Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Polr1h | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Polr1h (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of POLR1H mRNA | CTD | PMID:22206623 | Polr1h | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of POLR1H mRNA | CTD | PMID:22206623 | Polr1h | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Polr1h (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR1H mRNA | CTD | PMID:17942748 | Polr1h | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Polr1h (Mus musculus) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether affects the expression of POLR1H mRNA | CTD | PMID:30294300 | Polr1h | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POLR1H mRNA | CTD | PMID:21215274 | Polr1h | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of POLR1H mRNA | CTD | PMID:32109520 | Polr1h | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Polr1h (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR1H mRNA; [TIPARP gene mutant more ... | CTD | PMID:17942748|PMID:25975270 | Polr1h | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Polr1h (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of POLR1H mRNA | CTD | PMID:21570461 | Polr1h | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of POLR1H mRNA | CTD | PMID:21346803 | Polr1h | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of POLR1H mRNA | CTD | PMID:21346803 | Polr1h | Rat | 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the more ... | CTD | PMID:14726695 | Polr1h | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of POLR1H mRNA | CTD | PMID:30851411 | Polr1h | Rat | 2-methylcholine | affects expression | ISO | POLR1H (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of POLR1H mRNA | CTD | PMID:21179406 | Polr1h | Rat | 4,4'-diaminodiphenylmethane | affects expression | ISO | Polr1h (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane affects the expression of POLR1H mRNA | CTD | PMID:18648102 | Polr1h | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | bisphenol S results in decreased expression of POLR1H mRNA | CTD | PMID:39298647 | Polr1h | Rat | 4-phenylbutyric acid | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | 4-phenylbutyric acid results in decreased expression of POLR1H mRNA | CTD | PMID:14583596 | Polr1h | Rat | aflatoxin B1 | increases expression | ISO | Polr1h (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of POLR1H mRNA | CTD | PMID:19770486 | Polr1h | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ZNRD1 mRNA | CTD | PMID:35163327 | Polr1h | Rat | antirheumatic drug | increases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of POLR1H mRNA | CTD | PMID:24449571 | Polr1h | Rat | arsane | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Polr1h | Rat | arsenic atom | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Polr1h | Rat | arsenite(3-) | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to POLR1H mRNA] | CTD | PMID:32406909 | Polr1h | Rat | benzo[a]pyrene | increases methylation | ISO | POLR1H (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of POLR1H promoter | CTD | PMID:27901495 | Polr1h | Rat | benzo[a]pyrene | increases expression | ISO | Polr1h (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of POLR1H mRNA | CTD | PMID:22228805 | Polr1h | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of POLR1H mRNA | CTD | PMID:20382639 | Polr1h | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of POLR1H mRNA | CTD | PMID:25181051 | Polr1h | Rat | bisphenol A | affects expression | ISO | POLR1H (Homo sapiens) | 6480464 | bisphenol A affects the expression of POLR1H mRNA | CTD | PMID:30903817 | Polr1h | Rat | bisphenol F | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of POLR1H gene | CTD | PMID:31601247 | Polr1h | Rat | cadmium atom | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of POLR1H more ... | CTD | PMID:35301059 | Polr1h | Rat | cadmium dichloride | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of ZNRD1 mRNA | CTD | PMID:38568856 | Polr1h | Rat | cadmium dichloride | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of POLR1H more ... | CTD | PMID:35301059 | Polr1h | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of POLR1H mRNA | CTD | PMID:33453195 | Polr1h | Rat | cadmium sulfate | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | cadmium sulfate results in decreased expression of POLR1H mRNA | CTD | PMID:19274763 | Polr1h | Rat | calyculin A | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | calyculin A results in decreased expression of POLR1H mRNA | CTD | PMID:25270620 | Polr1h | Rat | CGP 52608 | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to POLR1H gene] | CTD | PMID:28238834 | Polr1h | Rat | chlorpyrifos | increases expression | ISO | Polr1h (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of POLR1H mRNA | CTD | PMID:37019170 | Polr1h | Rat | copper(II) sulfate | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of POLR1H mRNA | CTD | PMID:19549813 | Polr1h | Rat | coumestrol | increases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Coumestrol results in increased expression of POLR1H mRNA | CTD | PMID:19167446 | Polr1h | Rat | cyclosporin A | increases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of POLR1H mRNA | CTD | PMID:27989131 | Polr1h | Rat | Dibutyl phosphate | affects expression | ISO | POLR1H (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of ZNRD1 mRNA | CTD | PMID:37042841 | Polr1h | Rat | dibutyl phthalate | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of POLR1H mRNA | CTD | PMID:17361019 | Polr1h | Rat | dicrotophos | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of POLR1H mRNA | CTD | PMID:28302478 | Polr1h | Rat | doxorubicin | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the more ... | CTD | PMID:14726695 | Polr1h | Rat | doxorubicin | increases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of POLR1H mRNA | CTD | PMID:29803840 | Polr1h | Rat | doxorubicin | decreases response to substance | ISO | POLR1H (Homo sapiens) | 6480464 | POLR1H protein results in decreased susceptibility to Doxorubicin | CTD | PMID:14726695|PMID:16609701 | Polr1h | Rat | doxorubicin | increases secretion | ISO | POLR1H (Homo sapiens) | 6480464 | POLR1H protein results in increased secretion of Doxorubicin | CTD | PMID:14726695 | Polr1h | Rat | ethanol | increases expression | ISO | Polr1h (Mus musculus) | 6480464 | Ethanol results in increased expression of POLR1H mRNA | CTD | PMID:30319688 | Polr1h | Rat | etoposide | decreases response to substance | ISO | POLR1H (Homo sapiens) | 6480464 | POLR1H protein results in decreased susceptibility to Etoposide | CTD | PMID:14726695 | Polr1h | Rat | etoposide | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide] | CTD | PMID:14726695 | Polr1h | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of POLR1H mRNA | CTD | PMID:24793618 | Polr1h | Rat | folic acid | multiple interactions | ISO | Polr1h (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of POLR1H mRNA | CTD | PMID:22206623 | Polr1h | Rat | folpet | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | folpet results in decreased expression of POLR1H mRNA | CTD | PMID:31558096 | Polr1h | Rat | fulvestrant | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of POLR1H gene | CTD | PMID:31601247 | Polr1h | Rat | hydrogen peroxide | affects expression | ISO | POLR1H (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of POLR1H mRNA | CTD | PMID:21179406 | Polr1h | Rat | lead diacetate | increases expression | ISO | POLR1H (Homo sapiens) | 6480464 | lead acetate results in increased expression of ZNRD1 mRNA | CTD | PMID:38568856 | Polr1h | Rat | manganese atom | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Polr1h | Rat | manganese(0) | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Polr1h | Rat | manganese(II) chloride | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Polr1h | Rat | methotrexate | decreases response to substance | ISO | POLR1H (Homo sapiens) | 6480464 | POLR1H protein results in decreased susceptibility to Methotrexate | CTD | PMID:16609701 | Polr1h | Rat | nitrates | multiple interactions | ISO | Polr1h (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of POLR1H more ... | CTD | PMID:35964746 | Polr1h | Rat | paracetamol | affects expression | ISO | Polr1h (Mus musculus) | 6480464 | Acetaminophen affects the expression of POLR1H mRNA | CTD | PMID:17562736 | Polr1h | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of POLR1H mRNA | CTD | PMID:33387578 | Polr1h | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ZNRD1 mRNA | CTD | PMID:35163327 | Polr1h | Rat | phenobarbital | affects expression | ISO | POLR1H (Homo sapiens) | 6480464 | Phenobarbital affects the expression of POLR1H mRNA | CTD | PMID:19159669 | Polr1h | Rat | propiconazole | increases expression | ISO | Polr1h (Mus musculus) | 6480464 | propiconazole results in increased expression of POLR1H mRNA | CTD | PMID:21278054 | Polr1h | Rat | quercetin | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Quercetin results in decreased expression of POLR1H mRNA | CTD | PMID:21632981 | Polr1h | Rat | rac-lactic acid | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of POLR1H mRNA | CTD | PMID:30851411 | Polr1h | Rat | resveratrol | decreases expression | ISO | Polr1h (Mus musculus) | 6480464 | Resveratrol results in decreased expression of POLR1H protein | CTD | PMID:25505154 | Polr1h | Rat | resveratrol | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of POLR1H mRNA; [Plant Extracts co-treated more ... | CTD | PMID:23557933 | Polr1h | Rat | sirolimus | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | Sirolimus inhibits the reaction [TP73 protein results in increased expression of POLR1H mRNA] | CTD | PMID:21245298 | Polr1h | Rat | sodium arsenite | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Polr1h | Rat | sodium arsenite | decreases methylation | ISO | Polr1h (Mus musculus) | 6480464 | sodium arsenite results in decreased methylation of ZNRD1 gene | CTD | PMID:39894169 | Polr1h | Rat | sunitinib | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of POLR1H mRNA | CTD | PMID:31533062 | Polr1h | Rat | temozolomide | increases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Temozolomide results in increased expression of POLR1H mRNA | CTD | PMID:31758290 | Polr1h | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of POLR1H mRNA | CTD | PMID:31150632 | Polr1h | Rat | tetrachloromethane | increases expression | ISO | Polr1h (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of POLR1H mRNA | CTD | PMID:31919559 | Polr1h | Rat | tolcapone | decreases expression | EXP | | 6480464 | Tolcapone results in decreased expression of POLR1H mRNA | CTD | PMID:24136188 | Polr1h | Rat | valproic acid | affects expression | ISO | POLR1H (Homo sapiens) | 6480464 | Valproic Acid affects the expression of POLR1H mRNA | CTD | PMID:25979313 | Polr1h | Rat | valproic acid | decreases expression | ISO | POLR1H (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of POLR1H mRNA | CTD | PMID:23179753|PMID:27188386|PMID:28001369 | Polr1h | Rat | verapamil | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the more ... | CTD | PMID:14726695 | Polr1h | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of POLR1H mRNA | CTD | PMID:23869203 | Polr1h | Rat | vincristine | decreases response to substance | ISO | POLR1H (Homo sapiens) | 6480464 | POLR1H protein results in decreased susceptibility to Vincristine | CTD | PMID:14726695 | Polr1h | Rat | vincristine | multiple interactions | ISO | POLR1H (Homo sapiens) | 6480464 | Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Vincristine] | CTD | PMID:14726695 | Polr1h | Rat | XL147 | multiple interactions | ISO | Polr1h (Mus musculus) | 6480464 | XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of POLR1H mRNA] | CTD | PMID:29891994 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















