Gene: Adnp (activity-dependent neuroprotective protein)
Mus musculus
Symbol:
Adnp
Name:
activity-dependent neuroprotective protein
Description:
ENCODES a protein that exhibits chromatin binding; beta-tubulin binding (ortholog); copper ion binding (ortholog); INVOLVED IN negative regulation of neuron apoptotic process; activation of protein kinase activity (ortholog); negative regulation of gene expression (ortholog); ASSOCIATED WITH abnormal embryonic tissue morphology; complete embryonic lethality between somite formation and embryo turning; open neural tube; ASSOCIATED WITH Alzheimer Disease; Craniocerebral Trauma; Neural Tube Defects; FOUND IN extracellular space; axon (ortholog); cytoplasm (ortholog); INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AA589558; activity-dependent neuroprotector homeobox protein; mKIAA0784; OTTMUSP00000017175; OTTMUSP00000017176
Orthologs:
Homo sapiens : ADNP
(activity-dependent neuroprotector homeobox)
HGNC
Rattus norvegicus : Adnp
(activity-dependent neuroprotector homeobox)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 168,180,965 - 168,207,062 - NCBI Mouse cM Map 2 - NCBI Mouse Celera Assembly 2 174,124,697 - 174,151,114 - NCBI Mouse Genome Assembly Build 37 2 168,006,465 - 168,032,562 - NCBI Mouse Genome Assembly Build 36.1 2 168,006,465 - 168,032,562 - NCBI Mouse Cytogenetic Map 2 H3 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
(S)-nicotine multiple interactions EXP 6480464 Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA]; more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP 6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; more ... CTD PMID:20230807 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ADNP mRNA CTD PMID:21570461 aflatoxin B1 decreases expression ISO RGD:737453 6480464 Aflatoxin B1 results in decreased expression of ADNP mRNA CTD PMID:21641981 ammonium chloride affects expression ISO RGD:71030 6480464 Ammonium Chloride affects the expression of ADNP mRNA CTD PMID:16483693 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ADNP mRNA CTD PMID:21715664 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of ADNP mRNA CTD PMID:19770486 dibutyl phthalate decreases expression ISO RGD:71030 6480464 Dibutyl Phthalate results in decreased expression of ADNP mRNA CTD PMID:21266533 formaldehyde decreases expression ISO RGD:737453 6480464 Formaldehyde results in decreased expression of ADNP mRNA CTD PMID:20655997 hydrogen peroxide affects expression ISO RGD:737453 6480464 Hydrogen Peroxide affects the expression of ADNP mRNA CTD PMID:21179406 indomethacin decreases expression ISO RGD:737453 6480464 Indomethacin results in decreased expression of ADNP mRNA CTD PMID:16984733 kainic acid multiple interactions ISO RGD:71030 6480464 Enzyme Inhibitors inhibits the reaction [Kainic Acid results in decreased expression of ADNP protein] CTD PMID:18375135 kainic acid decreases expression ISO RGD:71030 6480464 Kainic Acid results in decreased expression of ADNP mRNA; more ... CTD PMID:18375135 paracetamol decreases expression ISO RGD:737453 6480464 Acetaminophen results in decreased expression of ADNP mRNA CTD PMID:21420995 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADNP mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:71030 6480464 pirinixic acid results in increased expression of ADNP mRNA CTD PMID:12832660 quercetin decreases expression ISO RGD:737453 6480464 Quercetin results in decreased expression of ADNP mRNA CTD PMID:21632981 rotenone decreases expression ISO RGD:71030 6480464 Rotenone results in decreased expression of ADNP mRNA CTD PMID:19013527 uranium atom affects expression ISO RGD:737453 6480464 Uranium affects the expression of ADNP mRNA CTD PMID:15672453 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of ADNP mRNA CTD PMID:20546886
Biological Process
activation of protein kinase activity ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of gene expression ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of neuron apoptotic process IDA 2290270 MGI:MGI:1331215|PMID:10037502 MGI MGI:MGI:1331215 PMID:10037502 negative regulation of neuron apoptotic process ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of protein binding ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of synaptic transmission ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nitric oxide homeostasis ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of axon extension ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of cGMP biosynthetic process ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of neuron projection development ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of peptidyl-tyrosine phosphorylation ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of synapse assembly ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of protein ADP-ribosylation ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of transcription, DNA-dependent IEA InterPro:IPR001356 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 regulation of transcription, DNA-dependent IEA UniProtKB-KW:KW-0805 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 short-term memory ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
axon ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytoplasm ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 dendrite ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 extracellular space IDA 2290270 MGI:MGI:1331215|PMID:10037502 MGI MGI:MGI:1331215 PMID:10037502 extracellular space ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 neuronal cell body ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleus IC GO:0003682 2290270 MGI:MGI:3701370|PMID:17222401 MGI MGI:MGI:3701370 PMID:17222401 nucleus ISO UniProtKB:Q9H2P0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleus ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
Molecular Function
beta-tubulin binding ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 chromatin binding IDA 2290270 MGI:MGI:3701370|PMID:17222401 MGI MGI:MGI:3701370 PMID:17222401 copper ion binding ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 DNA binding IEA UniProtKB-KW:KW-0238|UniProtKB-KW:KW-0371 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 DNA binding IEA InterPro:IPR009057 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleic acid binding IEA InterPro:IPR013087 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 peptide binding ISO UniProtKB:Q9JKL8 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein binding IPI UniProtKB:Q61686 2290270 MGI:MGI:3701370|PMID:17222401 MGI MGI:MGI:3701370 PMID:17222401 sequence-specific DNA binding IEA InterPro:IPR001356 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 sequence-specific DNA binding transcription factor activity IEA InterPro:IPR001356 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 zinc ion binding IEA InterPro:IPR007087 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
1558748 Vacq1_m voluntary alcohol consumption QTL 1 (mouse) Not determined 2 163579319 181880033 Mouse 1301677 Alcp6_m alcohol preference locus 6 (mouse) Not determined 2 163579319 181880033 Mouse 1301348 Alcp5_m alcohol preference locus 5 (mouse) Not determined 2 163579319 181880033 Mouse 1302003 Sluc17_m susceptibility to lung cancer 17 (mouse) Not determined 2 162526405 181880033 Mouse 1301726 Tlq1_m telomere length QTL 1 (mouse) Not determined 2 161840938 181880033 Mouse 1302122 Eae8_m susceptibility to experimental allergic encephalomyelitis 8 (mouse) Not determined 2 161535250 181880033 Mouse 1357537 Lith12_m lithogenic gene 12 (mouse) Not determined 2 156180172 181880033 Mouse 1300622 Cfld1_m cystic fibrosis lung disease 1 (mouse) Not determined 2 155807628 181880033 Mouse 1301354 Hcs4_m hepatocarcinogenesis susceptibility 4 (mouse) Not determined 2 153958112 181880033 Mouse 1301270 Dloc1_m duration of locomotor activity 1 (mouse) Not determined 2 152101357 181880033 Mouse 4141098 Hemq2_m hematocrit QTL 2 (mouse) Not determined 2 152101357 181880033 Mouse 1558867 Gnf3_m growth and fatness 3 (mouse) Not determined 2 152101357 169683177 Mouse 1301019 Bmd6_m bone mineral density 6 (mouse) Not determined 2 151761877 181880033 Mouse 4141997 Bmgr3_m bone marrow graft rejection 3 (mouse) Not determined 2 150857642 181880033 Mouse 4142450 Lmr16_m leishmaniasis resistance 16 (mouse) Not determined 2 150195801 181880033 Mouse 1301085 Lrnx10_m learning-contextual 10 (mouse) Not determined 2 150195801 181880033 Mouse 1300751 Bdt1_m bone density traits 1 (mouse) Not determined 2 149972482 181880033 Mouse 1558917 Gct8_m granulosa cell tumorigenesis 8 (mouse) Not determined 2 149220487 181880033 Mouse 4141170 Ua1_m urinary albuminuria 1 (mouse) Not determined 2 148648473 181880033 Mouse 4142211 Nilac3_m nicotine induced locomotor activity 3 (mouse) Not determined 2 148648473 181880033 Mouse 1300806 Aod4_m autoimmune ovarian dysgenesis 4 (mouse) Not determined 2 145212535 179212657 Mouse 1558972 Erars1_m erosive arthritis susceptibility 1 (mouse) Not determined 2 145170578 179170702 Mouse 4142387 Bdlnq7_m body length QTL 7 (mouse) Not determined 2 143286681 177286824 Mouse 1300846 Pbwg11_m postnatal body weight growth 11 (mouse) Not determined 2 138950416 172950545 Mouse 1558815 Gstml_m gestational survival modifier locus (mouse) Not determined 2 138950416 172950545 Mouse 4141980 Tcq2_m total cholesterol QTL 2 (mouse) Not determined 2 138693152 172693260 Mouse 4142019 Swq6_m spleen weight QTL 6 (mouse) Not determined 2 138693152 172693260 Mouse 1302164 Psl2_m promotion susceptibility QTL 2 (mouse) Not determined 2 137338345 171338483 Mouse 1301865 Hdlq19_m HDL QTL 19 (mouse) Not determined 2 135683037 169683177 Mouse 4141703 Chlq13_m circulating hormone level QTL 13 (mouse) Not determined 2 135683037 169683177 Mouse 1301907 Rends_m renal disease susceptibility (mouse) Not determined 2 135683037 169683177 Mouse 4141740 Vmmt3_m vertebral morphology and mechanical traits 3 (mouse) Not determined 2 135683037 169683177 Mouse 1301280 Bglq2_m body growth late QTL 2 (mouse) Not determined 2 134624757 168624945 Mouse 1300676 Prdt2_m prion disease incubation time 2 (mouse) Not determined 2 121731402 181608066 Mouse 1301618 Bglu1_m blood glucose level 1 (mouse) Not determined 2 117938185 174308571 Mouse