Htr7 (5-hydroxytryptamine receptor 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Htr7 (5-hydroxytryptamine receptor 7) Rattus norvegicus
Analyze
Symbol: Htr7
Name: 5-hydroxytryptamine receptor 7
RGD ID: 71034
Description: Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including axon terminus; neuronal cell body; and synaptic vesicle. Is active in postsynaptic membrane and presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-7; 5-HT-X; 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5Ht7; GPRFO; high affinity serotonin receptor (5HT7); high affinity serotonin receptor (5HT7) gene; LOC103694905; serotonin receptor 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Htr7em1Geh ; Htr7em1Msu
Genetic Models: SD-Htr7em1Msu ; WI-Htr7em1Geh
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,049,064 - 243,173,636 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1243,049,081 - 243,173,230 (-)EnsemblGRCr8
mRatBN7.21233,636,442 - 233,761,063 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,636,452 - 233,760,626 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1242,035,877 - 242,157,610 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,959,213 - 249,074,281 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,797,382 - 241,912,442 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,547,964 - 254,671,811 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,547,620 - 254,671,778 (-)Ensemblrn6Rnor6.0
Rnor_5.01261,759,122 - 261,879,914 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41240,136,279 - 240,260,620 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1230,737,463 - 230,859,847 (-)NCBICelera
RGSC_v3.11240,308,574 - 240,434,503 (-)NCBI
Cytogenetic Map1q53NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-carboxamidotryptamine  (ISO)
5-fluorouracil  (ISO)
5-methoxytryptamine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-OH-DPAT  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
atorvastatin calcium  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (ISO)
buta-1,3-diene  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyproheptadine  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dioxygen  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
isoprenaline  (EXP)
ketanserin  (ISO)
L-methionine  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lisuride  (ISO)
lurasidone hydrochloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesulergine  (ISO)
metergoline  (ISO)
methiothepin  (ISO)
methylphenidate  (EXP)
mianserin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
paliperidone palmitate  (ISO)
PD 0325901  (ISO)
risperidone  (ISO)
ritanserin  (ISO)
rotenone  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
spiperone  (ISO)
tamoxifen  (ISO)
testosterone undecanoate  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
vortioxetine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. null null
2. Blockade of 5-HT7 receptors reduces tactile allodynia in the rat. Amaya-Castellanos E, etal., Pharmacol Biochem Behav. 2011 Oct;99(4):591-7. Epub 2011 Jun 15.
3. Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions. Brenchat A, etal., Eur J Pain. 2012 Jan;16(1):72-81. doi: 10.1016/j.ejpain.2011.07.004.
4. Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research. Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24.
5. Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: immunocytochemical evidence. Doly S, etal., J Comp Neurol. 2005 Sep 26;490(3):256-69.
6. Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. Galici R, etal., Behav Pharmacol. 2008 Mar;19(2):153-9.
7. Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat. Gasbarri A, etal., Behav Brain Res. 2008 Dec 16;195(1):164-70. Epub 2008 Jan 9.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. Geurts FJ, etal., J Chem Neuroanat 2002 Jun;24(1):65-74.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy. Graf M, etal., Neurosci Lett. 2004 Apr 8;359(1-2):45-8.
12. A 5-HT7 heteroreceptor-mediated inhibition of serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction. Harsing LG Jr, etal., Neurochem Res. 2004 Aug;29(8):1487-97.
13. The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. Hedlund PB and Sutcliffe JG, Neurosci Lett. 2007 Mar 13;414(3):247-51. Epub 2007 Jan 11.
14. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. Heidmann DE, etal., J Neurochem 1997 Apr;68(4):1372-81.
15. The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. Horiguchi M, etal., J Pharmacol Exp Ther. 2011 Aug;338(2):605-14. Epub 2011 May 10.
16. Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. Lenglet S, etal., Endocrinology 2002 May;143(5):1748-60.
17. Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. Leo D, etal., Genes Brain Behav. 2009 Apr;8(3):356-68. Epub 2009 Feb 19.
18. Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model. Liy-Salmeron G and Meneses A, Hippocampus. 2008;18(9):965-74.
19. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Lovenberg TW, etal., Neuron 1993 Sep;11(3):449-58.
20. Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties. Matott MP and Kline DD, Brain Res. 2016 Mar 15;1635:12-26. doi: 10.1016/j.brainres.2016.01.017. Epub 2016 Jan 15.
21. Gene Data Set MGD Curation, June 12, 2002
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Monti JM, etal., Behav Brain Res. 2008 Aug 22;191(2):184-9. Epub 2008 Mar 25.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors. Parga J, etal., Dev Neurobiol. 2007 Jan;67(1):10-22.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. Effects of repetitive administration of tianeptine, zinc hydroaspartate and electroconvulsive shock on the reactivity of 5-HT(7) receptors in rat hippocampus. Pitra P, etal., Pharmacol Rep. 2007 Nov-Dec;59(6):627-35.
29. Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats. Read KE, etal., Br J Pharmacol. 2003 Sep;140(1):53-60. Epub 2003 Jul 29.
30. 5-Hydroxytryptamine potentiates neurogenic contractions of rat isolated urinary bladder through both 5-HT(7) and 5-HT(2C) receptors. Rekik M, etal., Eur J Pharmacol. 2011 Jan 10;650(1):403-10. Epub 2010 Oct 20.
31. GOA pipeline RGD automated data pipeline
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test. Rocha-Gonzalez HI, etal., Pain. 2005 Sep;117(1-2):182-92.
34. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Ruat M, etal., Proc Natl Acad Sci U S A 1993 Sep 15;90(18):8547-51.
35. 5-HT does not lower blood pressure in the 5-HT7 knockout rat. Seitz BM, etal., Physiol Genomics. 2019 Jul 1;51(7):302-310. doi: 10.1152/physiolgenomics.00031.2019. Epub 2019 May 24.
36. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. Shen Y, etal., J Biol Chem 1993 Aug 25;268(24):18200-4.
37. Imipramine counteracts corticosterone-induced alterations in the effects of the activation of 5-HT(7) receptors in rat hippocampus. Tokarski K, etal., J Physiol Pharmacol. 2009 Jun;60(2):83-8.
38. The 5-HT(7) receptor antagonist SB 269970 counteracts restraint stress-induced attenuation of long-term potentiation in rat frontal cortex. Tokarski K, etal., J Physiol Pharmacol. 2011 Dec;62(6):663-7.
39. Selective inhibition of 5-HT7 receptor reduces CGRP release in an experimental model for migraine. Wang X, etal., Headache. 2010 Apr;50(4):579-87. Epub 2010 Mar 5.
40. Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression. Wesolowska A, etal., Neuropharmacology. 2006 Sep;51(3):578-86. Epub 2006 Jul 7.
41. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Witkin JM, etal., Epilepsy Res. 2007 Jun;75(1):39-45. Epub 2007 May 7.
42. Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury. Yelleswarapu NK, etal., Neurosci Lett. 2012 Mar 21.
43. Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. Zlojutro M, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):44-58. doi: 10.1002/ajmg.b.31136. Epub 2010 Nov 2.
44. Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome. Zou BC, etal., Chin Med J (Engl). 2007 Dec 5;120(23):2069-74.
Additional References at PubMed
PMID:8517926   PMID:15707674   PMID:16759802   PMID:16901936   PMID:17543469   PMID:17853773   PMID:18996171   PMID:19302555   PMID:19447286   PMID:19629447   PMID:19805745   PMID:20071609  
PMID:21248402   PMID:21403818   PMID:21538661   PMID:22543085   PMID:22922122   PMID:23164613   PMID:23542440   PMID:23603557   PMID:23672716   PMID:23694713   PMID:23742863   PMID:24129596  
PMID:24162801   PMID:24603678   PMID:24709857   PMID:26470809   PMID:26773257   PMID:26979176   PMID:27178363   PMID:27393215   PMID:28987281   PMID:29384698   PMID:29730242   PMID:31846086  
PMID:32329363   PMID:34199392   PMID:36344870  


Genomics

Comparative Map Data
Htr7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,049,064 - 243,173,636 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1243,049,081 - 243,173,230 (-)EnsemblGRCr8
mRatBN7.21233,636,442 - 233,761,063 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,636,452 - 233,760,626 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1242,035,877 - 242,157,610 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,959,213 - 249,074,281 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,797,382 - 241,912,442 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,547,964 - 254,671,811 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,547,620 - 254,671,778 (-)Ensemblrn6Rnor6.0
Rnor_5.01261,759,122 - 261,879,914 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41240,136,279 - 240,260,620 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1230,737,463 - 230,859,847 (-)NCBICelera
RGSC_v3.11240,308,574 - 240,434,503 (-)NCBI
Cytogenetic Map1q53NCBI
HTR7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381090,740,823 - 90,858,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1090,740,823 - 90,858,039 (-)Ensemblhg38GRCh38
GRCh371092,500,580 - 92,617,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361092,490,555 - 92,607,651 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341092,490,557 - 92,607,651NCBI
Celera1086,247,007 - 86,364,124 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1086,129,586 - 86,246,677 (-)NCBIHuRef
CHM1_11092,778,457 - 92,895,518 (-)NCBICHM1_1
T2T-CHM13v2.01091,624,488 - 91,741,713 (-)NCBIT2T-CHM13v2.0
Htr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391935,935,815 - 36,035,533 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1935,936,134 - 36,034,907 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381935,958,415 - 36,058,133 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1935,958,734 - 36,057,507 (-)Ensemblmm10GRCm38
MGSCv371936,033,217 - 36,131,850 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361936,025,416 - 36,122,486 (-)NCBIMGSCv36mm8
Celera1936,736,456 - 36,835,310 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1930.3NCBI
Htr7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554252,321,420 - 2,420,530 (+)Ensembl
ChiLan1.0NW_0049554252,321,420 - 2,420,420 (+)NCBIChiLan1.0ChiLan1.0
HTR7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28102,745,099 - 102,888,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110102,751,872 - 102,893,463 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01087,480,970 - 87,598,212 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11091,008,278 - 91,125,416 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,009,941 - 91,125,158 (-)EnsemblpanPan2panpan1.1
HTR7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,438,872 - 5,524,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl285,440,388 - 5,524,191 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha285,605,815 - 5,691,701 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0285,658,606 - 5,744,502 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,660,149 - 5,744,487 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1285,415,879 - 5,501,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0285,454,660 - 5,540,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0285,588,358 - 5,595,285 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htr7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,937,016 - 42,106,548 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366013,569,544 - 3,626,797 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366013,569,626 - 3,626,782 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14102,444,588 - 102,548,907 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114102,443,312 - 102,548,894 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214111,526,055 - 111,660,097 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1984,081,713 - 84,191,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl984,083,396 - 84,190,876 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604844,783,137 - 44,901,015 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247371,960,057 - 2,067,038 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247371,960,985 - 2,067,086 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Htr7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1237,777,483 - 37,890,023 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Htr7
822 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:193
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000025450, ENSRNOT00000025493
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH132467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,689,317 - 233,689,502 (+)MAPPERmRatBN7.2
Rnor_6.01254,600,468 - 254,600,652NCBIRnor6.0
Rnor_5.01261,812,236 - 261,812,420UniSTSRnor5.0
RGSC_v3.41240,187,535 - 240,187,719UniSTSRGSC3.4
Celera1230,788,543 - 230,788,727UniSTS
Cytogenetic Map1q53UniSTS
RH66814  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81243,059,762 - 243,059,903 (+)Marker Load Pipeline
mRatBN7.21233,647,144 - 233,647,284 (+)MAPPERmRatBN7.2
Rnor_6.01254,558,311 - 254,558,450NCBIRnor6.0
Rnor_5.01261,769,469 - 261,769,608UniSTSRnor5.0
RGSC_v3.41240,145,378 - 240,145,517UniSTSRGSC3.4
Celera1230,746,558 - 230,746,697UniSTS
Cytogenetic Map1q53UniSTS
Htr7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,759,790 - 233,760,331 (+)MAPPERmRatBN7.2
Rnor_6.01254,670,943 - 254,671,483NCBIRnor6.0
Rnor_5.01261,879,084 - 261,879,624UniSTSRnor5.0
RGSC_v3.41240,259,967 - 240,260,507UniSTSRGSC3.4
Celera1230,859,194 - 230,859,734UniSTS
Cytogenetic Map1q53UniSTS
RH143843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,636,861 - 233,636,980 (+)MAPPERmRatBN7.2
Rnor_6.01254,548,030 - 254,548,148NCBIRnor6.0
Rnor_5.01261,759,188 - 261,759,306UniSTSRnor5.0
RGSC_v3.41240,135,095 - 240,135,213UniSTSRGSC3.4
Celera1230,736,279 - 230,736,397UniSTS
RH 3.4 Map11585.11UniSTS
Cytogenetic Map1q53UniSTS
UniSTS:495969  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81243,172,493 - 243,172,585 (+)Marker Load Pipeline
mRatBN7.21233,759,890 - 233,759,981 (+)MAPPERmRatBN7.2
Rnor_6.01254,671,043 - 254,671,133NCBIRnor6.0
Rnor_5.01261,879,184 - 261,879,274UniSTSRnor5.0
RGSC_v3.41240,260,067 - 240,260,157UniSTSRGSC3.4
Celera1230,859,294 - 230,859,384UniSTS
Cytogenetic Map1q53UniSTS
Htr7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,638,000 - 233,638,107 (+)MAPPERmRatBN7.2
Rnor_6.01254,549,169 - 254,549,275NCBIRnor6.0
Rnor_5.01261,760,327 - 261,760,433UniSTSRnor5.0
RGSC_v3.41240,136,234 - 240,136,340UniSTSRGSC3.4
Celera1230,737,418 - 230,737,524UniSTS
Cytogenetic Map1q53UniSTS


Genetic Models
This gene Htr7 is modified in the following models/strains:
SD-Htr7em1Msu     WI-Htr7em1Geh    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 2 55 178 99 91 61 86 61 12 331 176 11 145 74 105 30 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000025450   ⟹   ENSRNOP00000025450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,049,081 - 243,173,048 (-)Ensembl
mRatBN7.2 Ensembl1233,636,459 - 233,760,444 (-)Ensembl
Rnor_6.0 Ensembl1254,547,627 - 254,671,596 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000025493   ⟹   ENSRNOP00000025493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,636,452 - 233,760,436 (-)Ensembl
Rnor_6.0 Ensembl1254,547,937 - 254,671,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078150   ⟹   ENSRNOP00000071410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,646,241 - 233,760,626 (-)Ensembl
Rnor_6.0 Ensembl1254,547,620 - 254,671,588 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082732   ⟹   ENSRNOP00000074238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,058,680 - 243,173,230 (-)Ensembl
mRatBN7.2 Ensembl1233,646,062 - 233,760,626 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089855   ⟹   ENSRNOP00000073500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,050,668 - 243,172,948 (-)Ensembl
mRatBN7.2 Ensembl1233,638,103 - 233,760,626 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111885   ⟹   ENSRNOP00000082600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,049,391 - 243,173,230 (-)Ensembl
mRatBN7.2 Ensembl1233,636,769 - 233,760,626 (-)Ensembl
RefSeq Acc Id: NM_022938   ⟹   NP_075227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,050,668 - 243,173,048 (-)NCBI
mRatBN7.21233,638,046 - 233,760,444 (-)NCBI
Rnor_6.01254,549,214 - 254,671,596 (-)NCBI
Rnor_5.01261,759,122 - 261,879,914 (-)NCBI
RGSC_v3.41240,136,279 - 240,260,620 (-)RGD
Celera1230,737,463 - 230,859,847 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231307   ⟹   XP_006231369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,049,064 - 243,173,629 (-)NCBI
mRatBN7.21233,636,442 - 233,761,056 (-)NCBI
Rnor_6.01254,547,964 - 254,671,811 (-)NCBI
Rnor_5.01261,759,122 - 261,879,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089833   ⟹   XP_038945761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,049,064 - 243,090,072 (-)NCBI
mRatBN7.21233,636,442 - 233,680,229 (-)NCBI
RefSeq Acc Id: XM_039089840   ⟹   XP_038945768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,050,757 - 243,173,636 (-)NCBI
mRatBN7.21233,639,589 - 233,761,063 (-)NCBI
RefSeq Acc Id: NP_075227   ⟸   NM_022938
- UniProtKB: A6I144 (UniProtKB/TrEMBL),   A0A0G2K0E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231369   ⟸   XM_006231307
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000071410   ⟸   ENSRNOT00000078150
Ensembl Acc Id: ENSRNOP00000025493   ⟸   ENSRNOT00000025493
Ensembl Acc Id: ENSRNOP00000025450   ⟸   ENSRNOT00000025450
RefSeq Acc Id: XP_038945761   ⟸   XM_039089833
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945768   ⟸   XM_039089840
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5P0 (UniProtKB/TrEMBL),   P97842 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082600   ⟸   ENSRNOT00000111885
Ensembl Acc Id: ENSRNOP00000073500   ⟸   ENSRNOT00000089855
Ensembl Acc Id: ENSRNOP00000074238   ⟸   ENSRNOT00000082732
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32305-F1-model_v2 AlphaFold P32305 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71034 AgrOrtholog
BioCyc Gene G2FUF-55834 BioCyc
Ensembl Genes ENSRNOG00000018827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025450 ENTREZGENE
  ENSRNOT00000025450.8 UniProtKB/Swiss-Prot
  ENSRNOT00000111885 ENTREZGENE
  ENSRNOT00000111885.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT_7_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:65032 UniProtKB/Swiss-Prot
NCBI Gene 65032 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  IP13425P-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Htr7 PhenoGen
PRINTS 5HT7RECEPTR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018827 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT7R_RAT UniProtKB/Swiss-Prot
  A0A0G2K0E3 ENTREZGENE
  A0A0G2K5P0 ENTREZGENE
  A0A8L2R8K1 ENTREZGENE, UniProtKB/TrEMBL
  A6I144 ENTREZGENE, UniProtKB/TrEMBL
  P32305 ENTREZGENE
  P97842 ENTREZGENE, UniProtKB/TrEMBL
  P97936 ENTREZGENE
UniProt Secondary P97936 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Htr7  5-hydroxytryptamine receptor 7  LOC103694905  5-hydroxytryptamine receptor 7  Data merged from RGD:9265298 737654 PROVISIONAL
2016-02-11 Htr7  5-hydroxytryptamine receptor 7  Htr7  5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694905  5-hydroxytryptamine receptor 7      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-06 Htr7  5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled  Htr7  5-hydroxytryptamine (serotonin) receptor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Htr7  5-hydroxytryptamine (serotonin) receptor 7      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in Purkinje cells 727384
gene_process activation results in aldosterone secretion via the adenylyl cyclase/PKA pathway and the calcium influx 729310