Spata31 (spermatogenesis associated 31) - Rat Genome Database

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Gene: Spata31 (spermatogenesis associated 31) Rattus norvegicus
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Symbol: Spata31
Name: spermatogenesis associated 31
RGD ID: 727950
Description: Enables actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in acrosomal vesicle. Orthologous to several human genes including SPATA31A6 (SPATA31 subfamily A member 6); INTERACTS WITH 2-methoxyethanol; vinclozolin; benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acrosome-expressed protein 1; acrosome-specific protein VAD1.3; Aep1; Fam75a4; family with sequence similarity 75, member A4; LOC353306; MGC94993; SPATA31 subfamily A member 5; SPATA31 subfamily A, member 5; Spata31a5; spermatogenesis associated 31 subfamily A, member 5; spermatogenesis-associated protein 31; vitamin A-deficient testicular protein 11-like
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr817249,433 - 255,219 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl17249,439 - 255,219 (-)EnsemblGRCr8
mRatBN7.217243,648 - 249,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17243,654 - 249,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx17277,168 - 282,993 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,819,738 - 1,825,563 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017274,583 - 280,408 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd17258,797 - 264,583 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive17242,368 - 248,156 (-)NCBILyon_Normotensive
Lyon_Hypertensive17242,388 - 248,176 (-)NCBILyon_Hypertensive
F344_StmMcwi17626,239 - 632,025 (-)NCBIF344_StmMcwi
Rnor_6.0172,417,700 - 2,423,486 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,417,635 - 2,423,572 (-)Ensemblrn6Rnor6.0
Rnor_5.0172,400,210 - 2,405,996 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4175,716,545 - 5,722,331 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,259,605 - 2,265,391 (+)NCBICelera
RGSC_v3.1175,716,551 - 5,717,470 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display. Luk JM, etal., Biochem Biophys Res Commun 2003 Aug 8;307(4):782-90.
2. Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis. Luk JM, etal., J Cell Physiol. 2006 Dec;209(3):755-66.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. The testis-specific VAD1.3/AEP1 interacts with beta-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence. Zuo Y, etal., Biochem Biophys Res Commun. 2010 Oct 15;401(2):275-80. Epub 2010 Sep 17.
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Spata31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr817249,433 - 255,219 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl17249,439 - 255,219 (-)EnsemblGRCr8
mRatBN7.217243,648 - 249,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17243,654 - 249,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx17277,168 - 282,993 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,819,738 - 1,825,563 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017274,583 - 280,408 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd17258,797 - 264,583 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive17242,368 - 248,156 (-)NCBILyon_Normotensive
Lyon_Hypertensive17242,388 - 248,176 (-)NCBILyon_Hypertensive
F344_StmMcwi17626,239 - 632,025 (-)NCBIF344_StmMcwi
Rnor_6.0172,417,700 - 2,423,486 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,417,635 - 2,423,572 (-)Ensemblrn6Rnor6.0
Rnor_5.0172,400,210 - 2,405,996 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4175,716,545 - 5,722,331 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,259,605 - 2,265,391 (+)NCBICelera
RGSC_v3.1175,716,551 - 5,717,470 (+)NCBI
Cytogenetic Map17p14NCBI
SPATA31A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38942,183,659 - 42,189,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl942,183,659 - 42,189,887 (+)Ensemblhg38GRCh38
GRCh37943,624,502 - 43,630,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36943,564,496 - 43,570,753 (-)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map9p11.2NCBI
HuRef939,190,178 - 39,193,579 (-)NCBIHuRef
CHM1_1943,563,812 - 43,570,041 (-)NCBICHM1_1
T2T-CHM13v2.0943,734,207 - 43,740,441 (+)NCBIT2T-CHM13v2.0
Spata31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391365,065,220 - 65,071,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1365,065,220 - 65,071,008 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381364,917,406 - 64,923,195 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,917,406 - 64,923,194 (+)Ensemblmm10GRCm38
MGSCv371365,018,714 - 65,024,503 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361364,932,256 - 64,937,975 (+)NCBIMGSCv36mm8
Celera1366,562,718 - 66,568,601 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1334.21NCBI
LOC606788
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1169,725,958 - 69,733,216 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha170,503,611 - 70,510,854 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0169,956,795 - 69,970,784 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UNSW_CanFamBas_1.0169,602,645 - 69,613,140 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0170,312,079 - 70,322,573 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Spata31
138 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000024504
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 2 16 4 6 4 1 4 11 1 16 3 21 2

Sequence


Ensembl Acc Id: ENSRNOT00000024504   ⟹   ENSRNOP00000024504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl17249,439 - 255,219 (-)Ensembl
mRatBN7.2 Ensembl17243,654 - 249,434 (-)Ensembl
Rnor_6.0 Ensembl172,417,635 - 2,423,572 (-)Ensembl
RefSeq Acc Id: NM_001008359   ⟹   NP_001008360
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817249,433 - 255,219 (-)NCBI
mRatBN7.217243,648 - 249,434 (-)NCBI
Dahl_SR_JrHsd17258,797 - 264,583 (-)NCBI
Lyon_Normotensive17242,368 - 248,156 (-)NCBI
Lyon_Hypertensive17242,388 - 248,176 (-)NCBI
F344_StmMcwi17626,239 - 632,025 (-)NCBI
Rnor_6.0172,417,700 - 2,423,486 (-)NCBI
Rnor_5.0172,400,210 - 2,405,996 (-)NCBI
RGSC_v3.4175,716,545 - 5,722,331 (-)RGD
Celera172,259,605 - 2,265,391 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008360 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85936 (Get FASTA)   NCBI Sequence Viewer  
  AAP42847 (Get FASTA)   NCBI Sequence Viewer  
  B6VQA5 (Get FASTA)   NCBI Sequence Viewer  
  EDL84445 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024504
  ENSRNOP00000024504.4
RefSeq Acc Id: NP_001008360   ⟸   NM_001008359
- UniProtKB: Q5U2N7 (UniProtKB/Swiss-Prot),   Q7TSL1 (UniProtKB/Swiss-Prot),   B6VQA5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024504   ⟸   ENSRNOT00000024504

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B6VQA5-F1-model_v2 AlphaFold B6VQA5 1-1048 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700266
Promoter ID:EPDNEW_R10790
Type:initiation region
Name:Spata31a5_1
Description:SPATA31 subfamily A, member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,423,482 - 2,423,542EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727950 AgrOrtholog
BioCyc Gene G2FUF-10556 BioCyc
Ensembl Genes ENSRNOG00000018202 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024504 ENTREZGENE
  ENSRNOT00000024504.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115545 IMAGE-MGC_LOAD
InterPro SPATA31/FAM205 UniProtKB/Swiss-Prot
KEGG Report rno:353306 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94993 IMAGE-MGC_LOAD
NCBI Gene 353306 ENTREZGENE
PANTHER ACROSOME-SPECIFIC PROTEIN UniProtKB/Swiss-Prot
  SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED UniProtKB/Swiss-Prot
Pfam FAM75 UniProtKB/Swiss-Prot
PhenoGen Spata31 PhenoGen
RatGTEx ENSRNOG00000018202 RatGTEx
UniProt B6VQA5 ENTREZGENE
  Q5U2N7 ENTREZGENE
  Q7TSL1 ENTREZGENE
  SPT31_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5U2N7 UniProtKB/Swiss-Prot
  Q7TSL1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-06 Spata31  spermatogenesis associated 31  Spata31a5  SPATA31 subfamily A member 5  Name and Symbol changed 629549 APPROVED
2018-02-28 Spata31a5  SPATA31 subfamily A member 5  Spata31a5  SPATA31 subfamily A, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-25 Spata31a5  SPATA31 subfamily A, member 5  Spata31  spermatogenesis associated 31  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-25 Spata31a5  spermatogenesis associated 31 subfamily A, member 5  Spata31a5  SPATA31 subfamily A, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Fam75a4  family with sequence similarity 75, member A4  LOC353306  vitamin A-deficient testicular protein 11-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 LOC353306        Symbol and Name status set to provisional 70820 PROVISIONAL