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Gene: Clic6 (chloride intracellular channel 6) Rattus norvegicus

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Symbol:

Clic6

Name:

chloride intracellular channel 6

RGD ID:

727938

Description:

Enables dopamine receptor binding activity and identical protein binding activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human CLIC6 (chloride intracellular channel 6); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chloride intracellular channel protein 6; Clic6b; glutaredoxin-like oxidoreductase CLIC6; intracellular chloride channel 6b

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CLIC6 (chloride intracellular channel 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Clic6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Clic6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CLIC6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CLIC6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Clic6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CLIC6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CLIC6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Clic6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Clic6 (chloride intracellular channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ORAI1 (ORAI calcium release-activated calcium modulator 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CLIC6 (chloride intracellular channel 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Clic6 (chloride intracellular channel 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Clic	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Clic	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	exc-4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	exl-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	clic6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	clic6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	45,223,715 - 45,266,261 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	45,223,669 - 45,267,344 (+)	Ensembl				GRCr8
mRatBN7.2	11	31,737,813 - 31,780,360 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	31,737,813 - 31,780,061 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	40,432,325 - 40,474,994 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	33,103,806 - 33,146,473 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	32,262,687 - 32,305,152 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	32,655,653 - 32,698,004 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	32,655,616 - 32,699,382 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	36,259,974 - 36,302,131 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	32,516,492 - 32,559,195 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	31,389,140 - 31,431,254 (+)	NCBI		Celera
RGSC_v3.1	11	32,572,734 - 32,615,438 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

myoepithelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

D-glucose (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

fonofos (ISO)

fructose (ISO)

genistein (ISO)

glucose (ISO)

glycidol (EXP)

L-methionine (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

Mesaconitine (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (ISO)

panobinostat (ISO)

parathion (ISO)

permethrin (ISO)

phenylmercury acetate (ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (EXP)

sulforaphane (ISO)

terbufos (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

chloride transport (IEA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

Cellular Component

chloride channel complex (IEA)

cytoplasm (IEA)

membrane (IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IEA)

Molecular Function

chloride channel activity (IEA,ISO,ISS)

D2 dopamine receptor binding (IBA,IPI)

D3 dopamine receptor binding (IBA,IPI)

D4 dopamine receptor binding (IBA,IPI)

identical protein binding (IPI)

oxidoreductase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.	Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19056867

Genomics

Comparative Map Data

Clic6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	45,223,715 - 45,266,261 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	45,223,669 - 45,267,344 (+)	Ensembl				GRCr8
mRatBN7.2	11	31,737,813 - 31,780,360 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	31,737,813 - 31,780,061 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	40,432,325 - 40,474,994 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	33,103,806 - 33,146,473 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	32,262,687 - 32,305,152 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	32,655,653 - 32,698,004 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	32,655,616 - 32,699,382 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	36,259,974 - 36,302,131 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	32,516,492 - 32,559,195 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	31,389,140 - 31,431,254 (+)	NCBI		Celera
RGSC_v3.1	11	32,572,734 - 32,615,438 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

CLIC6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	34,668,994 - 34,718,223 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	34,668,994 - 34,718,227 (+)	Ensembl			hg38	GRCh38
GRCh37	21	36,041,293 - 36,090,521 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	34,963,558 - 35,012,389 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	34,963,557 - 35,012,389	NCBI
Celera	21	21,241,258 - 21,290,092 (+)	NCBI		Celera
Cytogenetic Map	21	q22.12	NCBI
HuRef	21	21,520,561 - 21,569,502 (+)	NCBI		HuRef
CHM1_1	21	35,603,984 - 35,652,808 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	33,051,578 - 33,100,790 (+)	NCBI		T2T-CHM13v2.0

Clic6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	92,295,035 - 92,338,129 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	92,282,624 - 92,338,131 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	92,498,147 - 92,541,241 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	92,485,736 - 92,541,243 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	92,498,392 - 92,541,486 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	92,387,006 - 92,430,100 (+)	NCBI		MGSCv36	mm8
Celera	16	93,581,042 - 93,624,278 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	53.64	NCBI

Clic6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	34,003,309 - 34,042,568 (+)	Ensembl
ChiLan1.0	NW_004955407	34,002,656 - 34,042,524 (+)	NCBI	ChiLan1.0	ChiLan1.0

CLIC6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	30,792,009 - 30,841,205 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	25,650,076 - 25,698,983 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	21,041,763 - 21,089,958 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	34,409,056 - 34,457,307 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

CLIC6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	30,003,448 - 30,102,939 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	30,091,335 - 30,100,842 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	29,156,624 - 29,202,157 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	29,303,623 - 29,403,853 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	29,358,233 - 29,403,507 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	29,224,227 - 29,269,813 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	29,238,956 - 29,284,553 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	29,675,108 - 29,775,259 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Clic6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	29,651,093 - 29,693,204 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	7,774,597 - 7,816,702 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	7,774,962 - 7,816,658 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLIC6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	198,251,119 - 198,303,857 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	198,250,702 - 198,303,830 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	208,079,952 - 208,131,097 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLIC6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	78,703,815 - 78,752,183 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666054	6,522,713 - 6,569,852 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Clic6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	22,816,292 - 22,861,613 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	22,807,618 - 22,861,521 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Clic6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	52,079,095 - 52,121,868 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Clic6
283 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	29
Count of miRNA genes:	28
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000034383
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
1598841	Memor7	Memory QTL 7			exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	11	33306008	78306008	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	3818154	48818154	Rat
1598811	Bp291	Blood pressure QTL 291	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	33306008	78306008	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	10806125	55806125	Rat
634341	Bw121	Body weight QTL 121	3.56		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	11	35323199	55805892	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	29958996	57754989	Rat
2290451	Scl58	Serum cholesterol level QTL 58	3.48		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	11	26318031	55806125	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	31915469	76915469	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	36428416	81428416	Rat
1600394	Edcs1	Endometrial carcinoma susceptibility QTL1	2.9	0.04	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	11	12823152	57823152	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	34618760	79618760	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	36749459	81749459	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	36749459	81749459	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
631510	Spl2	Serum phospholipid level QTL 2	4.1		blood phospholipid amount (VT:0006084)	serum phospholipid level (CMO:0001171)	11	27556685	72556685	Rat

Markers in Region

5730466J16Rik

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	31,771,139 - 31,772,058 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	32,689,090 - 32,690,008	NCBI	Rnor6.0
Rnor_5.0	11	36,293,217 - 36,294,135	UniSTS	Rnor5.0
RGSC_v3.4	11	32,550,281 - 32,551,199	UniSTS	RGSC3.4
Celera	11	31,422,344 - 31,423,262	UniSTS
Cytogenetic Map	11	q11	UniSTS

G45351

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	31,757,540 - 31,757,829 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	32,675,379 - 32,675,667	NCBI	Rnor6.0
Rnor_5.0	11	36,279,506 - 36,279,794	UniSTS	Rnor5.0
RGSC_v3.4	11	32,536,680 - 32,536,968	UniSTS	RGSC3.4
Celera	11	31,408,743 - 31,409,031	UniSTS
Cytogenetic Map	11	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	5	46	136	45	48	21	9	21	6	152	73	4	120	38	92	27	2	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_176078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY191249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000034383 ⟹ ENSRNOP00000033206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	45,223,669 - 45,267,344 (+)	Ensembl
mRatBN7.2 Ensembl	11	31,737,813 - 31,780,061 (+)	Ensembl
Rnor_6.0 Ensembl	11	32,655,653 - 32,698,004 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084412 ⟹ ENSRNOP00000068644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	32,655,616 - 32,699,382 (+)	Ensembl

RefSeq Acc Id:

NM_176078 ⟹ NP_788267

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	45,223,715 - 45,266,261 (+)	NCBI
mRatBN7.2	11	31,737,813 - 31,780,360 (+)	NCBI
Rnor_6.0	11	32,655,653 - 32,698,004 (+)	NCBI
Rnor_5.0	11	36,259,974 - 36,302,131 (+)	NCBI
RGSC_v3.4	11	32,516,492 - 32,559,195 (+)	RGD
Celera	11	31,389,140 - 31,431,254 (+)	RGD

Sequence:

show sequence

GAATTCGGCAGAGCTTCGAAAGAGTTGAGAGGCAAGCTGAGTTCTTTAGCCCCACACCCCAGAC
TGAGCATAAGGATTGGGGTCCGGGTGCGAATTTAGAAGAAGCACGAACGCTTGAGGAAGAGCCC
AAAGACCTTAAGTCAGGGAAAAGGGACATAGAGTCTTGGGGCCCTCTGGATTTCGCATCAAGCG
AAACCTTTGCTTCCAGAGCCCAGAGTGCGGTGTCCTCTCGGAGGAGGCACGGCAGCCCCTGCCC
CTCACCCCTGAGCGGCGTCGAGGAAGGGTGTTTTGAAGGGTGTTTTATCATGGCTGAGGCCACG
GAGCCCAAGGAGGTCTCTTCGGGTTCCCAAGGGCAACCAGAAGGTGCGGTGATCGAGGGACCAG
GAGAGCCTGGGGCTGCGGACCTGGAGGGGCGGGAAGCGAGCGAGGGAGCTGCAGAGGCACCCAG
GGACCTGGGGGAGGGCGCGGAGGCCATGGCCTCAGGGAAGGAGGAAGGAGGCTGTGGGCAGGAT
GGGGAAATCGGGGAAGTGCAGGCGCAGGACCCGCGCCCGGGCCCCGGGACGGAGACACCGGGCA
CCAGTGGAGCTCCGGGTGAAGCGGAGGCTGCGGAATGCGACTCCGAGGGCGCCTTGATCCCGCA
GAGCGGAGGAGGCGCCAAGCGCCAGCAGGTGCAGGGAACGAGCTCGGGGCTAGACGCTCAGGGT
GAGGCCCCTGAGGTCCCCGAGGACGCTCGCCGGGAGCCAGAGGACCCCAAGGCTTCAGAGGCAG
GGGAAGAGGCAGAATCTGGTCAGGAAGCTCTGGGAGGCAGCGCGCCAGAGTCGCAGATCAATCC
AGAAGTCCAGGGACCTGTAGGGGACAACATGGACACAGAGGCCCCCGCAGGAGAGCCACAGGGG
TCAGAGGGAGAGCCCCAGGGTGGAGGGGAAAGCAGCCCTCAGCCCCAGGATGAGGCGATTGAGA
TTGCAGCCGCAGAGGTTGGAGGGCACGAGCCCGGGGAGCTGGCGGGCGCTTCAGCCGCAGACGC
CAAGGGGGAAGGGGAAACCCTGAGGAAAGATGGGTTCGAGGAAGCTGCTCCCGAGGAGGCAAGA
GTAGACTCTGGCGAGAATGGGTTCGAGGAAGCAGCTCCCGAGGAGGCAAGAGTAGACTCTGGAG
AGAATAGGGACCAGGGCAGGCTCCAGGAGGAGACCGGGGAGGAAGAAGCGAGACCGGAATCCGG
GTTGAAGGGACCCTGCGAGGAGGCGATCCAAGAGAAGGCCCCCGACGGCAGCCTTGATGGAGAG
GAGGCCAAATCCACCGGGCACGAGGAGTCGCAAGTGGAGCTCAGTAACCACCTAGCGGAGGAGA
CCAGCGCCCAGGGCGGAGAAGAGTTGGGGCGAGTGAATGGACGTAGGGAGAACGGCCCAGCTTC
GGAGGAGGGGGATCTGGGACAGGAGCACGACATCACCCTCTTTGTCAAGGCTGGCTCTGATGGA
GAGAGCATCGGAAACTGCCCATTCTCACAGCGTCTCTTTATGATCCTCTGGCTAAAGGGTGTTA
TATTCAATGTGACAACGGTGGACCTGAAACGGAAGCCTGCAGACCTGCAGAACCTGGCTCCTGG
GACCAACCCTCCTTTCATGACTTTTGATGGTGAAGTCAAGACAGATGTGAATAAGATTGAGGAG
TTCTTAGAGGAGAAGTTAGTCCCCCCGAGGTACCCTAAGCTGGGAACCCAACACCCTGAATCCA
ACTCAGCGGGAAATGACGTTTTTGCCAAATTCTCAGCGTTTATTAAGAACACCAAGAAGGATGC
AAATGACATTTATGAAAAGAACCTACTACGGGCCCTGAAGAAGCTGGACAGTTACTTAAACAGC
CCGCTGCCAGACGAAATAGATGCCTACAGTACGGAGGATGTCACTGTTTCCCAGAGGAAGTTTC
TGGATGGGGATGAGCTCACACTGGCCGACTGTAACCTCTTACCCAAGCTCCACATCATTAAGAT
TGTGGCCAAGAAATACAGAGGTTTTGAGTTTCCTTCTGAAATGACTGGCATTTGGCGGTACTTG
AACAATGCTTATGCCCGGGACGAGTTCACTAACACGTGTCCAGCTGACCAGGAGATTGAACACG
CGTATTCAGACGCAGCGAAAAGGATGAAGTAATGCTGGCTTGCGTCTTTCCTCAGATGAGTGAA
CAGGGCTTCCAGGAGGACCTTCTATGTTTCTTCCCCAAAACAGCTTTTGCAAAAAGAACGCTGG
ACTCTCTAAATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_788267	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO38057	(Get FASTA)	NCBI Sequence Viewer
	EDM10768	(Get FASTA)	NCBI Sequence Viewer
	EDM10769	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033206
GenBank Protein	Q811Q2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_788267 ⟸ NM_176078

- UniProtKB:

Q811Q2 (UniProtKB/Swiss-Prot), A0A0G2JTB6 (UniProtKB/TrEMBL), F1M9X4 (UniProtKB/TrEMBL), A6JLK3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEATEPKEVSSGSQGQPEGAVIEGPGEPGAADLEGREASEGAAEAPRDLGEGAEAMASGKEEG
GCGQDGEIGEVQAQDPRPGPGTETPGTSGAPGEAEAAECDSEGALIPQSGGGAKRQQVQGTSSG
LDAQGEAPEVPEDARREPEDPKASEAGEEAESGQEALGGSAPESQINPEVQGPVGDNMDTEAPA
GEPQGSEGEPQGGGESSPQPQDEAIEIAAAEVGGHEPGELAGASAADAKGEGETLRKDGFEEAA
PEEARVDSGENGFEEAAPEEARVDSGENRDQGRLQEETGEEEARPESGLKGPCEEAIQEKAPDG
SLDGEEAKSTGHEESQVELSNHLAEETSAQGGEELGRVNGRRENGPASEEGDLGQEHDITLFVK
AGSDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDV
NKIEEFLEEKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANDIYEKNLLRALKKLD
SYLNSPLPDEIDAYSTEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRGFEFPSEMTG
IWRYLNNAYARDEFTNTCPADQEIEHAYSDAAKRMK

hide sequence

Ensembl Acc Id:

ENSRNOP00000068644 ⟸ ENSRNOT00000084412

Ensembl Acc Id:

ENSRNOP00000033206 ⟸ ENSRNOT00000034383

Protein Domains

GST C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q811Q2-F1-model_v2	AlphaFold	Q811Q2	1-612	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698068

Promoter ID:

EPDNEW_R8593

Type:

multiple initiation site

Name:

Clic6_1

Description:

chloride intracellular channel 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	32,655,621 - 32,655,681	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727938	AgrOrtholog
BioCyc Gene	G2FUF-21833	BioCyc
Ensembl Genes	ENSRNOG00000026870	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000034383	ENTREZGENE
Gene3D-CATH	1.20.1050.10	UniProtKB/Swiss-Prot
	Glutaredoxin	UniProtKB/Swiss-Prot
InterPro	CLIC	UniProtKB/Swiss-Prot
	CLIC_N	UniProtKB/Swiss-Prot
	Glutathione-S-Trfase_C-like	UniProtKB/Swiss-Prot
	Glutathione-S-Trfase_C_sf	UniProtKB/Swiss-Prot
	Glutathione_S-Trfase	UniProtKB/Swiss-Prot
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:304081	UniProtKB/Swiss-Prot
NCBI Gene	304081	ENTREZGENE
PANTHER	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED	UniProtKB/Swiss-Prot
	PTHR45476:SF1	UniProtKB/Swiss-Prot
Pfam	CLIC-like_N	UniProtKB/Swiss-Prot
	GST_C_2	UniProtKB/Swiss-Prot
PhenoGen	Clic6	PhenoGen
PRINTS	INTCLCHANNEL	UniProtKB/Swiss-Prot
PROSITE	GST_CTER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000026870	RatGTEx
Superfamily-SCOP	SSF47616	UniProtKB/Swiss-Prot
	SSF52833	UniProtKB/Swiss-Prot
UniProt	A0A0G2JTB6	ENTREZGENE
	A6JLK3	ENTREZGENE, UniProtKB/TrEMBL
	A6JLK4_RAT	UniProtKB/TrEMBL
	CLIC6_RAT	UniProtKB/Swiss-Prot
	F1M9X4	ENTREZGENE, UniProtKB/TrEMBL
	Q811Q2	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-10-03	Clic6		CLIC6	chloride intracellular channel 6	Symbol updated	1299863	APPROVED
2004-09-10	CLIC6	chloride intracellular channel 6	Clic6b	intracellular chloride channel 6b	Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	member of the intracellular chloride channel family	1302428
gene_expression	expressed in choroid plexus, striatal proliferative subventricular zone, cerebellum and posterior lobe of pituitary in the adult brain	1302428

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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