Cbx7 (chromobox 7) - Rat Genome Database

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Gene: Cbx7 (chromobox 7) Rattus norvegicus
Analyze
Symbol: Cbx7
Name: chromobox 7
RGD ID: 735027
Description: Predicted to enable chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Involved in developmental process involved in reproduction; positive regulation of transcription elongation by RNA polymerase II; and response to xenobiotic stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of PRC1 complex and heterochromatin. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7); PARTICIPATES IN histone modification pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromobox homolog 7; chromobox protein homolog 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,341,030 - 113,358,716 (-)NCBIGRCr8
mRatBN7.27111,460,656 - 111,479,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,208,676 - 113,225,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,432,223 - 115,449,524 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,401,568 - 115,418,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,136,067 - 121,153,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,136,058 - 121,153,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,126,405 - 121,144,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,148,413 - 118,165,701 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,182,643 - 118,199,931 (-)NCBI
Celera7107,790,484 - 107,807,779 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aripiprazole  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
fenoldopam  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead diacetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
N(4)-hydroxycytidine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thimerosal  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytosol  (IEA,ISO)
heterochromatin  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
PcG protein complex  (ISO,ISS)
PRC1 complex  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex. Cheng MC, etal., Int J Neuropsychopharmacol. 2007 Sep 17;:1-10.
2. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Chubb D, etal., Nat Genet. 2013 Oct;45(10):1221-5. doi: 10.1038/ng.2733. Epub 2013 Aug 18.
3. Polycomb genes are associated with response to imatinib in chronic myeloid leukemia. Crea F, etal., Epigenomics. 2015 Aug;7(5):757-65. doi: 10.2217/epi.15.35. Epub 2015 Sep 7.
4. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Federico A, etal., Cancer Res. 2009 Sep 1;69(17):7079-87. doi: 10.1158/0008-5472.CAN-09-1542. Epub 2009 Aug 25.
5. CBX7 is a tumor suppressor in mice and humans. Forzati F, etal., J Clin Invest. 2012 Feb 1;122(2):612-23. doi: 10.1172/JCI58620. Epub 2012 Jan 3.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. PRC1 complex diversity: where is it taking us? Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
8. Polycomb CBX7 has a unifying role in cellular lifespan. Gil J, etal., Nat Cell Biol 2004 Jan;6(1):67-72. Epub 2003 Nov 30.
9. [Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues] Guan ZP, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jul;45(7):597-600.
10. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Hinz S, etal., Tumour Biol. 2008;29(5):323-9. doi: 10.1159/000170879. Epub 2008 Nov 5.
11. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Karamitopoulou E, etal., Eur J Cancer. 2010 May;46(8):1438-44. doi: 10.1016/j.ejca.2010.01.033. Epub 2010 Feb 23.
12. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/beta-catenin pathway. Kim HY, etal., FASEB J. 2015 Jan;29(1):300-13. doi: 10.1096/fj.14-253997. Epub 2014 Oct 28.
13. Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding. Klauke K, etal., Stem Cell Reports. 2015 Jan 13;4(1):74-89. doi: 10.1016/j.stemcr.2014.10.012. Epub 2014 Nov 26.
14. Altered expression of polycomb group genes in glioblastoma multiforme. Li G, etal., PLoS One. 2013 Nov 15;8(11):e80970. doi: 10.1371/journal.pone.0080970. eCollection 2013.
15. Epigenetic control of female puberty. Lomniczi A, etal., Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27.
16. Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein. Mansueto G, etal., Genes Cancer. 2010 Mar;1(3):210-24. doi: 10.1177/1947601910366860.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hurthle Cell Adenomas and Carcinomas). Monaco M, etal., Eur Thyroid J. 2014 Dec;3(4):211-6. doi: 10.1159/000367989. Epub 2014 Oct 15.
19. Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Pallante P, etal., Cancer Res. 2008 Aug 15;68(16):6770-8. doi: 10.1158/0008-5472.CAN-08-0695.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Role of the chromobox protein CBX7 in lymphomagenesis. Scott CL, etal., Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. Epub 2007 Mar 20.
25. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Shinjo K, etal., Int J Cancer. 2014 Jul 15;135(2):308-18. doi: 10.1002/ijc.28692. Epub 2014 Jan 10.
26. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Oncogenic role of the chromobox protein CBX7 in gastric cancer. Zhang XW, etal., J Exp Clin Cancer Res. 2010 Aug 19;29:114. doi: 10.1186/1756-9966-29-114.
Additional References at PubMed
PMID:15489334   PMID:16537902   PMID:19636380   PMID:21282530   PMID:22056776   PMID:23870131   PMID:36222130  


Genomics

Comparative Map Data
Cbx7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,341,030 - 113,358,716 (-)NCBIGRCr8
mRatBN7.27111,460,656 - 111,479,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,208,676 - 113,225,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,432,223 - 115,449,524 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,401,568 - 115,418,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,136,067 - 121,153,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,136,058 - 121,153,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,126,405 - 121,144,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,148,413 - 118,165,701 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,182,643 - 118,199,931 (-)NCBI
Celera7107,790,484 - 107,807,779 (-)NCBICelera
Cytogenetic Map7q34NCBI
CBX7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,130,772 - 39,152,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,120,167 - 39,152,680 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,526,777 - 39,548,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,856,723 - 37,878,484 (-)NCBINCBI36Build 36hg18NCBI36
Build 342237,851,280 - 37,873,038NCBI
Celera2223,328,820 - 23,350,581 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,493,890 - 22,515,575 (-)NCBIHuRef
CHM1_12239,485,611 - 39,507,403 (-)NCBICHM1_1
T2T-CHM13v2.02239,601,155 - 39,623,071 (-)NCBIT2T-CHM13v2.0
Cbx7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,800,005 - 79,855,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,800,008 - 79,855,320 (-)EnsemblGRCm39 Ensembl
GRCm381579,915,804 - 79,971,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,915,807 - 79,971,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv371579,746,237 - 79,763,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,740,244 - 79,759,866 (-)NCBIMGSCv36mm8
Celera1582,033,986 - 82,050,640 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Cbx7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,086,186 - 25,100,039 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,079,627 - 25,100,039 (-)NCBIChiLan1.0ChiLan1.0
CBX7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,978,435 - 49,000,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,669,911 - 51,691,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,037,529 - 20,059,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,854,049 - 37,876,861 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,854,056 - 37,876,084 (-)Ensemblpanpan1.1panPan2
CBX7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,876,022 - 25,896,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,876,016 - 25,893,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,810,682 - 25,832,138 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,627,291 - 26,648,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,627,343 - 26,648,764 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,340,710 - 26,362,175 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,661,555 - 26,681,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,836,680 - 26,858,133 (+)NCBIUU_Cfam_GSD_1.0
Cbx7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,400,883 - 9,418,070 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,410,308 - 2,428,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,411,171 - 2,428,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBX7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,070,353 - 9,087,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,070,312 - 9,090,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,355,114 - 6,372,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBX7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,776,618 - 21,798,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,775,931 - 21,798,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,958,387 - 103,980,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbx7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,133,569 - 9,151,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,133,587 - 9,151,216 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cbx7
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:198
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000022631
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 7 14 2 17 18 12 10
Low 39 50 41 5 41 8 9 57 17 29 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022631   ⟹   ENSRNOP00000022631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)Ensembl
Rnor_6.0 Ensembl7121,136,067 - 121,153,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077731   ⟹   ENSRNOP00000074584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,461,688 - 111,477,973 (-)Ensembl
Rnor_6.0 Ensembl7121,136,058 - 121,153,231 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115396   ⟹   ENSRNOP00000076579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,463,166 - 111,477,973 (-)Ensembl
RefSeq Acc Id: NM_199117   ⟹   NP_954548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,346 (-)NCBI
mRatBN7.27111,460,656 - 111,477,973 (-)NCBI
Rnor_6.07121,136,067 - 121,153,383 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
RGSC_v3.47118,148,413 - 118,165,701 (-)RGD
Celera7107,790,484 - 107,807,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242020   ⟹   XP_006242082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,460,656 - 111,478,046 (-)NCBI
Rnor_6.07121,136,067 - 121,153,489 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242021   ⟹   XP_006242083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,343,133 - 113,358,716 (-)NCBI
mRatBN7.27111,462,756 - 111,478,053 (-)NCBI
Rnor_6.07121,138,216 - 121,153,490 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242022   ⟹   XP_006242084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,462,754 - 111,479,231 (-)NCBI
Rnor_6.07121,138,485 - 121,153,503 (-)NCBI
Rnor_5.07121,126,405 - 121,144,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079590   ⟹   XP_038935518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,025 (-)NCBI
mRatBN7.27111,460,656 - 111,477,674 (-)NCBI
RefSeq Acc Id: XM_039079591   ⟹   XP_038935519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,460,656 - 111,478,036 (-)NCBI
RefSeq Acc Id: XM_039079592   ⟹   XP_038935520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,462,754 - 111,478,036 (-)NCBI
RefSeq Acc Id: XM_039079593   ⟹   XP_038935521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,358,716 (-)NCBI
mRatBN7.27111,460,656 - 111,478,034 (-)NCBI
RefSeq Acc Id: XM_063263925   ⟹   XP_063119995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,341,030 - 113,356,299 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_954548   ⟸   NM_199117
- UniProtKB: P60889 (UniProtKB/Swiss-Prot),   A6HSV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242082   ⟸   XM_006242020
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCQ7 (UniProtKB/TrEMBL),   A6HSV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242083   ⟸   XM_006242021
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCQ7 (UniProtKB/TrEMBL),   A6HSV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242084   ⟸   XM_006242022
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000074584   ⟸   ENSRNOT00000077731
RefSeq Acc Id: ENSRNOP00000022631   ⟸   ENSRNOT00000022631
RefSeq Acc Id: XP_038935519   ⟸   XM_039079591
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935521   ⟸   XM_039079593
- Peptide Label: isoform X7
- UniProtKB: A0A8L2UR72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935518   ⟸   XM_039079590
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038935520   ⟸   XM_039079592
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000076579   ⟸   ENSRNOT00000115396
RefSeq Acc Id: XP_063119995   ⟸   XM_063263925
- Peptide Label: isoform X5
Protein Domains
Chromo

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60889-F1-model_v2 AlphaFold P60889 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695491
Promoter ID:EPDNEW_R6016
Type:single initiation site
Name:Cbx7_1
Description:chromobox 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07121,153,391 - 121,153,451EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735027 AgrOrtholog
BioCyc Gene G2FUF-32731 BioCyc
Ensembl Genes ENSRNOG00000016875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022631.7 UniProtKB/TrEMBL
  ENSRNOT00000077731.2 UniProtKB/TrEMBL
  ENSRNOT00000115396.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621139 IMAGE-MGC_LOAD
InterPro CBX7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo/chromo_shadow_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo_dom_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromodomain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72633 IMAGE-MGC_LOAD
NCBI Gene 362962 ENTREZGENE
PANTHER CHROMOBOX PROTEIN HOMOLOG 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47277 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cbx7 PhenoGen
PRINTS CHROMODOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CHROMO_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHROMO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016875 RatGTEx
SMART CHROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0I1_RAT UniProtKB/TrEMBL
  A0A8L2QCQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UR72 ENTREZGENE, UniProtKB/TrEMBL
  A6HSV0 ENTREZGENE, UniProtKB/TrEMBL
  A6HSV1 ENTREZGENE, UniProtKB/TrEMBL
  CBX7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Cbx7  chromobox 7  Cbx7  chromobox homolog 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cbx7  chromobox homolog 7    chromobox 7  Name updated 1299863 APPROVED