Aars1 (alanyl-tRNA synthetase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Aars1 (alanyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Aars1
Name: alanyl-tRNA synthetase 1
RGD ID: 1304832
Description: Enables several functions, including ATP binding activity; alanine-tRNA ligase activity; and tRNA binding activity. Involved in alanyl-tRNA aminoacylation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; leukodystrophy; and nonphotosensitive trichothiodystrophy 8. Orthologous to human AARS1 (alanyl-tRNA synthetase 1); PARTICIPATES IN alanine metabolic pathway; lactic acidosis pathway; primary hyperoxaluria type 1 pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aars; alanine--tRNA ligase; alanine--tRNA ligase, cytoplasmic; alanyl-tRNA synthetase; alanyl-tRNA synthetase, cytoplasmic; alaRS; LOC292023
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau8
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,906,694 - 55,930,499 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1955,906,702 - 55,930,497 (+)EnsemblGRCr8
mRatBN7.21938,999,130 - 39,021,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,999,163 - 39,021,147 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1945,803,476 - 45,825,481 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,456,819 - 46,478,824 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,767,870 - 48,789,877 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,193,264 - 43,215,281 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,193,257 - 43,215,281 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,018,025 - 54,040,573 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41940,952,408 - 40,974,425 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,390,301 - 38,412,318 (+)NCBICelera
RGSC_v3.11940,957,348 - 40,979,299 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brequinar  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
GSK-J4  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methidathion  (ISO)
methylparaben  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prostaglandin A1  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO)
nucleus  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Alanyl-tRNA synthetase from Escherichia coli, Bombyx mori and Ratus ratus. Existence of common structural features. Dignam JD, etal., Eur J Biochem. 1991 May 23;198(1):201-10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16906134   PMID:19946888   PMID:20010690   PMID:20458337   PMID:25422440   PMID:27622773   PMID:28493438   PMID:29769718  


Genomics

Comparative Map Data
Aars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,906,694 - 55,930,499 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1955,906,702 - 55,930,497 (+)EnsemblGRCr8
mRatBN7.21938,999,130 - 39,021,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,999,163 - 39,021,147 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1945,803,476 - 45,825,481 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,456,819 - 46,478,824 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,767,870 - 48,789,877 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,193,264 - 43,215,281 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,193,257 - 43,215,281 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,018,025 - 54,040,573 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41940,952,408 - 40,974,425 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,390,301 - 38,412,318 (+)NCBICelera
RGSC_v3.11940,957,348 - 40,979,299 (+)NCBI
Cytogenetic Map19q12NCBI
AARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,252,298 - 70,289,506 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,251,983 - 70,289,707 (-)Ensemblhg38GRCh38
GRCh371670,286,201 - 70,323,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,843,798 - 68,880,913 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341668,843,797 - 68,880,913NCBI
Celera1655,204,771 - 55,241,876 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1656,119,458 - 56,156,083 (-)NCBIHuRef
CHM1_11671,693,759 - 71,730,869 (-)NCBICHM1_1
T2T-CHM13v2.01676,063,291 - 76,100,495 (-)NCBIT2T-CHM13v2.0
Aars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,759,781 - 111,784,237 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,759,776 - 111,784,296 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,027,778 - 111,055,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,033,144 - 111,057,664 (+)Ensemblmm10GRCm38
MGSCv378113,557,867 - 113,580,770 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368113,920,642 - 113,943,545 (+)NCBIMGSCv36mm8
Celera8115,257,943 - 115,280,837 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.9NCBI
Aars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,089,235 - 3,115,230 (-)Ensembl
ChiLan1.0NW_0049554843,090,678 - 3,115,224 (-)NCBIChiLan1.0ChiLan1.0
AARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21883,876,270 - 83,912,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,807,117 - 89,843,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01654,727,601 - 54,763,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11670,086,735 - 70,121,902 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,086,735 - 70,121,902 (-)EnsemblpanPan2panpan1.1
AARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,288,780 - 76,343,262 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,288,782 - 76,343,207 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha576,250,625 - 76,276,397 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0576,725,260 - 76,750,984 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,725,265 - 76,748,174 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,547,302 - 76,573,204 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,370,741 - 76,396,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,862,531 - 76,888,314 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,294,883 - 36,320,498 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,268,491 - 23,294,496 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,268,613 - 23,294,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,298,330 - 13,321,383 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1613,298,336 - 13,321,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,363,115 - 13,385,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,399,717 - 53,433,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,395,638 - 53,433,461 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604716,186,832 - 16,220,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,540,633 - 12,567,376 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,540,969 - 12,566,989 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aars1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11730,728,728 - 30,750,176 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aars1
117 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:173
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000025052
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH126058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,020,870 - 39,021,067 (-)MAPPERmRatBN7.2
Rnor_6.01943,193,344 - 43,193,540NCBIRnor6.0
Rnor_5.01954,018,107 - 54,018,303UniSTSRnor5.0
RGSC_v3.41940,974,149 - 40,974,345UniSTSRGSC3.4
Celera1938,412,042 - 38,412,238UniSTS
Cytogenetic Map19q12UniSTS
AI316495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,020,648 - 39,020,794 (-)MAPPERmRatBN7.2
Rnor_6.01943,193,617 - 43,193,762NCBIRnor6.0
Rnor_5.01954,018,380 - 54,018,525UniSTSRnor5.0
RGSC_v3.41940,973,927 - 40,974,072UniSTSRGSC3.4
Celera1938,411,820 - 38,411,965UniSTS
Cytogenetic Map19q12UniSTS
RH137129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,020,826 - 39,021,012 (-)MAPPERmRatBN7.2
Rnor_6.01943,193,399 - 43,193,584NCBIRnor6.0
Rnor_5.01954,018,162 - 54,018,347UniSTSRnor5.0
RGSC_v3.41940,974,105 - 40,974,290UniSTSRGSC3.4
Celera1938,411,998 - 38,412,183UniSTS
Cytogenetic Map19q12UniSTS
RH66606  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81955,925,015 - 55,925,623 (+)Marker Load Pipeline
mRatBN7.21939,015,663 - 39,016,271 (-)MAPPERmRatBN7.2
Rnor_6.01943,198,140 - 43,198,747NCBIRnor6.0
Rnor_5.01954,022,903 - 54,023,510UniSTSRnor5.0
RGSC_v3.41940,968,942 - 40,969,549UniSTSRGSC3.4
Celera1938,406,835 - 38,407,442UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 12 67 177 91 90 59 94 59 6 372 194 11 163 94 92 31 29 29

Sequence


Ensembl Acc Id: ENSRNOT00000025052   ⟹   ENSRNOP00000025051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,906,702 - 55,930,497 (+)Ensembl
mRatBN7.2 Ensembl1938,999,163 - 39,021,147 (+)Ensembl
Rnor_6.0 Ensembl1943,193,264 - 43,215,281 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082151   ⟹   ENSRNOP00000075266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1943,193,257 - 43,215,077 (-)Ensembl
RefSeq Acc Id: NM_001100517   ⟹   NP_001093987
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,908,482 - 55,930,499 (+)NCBI
mRatBN7.21938,999,130 - 39,021,147 (+)NCBI
Rnor_6.01943,193,264 - 43,215,281 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
RGSC_v3.41940,952,408 - 40,974,425 (+)RGD
Celera1938,390,301 - 38,412,318 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255582   ⟹   XP_006255644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,908,524 - 55,930,499 (+)NCBI
mRatBN7.21938,999,203 - 39,021,152 (+)NCBI
Rnor_6.01943,193,264 - 43,215,208 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255583   ⟹   XP_006255645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,906,697 - 55,930,499 (+)NCBI
mRatBN7.21938,999,161 - 39,021,152 (+)NCBI
Rnor_6.01943,193,264 - 43,215,227 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277940   ⟹   XP_063134010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,906,694 - 55,930,499 (+)NCBI
RefSeq Acc Id: XM_063277941   ⟹   XP_063134011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,906,697 - 55,930,499 (+)NCBI
RefSeq Acc Id: NP_001093987   ⟸   NM_001100517
- UniProtKB: A6IZ80 (UniProtKB/Swiss-Prot),   Q4G057 (UniProtKB/Swiss-Prot),   P50475 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255645   ⟸   XM_006255583
- Peptide Label: isoform X1
- UniProtKB: A6IZ80 (UniProtKB/Swiss-Prot),   Q4G057 (UniProtKB/Swiss-Prot),   P50475 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255644   ⟸   XM_006255582
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000075266   ⟸   ENSRNOT00000082151
Ensembl Acc Id: ENSRNOP00000025051   ⟸   ENSRNOT00000025052
RefSeq Acc Id: XP_063134010   ⟸   XM_063277940
- Peptide Label: isoform X1
- UniProtKB: Q4G057 (UniProtKB/Swiss-Prot),   P50475 (UniProtKB/Swiss-Prot),   A6IZ80 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063134011   ⟸   XM_063277941
- Peptide Label: isoform X1
- UniProtKB: Q4G057 (UniProtKB/Swiss-Prot),   P50475 (UniProtKB/Swiss-Prot),   A6IZ80 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50475-F1-model_v2 AlphaFold P50475 1-968 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701140
Promoter ID:EPDNEW_R11664
Type:initiation region
Name:Aars_1
Description:alanyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,215,208 - 43,215,268EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304832 AgrOrtholog
BioCyc Gene G2FUF-5668 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000018404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025052 ENTREZGENE
  ENSRNOT00000025052.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.30.130 UniProtKB/Swiss-Prot
  3.10.310.40 UniProtKB/Swiss-Prot
  Bira Bifunctional Protein, Domain 2 UniProtKB/Swiss-Prot
  Threonyl-trna Synthetase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7385432 IMAGE-MGC_LOAD
InterPro aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Ala-tRNA-lgiase_IIc UniProtKB/Swiss-Prot
  Ala-tRNA-ligase_IIc_anticod-bd UniProtKB/Swiss-Prot
  Ala-tRNA-synth_IIc_core UniProtKB/Swiss-Prot
  Ala-tRNA-synth_IIc_N UniProtKB/Swiss-Prot
  Ala-tRNA_ligase UniProtKB/Swiss-Prot
  Ala_tRNA_ligase_euk/bac UniProtKB/Swiss-Prot
  DHHA1_dom UniProtKB/Swiss-Prot
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot
  Transl_B-barrel_sf UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
KEGG Report rno:292023 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112731 IMAGE-MGC_LOAD
NCBI Gene 292023 ENTREZGENE
PANTHER ALANINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/Swiss-Prot
  ALANYL-TRNA SYNTHETASE UniProtKB/Swiss-Prot
Pfam DHHA1 UniProtKB/Swiss-Prot
  tRNA-synt_2c UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
PhenoGen Aars1 PhenoGen
PRINTS TRNASYNTHALA UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II_ALA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018404 RatGTEx
SMART tRNA_SAD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101353 UniProtKB/Swiss-Prot
  SSF50447 UniProtKB/Swiss-Prot
  SSF55186 UniProtKB/Swiss-Prot
  SSF55681 UniProtKB/Swiss-Prot
UniProt A6IZ80 ENTREZGENE
  P50475 ENTREZGENE
  Q4G057 ENTREZGENE
  SYAC_RAT UniProtKB/Swiss-Prot
UniProt Secondary A6IZ80 UniProtKB/Swiss-Prot
  Q4G057 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Aars1  alanyl-tRNA synthetase 1  Aars  alanyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Aars  alanyl-tRNA synthetase  Aars_predicted  alanyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Aars_predicted  alanyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED