Adnp (activity-dependent neuroprotector homeobox) - Rat Genome Database

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Gene: Adnp (activity-dependent neuroprotector homeobox) Rattus norvegicus
Analyze
Symbol: Adnp
Name: activity-dependent neuroprotector homeobox
RGD ID: 71030
Description: Enables beta-tubulin binding activity; copper ion binding activity; and peptide binding activity. Involved in several processes, including estrous cycle; positive regulation of cellular component organization; and short-term memory. Located in several cellular components, including axon; dendrite; and neuronal cell body. Used to study brain infarction and ischemia. Human ortholog(s) of this gene implicated in Helsmoortel-Van Der Aa Syndrome. Orthologous to human ADNP (activity dependent neuroprotector homeobox); INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activity-dependent neuroprotective protein; activity-dependent neuroprotector homeobox protein; NAP peptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,310,258 - 177,340,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3177,310,258 - 177,336,188 (-)EnsemblGRCr8
mRatBN7.23156,886,921 - 156,921,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,891,381 - 156,917,312 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,686,196 - 160,712,108 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,185,277 - 169,211,206 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,926,977 - 166,952,906 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,937,188 - 164,964,819 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)Ensemblrn6Rnor6.0
Rnor_5.03171,077,543 - 171,087,330 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43159,345,280 - 159,355,067 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3155,464,855 - 155,474,635 (-)NCBICelera
RGSC_v3.13159,253,471 - 159,255,943 (-)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-nitroindazole  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (EXP)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
nickel subsulfide  (EXP)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Vasoactive intestinal peptide and related molecules induce nitrite accumulation in the extracellular milieu of rat cerebral cortical cultures. Ashur-Fabian O, etal., Neurosci Lett 2001 Jul 20;307(3):167-70.
2. The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide. Ashur-Fabian O, etal., Peptides. 2003 Sep;24(9):1413-23.
3. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. Bassan M, etal., J Neurochem. 1999 Mar;72(3):1283-93.
4. A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice. Beni-Adani L, etal., J Pharmacol Exp Ther. 2001 Jan;296(1):57-63.
5. Xenon induces transcription of ADNP in neonatal rat brain. Cattano D, etal., Neurosci Lett. 2008 Aug 8;440(3):217-21. Epub 2008 May 28.
6. Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling. Chen S and Charness ME, Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19962-7. Epub 2008 Dec 1.
7. Peptide-mediated protection from ethanol-induced neural tube defects. Chen SY, etal., Dev Neurosci. 2005 Jan-Feb;27(1):13-9.
8. Nitric Oxide Regulates Activity-Dependent Neuroprotective Protein (ADNP) in the Dentate Gyrus of the Rodent Model of Kainic Acid-Induced Seizure. Cosgrave AS, etal., J Mol Neurosci. 2009 Jan 7.
9. Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina. Dangoor D, etal., Peptides. 2005 Dec;26(12):2579-84. Epub 2005 Jul 14.
10. Peptide neuroprotection through specific interaction with brain tubulin. Divinski I, etal., J Neurochem. 2006 Aug;98(3):973-84.
11. Subcellular localization and secretion of activity-dependent neuroprotective protein in astrocytes. Furman S, etal., Neuron Glia Biol. 2004 Aug;1(3):193-199.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Expression of activity-dependent neuroprotective protein in the brain of adult rats. Gennet N, etal., Histol Histopathol. 2008 Mar;23(3):309-17.
14. NAP accelerates the performance of normal rats in the water maze. Gozes I, etal., J Mol Neurosci. 2002 Aug-Oct;19(1-2):167-70.
15. NAP mechanisms of neuroprotection. Gozes I, etal., J Mol Neurosci. 2004;24(1):67-72.
16. Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze. Gozes I, etal., J Pharmacol Exp Ther 2000 Jun;293(3):1091-8.
17. The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush. Jehle T, etal., Graefes Arch Clin Exp Ophthalmol. 2008 Sep;246(9):1255-63. Epub 2008 Apr 15.
18. Neuroprotective effect of the peptides ADNF-9 and NAP on hypoxic-ischemic brain injury in neonatal rats. Kumral A, etal., Brain Res. 2006 Oct 18;1115(1):169-78. Epub 2006 Aug 30.
19. NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death. Leker RR, etal., Stroke 2002 Apr;33(4):1085-92.
20. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. Matsuoka Y, etal., J Pharmacol Exp Ther. 2008 Apr;325(1):146-53. Epub 2008 Jan 16.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease. Offen D, etal., Brain Res 2000 Jan 31;854(1-2):257-62.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures. Smith-Swintosky VL, etal., J Mol Neurosci. 2005;25(3):225-38.
27. VIP and peptides related to activity-dependent neurotrophic factor protect PC12 cells against oxidative stress. Steingart RA, etal., J Mol Neurosci 2000 Dec;15(3):137-45.
28. PolyADP-ribosylation is involved in neurotrophic activity. Visochek L, etal., J Neurosci. 2005 Aug 10;25(32):7420-8.
29. Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. Vulih-Shultzman I, etal., J Pharmacol Exp Ther. 2007 Nov;323(2):438-49. Epub 2007 Aug 24.
30. Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity. Wilkemeyer MF, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8543-8. Epub 2003 Jun 13.
31. Cloning and characterization of the human activity-dependent neuroprotective protein. Zamostiano R, etal., J Biol Chem 2001 Jan 5;276(1):708-14.
32. Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus. Zhang TA, etal., Neuroscience. 2005;134(2):583-93.
33. Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP. Zusev M and Gozes I, Regul Pept. 2004 Dec 15;123(1-3):33-41.
Additional References at PubMed
PMID:8889548   PMID:17222401   PMID:17952636   PMID:22454142   PMID:23272107   PMID:25178163   PMID:27003787   PMID:38673966  


Genomics

Comparative Map Data
Adnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,310,258 - 177,340,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3177,310,258 - 177,336,188 (-)EnsemblGRCr8
mRatBN7.23156,886,921 - 156,921,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,891,381 - 156,917,312 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,686,196 - 160,712,108 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,185,277 - 169,211,206 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,926,977 - 166,952,906 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,937,188 - 164,964,819 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)Ensemblrn6Rnor6.0
Rnor_5.03171,077,543 - 171,087,330 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43159,345,280 - 159,355,067 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3155,464,855 - 155,474,635 (-)NCBICelera
RGSC_v3.13159,253,471 - 159,255,943 (-)NCBI
Cytogenetic Map3q42NCBI
ADNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,888,918 - 50,931,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2050,888,916 - 50,931,437 (-)Ensemblhg38GRCh38
GRCh372049,505,455 - 49,547,974 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,940,290 - 48,980,934 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342048,940,289 - 48,980,934NCBI
Celera2046,211,143 - 46,251,787 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2046,255,283 - 46,295,816 (-)NCBIHuRef
CHM1_12049,412,276 - 49,452,793 (-)NCBICHM1_1
T2T-CHM13v2.02052,659,514 - 52,702,036 (-)NCBIT2T-CHM13v2.0
Adnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,022,885 - 168,049,032 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2168,022,906 - 168,049,032 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382168,180,965 - 168,207,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,180,986 - 168,207,112 (-)Ensemblmm10GRCm38
MGSCv372168,006,465 - 168,032,562 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362168,006,465 - 168,032,562 (-)NCBIMGSCv36mm8
Celera2174,124,697 - 174,151,114 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.41NCBI
Adnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,492,257 - 7,531,862 (+)Ensembl
ChiLan1.0NW_0049554457,498,223 - 7,530,828 (+)NCBIChiLan1.0ChiLan1.0
ADNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22156,639,252 - 56,680,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12056,632,380 - 56,673,982 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02047,233,696 - 47,276,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12048,361,036 - 48,400,399 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,361,043 - 48,400,387 (-)EnsemblpanPan2panpan1.1
ADNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12437,211,776 - 37,245,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2437,213,942 - 37,243,702 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2436,453,839 - 36,487,910 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02437,921,440 - 37,955,536 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,922,782 - 37,953,382 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12437,156,924 - 37,191,002 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02437,290,872 - 37,324,932 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,835,833 - 37,869,965 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,401,492 - 188,429,717 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365143,855,672 - 3,885,718 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365143,855,113 - 3,883,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,317,913 - 52,332,079 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11752,316,388 - 52,350,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,757,490 - 58,790,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,037,446 - 13,080,287 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,039,866 - 13,081,161 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605061,470,166 - 61,513,443 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247904,832,494 - 4,854,845 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247904,822,467 - 4,854,852 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Adnp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15149,797,437 - 149,827,216 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:174
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000014595
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH134339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,891,420 - 156,891,609 (+)MAPPERmRatBN7.2
Rnor_6.03164,937,228 - 164,937,416NCBIRnor6.0
Rnor_5.03171,077,583 - 171,077,771UniSTSRnor5.0
RGSC_v3.43159,345,320 - 159,345,508UniSTSRGSC3.4
Celera3155,464,895 - 155,465,083UniSTS
RH 3.4 Map31480.7UniSTS
Cytogenetic Map3q42UniSTS
Adnp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,895,486 - 156,895,873 (+)MAPPERmRatBN7.2
Rnor_6.03164,941,293 - 164,941,679NCBIRnor6.0
Rnor_5.03171,081,648 - 171,082,034UniSTSRnor5.0
RGSC_v3.43159,349,385 - 159,349,771UniSTSRGSC3.4
Celera3155,468,960 - 155,469,346UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014595   ⟹   ENSRNOP00000014595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3177,310,258 - 177,336,188 (-)Ensembl
mRatBN7.2 Ensembl3156,891,381 - 156,917,312 (-)Ensembl
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)Ensembl
RefSeq Acc Id: NM_001347532   ⟹   NP_001334461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,310,258 - 177,336,188 (-)NCBI
mRatBN7.23156,891,381 - 156,917,312 (-)NCBI
RefSeq Acc Id: XM_039105806   ⟹   XP_038961734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,310,261 - 177,336,733 (-)NCBI
mRatBN7.23156,889,885 - 156,921,051 (-)NCBI
RefSeq Acc Id: XM_039105808   ⟹   XP_038961736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,310,261 - 177,336,728 (-)NCBI
mRatBN7.23156,889,885 - 156,921,051 (-)NCBI
RefSeq Acc Id: XM_039105809   ⟹   XP_038961737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,310,261 - 177,340,379 (-)NCBI
mRatBN7.23156,886,921 - 156,921,500 (-)NCBI
Ensembl Acc Id: ENSRNOP00000014595   ⟸   ENSRNOT00000014595
RefSeq Acc Id: XP_038961737   ⟸   XM_039105809
- Peptide Label: isoform X1
- UniProtKB: Q9JKL8 (UniProtKB/Swiss-Prot),   G3V7G3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038961736   ⟸   XM_039105808
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961734   ⟸   XM_039105806
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001334461   ⟸   NM_001347532

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKL8-F1-model_v2 AlphaFold Q9JKL8 1-1103 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71030 AgrOrtholog
BioCyc Gene G2FUF-46706 BioCyc
Ensembl Genes ENSRNOG00000010975 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014595.7 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro ADNP/ADNP2 UniProtKB/Swiss-Prot
  ADNP_Znf UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:64622 UniProtKB/Swiss-Prot
NCBI Gene 64622 ENTREZGENE
PANTHER ACTIVITY-DEPENDENT NEUROPROTECTOR HOMEOBOX PROTEIN UniProtKB/Swiss-Prot
  PTHR15740 UniProtKB/Swiss-Prot
Pfam ADNP_N UniProtKB/Swiss-Prot
  Homeodomain UniProtKB/Swiss-Prot
PhenoGen Adnp PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010975 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt ADNP_RAT UniProtKB/Swiss-Prot
  G3V7G3 ENTREZGENE
  Q9JKL8 ENTREZGENE
UniProt Secondary G3V7G3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adnp  activity-dependent neuroprotector homeobox  Adnp  activity-dependent neuroprotective protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Adnp  activity-dependent neuroprotective protein      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains the orthologous human protein contains nine zinc finger regions and a homeobox domain suggesting it could function as a trancription factor; protein is upregulated in malignant cells and has been shown to contribute to the maintenance of cell viability 1358231
gene_function the conserved, active peptide fragment NAPVSIPQ (NAP peptide) from Adnp prevents cytotoxicity in tetrodotoxin-treated cultured cortical neurons 1358224
gene_function the NAP peptide of Adnp reduces motor disability and infarct volumes, two measurements of cerebral injury, in a model of stroke in SHR rats, apparently by reducing the number of cells undergoing apoptosis; neuroprotection is still apparent for at least 30 days after administration of the peptide 1358226
gene_function daily intranasal administration of the NAP peptide improved short-term spatial memory in rats treated with the cholinotoxin ethylcholine aziridium, presumably by protecting agains loss of choline acetyl transferase activity; pretreatment with NAP significantly improved performance 1358227
gene_function the NAP peptide causes an increase in cGMP production in cultured cerebral cortical cells at concentrations previously associated with neuroprotection; NAP also increases NO production in these cells, apparently by a different mechanism than required for the cGMP effect 1358228
gene_function the NAP peptide protects cultured neurons against dopamine toxicity, suggesting that its neuroprotective activities could be mediated through an increase in cellular resistance to oxidative stress 1358229
gene_function NAP peptide given in the presence of hydrogen peroxide increases cell survival rate in the rat PC12 cell line compared to exposure to hydrogen peroxide alone 1358230