Ap2b1 (adaptor related protein complex 2 subunit beta 1) - Rat Genome Database

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Gene: Ap2b1 (adaptor related protein complex 2 subunit beta 1) Rattus norvegicus
Analyze
Symbol: Ap2b1
Name: adaptor related protein complex 2 subunit beta 1
RGD ID: 71048
Description: Enables clathrin binding activity. Involved in several processes, including clathrin coat assembly; positive regulation of endocytosis; and postsynaptic neurotransmitter receptor internalization. Part of clathrin coat. Is active in glutamatergic synapse; postsynaptic endocytic zone; and synaptic vesicle. Is extrinsic component of presynaptic endocytic zone membrane. Biomarker of middle cerebral artery infarction. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; AP-1 complex subunit beta-1-like; AP-2 complex subunit beta; AP-2 complex subunit beta-like; AP105B; beta adaptin; beta-2-adaptin; beta-adaptin; beta2-adaptin; clathrin assembly protein complex 2 beta large chain; LOC100912146; LOC103690090; plasma membrane adaptor HA2/AP2 adaptin beta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ap2b1-ps1  
Candidate Gene For: Bp302
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,596,925 - 68,702,547 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,597,093 - 68,702,539 (+)EnsemblGRCr8
mRatBN7.21068,099,397 - 68,205,023 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,099,547 - 68,205,013 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,723,218 - 72,825,030 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,228,605 - 72,330,413 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,692,649 - 67,794,463 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,516,462 - 70,621,973 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,520,206 - 70,621,977 (+)Ensemblrn6Rnor6.0
Rnor_5.01071,068,935 - 71,083,997 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01071,035,406 - 71,067,828 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,386,233 - 71,488,000 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,045,800 - 67,146,677 (+)NCBICelera
RGSC_v3.11071,399,684 - 71,502,555 (+)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clozapine  (EXP)
cocaine  (EXP)
coumarin  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
haloperidol  (EXP)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
2. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. Fukamachi K, etal., J Biol Chem 2002 Nov 15;277(46):43549-52.
3. The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. Gallusser A and Kirchhausen T, EMBO J. 1993 Dec 15;12(13):5237-44.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. AP180 and AP-2 interact directly in a complex that cooperatively assembles clathrin. Hao W, etal., J Biol Chem. 1999 Aug 6;274(32):22785-94.
6. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Kastning K, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2991-6. Epub 2007 Feb 8.
7. Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. Kirchhausen T, etal., Proc Natl Acad Sci U S A 1989 Apr;86(8):2612-6.
8. Gene Data Set MGD Curation, June 12, 2002
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. A conserved clathrin assembly motif essential for synaptic vesicle endocytosis. Morgan JR, etal., J Neurosci. 2000 Dec 1;20(23):8667-76.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Targeting signals and subunit interactions in coated vesicle adaptor complexes. Page LJ and Robinson MS, J Cell Biol. 1995 Nov;131(3):619-30.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Conservation and diversity in families of coated vesicle adaptins. Ponnambalam S, etal., J Biol Chem 1990 Mar 25;265(9):4814-20.
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. Rudinskiy N, etal., J Biol Chem. 2009 May 1;284(18):12447-58. doi: 10.1074/jbc.M804740200. Epub 2009 Feb 24.
17. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
18. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. Takei K, etal., J Cell Biol. 1996 Jun;133(6):1237-50. doi: 10.1083/jcb.133.6.1237.
19. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
20. Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. Tokumitsu H, etal., FEBS Lett. 2006 Oct 16;580(24):5797-801. Epub 2006 Sep 27.
Additional References at PubMed
PMID:9694653   PMID:11382783   PMID:12086608   PMID:12234931   PMID:12477932   PMID:15533940   PMID:15728179   PMID:16903783   PMID:19509056   PMID:19946888   PMID:21499258   PMID:21700703  
PMID:22871113   PMID:23676497   PMID:24217640   PMID:25807483   PMID:26514267   PMID:28131823   PMID:29476059   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Ap2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,596,925 - 68,702,547 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,597,093 - 68,702,539 (+)EnsemblGRCr8
mRatBN7.21068,099,397 - 68,205,023 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,099,547 - 68,205,013 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,723,218 - 72,825,030 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,228,605 - 72,330,413 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,692,649 - 67,794,463 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,516,462 - 70,621,973 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,520,206 - 70,621,977 (+)Ensemblrn6Rnor6.0
Rnor_5.01071,068,935 - 71,083,997 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01071,035,406 - 71,067,828 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,386,233 - 71,488,000 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,045,800 - 67,146,677 (+)NCBICelera
RGSC_v3.11071,399,684 - 71,502,555 (+)NCBI
Cytogenetic Map10q26NCBI
AP2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,587,322 - 35,726,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,578,046 - 35,726,417 (+)Ensemblhg38GRCh38
GRCh371733,914,341 - 34,053,432 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,938,395 - 31,077,549 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341730,938,405 - 31,077,541NCBI
Celera1730,824,398 - 30,963,574 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,099,253 - 30,238,599 (+)NCBIHuRef
CHM1_11733,978,907 - 34,118,050 (+)NCBICHM1_1
T2T-CHM13v2.01736,535,193 - 36,674,326 (+)NCBIT2T-CHM13v2.0
Ap2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,189,545 - 83,295,861 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,189,850 - 83,295,861 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381183,298,719 - 83,405,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,299,024 - 83,405,035 (+)Ensemblmm10GRCm38
MGSCv371183,116,199 - 83,218,537 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361183,118,892 - 83,221,230 (+)NCBIMGSCv36mm8
Celera1192,894,853 - 92,999,587 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
Ap2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,064,220 - 10,175,627 (+)Ensembl
ChiLan1.0NW_00495548110,061,021 - 10,175,070 (+)NCBIChiLan1.0ChiLan1.0
AP2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,750,972 - 28,892,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,632,528 - 30,769,787 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,070,132 - 21,208,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,363,115 - 21,501,720 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,363,121 - 21,501,721 (-)EnsemblpanPan2panpan1.1
AP2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,946,761 - 38,078,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,946,788 - 38,078,041 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha937,170,891 - 37,302,120 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0938,758,380 - 38,889,742 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,756,039 - 38,889,684 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,541,221 - 37,673,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,826,684 - 37,958,055 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,914,210 - 38,045,500 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,949,807 - 37,069,908 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,233 - 127,715 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364905,156 - 127,666 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,800,972 - 39,932,643 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11239,803,105 - 39,940,801 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AP2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,061,662 - 29,198,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1629,061,568 - 29,201,464 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666075774,355 - 913,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,090,656 - 3,208,593 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248753,085,518 - 3,206,930 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ap2b1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1987,279,064 - 87,384,500 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ap2b1
607 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1550
Count of miRNA genes:323
Interacting mature miRNAs:429
Transcripts:ENSRNOT00000013363, ENSRNOT00000013629
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Mco43  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81068,691,394 - 68,691,511 (+)Marker Load Pipeline
mRatBN7.21068,193,870 - 68,193,987 (+)MAPPERmRatBN7.2
Rnor_6.01070,610,873 - 70,610,989NCBIRnor6.0
Rnor_5.01071,072,897 - 71,073,013UniSTSRnor5.0
Rnor_5.01070,244,698 - 70,244,814UniSTSRnor5.0
RGSC_v3.41071,476,899 - 71,477,016RGDRGSC3.4
RGSC_v3.41071,476,900 - 71,477,016UniSTSRGSC3.4
Celera1067,135,547 - 67,135,663UniSTS
RGSC_v3.11071,490,756 - 71,490,873RGD
Cytogenetic Map10q26UniSTS
D10Chm192  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,127,447 - 68,127,614 (+)MAPPERmRatBN7.2
mRatBN7.21068,127,447 - 68,127,673 (+)MAPPERmRatBN7.2
Rnor_6.01070,544,457 - 70,544,680NCBIRnor6.0
Rnor_6.01070,544,457 - 70,544,621NCBIRnor6.0
Rnor_5.01070,178,283 - 70,178,448NCBIRnor5.0
Rnor_5.01071,059,656 - 71,059,821NCBIRnor5.0
Rnor_5.01071,059,656 - 71,059,880NCBIRnor5.0
Rnor_5.01070,178,283 - 70,178,507NCBIRnor5.0
RGSC_v3.41071,410,484 - 71,410,707UniSTSRGSC3.4
RGSC_v3.41071,410,484 - 71,410,648UniSTSRGSC3.4
Celera1067,070,051 - 67,070,274UniSTS
Celera1067,070,051 - 67,070,215UniSTS
Cytogenetic Map10q26UniSTS
D10Chm187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,109,898 - 68,110,141 (+)MAPPERmRatBN7.2
Rnor_6.01070,526,913 - 70,527,155NCBIRnor6.0
Rnor_5.01071,042,113 - 71,042,355UniSTSRnor5.0
Rnor_5.01070,160,740 - 70,160,982UniSTSRnor5.0
RGSC_v3.41071,392,940 - 71,393,182UniSTSRGSC3.4
Celera1067,052,507 - 67,052,749UniSTS
Cytogenetic Map10q26UniSTS
D10Chm146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,128,848 - 68,129,068 (+)MAPPERmRatBN7.2
Rnor_6.01070,545,856 - 70,546,075NCBIRnor6.0
Rnor_5.01071,061,056 - 71,061,275UniSTSRnor5.0
Rnor_5.01070,179,683 - 70,179,902UniSTSRnor5.0
RGSC_v3.41071,411,883 - 71,412,102UniSTSRGSC3.4
Celera1067,071,450 - 67,071,669UniSTS
Cytogenetic Map10q26UniSTS
D10Chm189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,116,834 - 68,117,007 (+)MAPPERmRatBN7.2
Rnor_6.01070,533,845 - 70,534,017NCBIRnor6.0
Rnor_5.01071,049,045 - 71,049,217UniSTSRnor5.0
Rnor_5.01070,167,672 - 70,167,844UniSTSRnor5.0
RGSC_v3.41071,399,872 - 71,400,044UniSTSRGSC3.4
Celera1067,059,439 - 67,059,611UniSTS
Cytogenetic Map10q26UniSTS
D10Chm191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,127,046 - 68,127,237 (+)MAPPERmRatBN7.2
Rnor_6.01070,544,056 - 70,544,246NCBIRnor6.0
Rnor_5.01071,059,256 - 71,059,446UniSTSRnor5.0
Rnor_5.01070,177,883 - 70,178,073UniSTSRnor5.0
RGSC_v3.41071,410,083 - 71,410,273UniSTSRGSC3.4
Celera1067,069,650 - 67,069,840UniSTS
Cytogenetic Map10q26UniSTS
D10Chm188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,113,349 - 68,113,592 (+)MAPPERmRatBN7.2
Rnor_6.01070,530,364 - 70,530,602NCBIRnor6.0
Rnor_5.01071,045,564 - 71,045,802UniSTSRnor5.0
Rnor_5.01070,164,191 - 70,164,429UniSTSRnor5.0
RGSC_v3.41071,396,391 - 71,396,629UniSTSRGSC3.4
Celera1067,055,958 - 67,056,196UniSTS
Cytogenetic Map10q26UniSTS
D10Chm147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,164,560 - 68,164,786 (+)MAPPERmRatBN7.2
Rnor_6.01070,581,568 - 70,581,793NCBIRnor6.0
Rnor_5.01070,215,393 - 70,215,618UniSTSRnor5.0
RGSC_v3.41071,447,595 - 71,447,820UniSTSRGSC3.4
Celera1067,107,082 - 67,107,307UniSTS
Cytogenetic Map10q26UniSTS
D10Chm190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,123,812 - 68,124,057 (+)MAPPERmRatBN7.2
Rnor_6.01070,540,823 - 70,541,067NCBIRnor6.0
Rnor_5.01071,056,023 - 71,056,267UniSTSRnor5.0
Rnor_5.01070,174,650 - 70,174,894UniSTSRnor5.0
RGSC_v3.41071,406,850 - 71,407,094UniSTSRGSC3.4
Celera1067,066,417 - 67,066,661UniSTS
Cytogenetic Map10q26UniSTS
D10Chm120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,166,668 - 68,166,913 (+)MAPPERmRatBN7.2
Rnor_6.01070,583,676 - 70,583,920NCBIRnor6.0
Rnor_5.01070,217,501 - 70,217,745UniSTSRnor5.0
RGSC_v3.41071,449,703 - 71,449,947UniSTSRGSC3.4
Celera1067,109,190 - 67,109,434UniSTS
Cytogenetic Map10q26UniSTS
D10Chm245  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,127,092 - 68,127,339 (+)MAPPERmRatBN7.2
Rnor_6.01070,544,102 - 70,544,348NCBIRnor6.0
Rnor_5.01071,059,302 - 71,059,548UniSTSRnor5.0
Rnor_5.01070,177,929 - 70,178,175UniSTSRnor5.0
RGSC_v3.41071,410,129 - 71,410,375UniSTSRGSC3.4
Celera1067,069,696 - 67,069,942UniSTS
Cytogenetic Map10q26UniSTS
D10Mco87  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81068,610,912 - 68,611,213 (+)Marker Load Pipeline
mRatBN7.21068,113,381 - 68,113,682 (+)MAPPERmRatBN7.2
Rnor_6.01070,530,396 - 70,530,692NCBIRnor6.0
Rnor_5.01070,164,223 - 70,164,519UniSTSRnor5.0
Rnor_5.01071,045,596 - 71,045,892UniSTSRnor5.0
RGSC_v3.41071,396,423 - 71,396,719UniSTSRGSC3.4
Celera1067,055,990 - 67,056,286UniSTS
Cytogenetic Map10q26UniSTS
D11Pas17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,145,471 - 68,145,631 (+)MAPPERmRatBN7.2
Rnor_6.01070,562,479 - 70,562,638NCBIRnor6.0
Rnor_5.01070,196,306 - 70,196,465UniSTSRnor5.0
RGSC_v3.41071,428,506 - 71,428,665UniSTSRGSC3.4
Celera1067,088,073 - 67,088,232UniSTS
Cytogenetic Map10q26UniSTS
RH127319  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,204,818 - 68,204,998 (+)MAPPERmRatBN7.2
mRatBN7.2134,290,540 - 34,290,720 (+)MAPPERmRatBN7.2
Rnor_6.0136,952,089 - 36,952,268NCBIRnor6.0
Rnor_6.01070,621,773 - 70,621,952NCBIRnor6.0
Rnor_5.01071,083,796 - 71,083,976NCBIRnor5.0
Rnor_5.01070,255,601 - 70,255,781NCBIRnor5.0
Rnor_5.0138,345,959 - 38,346,139NCBIRnor5.0
RGSC_v3.4174,457,158 - 4,457,337UniSTSRGSC3.4
RGSC_v3.41071,487,800 - 71,487,979UniSTSRGSC3.4
Celera1067,146,477 - 67,146,656UniSTS
Celera132,877,739 - 32,877,918UniSTS
Cytogenetic Map10q26UniSTS
AU046825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,173,055 - 68,173,147 (+)MAPPERmRatBN7.2
Rnor_6.01070,590,060 - 70,590,151NCBIRnor6.0
Rnor_5.01070,223,885 - 70,223,976UniSTSRnor5.0
RGSC_v3.41071,456,087 - 71,456,178UniSTSRGSC3.4
Celera1067,115,574 - 67,115,665UniSTS
Cytogenetic Map10q26UniSTS
Ap2b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,202,609 - 68,202,943 (-)MAPPERmRatBN7.2
mRatBN7.2134,292,605 - 34,292,939 (-)MAPPERmRatBN7.2
mRatBN7.21068,202,609 - 68,202,943 (+)MAPPERmRatBN7.2
mRatBN7.2134,292,605 - 34,292,939 (+)MAPPERmRatBN7.2
Rnor_6.01070,619,564 - 70,619,897NCBIRnor6.0
Rnor_6.0136,954,154 - 36,954,487NCBIRnor6.0
RGSC_v3.4174,459,223 - 4,459,556UniSTSRGSC3.4
RGSC_v3.41071,485,591 - 71,485,924UniSTSRGSC3.4
Celera1067,144,268 - 67,144,601UniSTS
Celera132,879,804 - 32,880,137UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map10q26UniSTS
UniSTS:259407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,292,682 - 34,293,258 (+)MAPPERmRatBN7.2
Rnor_6.0136,954,231 - 36,954,806NCBIRnor6.0
Rnor_5.0138,348,102 - 38,348,677UniSTSRnor5.0
RGSC_v3.4174,459,300 - 4,459,875UniSTSRGSC3.4
Celera132,879,881 - 32,880,456UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map10q26UniSTS
Ap2b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,202,612 - 68,202,943 (+)MAPPERmRatBN7.2
mRatBN7.2134,292,605 - 34,292,936 (+)MAPPERmRatBN7.2
Rnor_6.01070,619,567 - 70,619,897NCBIRnor6.0
Rnor_6.0136,954,154 - 36,954,484NCBIRnor6.0
RGSC_v3.4174,459,223 - 4,459,553UniSTSRGSC3.4
RGSC_v3.41071,485,594 - 71,485,924UniSTSRGSC3.4
Celera132,879,804 - 32,880,134UniSTS
Celera1067,144,271 - 67,144,601UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC119615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M77246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000085799   ⟹   ENSRNOP00000072290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,597,093 - 68,700,159 (+)Ensembl
mRatBN7.2 Ensembl1068,099,547 - 68,198,552 (+)Ensembl
Rnor_6.0 Ensembl1070,520,279 - 70,620,151 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088198   ⟹   ENSRNOP00000070905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,600,708 - 68,702,539 (+)Ensembl
mRatBN7.2 Ensembl1068,103,192 - 68,205,013 (+)Ensembl
Rnor_6.0 Ensembl1070,520,206 - 70,621,965 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090446   ⟹   ENSRNOP00000073619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,613,170 - 68,702,539 (+)Ensembl
mRatBN7.2 Ensembl1068,115,639 - 68,205,013 (+)Ensembl
Rnor_6.0 Ensembl1070,520,254 - 70,621,977 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117903   ⟹   ENSRNOP00000084537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,612,666 - 68,696,189 (+)Ensembl
mRatBN7.2 Ensembl1068,115,135 - 68,198,665 (+)Ensembl
RefSeq Acc Id: NM_080583   ⟹   NP_542150
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,723 - 68,702,543 (+)NCBI
mRatBN7.21068,103,192 - 68,205,019 (+)NCBI
Rnor_6.01070,520,206 - 70,621,973 (+)NCBI
Rnor_5.01071,035,406 - 71,067,828 (+)NCBI
Rnor_5.01071,068,935 - 71,083,997 (+)NCBI
RGSC_v3.41071,386,233 - 71,488,000 (+)RGD
Celera1067,045,800 - 67,146,677 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767936   ⟹   XP_008766158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,597,039 - 68,702,547 (+)NCBI
mRatBN7.21068,099,544 - 68,205,023 (+)NCBI
Rnor_6.01070,516,585 - 70,621,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767937   ⟹   XP_008766159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,596,925 - 68,702,547 (+)NCBI
mRatBN7.21068,099,397 - 68,205,023 (+)NCBI
Rnor_6.01070,516,462 - 70,621,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767938   ⟹   XP_008766160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,597,033 - 68,702,547 (+)NCBI
mRatBN7.21068,099,559 - 68,205,023 (+)NCBI
Rnor_6.01070,516,573 - 70,621,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767939   ⟹   XP_008766161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,700 - 68,702,547 (+)NCBI
mRatBN7.21068,103,171 - 68,204,223 (+)NCBI
Rnor_6.01070,519,470 - 70,619,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596973   ⟹   XP_017452462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,596,936 - 68,702,547 (+)NCBI
mRatBN7.21068,099,408 - 68,205,023 (+)NCBI
Rnor_6.01070,516,483 - 70,621,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268342   ⟹   XP_063124412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,702 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268343   ⟹   XP_063124413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,918 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268344   ⟹   XP_063124414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,601,234 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268345   ⟹   XP_063124415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,597,033 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268346   ⟹   XP_063124416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,597,051 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268347   ⟹   XP_063124417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,596,925 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268348   ⟹   XP_063124418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,719 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268349   ⟹   XP_063124419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,892 - 68,702,547 (+)NCBI
RefSeq Acc Id: XM_063268350   ⟹   XP_063124420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,600,719 - 68,687,491 (+)NCBI
Protein Sequences
Protein RefSeqs NP_542150 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766158 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766159 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766160 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766161 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452462 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124412 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124413 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124414 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124415 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124416 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124417 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124418 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124419 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124420 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40797 (Get FASTA)   NCBI Sequence Viewer  
  AAA40808 (Get FASTA)   NCBI Sequence Viewer  
  AAI03482 (Get FASTA)   NCBI Sequence Viewer  
  EDM05475 (Get FASTA)   NCBI Sequence Viewer  
  EDM05476 (Get FASTA)   NCBI Sequence Viewer  
  EDM05477 (Get FASTA)   NCBI Sequence Viewer  
  EDM05478 (Get FASTA)   NCBI Sequence Viewer  
  EDM05479 (Get FASTA)   NCBI Sequence Viewer  
  EDM05480 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070905
  ENSRNOP00000070905.1
  ENSRNOP00000072290
  ENSRNOP00000073619
GenBank Protein P62944 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_542150   ⟸   NM_080583
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766159   ⟸   XM_008767937
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766160   ⟸   XM_008767938
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766158   ⟸   XM_008767936
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766161   ⟸   XM_008767939
- Peptide Label: isoform X2
- UniProtKB: P62944 (UniProtKB/Swiss-Prot),   A6HHH4 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452462   ⟸   XM_017596973
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073619   ⟸   ENSRNOT00000090446
Ensembl Acc Id: ENSRNOP00000072290   ⟸   ENSRNOT00000085799
Ensembl Acc Id: ENSRNOP00000070905   ⟸   ENSRNOT00000088198
Ensembl Acc Id: ENSRNOP00000084537   ⟸   ENSRNOT00000117903
RefSeq Acc Id: XP_063124417   ⟸   XM_063268347
- Peptide Label: isoform X2
- UniProtKB: P62944 (UniProtKB/Swiss-Prot),   A6HHH4 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124415   ⟸   XM_063268345
- Peptide Label: isoform X2
- UniProtKB: P62944 (UniProtKB/Swiss-Prot),   A6HHH4 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124416   ⟸   XM_063268346
- Peptide Label: isoform X2
- UniProtKB: P62944 (UniProtKB/Swiss-Prot),   A6HHH4 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124412   ⟸   XM_063268342
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124418   ⟸   XM_063268348
- Peptide Label: isoform X2
- UniProtKB: P62944 (UniProtKB/Swiss-Prot),   A6HHH4 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124420   ⟸   XM_063268350
- Peptide Label: isoform X3
- UniProtKB: A0A8L2R623 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124419   ⟸   XM_063268349
- Peptide Label: isoform X2
- UniProtKB: P62944 (UniProtKB/Swiss-Prot),   A6HHH4 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124413   ⟸   XM_063268343
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124414   ⟸   XM_063268344
- Peptide Label: isoform X1
- UniProtKB: Q3ZB97 (UniProtKB/TrEMBL),   A0A8L2R7J3 (UniProtKB/TrEMBL)
Protein Domains
Beta-adaptin appendage C-terminal subdomain   Clathrin adaptor alpha/beta/gamma-adaptin appendage

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62944-F1-model_v2 AlphaFold P62944 1-937 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697531
Promoter ID:EPDNEW_R8053
Type:initiation region
Name:Ap2b1_1
Description:adaptor-related protein complex 2, beta 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,520,266 - 70,520,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71048 AgrOrtholog
BioCyc Gene G2FUF-23892 BioCyc
Ensembl Genes ENSRNOG00000061543 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085799 ENTREZGENE
  ENSRNOT00000088198 ENTREZGENE
  ENSRNOT00000088198.2 UniProtKB/Swiss-Prot
  ENSRNOT00000090446 ENTREZGENE
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
  2.60.40.1150 UniProtKB/Swiss-Prot
  3.30.310.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7929959 IMAGE-MGC_LOAD
InterPro AP_beta UniProtKB/Swiss-Prot
  AP_complex_bsu_1_2_4 UniProtKB/Swiss-Prot
  ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Armadillo UniProtKB/Swiss-Prot
  B-adaptin_app_sub_C UniProtKB/Swiss-Prot
  Clathrin/coatomer_adapt-like_N UniProtKB/Swiss-Prot
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/Swiss-Prot
  Clathrin_app_Ig-like_sf UniProtKB/Swiss-Prot
  Clathrin_b-adaptin_app_Ig-like UniProtKB/Swiss-Prot
  Coatomer/calthrin_app_sub_C UniProtKB/Swiss-Prot
  TBP_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:140670 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124574 IMAGE-MGC_LOAD
NCBI Gene 140670 ENTREZGENE
PANTHER PTHR11134 UniProtKB/Swiss-Prot
Pfam Adaptin_N UniProtKB/Swiss-Prot
  Alpha_adaptinC2 UniProtKB/Swiss-Prot
  B2-adapt-app_C UniProtKB/Swiss-Prot
PharmGKB AP2B1 RGD
PhenoGen Ap2b1 PhenoGen
PIRSF AP_complex_beta UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061543 RatGTEx
SMART Alpha_adaptinC2 UniProtKB/Swiss-Prot
  ARM UniProtKB/Swiss-Prot
  B2-adapt-app_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF49348 UniProtKB/Swiss-Prot
  SSF55711 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYC5_RAT UniProtKB/TrEMBL
  A0A8L2R623 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R7J3 ENTREZGENE, UniProtKB/TrEMBL
  A6HHH4 ENTREZGENE, UniProtKB/TrEMBL
  A6HHH5_RAT UniProtKB/TrEMBL
  AP2B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3ZB97 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P21851 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ap2b1  adaptor related protein complex 2 subunit beta 1  LOC103690090  AP-2 complex subunit beta-like  Data merged from RGD:9075723 737654 PROVISIONAL
2018-05-03 Ap2b1  adaptor related protein complex 2 subunit beta 1  Ap2b1  adaptor-related protein complex 2, beta 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Ap2b1  adaptor-related protein complex 2, beta 1 subunit  LOC100912146  AP-1 complex subunit beta-1-like  Data merged from RGD:6488731 737654 PROVISIONAL
2014-08-25 LOC103690090  AP-2 complex subunit beta-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100912146  AP-1 complex subunit beta-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Ap2b1  adaptor-related protein complex 2, beta 1 subunit      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function component of the adaptor complexes which link clathrin to receptors in coated vesicles; clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration 724707