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Gene: Pde8a (phosphodiesterase 8A) Rattus norvegicus

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Symbol:

Pde8a

Name:

phosphodiesterase 8A

RGD ID:

735125

Description:

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity; kinase binding activity; and protein kinase activator activity. Predicted to be involved in cellular response to epidermal growth factor stimulus; negative regulation of cAMP/PKA signal transduction; and positive regulation of ERK1 and ERK2 cascade. Orthologous to human PDE8A (phosphodiesterase 8A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cAMP-specific cyclic nucleotide phosphodiesterase PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; RNPDE8A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE8A (phosphodiesterase 8A)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pde8a (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pde8a (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDE8A (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE8A (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde8a (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE8A (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDE8A (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pde8a (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pde8a (phosphodiesterase 8A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pde8a (phosphodiesterase 8A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PDE8A (phosphodiesterase 8A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pde8a (phosphodiesterase 8A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	pde8a (phosphodiesterase 8A)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	PDE2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PDE2	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pde-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Pde8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pde8a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pde8a	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	144,575,203 - 144,698,216 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	144,575,428 - 144,698,215 (+)	Ensembl				GRCr8
mRatBN7.2	1	135,166,143 - 135,288,986 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	135,166,237 - 135,288,024 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	143,080,882 - 143,202,783 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	150,250,292 - 150,372,196 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	143,162,918 - 143,285,137 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	143,036,083 - 143,160,395 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	143,036,218 - 143,159,433 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	143,980,312 - 144,102,752 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	137,415,852 - 137,544,337 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	127,217,639 - 127,339,111 (+)	NCBI		Celera
RGSC_v3.1	1	137,494,257 - 137,622,743 (+)	NCBI
Cytogenetic Map	1	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic AMP (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

caffeine (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clodronic acid (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (EXP,ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dimethylarsinic acid (EXP)

dioxygen (ISO)

dipyridamole (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

flavonoids (EXP)

folic acid (ISO)

glafenine (EXP)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

ifosfamide (ISO)

lipopolysaccharide (ISO)

metformin (EXP)

methamphetamine (EXP)

mitoxantrone (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

potassium cyanide (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

Salinomycin (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

topotecan (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vitamin E (ISO)

zinc sulfate (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cAMP catabolic process (IEA)

cellular response to epidermal growth factor stimulus (IBA,IEA,ISO)

negative regulation of cAMP/PKA signal transduction (IBA)

positive regulation of ERK1 and ERK2 cascade (IBA,IEA,ISO)

signal transduction (IEA)

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity (IBA,IEA,ISO)

3',5'-cyclic-GMP phosphodiesterase activity (IBA,IEA,ISO)

3',5'-cyclic-nucleotide phosphodiesterase activity (IEA)

hydrolase activity (IEA)

kinase binding (IEA,ISO)

metal ion binding (IEA)

phosphoric diester hydrolase activity (IEA)

protein kinase activator activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

protein kinase A (PKA) signaling pathway (ISO)

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling.	Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.	Soderling SH, etal., Proc Natl Acad Sci U S A 1998 Jul 21;95(15):8991-6.

Additional References at PubMed

PMID:9618252	PMID:14597168	PMID:19056867	PMID:21821118	PMID:23509299

Genomics

Comparative Map Data

Pde8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	144,575,203 - 144,698,216 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	144,575,428 - 144,698,215 (+)	Ensembl				GRCr8
mRatBN7.2	1	135,166,143 - 135,288,986 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	135,166,237 - 135,288,024 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	143,080,882 - 143,202,783 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	150,250,292 - 150,372,196 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	143,162,918 - 143,285,137 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	143,036,083 - 143,160,395 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	143,036,218 - 143,159,433 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	143,980,312 - 144,102,752 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	137,415,852 - 137,544,337 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	127,217,639 - 127,339,111 (+)	NCBI		Celera
RGSC_v3.1	1	137,494,257 - 137,622,743 (+)	NCBI
Cytogenetic Map	1	q31	NCBI

PDE8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	84,980,467 - 85,139,142 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	84,980,440 - 85,139,145 (+)	Ensembl			hg38	GRCh38
GRCh37	15	85,523,698 - 85,682,373 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	83,326,209 - 83,483,377 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	15	61,951,944 - 62,111,125 (+)	NCBI		Celera
Cytogenetic Map	15	q25.3	NCBI
HuRef	15	61,609,653 - 61,768,261 (+)	NCBI		HuRef
CHM1_1	15	85,364,949 - 85,523,920 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	82,732,711 - 82,891,368 (+)	NCBI		T2T-CHM13v2.0

Pde8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	80,863,013 - 80,984,283 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	80,863,344 - 80,984,281 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	81,213,265 - 81,334,535 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	81,213,596 - 81,334,533 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	88,358,690 - 88,478,508 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	81,087,251 - 81,208,043 (+)	NCBI		MGSCv36	mm8
Celera	7	78,686,223 - 78,738,796 (+)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	45.71	NCBI

Pde8a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	14,063,123 - 14,125,220 (-)	Ensembl
ChiLan1.0	NW_004955416	14,063,117 - 14,204,297 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDE8A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	73,934,543 - 74,094,624 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	78,154,258 - 78,310,579 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	63,649,336 - 63,805,613 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	82,971,764 - 83,127,963 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	82,971,986 - 83,127,957 (+)	Ensembl			panPan2	panpan1.1

PDE8A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	54,278,498 - 54,367,492 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	54,128,680 - 54,367,400 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	56,852,891 - 57,008,693 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	54,631,013 - 54,787,194 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	54,631,028 - 54,787,190 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	54,151,873 - 54,307,649 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	54,360,516 - 54,516,720 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	54,702,916 - 54,859,444 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pde8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	129,171,415 - 129,324,830 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	17,095,318 - 17,163,114 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	17,009,696 - 17,163,105 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	52,410,779 - 52,557,645 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	52,410,766 - 52,558,482 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	57,896,426 - 57,969,573 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE8A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	3,214,183 - 3,367,051 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	3,213,165 - 3,367,571 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666059	43,694,868 - 43,851,671 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pde8a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	18,180,061 - 18,352,830 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624768	18,180,066 - 18,352,749 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pde8a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	118,921,668 - 119,044,373 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pde8a
996 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	120
Count of miRNA genes:	95
Interacting mature miRNAs:	106
Transcripts:	ENSRNOT00000025797
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	131179947	176179947	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	137611478	182611478	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	101228864	146228864	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130419227	175419227	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	132760429	191848948	Rat
631684	Bp117	Blood pressure QTL 117	8.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	120082258	165082258	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	112521556	157521556	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	142582336	182383862	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130419227	175419227	Rat
631570	Bp94	Blood pressure QTL 94		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132889797	152403053	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	139442053	223964440	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	127329268	206393015	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
61346	Rf2	Renal disease susceptibility QTL 2	3.7		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	142582180	153680016	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	124975316	152612788	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	141173126	169168317	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	140833106	185833106	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	116099376	191260518	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	101594089	146594089	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	131243790	176243790	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat
737974	Bp161	Blood pressure QTL 161		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	129182274	174182274	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	132760429	191848948	Rat
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	176289080	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	143092939	188092939	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	111949780	210707719	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	128019551	173019551	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	143092939	188092939	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	139442053	223964440	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	140048073	185048073	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	143092939	188092939	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	111949780	210707719	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	135021436	178317588	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	112521556	157521556	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	140048073	185048073	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	111949780	160574007	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	135021436	180021436	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132760429	191190115	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	132966869	206393015	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132760429	152404087	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	140915717	185915717	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	100345976	145345976	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	132760429	191848948	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat

Markers in Region

21.MMHAP17FRG9.seq

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	135,253,550 - 135,253,651 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	143,126,206 - 143,126,306	NCBI	Rnor6.0
Rnor_5.0	1	144,068,563 - 144,068,663	UniSTS	Rnor5.0
RGSC_v3.4	1	137,505,036 - 137,505,136	UniSTS	RGSC3.4
Celera	1	127,304,999 - 127,305,099	UniSTS
Cytogenetic Map	1	q31	UniSTS

RH143306

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	135,165,239 - 135,165,355 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	135,165,239 - 135,165,385 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	143,035,221 - 143,035,366	NCBI	Rnor6.0
Rnor_6.0	1	143,035,221 - 143,035,336	NCBI	Rnor6.0
Rnor_5.0	1	143,979,409 - 143,979,554	UniSTS	Rnor5.0
Rnor_5.0	1	143,979,409 - 143,979,524	UniSTS	Rnor5.0
RGSC_v3.4	1	137,414,855 - 137,414,970	UniSTS	RGSC3.4
RGSC_v3.4	1	137,414,855 - 137,415,000	UniSTS	RGSC3.4
Celera	1	127,216,326 - 127,216,471	UniSTS
Celera	1	127,216,326 - 127,216,441	UniSTS
RH 3.4 Map	1	1086.9	UniSTS
Cytogenetic Map	1	q31	UniSTS

RH140728

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	1	1400.3	UniSTS
Cytogenetic Map	1	q31	UniSTS

AI556676

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	135,270,754 - 135,271,095 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	143,143,410 - 143,143,750	NCBI	Rnor6.0
Rnor_5.0	1	144,085,767 - 144,086,107	UniSTS	Rnor5.0
RGSC_v3.4	1	137,522,240 - 137,522,580	UniSTS	RGSC3.4
Celera	1	127,322,203 - 127,322,543	UniSTS
Cytogenetic Map	1	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	88	59	6	352	188	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_198767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039113042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039113043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039113044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039113045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB092696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025797 ⟹ ENSRNOP00000025797

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	144,575,428 - 144,698,215 (+)	Ensembl
mRatBN7.2 Ensembl	1	135,166,237 - 135,288,024 (+)	Ensembl
Rnor_6.0 Ensembl	1	143,036,218 - 143,159,433 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096230 ⟹ ENSRNOP00000091374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	144,575,442 - 144,698,215 (+)	Ensembl
mRatBN7.2 Ensembl	1	135,235,946 - 135,288,024 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101888 ⟹ ENSRNOP00000078788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	144,575,428 - 144,698,215 (+)	Ensembl
mRatBN7.2 Ensembl	1	135,166,237 - 135,288,024 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103564 ⟹ ENSRNOP00000083621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	144,575,428 - 144,698,215 (+)	Ensembl
mRatBN7.2 Ensembl	1	135,166,237 - 135,288,024 (+)	Ensembl

RefSeq Acc Id:

NM_198767 ⟹ NP_942062

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,575,469 - 144,697,254 (+)	NCBI
mRatBN7.2	1	135,166,237 - 135,288,024 (+)	NCBI
Rnor_6.0	1	143,036,218 - 143,159,433 (+)	NCBI
Rnor_5.0	1	143,980,312 - 144,102,752 (+)	NCBI
RGSC_v3.4	1	137,415,852 - 137,544,337 (+)	RGD
Celera	1	127,217,639 - 127,339,111 (+)	RGD

Sequence:

show sequence

GGCCGTTTGCTGACCGGATCGCGGCTGCCAGCCAGCGTGTCCGCGGTGCCGCCGCCGCCAGGAT
GGGCTGCGCCCCGAGCATCCACATTTCCGACAACCGAGTGTCGAACCCCAGCGACAGCGACGGC
GAGGACGAGGACGTCCGGGTCCCCGCGCTGAGGTCTAGACAGCGATGGTCGACCCCGCCCGGGC
TCGTGGAGCCTCAGCCTCGCGACAGCGGTGCCTCGAAGGTATCAGTTGCTGATGTGCAATTTGG
CCCGATGAGATTTCATCAAGACCAGCTTCAGGTACTTTTAGTGTTTACCAAAGAAGATAGCCAG
TGTAATGGATTCTACAGGGCATGTGAAAAAGCCGGGTTTAAGTGCACAGTCACCAAGGAGGTGC
AGACTGTCCTTGCCTGTTTCCAGGACAAACTCCATGACATCATCATCATAGACCACAGAAATCC
CCGACAGATGGATGCGGAGGCAATGTGCAGGTCTATCAGATCATCAAAATTATCAGAAAACACA
GTTATTGTTGGCGTAGTACGCAGGGTGGACAAAGAAGAGGTGTCTTTAATGCCCTTCCTTGCCG
CTGGCTTCACGCGGAGGTATATAGAAAACCCCAACGTCATGGCCTGTTATAATGAACTGCTCCA
GTTGGCATTTGGAGAGGTGCGATCACAGCTGAAACTCAGGGCTTGTAACTCAGTGTTCACTGCG
TTAGAGAAGAGTCAAGAAGCGATTGAGATCACAAGTGAGGACCACATCATCCAGTATGCAAACC
CTGCATTTGAAACAACAATGGGTTATCAGTCGGGAGAACTAATAGGGAAGGAGTTAGCACAAGT
GCCCATCAATGAGAAGAAAGGTGACTTGCTGGATGCCATAAATTCCTGTGTCACAATCGACAAG
GAGTGGCAAGGAGTTTACCATACCCAAAAGAAAAATGGAGATAACATCCAACAAAATGTGAAGA
TAATACCTGTCATTGGGCAGGGAGGAAAAATCAGACACTATGTGTCCATTATCAGAGTGTGCAA
TGGCAGCAATAAGGTTGAGACCACAACTGAGTGTGTTCAGACTGATAGTCAAACAGATAGTCAG
GCAGGCAAGCATAAAGACAGGAGGAAACATTCGATGGACGTCAAAGCGGTTTCCTCCAGAACAA
GCGAAGTTTCCAATCAGAGAAGACATTCCTCTCTGGCCCGGATACATTCTATGATGATTGAGGC
ACCAATCACCAAGGTAATCAATATTCTTAGTGCTGCCCAGGAAAACAGTCCTGTGTCTGTGACA
GAAGCCTTGAACCATGTGCTGGATATCCTGAGAACCACTGAACTGTATTCACCCCAGTTTAATA
CTGAGGATGACCCTCACGCCACTGACCTCGTTGGGGGCTTAATGTCTGATGGCTTACGGAGGTT
TTCAGGAAATGAGTATACTCTTGCAACAAAAAGCCTTCGGCCATCTTCAAGCCAGTTGGCCGTC
CCCATCTCCCTTCATGATATCCCACCACGGATTGCTCAGGTCATAGAAAATGAGGAGCAATGGG
ACTTTGACATTTTTGAGCTGGAAGCTGCAACCCAAAATAGGCCTTTGATTTATCTAGGTCTCAA
AACGTTTGCTCGTTTTGAAATCTGTGAGTTCTTACAGTGCTCTGAGGCAACGCTGAAATCATGG
TTTCAAATTATTGAATCCAATTACCATTCCTCTAACCCCTACCACAATTCCACGCACGCCGCGG
ATGTGCTTCACGCCACTGCGTATTTCCTTTCCAGAAACAAGTTAAAGGACACTTTAGATCGCCT
TGATGAGGTCGCTGCCCTCATCGCTGCCACCATCCACGATGTGGATCACCCCGGGAGAACCAAC
TCTTTCCTCTGCAATGCGGGAAAGGAGCTGGCCGTACTGTACAATGACACTGCTGTGCTAGAGA
GCCACCACGCAGCGCTGGCCTTCCAGCTGACCCTTGAAAATGACAAATGCAATATCTTTAAAAA
CACAGACAGGAATGACTACCGGACACTACGCCAGAGTATCATTGACATGGTCCTAGCCACAGAG
ATGACAAAGCACTTTGAACACGTCAACAAATTTATCAACAGCATCAACAAGCCTCTGAAAGCAC
AGAAAAACGAGGTTCAGGAAACTGGCAGAAGTCTGGAAGATATAAGAGCCATGGTCAGGACTCC
AGAGAGCCGGACTCTCATCAAAAGGATGATGATTAAGTGTGCCGACGTGTCCAACCCCTGCCGG
CCCCTCGAGCACTGCATCGAGTGGGCTGCACGCATCTCAGAGGAGTATTTCTCCCAGACCGATG
AAGAGAAACAGCTGGACTTGCCTGTGGTGATGCCAGTGTTTGACAGAAACACCTGCAGCATCCC
CAAGTCTCAGATCTCCTTCATCGACTACTTCATCACAGACATGTTTGATGCCTGGGATGCCTTT
GTTTACCTGCCTAACCTTATGCGGCACCTGGAGGACAACTTCAAGTACTGGAAAGGACTGGATG
AGAAGGAGCTGTGCACCCTCCGGCCCCCTCCAGAATAGTGGGAGGTACACACTAGGCCCCCTGG

hide sequence

RefSeq Acc Id:

XM_006229438 ⟹ XP_006229500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,575,216 - 144,698,216 (+)	NCBI
mRatBN7.2	1	135,166,143 - 135,288,986 (+)	NCBI
Rnor_6.0	1	143,036,086 - 143,160,395 (+)	NCBI
Rnor_5.0	1	143,980,312 - 144,102,752 (+)	NCBI

Sequence:

show sequence

GCTGCCGCCGCGCCCGCAGCGCGATAAAAGGGGCGGCCGCGCTTCCTGACGCGAGACCCGCGCT
CGCCGCCGCCGCCCGCCAGCTCAGGCCGCGATGACACGGCGCCCGCGGCGGCCCCGAGGCGCCG
GGCGGGCCGTTTGCTGACCGGATCGCGGCTGCCAGCCAGCGTGTCCGCGGTGCCGCCGCCGCCA
GGATGGGCTGCGCCCCGAGCATCCACATTTCCGACAACCGAGTGTCGAACCCCAGCGACAGCGA
CGGCGAGGACGAGGACGTCCGGGTCCCCGCGCTGAGGTCTAGACAGCGATGGTCGACCCCGCCC
GGGCTCGTGGAGCCTCAGCCTCGCGACAGCGGTGCCTCGAAGGTATCAGTTGCTGATGTGCAAT
TTGGCCCGATGAGATTTCATCAAGACCAGCTTCAGGTACTTTTAGTGTTTACCAAAGAAGATAG
CCAGTGTAATGGATTCTACAGGGCATGTGAAAAAGCCGGGTTTAAGTGCACAGTCACCAAGGAG
GTGCAGACTGTCCTTGCCTGTTTCCAGGACAAACTCCATGACATCATCATCATAGACCACAGAA
ATCCCCGACAGATGGATGCGGAGGCAATGTGCAGGTCTATCAGATCATCAAAATTATCAGAAAA
CACAGTTATTGTTGGCGTAGTACGCAGGGTGGACAAAGAAGAGGTGTCTTTAATGCCCTTCCTT
GCCGCTGGCTTCACGCGGAGGTATATAGAAAACCCCAACGTCATGGCCTGTTATAATGAACTGC
TCCAGTTGGCATTTGGAGAGGTGCGATCACAGCTGAAACTCAGGGCTTGTAACTCAGTGTTCAC
TGCGTTAGAGAAGAGTCAAGAAGCGATTGAGATCACAAGTGAGGACCACATCATCCAGTATGCA
AACCCTGCATTTGAAACAACAATGGGTTATCAGTCGGGAGAACTAATAGGGAAGGAGTTAGCAC
AAGTGCCCATCAATGAGAAGAAAGGTGACTTGCTGGATGCCATAAATTCCTGTGTCACAATCGA
CAAGGAGTGGCAAGGAGTTTACCATACCCAAAAGAAAAATGGAGATAACATCCAACAAAATGTG
AAGATAATACCTGTCATTGGGCAGGGAGGAAAAATCAGACACTATGTGTCCATTATCAGAGTGT
GCAATGGCAGCAATAAGGTTGAGACCACAACTGAGTGTGTTCAGACTGATAGTCAAACAGATAG
TCAGGCAGGCAAGCATAAAGACAGGAGGAAACATTCGATGGACGTCAAAGCGGTTTCCTCCAGA
ACAAGCGAAGTTTCCAATCAGAGAAGACATTCCTCTCTGGCCCGGATACATTCTATGATGATTG
AGGCACCAATCACCAAGGTAATCAATATTCTTAGTGCTGCCCAGGAAAACAGTCCTGTGTCTGT
GACAGAAGCCTTGAACCATGTGCTGGATATCCTGAGAACCACTGAACTGTATTCACCCCAGTTT
AATACTGAGGATGACCCTCACGCCACTGACCTCGTTGGGGGCTTAATGTCTGATGGCTTACGGA
GGTTTTCAGGAAATGAGTATACTCTTGCAACAAAAAGCCTTCGGCCATCTTCAAGCCAGTTGGC
CGTCCCCATCTCCCTTCATGATATCCCACCACGGATTGCTCAGGTCATAGAAAATGAGGAGCAA
TGGGACTTTGACATTTTTGAGCTGGAAGCTGCAACCCAAAATAGGCCTTTGATTTATCTAGGTC
TCAAAACGTTTGCTCGTTTTGAAATCTGTGAGTTCTTACAGTGCTCTGAGGCAACGCTGAAATC
ATGGTTTCAAATTATTGAATCCAATTACCATTCCTCTAACCCCTACCACAATTCCACGCACGCC
GCGGATGTGCTTCACGCCACTGCGTATTTCCTTTCCAGAAACAAGTTAAAGGACACTTTAGATC
GCCTTGATGAGGTCGCTGCCCTCATCGCTGCCACCATCCACGATGTGGATCACCCCGGGAGAAC
CAACTCTTTCCTCTGCAATGCGGGAAAGGAGCTGGCCGTACTGTACAATGACACTGCTGTGCTA
GAGAGCCACCACGCAGCGCTGGCCTTCCAGCTGACCCTTGAAAATGACAAATGCAATATCTTTA
AAAACACAGACAGGAATGACTACCGGACACTACGCCAGAGTATCATTGACATGGTCCTAGCCAC
AGAGATGACAAAGCACTTTGAACACGTCAACAAATTTATCAACAGCATCAACAAGCCTCTGAAA
GCACAGAAAAACGAGGTTCAGGAAACTGGCAGAAGTCTGGAAGATATAAGAGCCATGGTCAGGA
CTCCAGAGAGCCGGACTCTCATCAAAAGGATGATGATTAAGTGTGCCGACGTGTCCAACCCCTG
CCGGCCCCTCGAGCACTGCATCGAGTGGGCTGCACGCATCTCAGAGGAGTATTTCTCCCAGACC
GATGAAGAGAAACAGCTGGACTTGCCTGTGGTGATGCCAGTGTTTGACAGAAACACCTGCAGCA
TCCCCAAGTCTCAGATCTCCTTCATCGACTACTTCATCACAGACATGTTTGATGCCTGGGATGC
CTTTGTTTACCTGCCTAACCTTATGCGGCACCTGGAGGACAACTTCAAGTACTGGAAAGGACTG
GATGAGAAGGAGCTGTGCACCCTCCGGCCCCCTCCAGAATAGTGGGAGTGGGGCTCACTCTAGT
ATGTGCCAGAGAAGCCACCGTCTGTGCAGACCAGGTTCTGAGCAGCCGCTGTCGTGAGTTCTGC
AGGTGCCTTCTCAGAGAAGAAATTGGATTTGACCATTTTCCCCCCTGAAATTTCATAATTGAAT
TTCTACAAGCCTGCCTCATTTTATACCATTTCTATAAAATGTGTCCTATAAAAGCAAAGCCACC
CTGGGCACCAGAGGCTGATATTTTACAACTAACATGGGATATTGGAGTCTAGGAATTTAAGGGT
TCTATCTTCTCACATTTCCAATAGCATAATACTGTAAAAGTGACATGACAAAATGCTAGTTTCA
TTTTAAACTTGTATTTTTTTCTGGATGAAATTAAACTATTTGTTTTTAAGAAGTCA

hide sequence

RefSeq Acc Id:

XM_039113042 ⟹ XP_038968970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,587,667 - 144,694,171 (+)	NCBI
mRatBN7.2	1	135,178,416 - 135,288,986 (+)	NCBI

RefSeq Acc Id:

XM_039113043 ⟹ XP_038968971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,595,431 - 144,694,171 (+)	NCBI
mRatBN7.2	1	135,184,183 - 135,288,986 (+)	NCBI

RefSeq Acc Id:

XM_039113044 ⟹ XP_038968972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,659,244 - 144,694,171 (+)	NCBI
mRatBN7.2	1	135,250,106 - 135,288,986 (+)	NCBI

RefSeq Acc Id:

XM_039113045 ⟹ XP_038968973

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,575,216 - 144,680,398 (+)	NCBI
mRatBN7.2	1	135,166,143 - 135,271,158 (+)	NCBI

RefSeq Acc Id:

XM_063262703 ⟹ XP_063118773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,575,203 - 144,694,171 (+)	NCBI

RefSeq Acc Id:

XM_063262704 ⟹ XP_063118774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	144,575,216 - 144,694,171 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_942062	(Get FASTA)	NCBI Sequence Viewer
	XP_006229500	(Get FASTA)	NCBI Sequence Viewer
	XP_038968970	(Get FASTA)	NCBI Sequence Viewer
	XP_038968971	(Get FASTA)	NCBI Sequence Viewer
	XP_038968972	(Get FASTA)	NCBI Sequence Viewer
	XP_038968973	(Get FASTA)	NCBI Sequence Viewer
	XP_063118773	(Get FASTA)	NCBI Sequence Viewer
	XP_063118774	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD00194	(Get FASTA)	NCBI Sequence Viewer
	EDM08678	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025797
	ENSRNOP00000025797.3
	ENSRNOP00000078788.1
	ENSRNOP00000083621.1
	ENSRNOP00000091374.2

RefSeq Acc Id:

NP_942062 ⟸ NM_198767

- UniProtKB:

Q76KC6 (UniProtKB/TrEMBL), A6JCF1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGCAPSIHISDNRVSNPSDSDGEDEDVRVPALRSRQRWSTPPGLVEPQPRDSGASKVSVADVQF
GPMRFHQDQLQVLLVFTKEDSQCNGFYRACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRN
PRQMDAEAMCRSIRSSKLSENTVIVGVVRRVDKEEVSLMPFLAAGFTRRYIENPNVMACYNELL
QLAFGEVRSQLKLRACNSVFTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQ
VPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVC
NGSNKVETTTECVQTDSQTDSQAGKHKDRRKHSMDVKAVSSRTSEVSNQRRHSSLARIHSMMIE
APITKVINILSAAQENSPVSVTEALNHVLDILRTTELYSPQFNTEDDPHATDLVGGLMSDGLRR
FSGNEYTLATKSLRPSSSQLAVPISLHDIPPRIAQVIENEEQWDFDIFELEAATQNRPLIYLGL
KTFARFEICEFLQCSEATLKSWFQIIESNYHSSNPYHNSTHAADVLHATAYFLSRNKLKDTLDR
LDEVAALIAATIHDVDHPGRTNSFLCNAGKELAVLYNDTAVLESHHAALAFQLTLENDKCNIFK
NTDRNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMVRT
PESRTLIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSI
PKSQISFIDYFITDMFDAWDAFVYLPNLMRHLEDNFKYWKGLDEKELCTLRPPPE

hide sequence

RefSeq Acc Id:	XP_006229500 ⟸ XM_006229438
- Peptide Label:	isoform X2
- UniProtKB:	Q76KC6 (UniProtKB/TrEMBL), A6JCF1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGCAPSIHISDNRVSNPSDSDGEDEDVRVPALRSRQRWSTPPGLVEPQPRDSGASKVSVADVQF GPMRFHQDQLQVLLVFTKEDSQCNGFYRACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRN PRQMDAEAMCRSIRSSKLSENTVIVGVVRRVDKEEVSLMPFLAAGFTRRYIENPNVMACYNELL QLAFGEVRSQLKLRACNSVFTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQ VPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVC NGSNKVETTTECVQTDSQTDSQAGKHKDRRKHSMDVKAVSSRTSEVSNQRRHSSLARIHSMMIE APITKVINILSAAQENSPVSVTEALNHVLDILRTTELYSPQFNTEDDPHATDLVGGLMSDGLRR FSGNEYTLATKSLRPSSSQLAVPISLHDIPPRIAQVIENEEQWDFDIFELEAATQNRPLIYLGL KTFARFEICEFLQCSEATLKSWFQIIESNYHSSNPYHNSTHAADVLHATAYFLSRNKLKDTLDR LDEVAALIAATIHDVDHPGRTNSFLCNAGKELAVLYNDTAVLESHHAALAFQLTLENDKCNIFK NTDRNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMVRT PESRTLIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSI PKSQISFIDYFITDMFDAWDAFVYLPNLMRHLEDNFKYWKGLDEKELCTLRPPPE hide sequence

Ensembl Acc Id:

ENSRNOP00000025797 ⟸ ENSRNOT00000025797

RefSeq Acc Id:	XP_038968973 ⟸ XM_039113045
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038968970 ⟸ XM_039113042
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6ABI0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968971 ⟸ XM_039113043
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6ABI0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968972 ⟸ XM_039113044
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000083621 ⟸ ENSRNOT00000103564

Ensembl Acc Id:

ENSRNOP00000078788 ⟸ ENSRNOT00000101888

Ensembl Acc Id:

ENSRNOP00000091374 ⟸ ENSRNOT00000096230

RefSeq Acc Id:	XP_063118773 ⟸ XM_063262703
- Peptide Label:	isoform X1
- UniProtKB:	A6JCF1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063118774 ⟸ XM_063262704
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZXE4 (UniProtKB/TrEMBL)

Protein Domains

PAS PDEase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q76KC6-F1-model_v2	AlphaFold	Q76KC6	1-823	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690154

Promoter ID:

EPDNEW_R678

Type:

single initiation site

Name:

Pde8a_1

Description:

phosphodiesterase 8A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	143,036,138 - 143,036,198	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735125	AgrOrtholog
BioCyc Gene	G2FUF-58715	BioCyc
Ensembl Genes	ENSRNOG00000019005	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025797	ENTREZGENE
	ENSRNOT00000025797.5	UniProtKB/TrEMBL
	ENSRNOT00000096230.2	UniProtKB/TrEMBL
	ENSRNOT00000101888.2	UniProtKB/TrEMBL
	ENSRNOT00000103564.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1300.10	UniProtKB/TrEMBL
	3.40.50.2300	UniProtKB/TrEMBL
	PAS domain	UniProtKB/TrEMBL
InterPro	Metal-dep_PHydrolase_HD_dom	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
	PAS-like_dom_sf	UniProtKB/TrEMBL
	PDE8-like_REC_N	UniProtKB/TrEMBL
	PDEase	UniProtKB/TrEMBL
	PDEase	UniProtKB/TrEMBL
	PDEase_catalytic_dom_sf	UniProtKB/TrEMBL
	PDEase_CS	UniProtKB/TrEMBL
KEGG Report	rno:308776	UniProtKB/TrEMBL
NCBI Gene	308776	ENTREZGENE
PANTHER	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE	UniProtKB/TrEMBL
Pfam	PAS_9	UniProtKB/TrEMBL
	PDE8A_N	UniProtKB/TrEMBL
	PDEase_I	UniProtKB/TrEMBL
PhenoGen	Pde8a	PhenoGen
PRINTS	PDIESTERASE1	UniProtKB/TrEMBL
PROSITE	PAS	UniProtKB/TrEMBL
	PDEASE_I	UniProtKB/TrEMBL
	PDEASE_I_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019005	RatGTEx
SMART	HDc	UniProtKB/TrEMBL
Superfamily-SCOP	HD-domain/PDEase-like	UniProtKB/TrEMBL
	SSF55785	UniProtKB/TrEMBL
UniProt	A0A8I5ZLP7_RAT	UniProtKB/TrEMBL
	A0A8I5ZXE4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ABI0	ENTREZGENE, UniProtKB/TrEMBL
	A6JCF1	ENTREZGENE, UniProtKB/TrEMBL
	Q76KC6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Pde8a	phosphodiesterase 8A			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)