Asic1 (acid sensing ion channel subunit 1) - Rat Genome Database

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Gene: Asic1 (acid sensing ion channel subunit 1) Rattus norvegicus
Analyze
Symbol: Asic1
Name: acid sensing ion channel subunit 1
RGD ID: 71062
Description: Enables inorganic cation transmembrane transporter activity and pH-gated monoatomic ion channel activity. Involved in monoatomic ion transmembrane transport. Acts upstream of or within inorganic cation transmembrane transport. Located in cell surface and membrane. Orthologous to human ASIC1 (acid sensing ion channel subunit 1); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Accn2; acid sensing ion channel 1; acid-sensing (proton-gated) ion channel 1; acid-sensing ion channel 1; acid-sensing ionic channel; amiloride-sensitive cation channel 2, neuronal; ASIC; BNaC2; brain sodium channel 2; proton gated cation channel ASIC1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,677,158 - 132,707,379 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7132,698,723 - 132,707,832 (+)EnsemblGRCr8
mRatBN7.27130,798,317 - 130,828,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,799,917 - 130,828,541 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7132,603,489 - 132,632,142 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,829,075 - 134,857,723 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,741,599 - 134,770,248 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,324,714 - 141,354,937 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)Ensemblrn6Rnor6.0
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47138,414,656 - 138,443,272 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7127,281,326 - 127,309,938 (+)NCBICelera
RGSC_v3.17138,491,092 - 138,517,829 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
bafilomycin A1  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flurbiprofen  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
sarin  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
spermine  (EXP,ISO)
sunitinib  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IDA)
dendrite  (IEA)
glutamatergic synapse  (IBA,IEA,ISO)
membrane  (IDA,IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
postsynaptic density membrane  (IEA,ISO)
postsynaptic membrane  (IEA)
synapse  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. Bassler EL, etal., J Biol Chem 2001 Sep 7;276(36):33782-7.
2. A sensory neuron-specific, proton-gated ion channel. Chen CC, etal., Proc Natl Acad Sci U S A 1998 Aug 18;95(17):10240-5.
3. [Effectiveness of ointment and cream containing silver salt of sulfathiazole in the treatment of leg ulcer] Filipiuk J, etal., Pol Tyg Lek 1978 Jul 17;33(29):1153-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels. Li T, etal., J Biol Chem. 2009 Feb 13;284(7):4689-94. doi: 10.1074/jbc.M805302200. Epub 2008 Dec 11.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Vestnik rentgenologii i radiologii Popov OG, etal., Vestn Rentgenol Radiol 1978 Nov-Dec;(6):35-40.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. A proton-gated cation channel involved in acid-sensing. Waldmann R, etal., Nature. 1997 Mar 13;386(6621):173-7. doi: 10.1038/386173a0.
Additional References at PubMed
PMID:9360943   PMID:10798398   PMID:10829030   PMID:11588175   PMID:11588592   PMID:11842212   PMID:11854527   PMID:11976391   PMID:11988176   PMID:12198124   PMID:12509480   PMID:12947112  
PMID:14960591   PMID:15369669   PMID:15452199   PMID:15470133   PMID:16085050   PMID:16169854   PMID:16505147   PMID:16723538   PMID:16949762   PMID:17204502   PMID:17548344   PMID:17872465  
PMID:17936312   PMID:18094106   PMID:18410516   PMID:18452213   PMID:18534561   PMID:18723775   PMID:19257932   PMID:19376200   PMID:19482897   PMID:19730136   PMID:19812697   PMID:20019330  
PMID:20162006   PMID:20179994   PMID:20185828   PMID:20385551   PMID:20427715   PMID:20442265   PMID:20675379   PMID:20844750   PMID:21346156   PMID:22205392   PMID:22231470   PMID:22553040  
PMID:22760635   PMID:22792205   PMID:22890703   PMID:23994523   PMID:24247984   PMID:24261866   PMID:24573273   PMID:24695733   PMID:24821433   PMID:24939363   PMID:25377529   PMID:25744567  
PMID:25828470   PMID:26174503   PMID:26248594   PMID:26384841   PMID:26562527   PMID:26680001   PMID:26702130   PMID:26715049   PMID:26722526   PMID:26823770   PMID:28321113   PMID:28825196  
PMID:29019932   PMID:29070491   PMID:29086909   PMID:29226878   PMID:29273849   PMID:29739981   PMID:30397978   PMID:30487596   PMID:30720055   PMID:30938088   PMID:31675256   PMID:31820348  
PMID:32006608   PMID:32237041   PMID:32502377   PMID:32678496   PMID:32702049   PMID:32887365   PMID:33314662   PMID:33450275   PMID:34282280   PMID:34310912   PMID:34487355   PMID:34918385  
PMID:35292759   PMID:35343594   PMID:35561854   PMID:35643339   PMID:36162458   PMID:36279671   PMID:36463203   PMID:36852448   PMID:39019215  


Genomics

Comparative Map Data
Asic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,677,158 - 132,707,379 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7132,698,723 - 132,707,832 (+)EnsemblGRCr8
mRatBN7.27130,798,317 - 130,828,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,799,917 - 130,828,541 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7132,603,489 - 132,632,142 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,829,075 - 134,857,723 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,741,599 - 134,770,248 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,324,714 - 141,354,937 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)Ensemblrn6Rnor6.0
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47138,414,656 - 138,443,272 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7127,281,326 - 127,309,938 (+)NCBICelera
RGSC_v3.17138,491,092 - 138,517,829 (+)NCBI
Cytogenetic Map7q36NCBI
ASIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381250,057,596 - 50,083,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1250,057,548 - 50,083,621 (+)Ensemblhg38GRCh38
GRCh371250,451,379 - 50,477,394 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,737,754 - 48,763,661 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341248,737,753 - 48,763,660NCBI
Celera1249,246,955 - 49,272,856 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,485,455 - 47,510,311 (+)NCBIHuRef
CHM1_11250,417,567 - 50,443,552 (+)NCBICHM1_1
T2T-CHM13v2.01250,020,656 - 50,046,680 (+)NCBIT2T-CHM13v2.0
Asic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,568,090 - 99,599,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,568,249 - 99,599,011 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381599,670,197 - 99,701,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,670,368 - 99,701,130 (+)Ensemblmm10GRCm38
MGSCv371599,501,149 - 99,531,559 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361599,498,752 - 99,529,162 (+)NCBIMGSCv36mm8
Celera15101,826,413 - 101,856,974 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Asic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547635,638 - 658,541 (+)Ensembl
ChiLan1.0NW_004955547635,714 - 658,541 (+)NCBIChiLan1.0ChiLan1.0
ASIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,105,768 - 44,132,086 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,102,536 - 44,128,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,672,253 - 38,698,247 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,569,149 - 39,593,822 (-)NCBIPanPan1.1PanPan1.1panPan2
ASIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,638,826 - 4,663,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2741,594,907 - 41,619,336 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0274,687,973 - 4,712,419 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,687,975 - 4,711,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,652,821 - 4,677,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,642,373 - 4,667,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,989,720 - 42,014,370 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Asic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,418,273 - 65,444,825 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,720,523 - 7,746,579 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,720,591 - 7,746,557 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,965,084 - 15,991,876 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1515,965,082 - 15,991,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,354,884 - 16,365,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASIC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,286,665 - 46,313,016 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1146,287,787 - 46,314,177 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037199,808,378 - 199,835,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asic1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,228,440 - 2,253,004 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248162,228,440 - 2,253,798 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Asic1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11272,471,845 - 272,501,267 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Asic1
145 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1076
Count of miRNA genes:258
Interacting mature miRNAs:332
Transcripts:ENSRNOT00000025476, ENSRNOT00000047887
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
AU047966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,799,776 - 130,800,018 (+)MAPPERmRatBN7.2
Rnor_6.07141,326,181 - 141,326,422NCBIRnor6.0
Rnor_5.0X115,830,829 - 115,831,070UniSTSRnor5.0
RGSC_v3.47138,414,516 - 138,414,757UniSTSRGSC3.4
Celera7127,281,186 - 127,281,427UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 160 85 84 53 83 53 6 337 181 10 138 79 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001414903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB049451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ006519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ309926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO398759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV721841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000077175   ⟹   ENSRNOP00000072206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,698,723 - 132,707,007 (+)Ensembl
mRatBN7.2 Ensembl7130,819,879 - 130,828,163 (+)Ensembl
Rnor_6.0 Ensembl7141,346,398 - 141,352,884 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084075   ⟹   ENSRNOP00000070082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7141,326,950 - 141,352,452 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088191   ⟹   ENSRNOP00000068902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,698,723 - 132,707,832 (+)Ensembl
mRatBN7.2 Ensembl7130,799,917 - 130,828,541 (+)Ensembl
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)Ensembl
RefSeq Acc Id: NM_001414903   ⟹   NP_001401832
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,677,933 - 132,707,379 (+)NCBI
mRatBN7.27130,799,087 - 130,828,535 (+)NCBI
RefSeq Acc Id: NM_024154   ⟹   NP_077068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,678,707 - 132,707,379 (+)NCBI
mRatBN7.27130,799,861 - 130,828,535 (+)NCBI
Rnor_6.07141,326,321 - 141,354,937 (+)NCBI
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBI
RGSC_v3.47138,414,656 - 138,443,272 (+)RGD
Celera7127,281,326 - 127,309,938 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257378   ⟹   XP_006257440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,698,516 - 132,707,379 (+)NCBI
mRatBN7.27130,819,646 - 130,828,535 (+)NCBI
Rnor_6.07141,346,089 - 141,354,937 (+)NCBI
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595125   ⟹   XP_017450614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,678,756 - 132,707,379 (+)NCBI
mRatBN7.27130,799,931 - 130,828,535 (+)NCBI
Rnor_6.07141,326,319 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595126   ⟹   XP_017450615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,677,158 - 132,707,379 (+)NCBI
mRatBN7.27130,798,317 - 130,828,535 (+)NCBI
Rnor_6.07141,324,714 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079937   ⟹   XP_038935865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,677,160 - 132,707,379 (+)NCBI
mRatBN7.27130,798,318 - 130,828,535 (+)NCBI
RefSeq Acc Id: XM_063264284   ⟹   XP_063120354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,698,504 - 132,707,379 (+)NCBI
RefSeq Acc Id: XM_063264285   ⟹   XP_063120355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,701,259 - 132,707,379 (+)NCBI
RefSeq Acc Id: XM_063264286   ⟹   XP_063120356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,701,262 - 132,707,379 (+)NCBI
RefSeq Acc Id: NP_077068   ⟸   NM_024154
- UniProtKB: Q91YB8 (UniProtKB/Swiss-Prot),   O88762 (UniProtKB/Swiss-Prot),   Q99NA1 (UniProtKB/Swiss-Prot),   P55926 (UniProtKB/Swiss-Prot),   A6KCG6 (UniProtKB/TrEMBL),   A0A8L2R026 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257440   ⟸   XM_006257378
- Peptide Label: isoform X2
- UniProtKB: A6KCG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450615   ⟸   XM_017595126
- Peptide Label: isoform X3
- UniProtKB: A0A8L2R026 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450614   ⟸   XM_017595125
- Peptide Label: isoform X3
- UniProtKB: A0A8L2R026 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072206   ⟸   ENSRNOT00000077175
Ensembl Acc Id: ENSRNOP00000070082   ⟸   ENSRNOT00000084075
Ensembl Acc Id: ENSRNOP00000068902   ⟸   ENSRNOT00000088191
RefSeq Acc Id: XP_038935865   ⟸   XM_039079937
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001401832   ⟸   NM_001414903
- UniProtKB: Q91YB8 (UniProtKB/Swiss-Prot),   P55926 (UniProtKB/Swiss-Prot),   O88762 (UniProtKB/Swiss-Prot),   Q99NA1 (UniProtKB/Swiss-Prot),   A6KCG6 (UniProtKB/TrEMBL),   A0A8L2R026 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120354   ⟸   XM_063264284
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120355   ⟸   XM_063264285
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063120356   ⟸   XM_063264286
- Peptide Label: isoform X6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55926-F1-model_v2 AlphaFold P55926 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71062 AgrOrtholog
BioCyc Gene G2FUF-32063 BioCyc
Ensembl Genes ENSRNOG00000059765 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077175 ENTREZGENE
  ENSRNOT00000077175.2 UniProtKB/Swiss-Prot
Gene3D-CATH acid-sensing ion channel 1 domain UniProtKB/Swiss-Prot
  Acid-sensing ion channel domain UniProtKB/Swiss-Prot
  YojJ-like UniProtKB/Swiss-Prot
InterPro ENaC UniProtKB/Swiss-Prot
  ENaC_chordates UniProtKB/Swiss-Prot
  ENaC_CS UniProtKB/Swiss-Prot
KEGG Report rno:79123 UniProtKB/Swiss-Prot
NCBI Gene 79123 ENTREZGENE
PANTHER ACID-SENSING ION CHANNEL 1 UniProtKB/Swiss-Prot
  PTHR11690 UniProtKB/Swiss-Prot
Pfam ASC UniProtKB/Swiss-Prot
PhenoGen Asic1 PhenoGen
PRINTS AMINACHANNEL UniProtKB/Swiss-Prot
PROSITE ASC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000059765 RatGTEx
UniProt A0A8L2R026 ENTREZGENE, UniProtKB/TrEMBL
  A6KCG6 ENTREZGENE, UniProtKB/TrEMBL
  A6KCG7 ENTREZGENE, UniProtKB/TrEMBL
  ASIC1_RAT UniProtKB/Swiss-Prot
  O88762 ENTREZGENE
  P55926 ENTREZGENE
  Q91YB8 ENTREZGENE
  Q99NA1 ENTREZGENE
UniProt Secondary O88762 UniProtKB/Swiss-Prot
  Q91YB8 UniProtKB/Swiss-Prot
  Q99NA1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Asic1  acid sensing ion channel subunit 1  Asic1  acid sensing ion channel 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Asic1  acid sensing ion channel 1  Asic1  acid-sensing (proton-gated) ion channel 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Asic1  acid-sensing (proton-gated) ion channel 1  Accn2  amiloride-sensitive cation channel 2, neuronal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Accn2  amiloride-sensitive cation channel 2, neuronal      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression splice variant ASIC-beta is expressed specifically in a subset of sensory neurons  
gene_process its heterologous expression induces an amiloride-sensitive cation (Na(+) > Ca(2+) > K(+)) channel which is transiently activated by rapid extracellular acidification 724707