Abcb6 (ATP binding cassette subfamily B member 6) - Rat Genome Database

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Gene: Abcb6 (ATP binding cassette subfamily B member 6) Rattus norvegicus
Analyze
Symbol: Abcb6
Name: ATP binding cassette subfamily B member 6
RGD ID: 71077
Description: Predicted to enable several functions, including ABC-type heme transporter activity; ATP binding activity; and ATP hydrolysis activity. Involved in intracellular copper ion homeostasis. Located in early endosome membrane; endolysosome membrane; and late endosome membrane. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; allethrin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABC-type heme transporter ABCB6; ATP-binding cassette sub-family B member 6; ATP-binding cassette sub-family B member 6, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 6; ATP-binding cassette, subfamily B (MDR/TAP), member 6; mammalian mitochondrial ABC protein 3; MGC93242; MTABC3; ubiquitously-expressed mammalian ABC half transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,117,222 - 84,125,939 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,117,220 - 84,125,526 (-)EnsemblGRCr8
mRatBN7.2976,668,554 - 76,677,263 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,668,554 - 76,676,924 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,113,131 - 85,121,409 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,242,022 - 90,250,300 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,628,235 - 88,636,513 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,373,950 - 82,382,228 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,373,946 - 82,382,272 (-)Ensemblrn6Rnor6.0
Rnor_5.0982,143,211 - 82,151,489 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,454,805 - 74,463,083 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,239,003 - 74,247,281 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
allethrin  (EXP)
amitrole  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bupropion  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferroheme b  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
heme b  (ISO)
ifosfamide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leflunomide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
midazolam  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (EXP)
reactive oxygen species  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. Furuya KN, etal., Cancer Res 1997 Sep 1;57(17):3708-16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cDNA cloning and tissue distribution of mRNA encoding a novel ATP-binding cassette (ABC) half-transporter. Hirsch-Ernst KI, etal., Biochem Biophys Res Commun 1998 Aug 10;249(1):151-5.
5. Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6. Jalil YA, etal., Am J Physiol Cell Physiol. 2008 Feb;294(2):C579-90. doi: 10.1152/ajpcell.00612.2006. Epub 2007 Dec 26.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. Mitsuhashi N, etal., J Biol Chem 2000 Jun 9;275(23):17536-40.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16390497   PMID:17006453   PMID:17661442   PMID:18279659   PMID:18614015   PMID:19056867   PMID:22100072   PMID:22226084   PMID:23519333  


Genomics

Comparative Map Data
Abcb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,117,222 - 84,125,939 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,117,220 - 84,125,526 (-)EnsemblGRCr8
mRatBN7.2976,668,554 - 76,677,263 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,668,554 - 76,676,924 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,113,131 - 85,121,409 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,242,022 - 90,250,300 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,628,235 - 88,636,513 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,373,950 - 82,382,228 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,373,946 - 82,382,272 (-)Ensemblrn6Rnor6.0
Rnor_5.0982,143,211 - 82,151,489 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,454,805 - 74,463,083 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,239,003 - 74,247,281 (-)NCBICelera
Cytogenetic Map9q33NCBI
ABCB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,209,772 - 219,218,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,209,766 - 219,219,012 (-)Ensemblhg38GRCh38
GRCh372220,074,494 - 220,083,680 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,782,738 - 219,791,916 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342219,899,998 - 219,909,177NCBI
Celera2213,844,200 - 213,853,379 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,927,785 - 211,937,009 (-)NCBIHuRef
CHM1_12220,080,323 - 220,089,548 (-)NCBICHM1_1
T2T-CHM13v2.02219,694,538 - 219,703,724 (-)NCBIT2T-CHM13v2.0
Abcb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,148,284 - 75,157,066 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,148,361 - 75,157,036 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38175,171,640 - 75,180,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,171,717 - 75,180,392 (-)Ensemblmm10GRCm38
MGSCv37175,168,214 - 75,176,857 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36175,054,787 - 75,063,430 (-)NCBIMGSCv36mm8
Celera175,662,505 - 75,671,146 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.62NCBI
Abcb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,215,408 - 14,222,172 (+)Ensembl
ChiLan1.0NW_00495545314,215,104 - 14,222,338 (+)NCBIChiLan1.0ChiLan1.0
ABCB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,840,220 - 121,849,516 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,855,185 - 121,864,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,467,345 - 106,476,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,058,771 - 225,067,626 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,058,771 - 225,067,626 (-)EnsemblpanPan2panpan1.1
ABCB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,760,478 - 25,767,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,760,477 - 25,769,841 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,586,363 - 26,593,649 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,775,702 - 25,782,979 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,775,712 - 25,783,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,680,124 - 25,687,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,615,230 - 25,622,496 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,636,067 - 25,643,357 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,285,868 - 175,292,790 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,625,374 - 1,635,694 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,628,649 - 1,635,599 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,246,187 - 121,254,331 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115121,246,180 - 121,254,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,280,959 - 134,289,134 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,113,729 - 105,122,948 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,112,797 - 105,122,358 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604094,273,392 - 94,282,846 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,797,943 - 5,808,448 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248235,797,897 - 5,805,055 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcb6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,530,916 - 148,539,585 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abcb6
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:105
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000025627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
BE098749  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8984,117,302 - 84,117,642 (+)Marker Load Pipeline
mRatBN7.2976,668,634 - 76,668,974 (+)MAPPERmRatBN7.2
Rnor_6.0982,374,031 - 82,374,370NCBIRnor6.0
Rnor_5.0982,143,292 - 82,143,631UniSTSRnor5.0
RGSC_v3.4974,454,886 - 74,455,225UniSTSRGSC3.4
Celera974,239,084 - 74,239,423UniSTS
RH 3.4 Map9742.48UniSTS
Cytogenetic Map9q33UniSTS
BQ193984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,676,981 - 76,677,143 (+)MAPPERmRatBN7.2
Rnor_6.0982,382,378 - 82,382,539NCBIRnor6.0
Rnor_5.0982,151,639 - 82,151,800UniSTSRnor5.0
RGSC_v3.4974,463,233 - 74,463,394UniSTSRGSC3.4
Celera974,247,431 - 74,247,592UniSTS
RH 3.4 Map9768.5UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025627   ⟹   ENSRNOP00000025627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,117,220 - 84,125,526 (-)Ensembl
mRatBN7.2 Ensembl976,668,554 - 76,676,924 (-)Ensembl
Rnor_6.0 Ensembl982,373,946 - 82,382,272 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084769   ⟹   ENSRNOP00000073171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,668,677 - 76,676,924 (-)Ensembl
Rnor_6.0 Ensembl982,373,963 - 82,377,010 (-)Ensembl
RefSeq Acc Id: NM_080582   ⟹   NP_542149
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,117,222 - 84,125,500 (-)NCBI
mRatBN7.2976,668,554 - 76,676,832 (-)NCBI
Rnor_6.0982,373,950 - 82,382,228 (-)NCBI
Rnor_5.0982,143,211 - 82,151,489 (-)NCBI
RGSC_v3.4974,454,805 - 74,463,083 (-)RGD
Celera974,239,003 - 74,247,281 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082971   ⟹   XP_038938899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,117,765 - 84,125,939 (-)NCBI
mRatBN7.2976,669,097 - 76,677,263 (-)NCBI
RefSeq Acc Id: XM_039082972   ⟹   XP_038938900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,117,222 - 84,123,486 (-)NCBI
mRatBN7.2976,668,554 - 76,674,819 (-)NCBI
RefSeq Acc Id: NP_542149   ⟸   NM_080582
- UniProtKB: O70595 (UniProtKB/Swiss-Prot),   A6JVY6 (UniProtKB/TrEMBL),   A0A0G2K4U1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073171   ⟸   ENSRNOT00000084769
Ensembl Acc Id: ENSRNOP00000025627   ⟸   ENSRNOT00000025627
RefSeq Acc Id: XP_038938900   ⟸   XM_039082972
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938899   ⟸   XM_039082971
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4U1 (UniProtKB/TrEMBL)
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70595-F1-model_v2 AlphaFold O70595 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696769
Promoter ID:EPDNEW_R7293
Type:initiation region
Name:Abcb6_1
Description:ATP binding cassette subfamily B member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,382,332 - 82,382,392EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71077 AgrOrtholog
BioCyc Gene G2FUF-27093 BioCyc
Ensembl Genes ENSRNOG00000018697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025627 ENTREZGENE
  ENSRNOT00000025627.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190755 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  MTABC_N UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Type_I_exporter UniProtKB/Swiss-Prot
KEGG Report rno:140669 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93242 IMAGE-MGC_LOAD
NCBI Gene 140669 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6 UniProtKB/Swiss-Prot
  PTHR24221 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
  MTABC_N UniProtKB/Swiss-Prot
PhenoGen Abcb6 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018697 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A0G2K4U1 ENTREZGENE
  A6JVY6 ENTREZGENE, UniProtKB/TrEMBL
  ABCB6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-19 Abcb6  ATP binding cassette subfamily B member 6  Abcb6  ATP-binding cassette, subfamily B (MDR/TAP), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcb6  ATP-binding cassette, subfamily B (MDR/TAP), member 6  Abcb6  ATP-binding cassette, sub-family B (MDR/TAP), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Abcb6  ATP-binding cassette, sub-family B (MDR/TAP), member 6      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression in frank hepatic carcinomas 631984
gene_domains contains an N-terminal membrane anchor domain and a single conserved C-terminal nucleotide binding fold 70650
gene_expression expressed in all tissues, abundant in testis 70650
gene_homology functionally simliar to fission yeast hmt1 transporter 70650
gene_homology functionally simliar to fission yeast hmt1 transporter 631984
gene_protein 836 amino acids 70650