Isg20 (interferon stimulated exonuclease gene 20) - Rat Genome Database

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Gene: Isg20 (interferon stimulated exonuclease gene 20) Rattus norvegicus
Analyze
Symbol: Isg20
Name: interferon stimulated exonuclease gene 20
RGD ID: 1306407
Description: Predicted to enable 3'-5' exonuclease activity and RNA binding activity. Predicted to be involved in several processes, including defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be active in nucleus. Orthologous to human ISG20 (interferon stimulated exonuclease gene 20); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon stimulated exonuclease; interferon stimulated exonuclease 20; interferon stimulated gene 20kDa; interferon-stimulated gene 20 kDa protein; interferon-stimulated protein; LOC293052; MGC105645
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,234,729 - 142,246,403 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1142,236,137 - 142,246,401 (+)EnsemblGRCr8
mRatBN7.21132,829,303 - 132,837,027 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,815,123 - 132,837,027 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1140,743,579 - 140,749,921 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,913,000 - 147,919,354 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,830,687 - 140,837,047 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,602,553 - 140,608,892 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,601,791 - 140,608,946 (+)Ensemblrn6Rnor6.0
Rnor_5.01141,576,507 - 141,582,790 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41134,631,524 - 134,637,868 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1124,899,911 - 124,905,952 (+)NCBICelera
RGSC_v3.11134,709,866 - 134,716,209 (+)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calyculin A  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diiodine  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
entinostat  (ISO)
etoposide  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
glutathione  (EXP)
Heliotrine  (ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
pyrogallol  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Cajal body  (IEA,ISO)
cytoplasm  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
PML body  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9235947   PMID:11401564   PMID:12477932   PMID:12594219   PMID:16514659   PMID:21036379  


Genomics

Comparative Map Data
Isg20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,234,729 - 142,246,403 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1142,236,137 - 142,246,401 (+)EnsemblGRCr8
mRatBN7.21132,829,303 - 132,837,027 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,815,123 - 132,837,027 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1140,743,579 - 140,749,921 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,913,000 - 147,919,354 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,830,687 - 140,837,047 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,602,553 - 140,608,892 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,601,791 - 140,608,946 (+)Ensemblrn6Rnor6.0
Rnor_5.01141,576,507 - 141,582,790 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41134,631,524 - 134,637,868 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1124,899,911 - 124,905,952 (+)NCBICelera
RGSC_v3.11134,709,866 - 134,716,209 (+)NCBI
Cytogenetic Map1q31NCBI
ISG20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381588,635,632 - 88,656,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1588,635,618 - 88,656,483 (+)Ensemblhg38GRCh38
GRCh371589,178,863 - 89,199,714 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,983,043 - 86,999,883 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341586,983,042 - 86,999,883NCBI
Celera1565,582,927 - 65,599,957 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,293,925 - 65,311,076 (+)NCBIHuRef
CHM1_11589,023,678 - 89,040,394 (+)NCBICHM1_1
T2T-CHM13v2.01586,390,338 - 86,411,119 (+)NCBIT2T-CHM13v2.0
Isg20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,561,136 - 78,570,144 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl778,563,172 - 78,570,144 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38778,913,396 - 78,920,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,913,424 - 78,920,396 (+)Ensemblmm10GRCm38
MGSCv37786,058,651 - 86,065,282 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36778,787,331 - 78,793,877 (+)NCBIMGSCv36mm8
Celera776,316,272 - 76,322,917 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.84NCBI
Isg20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,311,499 - 16,321,102 (-)Ensembl
ChiLan1.0NW_00495541616,305,534 - 16,321,596 (-)NCBIChiLan1.0ChiLan1.0
ISG20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,177,670 - 78,200,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,886,372 - 81,905,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01567,328,334 - 67,345,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11586,533,468 - 86,553,868 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,536,647 - 86,553,751 (+)EnsemblpanPan2panpan1.1
ISG20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,822,642 - 51,833,665 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,822,888 - 51,833,659 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha354,459,186 - 54,470,205 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0352,242,225 - 52,253,245 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,242,466 - 52,253,239 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,765,000 - 51,776,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,975,188 - 51,986,201 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,314,197 - 52,325,226 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Isg20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,699,172 - 131,717,763 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648314,617,384 - 14,635,331 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648314,616,796 - 14,635,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISG20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,183,599 - 191,195,475 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11191,155,853 - 191,195,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,616,902 - 212,628,301 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISG20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,178,118 - 7,195,460 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,178,769 - 7,196,387 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605939,651,841 - 39,669,260 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isg20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476815,949,470 - 15,960,653 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476815,949,591 - 15,958,816 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Isg20
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12121,332,660 - 121,347,642 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Isg20
112 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:15
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000024826
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760602142582180Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
RH130914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,836,710 - 132,836,921 (+)MAPPERmRatBN7.2
Rnor_6.01140,608,576 - 140,608,786NCBIRnor6.0
Rnor_5.01141,582,474 - 141,582,684UniSTSRnor5.0
RGSC_v3.41134,637,552 - 134,637,762UniSTSRGSC3.4
Celera1124,905,636 - 124,905,846UniSTS
RH 3.4 Map11060.8UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000085570   ⟹   ENSRNOP00000069045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,815,168 - 132,837,023 (+)Ensembl
Rnor_6.0 Ensembl1140,602,542 - 140,608,946 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091588   ⟹   ENSRNOP00000075245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1142,236,137 - 142,246,401 (+)Ensembl
mRatBN7.2 Ensembl1132,815,123 - 132,837,027 (+)Ensembl
Rnor_6.0 Ensembl1140,601,791 - 140,608,890 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097136   ⟹   ENSRNOP00000097119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1142,239,479 - 142,246,401 (+)Ensembl
mRatBN7.2 Ensembl1132,830,028 - 132,837,025 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106522   ⟹   ENSRNOP00000093889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1142,239,479 - 142,245,857 (+)Ensembl
mRatBN7.2 Ensembl1132,815,168 - 132,836,481 (+)Ensembl
RefSeq Acc Id: NM_001008510   ⟹   NP_001008510
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,240,059 - 142,246,403 (+)NCBI
mRatBN7.21132,830,679 - 132,837,027 (+)NCBI
Rnor_6.01140,602,553 - 140,608,892 (+)NCBI
Rnor_5.01141,576,507 - 141,582,790 (+)NCBI
RGSC_v3.41134,631,524 - 134,637,868 (+)RGD
Celera1124,899,911 - 124,905,952 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105635   ⟹   XP_038961563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,234,729 - 142,246,403 (+)NCBI
mRatBN7.21132,829,303 - 132,836,684 (+)NCBI
RefSeq Acc Id: XM_063284656   ⟹   XP_063140726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,234,729 - 142,246,065 (+)NCBI
RefSeq Acc Id: XM_063284659   ⟹   XP_063140729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,234,729 - 142,246,403 (+)NCBI
RefSeq Acc Id: XM_063284661   ⟹   XP_063140731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,234,729 - 142,243,907 (+)NCBI
RefSeq Acc Id: NP_001008510   ⟸   NM_001008510
- UniProtKB: Q5RJP5 (UniProtKB/TrEMBL),   A0A0G2JUC4 (UniProtKB/TrEMBL),   A0A8I6AIE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069045   ⟸   ENSRNOT00000085570
Ensembl Acc Id: ENSRNOP00000075245   ⟸   ENSRNOT00000091588
RefSeq Acc Id: XP_038961563   ⟸   XM_039105635
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000097119   ⟸   ENSRNOT00000097136
Ensembl Acc Id: ENSRNOP00000093889   ⟸   ENSRNOT00000106522
RefSeq Acc Id: XP_063140729   ⟸   XM_063284659
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JUC4 (UniProtKB/TrEMBL),   Q5RJP5 (UniProtKB/TrEMBL),   A0A8I6AIE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140726   ⟸   XM_063284656
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140731   ⟸   XM_063284661
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AIE3 (UniProtKB/TrEMBL)
Protein Domains
Exonuclease

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KA38-F1-model_v2 AlphaFold A0A0G2KA38 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690125
Promoter ID:EPDNEW_R649
Type:multiple initiation site
Name:Isg20_1
Description:interferon stimulated exonuclease gene 20
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01140,601,717 - 140,601,777EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306407 AgrOrtholog
BioCyc Gene G2FUF-58822 BioCyc
Ensembl Genes ENSRNOG00000054561 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091588 ENTREZGENE
  ENSRNOT00000091588.3 UniProtKB/TrEMBL
  ENSRNOT00000097136 ENTREZGENE
  ENSRNOT00000097136.2 UniProtKB/TrEMBL
  ENSRNOT00000106522.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7300717 IMAGE-MGC_LOAD
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/TrEMBL
  PolynucTfrase_RNaseH_fold UniProtKB/TrEMBL
  REXO1/3/4-like UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
KEGG Report rno:293052 UniProtKB/TrEMBL
MGC_CLONE MGC:105645 IMAGE-MGC_LOAD
NCBI Gene 293052 ENTREZGENE
PANTHER INTERFERON-STIMULATED GENE 20 KDA PROTEIN UniProtKB/TrEMBL
  RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED UniProtKB/TrEMBL
Pfam Exonuc_X-T UniProtKB/TrEMBL
PhenoGen Isg20 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054561 RatGTEx
SMART EXOIII UniProtKB/TrEMBL
Superfamily-SCOP RNaseH_fold UniProtKB/TrEMBL
UniProt A0A0G2JUC4 ENTREZGENE
  A0A0G2KA38_RAT UniProtKB/TrEMBL
  A0A8I6AIE3 ENTREZGENE, UniProtKB/TrEMBL
  A6JC37_RAT UniProtKB/TrEMBL
  A6JC38_RAT UniProtKB/TrEMBL
  A6JC39_RAT UniProtKB/TrEMBL
  Q5RJP5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JUC4 UniProtKB/TrEMBL
  A0A8I6AS37 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-10-22 Isg20  interferon stimulated exonuclease gene 20  Isg20  interferon stimulated exonuclease 20  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Isg20  interferon stimulated exonuclease 20    interferon-stimulated protein  Name updated 1299863 APPROVED
2005-12-06 Isg20  interferon-stimulated protein  Isg20_predicted  interferon-stimulated protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Isg20_predicted  interferon-stimulated protein (predicted)      Symbol and Name status set to approved 70820 APPROVED