GLP1R (glucagon like peptide 1 receptor) - Rat Genome Database

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Gene: GLP1R (glucagon like peptide 1 receptor) Homo sapiens
Analyze
Symbol: GLP1R
Name: glucagon like peptide 1 receptor
RGD ID: 736638
HGNC Page HGNC:4324
Description: Enables glucagon-like peptide 1 receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP-mediated signaling; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GLP-1; GLP-1 receptor; GLP-1-R; GLP-1R; GLP1 receptor; glucagon-like peptide 1 receptor; glucagon-like peptide-1 receptor; MGC138331; seven transmembrane helix receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,048,781 - 39,091,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,048,781 - 39,091,303 (+)EnsemblGRCh38hg38GRCh38
GRCh37639,016,557 - 39,059,079 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,124,595 - 39,163,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 34639,124,594 - 39,163,497NCBI
Celera640,569,967 - 40,608,942 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef638,734,906 - 38,773,876 (+)NCBIHuRef
CHM1_1639,019,249 - 39,058,215 (+)NCBICHM1_1
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA,TAS)
plasma membrane  (IBA,IDA,IEA,TAS)

References

References - curated
# Reference Title Reference Citation
1. Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: a possible role for dietary peptides. Aziz A, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R688-94. Epub 2005 May 5.
2. Expression levels of genes likely involved in glucose-sensing in the obese Zucker rat brain. Bogacka I, etal., Nutr Neurosci. 2004 Apr;7(2):67-74.
3. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. During MJ, etal., Nat Med. 2003 Sep;9(9):1173-9. Epub 2003 Aug 17.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Scrocchi LA, etal., Nat Med. 1996 Nov;2(11):1254-8.
8. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Xu G, etal., Diabetes. 1999 Dec;48(12):2270-6.
Additional References at PubMed
PMID:7517895   PMID:7589461   PMID:7843404   PMID:7958545   PMID:8112494   PMID:8194659   PMID:8216285   PMID:8392011   PMID:8404634   PMID:8405712   PMID:9213353   PMID:10382665  
PMID:10990079   PMID:11076863   PMID:11116211   PMID:12034449   PMID:12036966   PMID:12477932   PMID:14574404   PMID:15364163   PMID:15452121   PMID:15489334   PMID:15528268   PMID:15670850  
PMID:15686481   PMID:15975668   PMID:16644694   PMID:16931572   PMID:17444618   PMID:17475961   PMID:18240029   PMID:18248821   PMID:18287102   PMID:18372345   PMID:18541709   PMID:18577758  
PMID:19077438   PMID:19386626   PMID:19755420   PMID:19815559   PMID:19820010   PMID:19859570   PMID:19861722   PMID:19890029   PMID:19913121   PMID:20002095   PMID:20225248   PMID:20347207  
PMID:20374430   PMID:20452396   PMID:20468064   PMID:20483198   PMID:20529866   PMID:20628086   PMID:20649595   PMID:20690636   PMID:20800603   PMID:20805279   PMID:20823098   PMID:20835917  
PMID:21046358   PMID:21095545   PMID:21562063   PMID:21616920   PMID:21663496   PMID:21744074   PMID:21745271   PMID:21862620   PMID:21868452   PMID:21873635   PMID:21952200   PMID:22031513  
PMID:22079758   PMID:22105074   PMID:22112810   PMID:22147709   PMID:22147710   PMID:22234371   PMID:22412906   PMID:22492091   PMID:22693487   PMID:23091034   PMID:23362875   PMID:23592482  
PMID:23803499   PMID:23806684   PMID:23864651   PMID:23879380   PMID:24275181   PMID:24307763   PMID:24326362   PMID:24334921   PMID:24467746   PMID:24577752   PMID:24624910   PMID:24679032  
PMID:24687535   PMID:24878048   PMID:24969551   PMID:25044020   PMID:25071023   PMID:25119061   PMID:25200998   PMID:25330813   PMID:25376528   PMID:25376673   PMID:25416956   PMID:25451942  
PMID:25483438   PMID:25502804   PMID:25561730   PMID:25669907   PMID:25785276   PMID:25903129   PMID:25915883   PMID:25991051   PMID:26015316   PMID:26080318   PMID:26116235   PMID:26198634  
PMID:26238361   PMID:26272612   PMID:26381270   PMID:26384381   PMID:26495786   PMID:26598711   PMID:26636423   PMID:26640129   PMID:26655814   PMID:26661514   PMID:26672638   PMID:26679229  
PMID:26694823   PMID:26700562   PMID:26773924   PMID:26782560   PMID:26787264   PMID:26795287   PMID:26795291   PMID:26798195   PMID:26803771   PMID:26835799   PMID:26847401   PMID:26874994  
PMID:26886440   PMID:26936426   PMID:26936963   PMID:26968296   PMID:26969516   PMID:26975372   PMID:27013681   PMID:27037706   PMID:27037787   PMID:27038451   PMID:27042424   PMID:27043162  
PMID:27059784   PMID:27059816   PMID:27059958   PMID:27068973   PMID:27072494   PMID:27100083   PMID:27208775   PMID:27226600   PMID:27447052   PMID:27542128   PMID:27562916   PMID:27569426  
PMID:27717194   PMID:27858848   PMID:27974199   PMID:28035964   PMID:28077257   PMID:28094469   PMID:28230449   PMID:28283573   PMID:28514449   PMID:28514806   PMID:28560433   PMID:28562585  
PMID:28597972   PMID:28609478   PMID:28707223   PMID:29045658   PMID:29095968   PMID:29101219   PMID:29128339   PMID:29135069   PMID:29157578   PMID:29284659   PMID:29329976   PMID:29334697  
PMID:29412810   PMID:29412811   PMID:29412835   PMID:29412838   PMID:29444223   PMID:29466332   PMID:29488276   PMID:29671912   PMID:29717000   PMID:29725251   PMID:29731020   PMID:29813107  
PMID:29907137   PMID:29941447   PMID:30006590   PMID:30021884   PMID:30271789   PMID:30273843   PMID:30349227   PMID:30409537   PMID:30626614   PMID:30659271   PMID:30683681   PMID:30770099  
PMID:30836679   PMID:30883264   PMID:30957116   PMID:30969479   PMID:31000783   PMID:31023563   PMID:31098984   PMID:31131863   PMID:31294890   PMID:31510798   PMID:31630078   PMID:31686522  
PMID:32051237   PMID:32146725   PMID:32152292   PMID:32296183   PMID:32470349   PMID:32522585   PMID:32527131   PMID:32721233   PMID:33009421   PMID:33061822   PMID:33082272   PMID:33182425  
PMID:33199025   PMID:33292149   PMID:33369025   PMID:33460247   PMID:33477478   PMID:33544567   PMID:33554958   PMID:33631146   PMID:33891864   PMID:33920024   PMID:33921209   PMID:34127852  
PMID:34213657   PMID:34383800   PMID:34509564   PMID:34519040   PMID:34772827   PMID:35013280   PMID:35065096   PMID:35598685   PMID:35723666   PMID:35906358   PMID:36007775   PMID:36076972  
PMID:36177761   PMID:36339410   PMID:36373695   PMID:36465606   PMID:36499229   PMID:36592699   PMID:36675217   PMID:36774542   PMID:36799940   PMID:37235780   PMID:37280436   PMID:37364698  
PMID:37536118   PMID:37709961   PMID:37751301   PMID:37870292   PMID:37894845   PMID:37978261   PMID:38096145   PMID:38186168   PMID:38444070   PMID:38461904  


Genomics

Comparative Map Data
GLP1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,048,781 - 39,091,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,048,781 - 39,091,303 (+)EnsemblGRCh38hg38GRCh38
GRCh37639,016,557 - 39,059,079 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,124,595 - 39,163,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 34639,124,594 - 39,163,497NCBI
Celera640,569,967 - 40,608,942 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef638,734,906 - 38,773,876 (+)NCBIHuRef
CHM1_1639,019,249 - 39,058,215 (+)NCBICHM1_1
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBIT2T-CHM13v2.0
Glp1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,120,841 - 31,155,484 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,120,791 - 31,159,765 (+)EnsemblGRCm39 Ensembl
GRCm381730,901,867 - 30,936,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,901,817 - 30,940,791 (+)EnsemblGRCm38mm10GRCm38
MGSCv371731,038,812 - 31,073,455 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,628,889 - 30,663,545 (+)NCBIMGSCv36mm8
Celera1731,818,203 - 31,852,564 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Glp1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8208,973,393 - 9,011,622 (+)NCBIGRCr8
mRatBN7.2208,972,004 - 9,010,241 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl208,972,004 - 9,010,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,666,817 - 9,705,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,027,975 - 9,066,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,503,459 - 9,541,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,586,075 - 9,626,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02011,768,479 - 11,808,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,225,881 - 9,264,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,226,107 - 9,264,411 (+)NCBI
Celera2010,499,202 - 10,536,348 (+)NCBICelera
RH 3.4 Map20118.3RGD
Cytogenetic Map20p12NCBI
Glp1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,395,039 - 4,418,186 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554374,394,088 - 4,418,172 (-)NCBIChiLan1.0ChiLan1.0
GLP1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,545,422 - 53,595,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,415,037 - 49,470,541 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,637,838 - 38,680,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1639,818,361 - 39,860,999 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl639,823,373 - 39,855,784 (+)Ensemblpanpan1.1panPan2
GLP1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,999,963 - 8,030,335 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,999,997 - 8,025,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,007,600 - 8,053,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,461,837 - 8,508,323 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,469,301 - 8,503,729 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,989,087 - 8,035,354 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,066,878 - 8,113,116 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,172,302 - 8,218,559 (+)NCBIUU_Cfam_GSD_1.0
Glp1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,393,014 - 43,423,374 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,541,775 - 20,567,188 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,541,812 - 20,580,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLP1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,497,759 - 34,534,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,497,779 - 34,534,356 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,595,524 - 39,623,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLP1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11733,053,442 - 33,092,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1733,054,574 - 33,091,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604439,051,279 - 39,092,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glp1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475419,215,829 - 19,244,987 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475419,214,547 - 19,245,030 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GLP1R
34 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_002062.5(GLP1R):c.131G>A (p.Arg44His) single nucleotide variant not provided [RCV000904993] Chr6:39056449 [GRCh38]
Chr6:39024225 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.297C>T (p.His99=) single nucleotide variant not provided [RCV000946943] Chr6:39065724 [GRCh38]
Chr6:39033500 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.565C>T (p.Leu189=) single nucleotide variant not provided [RCV000972425] Chr6:39072917 [GRCh38]
Chr6:39040693 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.501C>T (p.Leu167=) single nucleotide variant not provided [RCV000914293] Chr6:39066295 [GRCh38]
Chr6:39034071 [GRCh37]
Chr6:6p21.2
likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_002062.5(GLP1R):c.237G>A (p.Ser79=) single nucleotide variant not provided [RCV000970137] Chr6:39057533 [GRCh38]
Chr6:39025309 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.1122C>T (p.His374=) single nucleotide variant not provided [RCV000954259] Chr6:39079642 [GRCh38]
Chr6:39047418 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.573A>G (p.Ala191=) single nucleotide variant not provided [RCV000961715] Chr6:39072925 [GRCh38]
Chr6:39040701 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.327C>T (p.Leu109=) single nucleotide variant not provided [RCV000884609] Chr6:39065754 [GRCh38]
Chr6:39033530 [GRCh37]
Chr6:6p21.2
benign
NM_002062.5(GLP1R):c.144C>G (p.Arg48=) single nucleotide variant not provided [RCV000960882] Chr6:39056462 [GRCh38]
Chr6:39024238 [GRCh37]
Chr6:6p21.2
benign
GRCh37/hg19 6p21.2(chr6:38830410-39034515)x1 copy number loss not provided [RCV001827667] Chr6:38830410..39034515 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.364G>T (p.Asp122Tyr) single nucleotide variant not specified [RCV004156742] Chr6:39065791 [GRCh38]
Chr6:39033567 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.1346C>T (p.Ala449Val) single nucleotide variant not specified [RCV004198410] Chr6:39086027 [GRCh38]
Chr6:39053803 [GRCh37]
Chr6:6p21.2
likely benign
NM_002062.5(GLP1R):c.988A>G (p.Ile330Val) single nucleotide variant not specified [RCV004075878] Chr6:39079145 [GRCh38]
Chr6:39046921 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.137G>A (p.Cys46Tyr) single nucleotide variant not specified [RCV004157640] Chr6:39056455 [GRCh38]
Chr6:39024231 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.130C>T (p.Arg44Cys) single nucleotide variant not specified [RCV004102289] Chr6:39056448 [GRCh38]
Chr6:39024224 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.14C>T (p.Pro5Leu) single nucleotide variant not specified [RCV004203107] Chr6:39048854 [GRCh38]
Chr6:39016630 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.32C>A (p.Ala11Glu) single nucleotide variant not specified [RCV004111362] Chr6:39048872 [GRCh38]
Chr6:39016648 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.241G>A (p.Val81Met) single nucleotide variant not specified [RCV004075745] Chr6:39057537 [GRCh38]
Chr6:39025313 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.1261C>T (p.Arg421Trp) single nucleotide variant not specified [RCV004110088] Chr6:39085942 [GRCh38]
Chr6:39053718 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.856A>G (p.Ile286Val) single nucleotide variant not specified [RCV004226077] Chr6:39078354 [GRCh38]
Chr6:39046130 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.806A>G (p.Tyr269Cys) single nucleotide variant not specified [RCV004086956] Chr6:39073752 [GRCh38]
Chr6:39041528 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.441C>G (p.Ile147Met) single nucleotide variant not specified [RCV004228441] Chr6:39066235 [GRCh38]
Chr6:39034011 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.802C>T (p.Leu268Phe) single nucleotide variant not specified [RCV004185827] Chr6:39073748 [GRCh38]
Chr6:39041524 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.1280T>A (p.Ile427Asn) single nucleotide variant not specified [RCV004211284] Chr6:39085961 [GRCh38]
Chr6:39053737 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.518A>G (p.His173Arg) single nucleotide variant not specified [RCV004088605] Chr6:39072870 [GRCh38]
Chr6:39040646 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.247G>A (p.Val83Ile) single nucleotide variant not specified [RCV004339434] Chr6:39057543 [GRCh38]
Chr6:39025319 [GRCh37]
Chr6:6p21.2
uncertain significance
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1
pathogenic
GRCh37/hg19 6p21.2(chr6:39054113-40272338)x3 copy number gain not provided [RCV003484641] Chr6:39054113..40272338 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.470C>T (p.Ser157Phe) single nucleotide variant not specified [RCV004393211] Chr6:39066264 [GRCh38]
Chr6:39034040 [GRCh37]
Chr6:6p21.2
uncertain significance
NM_002062.5(GLP1R):c.1122C>A (p.His374Gln) single nucleotide variant not specified [RCV004393209] Chr6:39079642 [GRCh38]
Chr6:39047418 [GRCh37]
Chr6:6p21.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:859
Count of miRNA genes:565
Interacting mature miRNAs:615
Transcripts:ENST00000373256
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D6S973  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,026,230 - 39,026,570UniSTSGRCh37
Celera640,579,640 - 40,579,995UniSTS
Cytogenetic Map6p21UniSTS
HuRef638,744,579 - 38,744,934UniSTS
Marshfield Genetic Map653.81UniSTS
Marshfield Genetic Map653.81RGD
deCODE Assembly Map657.81UniSTS
GDB:383796  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,053,917 - 39,054,054UniSTSGRCh37
Build 36639,161,895 - 39,162,032RGDNCBI36
Celera640,607,339 - 40,607,476RGD
Cytogenetic Map6p21UniSTS
HuRef638,772,273 - 38,772,410UniSTS
G15954  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,053,900 - 39,054,088UniSTSGRCh37
Build 36639,161,878 - 39,162,066RGDNCBI36
Celera640,607,322 - 40,607,510RGD
Cytogenetic Map6p21UniSTS
HuRef638,772,256 - 38,772,444UniSTS
GLP1R_7264  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,054,799 - 39,055,560UniSTSGRCh37
Build 36639,162,777 - 39,163,538RGDNCBI36
Celera640,608,221 - 40,608,982RGD
HuRef638,773,155 - 38,773,916UniSTS
RH46831  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,055,339 - 39,055,462UniSTSGRCh37
Build 36639,163,317 - 39,163,440RGDNCBI36
Celera640,608,761 - 40,608,884RGD
Cytogenetic Map6p21UniSTS
HuRef638,773,695 - 38,773,818UniSTS
GeneMap99-GB4 RH Map6131.94UniSTS
RH37424  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,025,827 - 39,025,946UniSTSGRCh37
Build 36639,133,805 - 39,133,924RGDNCBI36
Celera640,579,237 - 40,579,356RGD
Cytogenetic Map6p21UniSTS
HuRef638,744,176 - 38,744,295UniSTS
GeneMap99-GB4 RH Map6136.34UniSTS
SGC35239  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37639,053,901 - 39,054,120UniSTSGRCh37
Build 36639,161,879 - 39,162,098RGDNCBI36
Celera640,607,323 - 40,607,542RGD
Cytogenetic Map6p21UniSTS
HuRef638,772,257 - 38,772,476UniSTS
GeneMap99-GB4 RH Map6145.45UniSTS
Whitehead-RH Map6232.5UniSTS
GDB:460430  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 3 15 4 1 3 1 4 1 6 3 9 3
Low 183 770 247 51 44 19 997 252 880 53 375 467 32 40 677
Below cutoff 1365 1472 959 241 950 114 2454 924 2229 195 627 918 129 959 1475

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001743346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001743347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001743348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX646689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY439112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK819862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR138540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L23503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000373256   ⟹   ENSP00000362353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl639,048,781 - 39,091,303 (+)Ensembl
RefSeq Acc Id: NM_002062   ⟹   NP_002053
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,048,781 - 39,091,303 (+)NCBI
GRCh37639,016,557 - 39,056,657 (+)NCBI
Build 36639,124,595 - 39,163,498 (+)NCBI Archive
HuRef638,734,906 - 38,773,876 (+)ENTREZGENE
CHM1_1639,019,249 - 39,061,774 (+)NCBI
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136562
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,048,781 - 39,091,303 (+)NCBI
CHM1_1639,019,249 - 39,061,774 (+)NCBI
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136563
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,048,781 - 39,091,303 (+)NCBI
CHM1_1639,019,249 - 39,061,774 (+)NCBI
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002053   ⟸   NM_002062
- Peptide Label: precursor
- UniProtKB: Q2M229 (UniProtKB/Swiss-Prot),   Q99669 (UniProtKB/Swiss-Prot),   P43220 (UniProtKB/Swiss-Prot),   A0A142FHB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000362353   ⟸   ENST00000373256
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43220-F1-model_v2 AlphaFold P43220 1-463 view protein structure

Promoters
RGD ID:6873094
Promoter ID:EPDNEW_H9711
Type:initiation region
Name:GLP1R_1
Description:glucagon like peptide 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38639,048,781 - 39,048,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4324 AgrOrtholog
COSMIC GLP1R COSMIC
Ensembl Genes ENSG00000112164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373256 ENTREZGENE
  ENST00000373256.5 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000112164 GTEx
HGNC ID HGNC:4324 ENTREZGENE
Human Proteome Map GLP1R Human Proteome Map
InterPro 7tmB1_GLP1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2740 ENTREZGENE
OMIM 138032 OMIM
PANTHER PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45620:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28725 PharmGKB
PRINTS GLUCAGNFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCAGNLIKER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A142FHB8 ENTREZGENE, UniProtKB/TrEMBL
  GLP1R_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2M229 ENTREZGENE
  Q99669 ENTREZGENE
UniProt Secondary Q2M229 UniProtKB/Swiss-Prot
  Q99669 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 GLP1R  glucagon like peptide 1 receptor    glucagon-like peptide 1 receptor  Symbol and/or name change 5135510 APPROVED