Dsg4 (desmoglein 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Dsg4 (desmoglein 4) Rattus norvegicus
Analyze
Symbol: Dsg4
Name: desmoglein 4
RGD ID: 735015
Description: Enables calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within BMP signaling pathway; hair follicle development; and keratinocyte differentiation. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in desmosome. Used to study alopecia and hypotrichosis. Human ortholog(s) of this gene implicated in hypotrichosis and hypotrichosis 6. Orthologous to human DSG4 (desmoglein 4); INTERACTS WITH acrylamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: desmoglein-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dsg4hr
Genetic Models: OFA(SD)-Dsg4hr/Crl
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,995,902 - 12,032,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1811,995,902 - 12,032,908 (+)EnsemblGRCr8
mRatBN7.21811,720,844 - 11,757,927 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,720,975 - 11,756,234 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1811,922,992 - 11,958,017 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01812,710,645 - 12,745,680 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01811,982,280 - 12,017,306 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01812,056,113 - 12,092,858 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,056,113 - 12,092,858 (+)Ensemblrn6Rnor6.0
Rnor_5.01811,853,980 - 11,888,828 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41812,173,507 - 12,209,833 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1811,736,765 - 11,771,810 (+)NCBICelera
RGSC_v3.11812,200,152 - 12,236,479 (+)NCBI
Cytogenetic Map18p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alopecia  (IAGP)
genetic disease  (ISO)
hypotrichosis  (IAGP,IMP,ISO)
hypotrichosis 6  (ISO,ISS)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
desmosome  (IBA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo "hairless" rat. Bazzi H, etal., Differentiation. 2004 Oct;72(8):450-64. doi: 10.1111/j.1432-0436.2004.07208010.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene. Jahoda CA, etal., Genomics 2004 May;83(5):747-56.
4. A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model. Meyer B, etal., Differentiation. 2004 Dec;72(9-10):541-7. doi: 10.1111/j.1432-0436.2004.07209007.x.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. A recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosis. Rafiq MA, etal., J Invest Dermatol. 2004 Jul;123(1):247-8.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12705872   PMID:16382669   PMID:18692037   PMID:19683850   PMID:33995349  


Genomics

Comparative Map Data
Dsg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,995,902 - 12,032,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1811,995,902 - 12,032,908 (+)EnsemblGRCr8
mRatBN7.21811,720,844 - 11,757,927 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,720,975 - 11,756,234 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1811,922,992 - 11,958,017 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01812,710,645 - 12,745,680 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01811,982,280 - 12,017,306 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01812,056,113 - 12,092,858 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,056,113 - 12,092,858 (+)Ensemblrn6Rnor6.0
Rnor_5.01811,853,980 - 11,888,828 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41812,173,507 - 12,209,833 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1811,736,765 - 11,771,810 (+)NCBICelera
RGSC_v3.11812,200,152 - 12,236,479 (+)NCBI
Cytogenetic Map18p12NCBI
DSG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,376,777 - 31,414,909 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,376,777 - 31,414,912 (+)Ensemblhg38GRCh38
GRCh371828,956,740 - 28,994,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,210,738 - 27,247,877 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341827,210,737 - 27,247,877NCBI
Celera1825,763,866 - 25,801,005 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1825,812,756 - 25,849,925 (+)NCBIHuRef
CHM1_11828,884,023 - 28,921,163 (+)NCBICHM1_1
T2T-CHM13v2.01831,567,308 - 31,605,438 (+)NCBIT2T-CHM13v2.0
Dsg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,569,234 - 20,606,191 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,569,232 - 20,604,878 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381820,436,175 - 20,471,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,436,175 - 20,471,821 (+)Ensemblmm10GRCm38
MGSCv371820,594,676 - 20,630,322 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361820,579,185 - 20,614,831 (+)NCBIMGSCv36mm8
Celera1820,940,658 - 20,976,720 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.35NCBI
Dsg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540218,715,893 - 18,753,028 (+)Ensembl
ChiLan1.0NW_00495540218,724,959 - 18,754,232 (+)NCBIChiLan1.0ChiLan1.0
DSG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,769,668 - 48,807,807 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,462,264 - 34,500,403 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,595,021 - 24,633,182 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,192,145 - 28,230,358 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,192,145 - 28,230,358 (+)EnsemblpanPan2panpan1.1
DSG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1758,101,294 - 58,135,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,536,708 - 57,572,413 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0758,084,931 - 58,120,641 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl758,087,374 - 58,128,806 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,761,254 - 57,796,970 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,787,371 - 57,823,079 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0758,076,538 - 58,112,235 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dsg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,801,958 - 53,827,629 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,803,862 - 1,841,396 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,803,862 - 1,829,352 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,289,859 - 115,325,854 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16115,288,606 - 115,325,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26107,917,621 - 107,952,873 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,316,206 - 49,343,929 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,317,150 - 49,353,635 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605023,961,606 - 23,998,838 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,457,016 - 1,495,009 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247701,456,988 - 1,491,069 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dsg4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11523,194,442 - 23,229,440 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dsg4
279 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000038450
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Rat147  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81811,994,059 - 11,994,276 (+)Marker Load Pipeline
mRatBN7.21811,719,001 - 11,719,218 (+)MAPPERmRatBN7.2
Rnor_6.01812,053,943 - 12,054,159NCBIRnor6.0
Rnor_5.01811,851,810 - 11,852,026UniSTSRnor5.0
RGSC_v3.41812,171,531 - 12,171,748RGDRGSC3.4
RGSC_v3.41812,171,532 - 12,171,748UniSTSRGSC3.4
Celera1811,734,791 - 11,735,007UniSTS
RGSC_v3.11812,198,178 - 12,198,394RGD
RH 3.4 Map18133.1UniSTS
RH 3.4 Map18133.1RGD
RH 2.0 Map18759.5RGD
SHRSP x BN Map184.77RGD
Cytogenetic Map18p12UniSTS


Genetic Models
This gene Dsg4 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
16 3 13 17 12 6 55 33 8 3 3 24

Sequence


Ensembl Acc Id: ENSRNOT00000038450   ⟹   ENSRNOP00000031941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1811,995,902 - 12,032,908 (+)Ensembl
mRatBN7.2 Ensembl1811,720,975 - 11,756,234 (+)Ensembl
Rnor_6.0 Ensembl1812,056,113 - 12,092,858 (+)Ensembl
RefSeq Acc Id: NM_199490   ⟹   NP_955784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81811,995,902 - 12,032,908 (+)NCBI
mRatBN7.21811,720,844 - 11,757,927 (+)NCBI
Rnor_6.01812,056,113 - 12,092,858 (+)NCBI
Rnor_5.01811,853,980 - 11,888,828 (+)NCBI
RGSC_v3.41812,173,507 - 12,209,833 (+)RGD
Celera1811,736,765 - 11,771,810 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_955784 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ88398 (Get FASTA)   NCBI Sequence Viewer  
  EDL76089 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000105283
GenBank Protein Q6W3B0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_955784   ⟸   NM_199490
- Peptide Label: precursor
- UniProtKB: Q6W3B0 (UniProtKB/Swiss-Prot),   A6J2F7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031941   ⟸   ENSRNOT00000038450
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6W3B0-F1-model_v2 AlphaFold Q6W3B0 1-1040 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735015 AgrOrtholog
BioCyc Gene G2FUF-8233 BioCyc
Ensembl Genes ENSRNOG00000022364 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000038450 ENTREZGENE
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
InterPro Cadherin-domain_protein UniProtKB/Swiss-Prot
  Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot
  Desmosomal_cadherin UniProtKB/Swiss-Prot
KEGG Report rno:291754 UniProtKB/Swiss-Prot
NCBI Gene 291754 ENTREZGENE
PANTHER DESMOGLEIN FAMILY MEMBER UniProtKB/Swiss-Prot
  DESMOGLEIN-4 UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
  Cadherin_C UniProtKB/Swiss-Prot
PhenoGen Dsg4 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
  DESMOCADHERN UniProtKB/Swiss-Prot
  DESMOGLEIN UniProtKB/Swiss-Prot
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022364 RatGTEx
SMART SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot
UniProt A6J2F7 ENTREZGENE, UniProtKB/TrEMBL
  DSG4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dsg4  desmoglein 4      Symbol and Name status set to approved 1299863 APPROVED