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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71077
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb6
Name: ATP binding cassette subfamily B member 6
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb6decreases response to substanceISOABCB6 (Homo sapiens)6480464CTDABCB6 protein results in decreased susceptibility to Cadmium ChloridePMID:31053883
Abcb6increases expressionISOABCB6 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of ABCB6 mRNAPMID:25596134
Abcb6multiple interactionsISOABCB6 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ABCB6 mRNA; ABCB6 protein inhibits the reaction [HMT-1 gene mutant form results in increased susceptibility to Cadmium Chloride]PMID:31053883 PMID:35301059
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