300886; MGC95139

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MTHFS (methenyltetrahydrofolate synthetase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Mthfs (5, 10-methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mthfs (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MTHFS (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MTHFS (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mthfs (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC102167410 (5-formyltetrahydrofolate cyclo-ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MTHFS (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mthfs (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mthfs (methenyltetrahydrofolate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ST20-MTHFS (ST20-MTHFS readthrough)	HGNC	EggNOG
Alliance orthologs ³
Homo sapiens (human):	MTHFS (methenyltetrahydrofolate synthetase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mthfs (5, 10-methenyltetrahydrofolate synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mthfsl (5, 10-methenyltetrahydrofolate synthetase-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mthfs (5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FAU1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	FAU1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mthfs	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Mthfs	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y106G6E.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y106G6E.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mthfs	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mthfs	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	98,609,410 - 98,681,901 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	98,609,399 - 98,752,036 (+)	Ensembl				GRCr8
mRatBN7.2	8	89,729,498 - 89,801,998 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	89,729,508 - 89,799,089 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	95,394,939 - 95,444,440 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	93,594,149 - 93,643,652 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	91,457,900 - 91,507,365 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	96,564,877 - 96,614,386 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	96,564,877 - 96,614,348 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	96,071,796 - 96,121,086 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	94,058,605 - 94,108,277 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	89,291,095 - 89,340,497 (+)	NCBI		Celera
RGSC_v3.1	8	94,078,059 - 94,127,729 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cleft lip (ISO)

cleft palate (ISO)

colorectal cancer (ISO)

Neurodevelopmental Disorder with Microcephaly, Epilepsy, and Hypomyelination (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

4-hydroxynon-2-enal (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

belinostat (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

fenthion (ISO)

finasteride (EXP)

furan (EXP)

gentamycin (EXP)

glafenine (EXP)

irinotecan (ISO)

leflunomide (EXP)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

N-acetyldopamine (ISO)

nefazodone (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

Soman (EXP)

temozolomide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

folic acid catabolic process (ISO)

glutamate metabolic process (ISO)

tetrahydrofolate interconversion (ISO)

tetrahydrofolate metabolic process (ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (ISO)

mitochondrial matrix (ISO)

mitochondrion (ISO)

Molecular Function

5-formyltetrahydrofolate cyclo-ligase activity (IEA,ISO)

ATP binding (IEA,ISO)

folic acid binding (IEA,ISO)

ligase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

folate mediated one-carbon metabolic pathway (IEA)

folate metabolic pathway (ISO)

hereditary folate malabsorption pathway (ISO)

methotrexate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:7766710	PMID:12477932	PMID:12764149	PMID:18614015	PMID:19738041	PMID:34800366

Genomics

Comparative Map Data

Mthfs
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	98,609,410 - 98,681,901 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	98,609,399 - 98,752,036 (+)	Ensembl				GRCr8
mRatBN7.2	8	89,729,498 - 89,801,998 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	89,729,508 - 89,799,089 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	95,394,939 - 95,444,440 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	93,594,149 - 93,643,652 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	91,457,900 - 91,507,365 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	96,564,877 - 96,614,386 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	96,564,877 - 96,614,348 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	96,071,796 - 96,121,086 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	94,058,605 - 94,108,277 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	89,291,095 - 89,340,497 (+)	NCBI		Celera
RGSC_v3.1	8	94,078,059 - 94,127,729 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

MTHFS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	79,843,547 - 79,897,285 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	79,833,585 - 79,897,379 (-)	Ensembl			hg38	GRCh38
GRCh37	15	80,135,889 - 80,189,627 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	77,924,373 - 77,976,425 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	77,924,374 - 77,976,395	NCBI
Celera	15	57,073,628 - 57,125,676 (-)	NCBI		Celera
Cytogenetic Map	15	q25.1	NCBI
HuRef	15	56,894,007 - 56,947,724 (-)	NCBI		HuRef
CHM1_1	15	80,252,880 - 80,306,583 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	77,706,557 - 77,760,238 (-)	NCBI		T2T-CHM13v2.0

Mthfs
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	89,093,243 - 89,122,278 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	89,092,729 - 89,259,766 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	89,211,190 - 89,240,225 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	89,210,676 - 89,377,713 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	89,106,028 - 89,135,063 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	89,009,083 - 89,038,118 (+)	NCBI		MGSCv36	mm8
Celera	9	88,839,126 - 88,843,217 (+)	NCBI		Celera
Celera	9	87,292,813 - 87,293,205 (+)	NCBI		Celera
Cytogenetic Map	9	E3.1	NCBI
cM Map	9	47.24	NCBI

Mthfs
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955533	720,353 - 756,893 (-)	Ensembl
ChiLan1.0	NW_004955533	720,255 - 756,893 (-)	NCBI	ChiLan1.0	ChiLan1.0

MTHFS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	69,078,201 - 69,150,121 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	73,240,652 - 73,314,535 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	58,810,966 - 58,864,831 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	77,770,216 - 77,821,811 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	77,770,216 - 77,822,206 (-)	Ensembl			panPan2	panpan1.1

MTHFS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	57,480,935 - 57,514,836 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	60,139,116 - 60,173,501 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	57,913,790 - 57,950,014 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	57,913,875 - 57,950,438 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	57,413,049 - 57,447,505 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	57,620,059 - 57,654,466 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	57,967,073 - 58,003,248 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mthfs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	119,976,748 - 120,116,548 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	37,902,554 - 37,964,812 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	37,910,856 - 37,964,655 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC102167410
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	48,717,851 - 48,873,455 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	48,717,518 - 48,873,492 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	54,276,934 - 54,313,887 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MTHFS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	3,492,837 - 3,567,394 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	3,514,899 - 3,568,958 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	138,304,556 - 138,376,663 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mthfs
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624941	856,196 - 894,057 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mthfs
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	82,104,544 - 82,144,878 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mthfs
532 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	262
Count of miRNA genes:	158
Interacting mature miRNAs:	203
Transcripts:	ENSRNOT00000017879
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	97492344	116428905	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

RH127353

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	89,778,623 - 89,778,817 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	96,613,972 - 96,614,165	NCBI	Rnor6.0
Rnor_5.0	8	96,120,707 - 96,120,900	UniSTS	Rnor5.0
RGSC_v3.4	8	94,107,898 - 94,108,091	UniSTS	RGSC3.4
Celera	8	89,340,118 - 89,340,311	UniSTS
RH 3.4 Map	8	1011.1	UniSTS
Cytogenetic Map	8	q31	UniSTS

AI119695

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	89,776,717 - 89,776,828 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	96,612,066 - 96,612,176	NCBI	Rnor6.0
Rnor_5.0	8	96,118,801 - 96,118,911	UniSTS	Rnor5.0
RGSC_v3.4	8	94,105,992 - 94,106,102	UniSTS	RGSC3.4
Celera	8	89,338,212 - 89,338,322	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH133023

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	89,776,715 - 89,776,897 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	96,612,064 - 96,612,245	NCBI	Rnor6.0
Rnor_5.0	8	96,118,799 - 96,118,980	UniSTS	Rnor5.0
RGSC_v3.4	8	94,105,990 - 94,106,171	UniSTS	RGSC3.4
Celera	8	89,338,210 - 89,338,391	UniSTS
RH 3.4 Map	8	1013.1	UniSTS
Cytogenetic Map	8	q31	UniSTS

AW531027

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	89,729,089 - 89,729,242 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	96,564,441 - 96,564,593	NCBI	Rnor6.0
Rnor_5.0	8	96,071,394 - 96,071,546	UniSTS	Rnor5.0
RGSC_v3.4	8	94,058,158 - 94,058,310	UniSTS	RGSC3.4
Celera	8	89,290,649 - 89,290,801	UniSTS
RH 3.4 Map	8	1014.8	UniSTS
Cytogenetic Map	8	q31	UniSTS

Mthfs

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	89,776,628 - 89,776,693 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	96,611,977 - 96,612,041	NCBI	Rnor6.0
Rnor_5.0	8	96,118,712 - 96,118,776	UniSTS	Rnor5.0
RGSC_v3.4	8	94,105,903 - 94,105,967	UniSTS	RGSC3.4
Celera	8	89,338,123 - 89,338,187	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017879 ⟹ ENSRNOP00000017879

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	98,609,419 - 98,658,889 (+)	Ensembl
mRatBN7.2 Ensembl	8	89,729,508 - 89,779,036 (+)	Ensembl
Rnor_6.0 Ensembl	8	96,564,877 - 96,614,348 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113160 ⟹ ENSRNOP00000092187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	98,609,399 - 98,752,036 (+)	Ensembl
mRatBN7.2 Ensembl	8	89,729,508 - 89,799,089 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000147595 ⟹ ENSRNOP00000110178

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	98,609,399 - 98,680,824 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155987 ⟹ ENSRNOP00000103325

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	98,609,399 - 98,658,934 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161322 ⟹ ENSRNOP00000108859

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	98,609,399 - 98,731,481 (+)	Ensembl

RefSeq Acc Id:

NM_001009349 ⟹ NP_001009349

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	98,609,419 - 98,658,894 (+)	NCBI
mRatBN7.2	8	89,729,528 - 89,779,003 (+)	NCBI
Rnor_6.0	8	96,564,877 - 96,614,351 (+)	NCBI
Rnor_5.0	8	96,071,796 - 96,121,086 (+)	NCBI
RGSC_v3.4	8	94,058,605 - 94,108,277 (+)	RGD
Celera	8	89,291,095 - 89,340,497 (+)	RGD

Sequence:

show sequence

GAGGAAATGGCGGCGGTCACCGTAAACAGCGCCAAGCGGGGCCTGCGGGCCGAGCTGAAGCAGC
GCTTGCGAGCTTTGGGCGCCGAGGAACGGCTGCGCCAGTCTCACCTCCTCACACAGAAGGTGAT
TGCCCACAGTCAGTATCAAAATTCCAAAAGAATTTCCATCTTTCTGAGCATGCAAGATGAAATT
GAGACGGAAGAAATCATCAAGGACATTTTCAAACAAGGCAAAATCTGCTTCATCCCTCGGTACC
AGTTTCACAGCAATCACATGGACATGGTGAGGCTAACAGCACCTGAAGAAGTTGCTTTACTTCC
CAAGACATCTTGGAATATTCATCAGCCTGGTGAGGGAGATGTTCGGGAGGAGGCCTTATCCACT
GGTGGACTTGACCTCATCTTCCTTCCTGGCCTCGGGTTTGACAAAGATGGCAACCGGCTGGGTC
GGGGCAAGGGGTACTATGACACCTACCTGAAGCGCTGTGTACAGCATCAGAAAGTGAAGCCCTA
CACCTTGGCTTTGGCCTTTAGAGAGCAGATCTGTCCACAGATCCCAGTGGATGAGCACGACATG
AAGGTAGATGAAGTCCTTTACGAAGACTCCCCAACATCTTAAATTACACCACGACGACCACACT
TACTGCTTTGTACTGGCGTAAAGAAAATATGTATATTTTTCTCTTGTCACAAATGAATCAAAAT
GACACATTAAAGTGAATATGGATTGTCATTTTTAGTGTAAATATAAAATAATATAAAATCTTTT
TTTAGAAATCAATAGAAATGTTACTATTAGAATATTAATGCAAATGGAGTGGAAACTGCATGGT
TTTCAGCTTAGCTTTCTGGTGTTAAGATGTTACATTGACCTTTCTGTCTCTAGTTTAAATTAAG
TATTTATGAGTATTAGAGAAAGATAGAAATTGGATGTGAGTGAAGACACTGTTTTTTAATATCC
AGTCATAGGCCTGATTGCTCTGGCATATGGAGACTCAGCTGTTATTAATTGGTTTGGCAGTACT
TGGTATGGATAAAATATTCCCCAAGACTATTATTATACCACTTGATATATCATGGCTTCATTTA
CTCACCTTGAAGTTTTGTGTGTGACATTTTATAGCTTCATGTGGTGAGTAGATGGGAATCTTTT
GTGGTTTACATACTTTGATTCAGTTGATTGGTCTCTGGCCTTAGGACTTACATAAGGAATCATT
TCTGTTAAGTCGTGGGTTCCACTTGGAATGGAAGCTGCCCTGGATTGGACATTGCCAGATGGCC
TCACAGTTGGGAGAGGTACTTTTGTTGAGGGGAAAGATTTGGTTATCACAAGACACTCAGGGGT
CTTCCTGGACATGACTGCTTGCTTGGTTCCACCTGCAGCCTGTCACTAGCTCCTGCTGGCATTG
CCTCTGGGATGCCGTCTACATCTGCTCTCTCCTTCCTGTCTTCCTGCTCCCATTTTCTTCAGCT
CTCAGCATTTCTCAGCTCAAGTAGGCAGTCTCCATGCTCAGCTTCTTTTGCCTCCAATTTATTT
CAGGGATGATCTGGTAAGATATAAATCTAGTGTGGACACTCTGCATCAAAGTATTTTGGAGACA
TACATCTTAACAAGTAGATGCCTTCCCCTGTAGAAGAAATCCCTTGTAAGCCCCTCCCTCTTCT
GTCGTCTCTTCCCTCTCCCCCGTATGTCTTTCTGTGCATGCTGTAAGCGCCACAGGCTCTCTGT
CCAGTGCACGCTGCTTTCCTGCATCTCAGTGCTGGCTCCTGTATCTTCAGGACGCTGCCCTTGC
TTTGTTTCTCCAGGACGTGTTCCATGGCTCCCCTCCTGCCAGTTCTAGATCCTCCTTCCCTTGC
TGTGGCCATTGCCCATTTATCACATCATCCTGCAGAGCAGTTACTAGTGTCCATGTCTGTCCCT
TCATGAGGCTGTACGTTTGAAAGAACTTCTTGTCTTTGGTAGTTGACTGATGGAGAGTATTCGA
TAACATTTTTTAAAATCATAAACAGAATATATGTATAATTATTTCATTGTAAACACAGATCTAC
TATTTTTTTGCATAATAATATGCAGTTTGGTATTTCGTGTGCAAAAAGTAAATGTATATATATT
CTTTAAAAATGCCAATTCAGGTAAGAGTGGATCTGTACAATTTAGAATATGCAATGAGAAATGA
GAGAGAAATGGAATTACTATGAGCTGTGATGGCATTATATACTGATTAATCTTATTCAGTGTTA
CTTCAGTGGCAAGGATAAGGTAAATGTTATTATAACTGACATGACTGTTGGGGTGAAATAGTTA
AATCATAGAATTACTGAGCTGTTGCAGGTCGAGAAAGCTTTGCTTTCTTACCTATGTTGTTCTT
GTATTACAGAGAGCATGCAAGAGCAGGTATAGTTAGAACAGACAAATGACTTCCAGAACCTGCT
GGCCGCTTAGGATTCAGAACAATCAAAAGCCACATGATCTCTTTCTATAATGGCTAATCTTGTA
AACTTGATGGGGTTTAGAATTACCATAGAAACACGTCCCTGGGTATGTTTATGAGGGTGTTTCC
TGAAAGGTTTAATCAAACAGTGAAGACTTAATATGTCATAACTGTGTCTCATGGGGTGGGGCTG
AATGAGAAGGGGAAAATGAGTTGAGCACTAATGATCATTGATCTCTGCTTCCTGACTGTGGATG
CCTCTGGATGCTATAATGGATTATATATTGCCAAAATAAATAACTTCCTTAAGTTGTTTCTTAT
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039081167 ⟹ XP_038937095

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	98,609,410 - 98,681,901 (+)	NCBI
mRatBN7.2	8	89,729,498 - 89,801,998 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009349	(Get FASTA)	NCBI Sequence Viewer
	XP_038937095	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87144	(Get FASTA)	NCBI Sequence Viewer
	EDL77575	(Get FASTA)	NCBI Sequence Viewer
	EDL77576	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017879
	ENSRNOP00000017879.4
	ENSRNOP00000092187.2
	ENSRNOP00000103325.1
	ENSRNOP00000108859.1
	ENSRNOP00000110178.1

RefSeq Acc Id:

NP_001009349 ⟸ NM_001009349

- UniProtKB:

Q5M9F6 (UniProtKB/TrEMBL), A6I201 (UniProtKB/TrEMBL), F7FDD4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVTVNSAKRGLRAELKQRLRALGAEERLRQSHLLTQKVIAHSQYQNSKRISIFLSMQDEIET
EEIIKDIFKQGKICFIPRYQFHSNHMDMVRLTAPEEVALLPKTSWNIHQPGEGDVREEALSTGG
LDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRCVQHQKVKPYTLALAFREQICPQIPVDEHDMKV
DEVLYEDSPTS

hide sequence

Ensembl Acc Id:

ENSRNOP00000017879 ⟸ ENSRNOT00000017879

RefSeq Acc Id:	XP_038937095 ⟸ XM_039081167
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000092187 ⟸ ENSRNOT00000113160

Ensembl Acc Id:

ENSRNOP00000108859 ⟸ ENSRNOT00000161322

Ensembl Acc Id:

ENSRNOP00000110178 ⟸ ENSRNOT00000147595

Ensembl Acc Id:

ENSRNOP00000103325 ⟸ ENSRNOT00000155987

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5M9F6-F1-model_v2	AlphaFold	Q5M9F6	1-203	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696173

Promoter ID:

EPDNEW_R6698

Type:

multiple initiation site

Name:

Mthfs_1

Description:

methenyltetrahydrofolate synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	96,564,857 - 96,564,917	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306876	AgrOrtholog
BioCyc Gene	G2FUF-29591	BioCyc
BioCyc Pathway	1CMET2-PWY [folate transformations III (E. coli)]	BioCyc
BioCyc Pathway Image	1CMET2-PWY	BioCyc
Ensembl Genes	ENSRNOG00000013229	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017879	ENTREZGENE
	ENSRNOT00000017879.8	UniProtKB/TrEMBL
	ENSRNOT00000113160.2	UniProtKB/TrEMBL
	ENSRNOT00000147595.1	UniProtKB/TrEMBL
	ENSRNOT00000155987.1	UniProtKB/TrEMBL
	ENSRNOT00000161322.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10420	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7128624	IMAGE-MGC_LOAD
InterPro	FTHF_cligase	UniProtKB/TrEMBL
	FTHF_cligase-like_sf	UniProtKB/TrEMBL
	NagB/RpiA_transferase-like	UniProtKB/TrEMBL
KEGG Report	rno:300886	UniProtKB/TrEMBL
MGC_CLONE	MGC:95139	IMAGE-MGC_LOAD
NCBI Gene	300886	ENTREZGENE
PANTHER	ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE	UniProtKB/TrEMBL
	PTHR23407:SF1	UniProtKB/TrEMBL
Pfam	5-FTHF_cyc-lig	UniProtKB/TrEMBL
PharmGKB	MTHFS	RGD
PhenoGen	Mthfs	PhenoGen
PIRSF	FTHF_cligase	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013229	RatGTEx
Superfamily-SCOP	SSF100950	UniProtKB/TrEMBL
UniProt	A0A8I6AG23_RAT	UniProtKB/TrEMBL
	A0ABK0LII1_RAT	UniProtKB/TrEMBL
	A0ABK0LXC0_RAT	UniProtKB/TrEMBL
	A0ABK0M1I5_RAT	UniProtKB/TrEMBL
	A6I201	ENTREZGENE, UniProtKB/TrEMBL
	A6I202_RAT	UniProtKB/TrEMBL
	F7FDD4	ENTREZGENE, UniProtKB/TrEMBL
	Q5M9F6	ENTREZGENE
UniProt Secondary	Q5M9F6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-02-01	Mthfs	methenyltetrahydrofolate synthetase	Mthfs	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-08-29	Mthfs	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	Mthfs	5, 10-methenyltetrahydrofolate synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Mthfs	5, 10-methenyltetrahydrofolate synthetase	Mthfs	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Mthfs	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	Mthfs_predicted	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Mthfs_predicted	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways