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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71034
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr7
Name: 5-hydroxytryptamine receptor 7
Acc ID: CHEBI:73378
Term: mesulergine
Definition: A member of the class of ergot alkaloids that is known to act on serotonin and dopamine receptors.
Chemical ID: MESH:C031649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr7affects bindingISOHTR7 (Homo sapiens)6480464CTDmesulergine binds to HTR7 proteinPMID:20827463
Htr7multiple interactionsISOHTR7 (Homo sapiens)6480464CTD[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]PMID:14578406 PMID:20827463
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