ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope) - Rat Genome Database

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Gene: ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope) Homo sapiens
Analyze
Symbol: ERVFRD-1
Name: endogenous retrovirus group FRD member 1, envelope
RGD ID: 1606632
HGNC Page HGNC:33823
Description: Involved in syncytium formation by plasma membrane fusion. Acts upstream of or within myoblast fusion. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endogenous retrovirus group FRD member 1; endogenous retrovirus group FRD, member 1; envelope polyprotein; envFRD; ERVFRDE1; FLJ41944; FLJ90611; GLLL6191; HERV-FRD; HERV-FRD provirus ancestral Env polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; HERV-W/FRD; MGC87585; syncytin 2; syncytin-2; UNQ6191
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AC012078.1   AC108467.2   AC233981.1   AL136298.2   AL359854.1   LOC100533722   LOC100533730   LOC100533732   LOC100533733   LOC100533734   LOC100533735  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38611,102,489 - 11,111,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl611,102,324 - 11,111,845 (-)EnsemblGRCh38hg38GRCh38
GRCh37611,102,722 - 11,111,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36611,210,708 - 11,219,945 (-)NCBINCBI36Build 36hg18NCBI36
Celera612,331,189 - 12,340,538 (-)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef611,034,168 - 11,043,517 (-)NCBIHuRef
CHM1_1611,104,822 - 11,114,171 (-)NCBICHM1_1
T2T-CHM13v2.0610,970,408 - 10,979,644 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12970426   PMID:12975309   PMID:14557543   PMID:14574404   PMID:14694139   PMID:14702039   PMID:15476554   PMID:15489334   PMID:16140326   PMID:16303743   PMID:16344560  
PMID:16714059   PMID:18077339   PMID:18215254   PMID:18650494   PMID:19616006   PMID:21493955   PMID:21542922   PMID:21653829   PMID:21771862   PMID:21832049   PMID:21873635   PMID:23177091  
PMID:23492904   PMID:25781974   PMID:26853155   PMID:26875564   PMID:26992684   PMID:27486264   PMID:27589388   PMID:29750965   PMID:31318021   PMID:32145327   PMID:32296183   PMID:33504453  
PMID:33993053   PMID:35710838   PMID:36768581   PMID:37695891  


Genomics

Comparative Map Data
ERVFRD-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38611,102,489 - 11,111,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl611,102,324 - 11,111,845 (-)EnsemblGRCh38hg38GRCh38
GRCh37611,102,722 - 11,111,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36611,210,708 - 11,219,945 (-)NCBINCBI36Build 36hg18NCBI36
Celera612,331,189 - 12,340,538 (-)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef611,034,168 - 11,043,517 (-)NCBIHuRef
CHM1_1611,104,822 - 11,114,171 (-)NCBICHM1_1
T2T-CHM13v2.0610,970,408 - 10,979,644 (-)NCBIT2T-CHM13v2.0
Synb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391469,527,827 - 69,549,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1469,526,793 - 69,531,748 (-)EnsemblGRCm39 Ensembl
GRCm381469,290,378 - 69,312,408 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,289,344 - 69,294,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv371469,908,455 - 69,912,356 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1467,069,330 - 67,073,231 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.04NCBI
Ervfrd-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,787,680 - 27,794,732 (+)NCBIGRCr8
mRatBN7.21222,151,211 - 22,158,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,151,211 - 22,158,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,294,443 - 23,301,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,905,524 - 23,912,428 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,972,115 - 22,979,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,161,130 - 25,168,182 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,161,130 - 25,168,182 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,161,524 - 27,168,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,220,471 - 23,222,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1223,915,041 - 23,922,023 (+)NCBICelera
Cytogenetic Map12q12NCBI
ERVFRD-1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,749,397 - 25,758,717 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,739,431 - 21,748,751 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,940,832 - 10,950,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1611,216,488 - 11,225,808 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl611,217,693 - 11,219,309 (-)Ensemblpanpan1.1panPan2
LOC119881605
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0918,735,394 - 18,791,155 (-)NCBIROS_Cfam_1.0
ERVFRD-1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,033,479 - 61,042,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1761,039,949 - 61,041,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604411,133,315 - 11,142,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ERVFRD-1
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-23(chr6:389423-13474956)x3 copy number gain See cases [RCV000051896] Chr6:389423..13474956 [GRCh38]
Chr6:389423..13475188 [GRCh37]
Chr6:334423..13583167 [NCBI36]
Chr6:6p25.3-23		 pathogenic
GRCh38/hg38 6p25.3-22.3(chr6:106431-18360595)x3 copy number gain See cases [RCV000051869] Chr6:106431..18360595 [GRCh38]
Chr6:106431..18360826 [GRCh37]
Chr6:51431..18468805 [NCBI36]
Chr6:6p25.3-22.3		 pathogenic
GRCh38/hg38 6p25.3-24.1(chr6:164360-13339881)x3 copy number gain See cases [RCV000134022] Chr6:164360..13339881 [GRCh38]
Chr6:164360..13340113 [GRCh37]
Chr6:109360..13448092 [NCBI36]
Chr6:6p25.3-24.1		 pathogenic
GRCh38/hg38 6p25.2-24.1(chr6:4068792-13267799)x1 copy number loss See cases [RCV000136132] Chr6:4068792..13267799 [GRCh38]
Chr6:4069026..13268031 [GRCh37]
Chr6:4014025..13376010 [NCBI36]
Chr6:6p25.2-24.1		 pathogenic
GRCh38/hg38 6p25.3-22.3(chr6:152634-15732163)x3 copy number gain See cases [RCV000138121] Chr6:152634..15732163 [GRCh38]
Chr6:152634..15732394 [GRCh37]
Chr6:97634..15840373 [NCBI36]
Chr6:6p25.3-22.3		 likely benign
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33		 pathogenic
GRCh38/hg38 6p25.3-22.3(chr6:155807-17058414)x3 copy number gain See cases [RCV000140307] Chr6:155807..17058414 [GRCh38]
Chr6:155807..17058645 [GRCh37]
Chr6:100807..17166624 [NCBI36]
Chr6:6p25.3-22.3		 pathogenic
GRCh38/hg38 6p24.2-23(chr6:10601499-13987316)x1 copy number loss See cases [RCV000142410] Chr6:10601499..13987316 [GRCh38]
Chr6:10601732..13987547 [GRCh37]
Chr6:10709718..14095526 [NCBI36]
Chr6:6p24.2-23		 pathogenic
GRCh38/hg38 6p25.3-24.2(chr6:156974-11550817)x3 copy number gain See cases [RCV000142295] Chr6:156974..11550817 [GRCh38]
Chr6:156974..11551050 [GRCh37]
Chr6:101974..11659036 [NCBI36]
Chr6:6p25.3-24.2		 likely pathogenic
GRCh38/hg38 6p25.2-22.3(chr6:2862640-16697788)x1 copy number loss See cases [RCV000142435] Chr6:2862640..16697788 [GRCh38]
Chr6:2862874..16698019 [GRCh37]
Chr6:2807873..16805998 [NCBI36]
Chr6:6p25.2-22.3		 pathogenic
GRCh38/hg38 6p25.3-23(chr6:152634-14417003)x3 copy number gain See cases [RCV000143334] Chr6:152634..14417003 [GRCh38]
Chr6:152634..14417234 [GRCh37]
Chr6:97634..14525213 [NCBI36]
Chr6:6p25.3-23		 pathogenic
GRCh38/hg38 6p25.3-24.1(chr6:156974-13081201)x3 copy number gain See cases [RCV000143698] Chr6:156974..13081201 [GRCh38]
Chr6:156974..13081433 [GRCh37]
Chr6:101974..13189419 [NCBI36]
Chr6:6p25.3-24.1		 likely pathogenic
GRCh38/hg38 6p25.3-23(chr6:156974-13855925)x1 copy number loss See cases [RCV000143782] Chr6:156974..13855925 [GRCh38]
Chr6:156974..13856156 [GRCh37]
Chr6:101974..13964135 [NCBI36]
Chr6:6p25.3-23		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-24.1(chr6:204009-11608587)x1 copy number loss See cases [RCV000240433] Chr6:204009..11608587 [GRCh37]
Chr6:6p25.3-24.1		 pathogenic
GRCh37/hg19 6p25.1-22.3(chr6:5354402-17950079)x1 copy number loss See cases [RCV000240576] Chr6:5354402..17950079 [GRCh37]
Chr6:6p25.1-22.3		 pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:168775-24023234)x3 copy number gain See cases [RCV000240460] Chr6:168775..24023234 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:302272-18375047)x3 copy number gain See cases [RCV000446145] Chr6:302272..18375047 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
GRCh37/hg19 6p24.3-22.3(chr6:8269414-17402660)x3 copy number gain See cases [RCV000447409] Chr6:8269414..17402660 [GRCh37]
Chr6:6p24.3-22.3		 likely pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_207582.3(ERVFRD-1):c.374T>C (p.Ile125Thr) single nucleotide variant not specified [RCV004323657] Chr6:11104937 [GRCh38]
Chr6:11105170 [GRCh37]
Chr6:6p24.2		 uncertain significance
GRCh37/hg19 6p25.3-23(chr6:156974-13502033)x3 copy number gain not provided [RCV000682628] Chr6:156974..13502033 [GRCh37]
Chr6:6p25.3-23		 pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:156974-21955964)x3 copy number gain not provided [RCV000682629] Chr6:156974..21955964 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
GRCh37/hg19 6p25.1-24.2(chr6:6990611-11276452)x1 copy number loss not provided [RCV000682643] Chr6:6990611..11276452 [GRCh37]
Chr6:6p25.1-24.2		 pathogenic
Single allele duplication not provided [RCV000677944] Chr6:168775..24023234 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:156974-23221621)x3 copy number gain not provided [RCV000848108] Chr6:156974..23221621 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
GRCh37/hg19 6p24.3-22.3(chr6:8269414-17402660) copy number gain not specified [RCV002053552] Chr6:8269414..17402660 [GRCh37]
Chr6:6p24.3-22.3		 likely pathogenic
NM_207582.3(ERVFRD-1):c.806T>C (p.Ile269Thr) single nucleotide variant not specified [RCV004239956] Chr6:11104505 [GRCh38]
Chr6:11104738 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.53G>A (p.Arg18His) single nucleotide variant not specified [RCV004088315] Chr6:11105258 [GRCh38]
Chr6:11105491 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.347A>G (p.Asn116Ser) single nucleotide variant not specified [RCV004200468] Chr6:11104964 [GRCh38]
Chr6:11105197 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.1463G>T (p.Gly488Val) single nucleotide variant not specified [RCV004137106] Chr6:11103848 [GRCh38]
Chr6:11104081 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.629C>G (p.Ala210Gly) single nucleotide variant not specified [RCV004104073] Chr6:11104682 [GRCh38]
Chr6:11104915 [GRCh37]
Chr6:6p24.2		 uncertain significance
GRCh37/hg19 6p25.3-22.3(chr6:820000-21700000)x3 copy number gain See cases [RCV002509885] Chr6:820000..21700000 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
NM_207582.3(ERVFRD-1):c.554T>G (p.Leu185Trp) single nucleotide variant not specified [RCV004218409] Chr6:11104757 [GRCh38]
Chr6:11104990 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.523C>T (p.Pro175Ser) single nucleotide variant not specified [RCV004114890] Chr6:11104788 [GRCh38]
Chr6:11105021 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.701G>A (p.Arg234Gln) single nucleotide variant not specified [RCV004154507] Chr6:11104610 [GRCh38]
Chr6:11104843 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.232T>G (p.Trp78Gly) single nucleotide variant not specified [RCV004183442] Chr6:11105079 [GRCh38]
Chr6:11105312 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.785T>C (p.Ile262Thr) single nucleotide variant not specified [RCV004257848] Chr6:11104526 [GRCh38]
Chr6:11104759 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.674C>T (p.Ala225Val) single nucleotide variant not specified [RCV004264998] Chr6:11104637 [GRCh38]
Chr6:11104870 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.182C>T (p.Ser61Leu) single nucleotide variant not specified [RCV004360105] Chr6:11105129 [GRCh38]
Chr6:11105362 [GRCh37]
Chr6:6p24.2		 uncertain significance
GRCh37/hg19 6p25.3-22.3(chr6:156975-15478095)x3 copy number gain not provided [RCV003484635] Chr6:156975..15478095 [GRCh37]
Chr6:6p25.3-22.3		 pathogenic
NM_207582.3(ERVFRD-1):c.770T>C (p.Leu257Ser) single nucleotide variant not specified [RCV004380802] Chr6:11104541 [GRCh38]
Chr6:11104774 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.401G>T (p.Gly134Val) single nucleotide variant not specified [RCV004380800] Chr6:11104910 [GRCh38]
Chr6:11105143 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.571C>T (p.Arg191Trp) single nucleotide variant not specified [RCV004380801] Chr6:11104740 [GRCh38]
Chr6:11104973 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.209C>T (p.Ala70Val) single nucleotide variant not specified [RCV004380798] Chr6:11105102 [GRCh38]
Chr6:11105335 [GRCh37]
Chr6:6p24.2		 uncertain significance
NM_207582.3(ERVFRD-1):c.310C>T (p.Arg104Cys) single nucleotide variant not specified [RCV004380799] Chr6:11105001 [GRCh38]
Chr6:11105234 [GRCh37]
Chr6:6p24.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1015
Count of miRNA genes:411
Interacting mature miRNAs:447
Transcripts:ENST00000472091, ENST00000542862
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WIAF-1567  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37611,102,730 - 11,102,898UniSTSGRCh37
Build 36611,210,716 - 11,210,884RGDNCBI36
Celera612,331,197 - 12,331,365RGD
Cytogenetic Map6p24.2UniSTS
Cytogenetic Map6p24.1UniSTS
HuRef611,034,176 - 11,034,344UniSTS
GeneMap99-GB4 RH Map649.55UniSTS
NCBI RH Map6114.4UniSTS
SHGC-33794  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37611,102,729 - 11,102,855UniSTSGRCh37
Build 36611,210,715 - 11,210,841RGDNCBI36
Celera612,331,196 - 12,331,322RGD
Cytogenetic Map6p24.2UniSTS
Cytogenetic Map6p24.1UniSTS
HuRef611,034,175 - 11,034,301UniSTS
GeneMap99-GB4 RH Map647.45UniSTS
GeneMap99-GB4 RH Map647.84UniSTS
Whitehead-RH Map669.7UniSTS
NCBI RH Map6119.3UniSTS
GeneMap99-G3 RH Map6325.0UniSTS
AL031214  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37611,108,853 - 11,108,983UniSTSGRCh37
Build 36611,216,839 - 11,216,969RGDNCBI36
Celera612,337,320 - 12,337,450RGD
Cytogenetic Map6p24.2UniSTS
Cytogenetic Map6p24.1UniSTS
HuRef611,040,299 - 11,040,429UniSTS
PMC228468P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37611,105,170 - 11,105,283UniSTSGRCh37
Build 36611,213,156 - 11,213,269RGDNCBI36
Celera612,333,637 - 12,333,750RGD
Cytogenetic Map6p24.2UniSTS
Cytogenetic Map6p24.1UniSTS
HuRef611,036,616 - 11,036,729UniSTS
RH17888  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37611,102,781 - 11,102,981UniSTSGRCh37
Build 36611,210,767 - 11,210,967RGDNCBI36
Celera612,331,248 - 12,331,448RGD
Cytogenetic Map6p24.2UniSTS
Cytogenetic Map6p24.1UniSTS
HuRef611,034,227 - 11,034,427UniSTS
GeneMap99-GB4 RH Map649.55UniSTS
NCBI RH Map6114.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 5 1 5 3 4 3
Low 1213 43 152 67 186 6 883 710 85 133 325 395 62 610 312 1
Below cutoff 1080 2213 1190 394 1039 296 2929 1220 2351 209 923 856 99 582 2115

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000472091   ⟹   ENSP00000420174
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl611,102,489 - 11,111,725 (-)Ensembl
RefSeq Acc Id: ENST00000542862   ⟹   ENSP00000444461
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl611,102,491 - 11,105,674 (-)Ensembl
RefSeq Acc Id: ENST00000715229
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl611,102,324 - 11,111,845 (-)Ensembl
RefSeq Acc Id: NM_207582   ⟹   NP_997465
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38611,102,489 - 11,111,725 (-)NCBI
GRCh37611,102,722 - 11,112,071 (-)ENTREZGENE
Build 36611,210,708 - 11,219,945 (-)NCBI Archive
HuRef611,034,168 - 11,043,517 (-)ENTREZGENE
CHM1_1611,104,822 - 11,114,171 (-)NCBI
T2T-CHM13v2.0610,970,408 - 10,979,644 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_997465 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH68585 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88611 (Get FASTA)   NCBI Sequence Viewer  
  BAC11396 (Get FASTA)   NCBI Sequence Viewer  
  BAC85731 (Get FASTA)   NCBI Sequence Viewer  
  CAH68778 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000420174
  ENSP00000420174.1
  ENSP00000444461.1
GenBank Protein P60508 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_997465   ⟸   NM_207582
- Peptide Label: preproprotein
- UniProtKB: P60508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000444461   ⟸   ENST00000542862
RefSeq Acc Id: ENSP00000420174   ⟸   ENST00000472091

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60508-F1-model_v2 AlphaFold P60508 1-538 view protein structure

Promoters
RGD ID:6872086
Promoter ID:EPDNEW_H9191
Type:multiple initiation site
Name:ERVFRD-1_1
Description:endogenous retrovirus group FRD member 1, envelope
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9192  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38611,111,725 - 11,111,785EPDNEW
RGD ID:6872054
Promoter ID:EPDNEW_H9192
Type:initiation region
Name:ERVFRD-1_2
Description:endogenous retrovirus group FRD member 1, envelope
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9191  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38611,111,845 - 11,111,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33823 AgrOrtholog
COSMIC ERVFRD-1 COSMIC
Ensembl Genes ENSG00000244476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000472091 ENTREZGENE
  ENST00000472091.2 UniProtKB/Swiss-Prot
  ENST00000542862.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.210 UniProtKB/Swiss-Prot
GTEx ENSG00000244476 GTEx
HGNC ID HGNC:33823 ENTREZGENE
Human Proteome Map ERVFRD-1 Human Proteome Map
InterPro TLV/ENV_coat_polyprotein UniProtKB/Swiss-Prot
KEGG Report hsa:405754 UniProtKB/Swiss-Prot
NCBI Gene 405754 ENTREZGENE
OMIM 610524 OMIM
PANTHER PTHR10424 UniProtKB/Swiss-Prot
  SYNCYTIN-2 UniProtKB/Swiss-Prot
Pfam TLV_coat UniProtKB/Swiss-Prot
PharmGKB PA166180610 PharmGKB
Superfamily-SCOP Virus ectodomain UniProtKB/Swiss-Prot
UniProt P60508 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-04 ERVFRD-1  endogenous retrovirus group FRD member 1, envelope    endogenous retrovirus group FRD member 1  Symbol and/or name change 5135510 APPROVED
2015-12-22 ERVFRD-1  endogenous retrovirus group FRD member 1    endogenous retrovirus group FRD, member 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 ERVFRD-1  endogenous retrovirus group FRD, member 1  HERV-FRD  HERV-FRD provirus ancestral Env polyprotein  Symbol and/or name change 5135510 APPROVED