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Gene: Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2) Rattus norvegicus

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Symbol:

Dnaja2

Name:

DnaJ heat shock protein family (Hsp40) member A2

RGD ID:

71001

Description:

Predicted to enable ATPase activator activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Involved in carbon tetrachloride metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Biomarker of liver disease. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Cpr3; Dj3; DjA2; DnaJ (Hsp40) homolog, subfamily A, member 2; dnaJ homolog subfamily A member 2; Dnj3; Hirip4; MGC93325; Rdj2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RCBTB1 (RCC1 and BTB domain containing protein 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	DnaJ-H	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	YDJ1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dnj-19	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dnj-19	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dnaja2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dnaja2b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dnaja2b	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dnaja2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dnaja2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	37,671,019 - 37,689,163 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	37,670,945 - 37,690,120 (+)	Ensembl				GRCr8
mRatBN7.2	19	21,497,792 - 21,516,904 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	21,497,729 - 21,516,901 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	23,187,280 - 23,205,448 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	28,381,803 - 28,399,971 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	31,344,590 - 31,362,759 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	19	31,511,857 - 31,530,001 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	19	29,629,598 - 29,647,742 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	19	31,483,313 - 31,501,457 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	19	29,334,319 - 29,352,486 (+)	NCBI		F344_StmMcwi
Rnor_6.0	19	22,569,999 - 22,588,143 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	22,569,999 - 22,588,137 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	33,576,436 - 33,594,580 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	22,853,702 - 22,871,846 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	21,358,547 - 21,376,691 (+)	NCBI		Celera
RGSC_v3.1	19	22,858,527 - 22,876,671 (+)	NCBI
Cytogenetic Map	19	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

liver disease (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-dihydrocoumarin (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

aniline (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

ethanol (ISO)

fenofibrate (EXP,ISO)

fluoxetine (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glyphosate (ISO)

hydrogen peroxide (ISO)

hypochlorous acid (ISO)

indometacin (EXP,ISO)

ivermectin (ISO)

kojic acid (EXP)

limonene (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury atom (EXP)

mercury(0) (EXP)

Mesaconitine (EXP)

methimazole (EXP)

methoxychlor (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

ochratoxin A (ISO)

oxidopamine (EXP)

ozone (EXP)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phlorizin (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

Rebamipide (EXP)

resveratrol (ISO)

rotenone (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulfasalazine (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

uranium atom (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbon tetrachloride metabolic process (IEP)

cellular response to heat (IBA)

protein folding (IEA)

protein refolding (IBA,IEA,ISO)

response to heat (IEA)

Cellular Component

cytosol (IBA,IEA,ISO)

membrane (IEA)

Molecular Function

ATP binding (IEA)

ATPase activator activity (IBA,IEA,ISO,ISS)

heat shock protein binding (IEA)

Hsp70 protein binding (IEA)

metal ion binding (IEA)

protein binding (IPI,ISO)

protein-folding chaperone binding (IBA,IEA,ISO)

unfolded protein binding (IBA,IEA,ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

androgen signaling pathway (ISO)

cortisol signaling pathway (ISO)

Endoplasmic Reticulum-associated degradation pathway (IEA)

estrogen signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue.	Andres DA, etal., Arch Biochem Biophys 1997 Oct 1;346(1):113-24.
2.	Rdj2, a J protein family member, interacts with cellular prion PrP(C).	Beck KE, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):866-71. Epub 2006 Jun 6.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage.	Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
6.	Gene Data Set	MGD Curation, June 12, 2002
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	Chaperoning of glucocorticoid receptors.	Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
10.	Molecular chaperones throughout the life cycle of the androgen receptor.	Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.	Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
15.	Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70.	Terada K and Mori M, J Biol Chem. 2000 Aug 11;275(32):24728-34.

Additional References at PubMed

PMID:12477932	PMID:16169070	PMID:18595009	PMID:19056867	PMID:21231916	PMID:22871113	PMID:24318877	PMID:25002582	PMID:30053369

Genomics

Comparative Map Data

Dnaja2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	37,671,019 - 37,689,163 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	37,670,945 - 37,690,120 (+)	Ensembl				GRCr8
mRatBN7.2	19	21,497,792 - 21,516,904 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	21,497,729 - 21,516,901 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	23,187,280 - 23,205,448 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	28,381,803 - 28,399,971 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	31,344,590 - 31,362,759 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	19	31,511,857 - 31,530,001 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	19	29,629,598 - 29,647,742 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	19	31,483,313 - 31,501,457 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	19	29,334,319 - 29,352,486 (+)	NCBI		F344_StmMcwi
Rnor_6.0	19	22,569,999 - 22,588,143 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	22,569,999 - 22,588,137 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	33,576,436 - 33,594,580 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	22,853,702 - 22,871,846 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	21,358,547 - 21,376,691 (+)	NCBI		Celera
RGSC_v3.1	19	22,858,527 - 22,876,671 (+)	NCBI
Cytogenetic Map	19	p11	NCBI

DNAJA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	46,955,362 - 46,973,674 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	46,955,362 - 46,973,704 (-)	Ensembl			hg38	GRCh38
GRCh37	16	46,989,274 - 47,007,585 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	45,546,775 - 45,565,126 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	45,547,795 - 45,565,036	NCBI
Celera	16	31,497,392 - 31,515,743 (-)	NCBI		Celera
Cytogenetic Map	16	q11.2	NCBI
HuRef	16	32,879,590 - 32,897,952 (-)	NCBI		HuRef
CHM1_1	16	48,396,273 - 48,414,621 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	52,752,176 - 52,770,493 (-)	NCBI		T2T-CHM13v2.0

Dnaja2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	86,264,262 - 86,281,990 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	86,264,262 - 86,281,973 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	85,537,633 - 85,555,361 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	85,537,633 - 85,555,344 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	88,061,539 - 88,079,170 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	88,427,745 - 88,445,376 (-)	NCBI		MGSCv36	mm8
Celera	8	89,834,255 - 89,851,758 (-)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.61	NCBI

Dnaja2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	8,180,995 - 8,202,267 (+)	Ensembl
ChiLan1.0	NW_004955474	8,180,995 - 8,202,169 (+)	NCBI	ChiLan1.0	ChiLan1.0

DNAJA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	56,417,398 - 56,436,339 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	62,322,325 - 62,341,277 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	27,223,414 - 27,240,726 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	46,113,238 - 46,130,028 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	46,113,088 - 46,130,028 (-)	Ensembl			panPan2	panpan1.1

DNAJA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	67,903,292 - 67,916,267 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	64,478,251 - 64,494,696 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	68,460,779 - 68,477,225 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	68,460,772 - 68,477,787 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	65,273,419 - 65,289,848 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	66,296,767 - 66,313,250 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	67,288,195 - 67,304,637 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dnaja2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	59,238,017 - 59,254,800 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	335,851 - 350,933 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	334,275 - 351,051 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNAJA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	37,591,916 - 37,608,361 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	37,584,012 - 37,606,198 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	32,929,182 - 32,943,460 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DNAJA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	32,815,641 - 32,834,385 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666047	43,735,497 - 43,753,794 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dnaja2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624914	517,961 - 534,512 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624914	518,593 - 534,527 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dnaja2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	14,203,910 - 14,222,624 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dnaja2
37 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	42
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000022573
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	30099383	47207961	Rat

Markers in Region

D16S2601E

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	156,135,401 - 156,135,533 (+)	MAPPER	mRatBN7.2
mRatBN7.2	19	21,514,290 - 21,514,554 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	22,586,494 - 22,586,757	NCBI	Rnor6.0
Rnor_6.0	4	155,741,444 - 155,741,575	NCBI	Rnor6.0
Rnor_5.0	19	33,592,931 - 33,593,194	UniSTS	Rnor5.0
Rnor_5.0	4	222,762,210 - 222,762,341	UniSTS	Rnor5.0
RGSC_v3.4	4	159,385,925 - 159,386,056	UniSTS	RGSC3.4
RGSC_v3.4	19	22,870,197 - 22,870,460	UniSTS	RGSC3.4
Celera	19	21,375,042 - 21,375,305	UniSTS
Celera	4	144,955,665 - 144,955,796	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_032079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC135454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U95727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022573 ⟹ ENSRNOP00000022573

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,670,945 - 37,690,120 (+)	Ensembl
mRatBN7.2 Ensembl	19	21,497,729 - 21,516,901 (+)	Ensembl
Rnor_6.0 Ensembl	19	22,569,999 - 22,588,137 (+)	Ensembl

RefSeq Acc Id:

NM_032079 ⟹ NP_114468

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	37,671,019 - 37,689,163 (+)	NCBI
mRatBN7.2	19	21,497,792 - 21,515,940 (+)	NCBI
Dahl_SR_JrHsd	19	31,511,857 - 31,530,001 (+)	NCBI
Lyon_Normotensive	19	29,629,598 - 29,647,742 (+)	NCBI
Lyon_Hypertensive	19	31,483,313 - 31,501,457 (+)	NCBI
F344_StmMcwi	19	29,334,319 - 29,352,486 (+)	NCBI
Rnor_6.0	19	22,569,999 - 22,588,143 (+)	NCBI
Rnor_5.0	19	33,576,436 - 33,594,580 (+)	NCBI
RGSC_v3.4	19	22,853,702 - 22,871,846 (+)	RGD
Celera	19	21,358,547 - 21,376,691 (+)	RGD

Sequence:

show sequence

GTGCTGCCGGGCAGGCCGCCATGGCGAACGTGGCCGACACGAAGCTGTACGACATCCTGGGCGT
CCCTCCCGGCGCCAGCGAGAACGAGCTGAAGAAGGCATACCGAAAGTTAGCCAAAGAATACCAT
CCTGATAAGAATCCAAATGCTGGAGATAAATTTAAAGAAATAAGTTTTGCCTATGAAGTATTGT
CAAATCCAGAGAAGCGGGAGCTATATGACAGATATGGAGAACAAGGTCTACGGGAAGGCAGCGG
CGGGGGTGGCGGCATGGATGATATTTTCTCACATATTTTTGGTGGAGGATTGTTTGGCTTCATG
GGCAATCAAAGTAGAAGTCGAAATGGCAGAAGAAGAGGCGAGGACATGATGCATCCGCTGAAAG
TGTCTTTAGAAGACCTGTACAATGGCAAGACCACCAAGCTGCAGCTCAGCAAGAATGTGCTCTG
TAGCGCGTGCAGTGGCCAAGGTGGAAAGTCTGGAGCTGTTCAGAAATGCAGTGCTTGCCGGGGT
CGAGGTGTGCGCATTATGATAAGACAGCTGGCTCCAGGGATGGTACAGCAGATGCAGTCTGTGT
GCTCTGACTGTAATGGAGAAGGAGAGGTCATCAATGAAAAAGACCGCTGTAAAAAATGTGAAGG
AAAGAAGGTGATTAAAGAAGTCAAGATTCTGGAAGTTCATGTAGACAAAGGCATGAAACATGGA
CAGAGAATTACGTTCACTGGGGAAGCAGACCAGGCTCCAGGAGTGGAACCTGGAGATATTGTTC
TTTTGCTACAGGAAAAAGAACATGAGGTGTTCCAGAGAGATGGGAATGATCTGCATATGACATA
TAAGATAGGACTTGTTGAAGCTTTGTGTGGATTTCAGTTCACATTTAAACATCTTGATGCTCGT
CAGATTGTAGTGAAATACCCCCCTGGCAAAGTAATTGAACCAGGATGTGTTCGTGTTGTTCGAG
GCGAAGGAATGCCACAGTATCGTAATCCCTTTGAAAAGGGTGATCTTTACATAAAGTTTGATGT
GCAGTTTCCTGAAAACAACTGGATCAACCCAGACAAACTTTCTGAATTAGAAGACCTCCTGCCA
TCTAGACCAGAAGTTCCTAATGTAATTGGGGAGACAGAAGAAGTAGAGCTTCAGGAATTCGATA
GCACTCGAGGCTCTGGAGGTGGTCAGAGGCGTGAAGCCTACAACGACAGCTCTGATGAGGAAAG
CAGCAGCCATCATGGACCTGGAGTGCAGTGTGCCCATCAGTAAACTGCAGGCAACTGCACGGTG
GATTTTCTCCACATTTGCCGGATTTGCCAGCTGCTGGAGTACCTGATGAGTCCAGATGAACTGA
TGGACATCTGCTGATCTATGTGTAACTTCTAAACTTGGTATAGTATCCACAGAGTGTATAATTT
AAACTAACCACGGAGCTTTACGTCTTCATTTCGACTGTTCTATAGCAGAGTAAAGCACTTGAAA
TAAGACTCCCTTTCACATGTGGGTTATAAGTTTCAGTCCTGGTATCTGCTTGATTTTTATCAGT
TTTGTGTAGAGTTTATGTTTCCTATTTTAAACTCAGATCCAGCATTGTAAAGTTTGTACAATTC
GTCCTGAAGCTGTGTGTTTGGCTGCACCTGCATAAGCTGCTACAAATAGAATAAAGAATTCATA
GCCTGTATCTATCATTAGATGCATGGAAAACTGGGCTTTGCACACAATGGGTTTGAAGCTGACT
GGGAACAATGGAAAAAATTACATTAGCCATGGTTGTAAAGTTTTTTGGCTTTTTTTTAAAACCA
TTTTGTGAAAGGTTTCTGAAACTTGATAATAAAAAGCAGTTGGTGTAAATTAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_114468	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB64094	(Get FASTA)	NCBI Sequence Viewer
	AAH87010	(Get FASTA)	NCBI Sequence Viewer
	EDL87491	(Get FASTA)	NCBI Sequence Viewer
	EDL87492	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022573
GenBank Protein	O35824	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_114468 ⟸ NM_032079

- UniProtKB:

O35824 (UniProtKB/Swiss-Prot), Q5M9H7 (UniProtKB/TrEMBL), F7F428 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANVADTKLYDILGVPPGASENELKKAYRKLAKEYHPDKNPNAGDKFKEISFAYEVLSNPEKRE
LYDRYGEQGLREGSGGGGGMDDIFSHIFGGGLFGFMGNQSRSRNGRRRGEDMMHPLKVSLEDLY
NGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRGVRIMIRQLAPGMVQQMQSVCSDCNGE
GEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRITFTGEADQAPGVEPGDIVLLLQEKE
HEVFQRDGNDLHMTYKIGLVEALCGFQFTFKHLDARQIVVKYPPGKVIEPGCVRVVRGEGMPQY
RNPFEKGDLYIKFDVQFPENNWINPDKLSELEDLLPSRPEVPNVIGETEEVELQEFDSTRGSGG
GQRREAYNDSSDEESSSHHGPGVQCAHQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000022573 ⟸ ENSRNOT00000022573

Protein Domains

CR-type J

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35824-F1-model_v2	AlphaFold	O35824	1-412	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700990

Promoter ID:

EPDNEW_R11513

Type:

initiation region

Name:

Dnaja2_1

Description:

DnaJ heat shock protein family member A2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	22,569,905 - 22,569,965	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71001	AgrOrtholog
BioCyc Gene	G2FUF-6212	BioCyc
Ensembl Genes	ENSRNOG00000016251	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000022573	ENTREZGENE
Gene3D-CATH	1.10.287.110	UniProtKB/Swiss-Prot
	Heat shock protein DnaJ, cysteine-rich domain	UniProtKB/Swiss-Prot
	Urease metallochaperone UreE, N-terminal domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7191358	IMAGE-MGC_LOAD
InterPro	DnaJ	UniProtKB/Swiss-Prot
	DnaJ_C	UniProtKB/Swiss-Prot
	DnaJ_domain	UniProtKB/Swiss-Prot
	DnaJ_domain_CS	UniProtKB/Swiss-Prot
	DNJA1/2-like	UniProtKB/Swiss-Prot
	HSP40/DnaJ_pept-bd	UniProtKB/Swiss-Prot
	HSP_DnaJ_Cys-rich_dom	UniProtKB/Swiss-Prot
	HSP_DnaJ_Cys-rich_dom_sf	UniProtKB/Swiss-Prot
	J_dom_sf	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93325	IMAGE-MGC_LOAD
NCBI Gene	84026	ENTREZGENE
PANTHER	PTHR43888	UniProtKB/Swiss-Prot
Pfam	DnaJ	UniProtKB/Swiss-Prot
	DnaJ_C	UniProtKB/Swiss-Prot
	DnaJ_CXXCXGXG	UniProtKB/Swiss-Prot
PhenoGen	Dnaja2	PhenoGen
PRINTS	JDOMAIN	UniProtKB/Swiss-Prot
PROSITE	DNAJ_1	UniProtKB/Swiss-Prot
	DNAJ_2	UniProtKB/Swiss-Prot
	ZF_CR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016251	RatGTEx
SMART	DnaJ	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46565	UniProtKB/Swiss-Prot
	SSF49493	UniProtKB/Swiss-Prot
	SSF57938	UniProtKB/Swiss-Prot
UniProt	A6KDD5_RAT	UniProtKB/TrEMBL
	DNJA2_RAT	UniProtKB/Swiss-Prot
	F7F428	ENTREZGENE, UniProtKB/TrEMBL
	O35824	ENTREZGENE
	Q5M9H7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Dnaja2	DnaJ heat shock protein family (Hsp40) member A2	Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	ubiquitously expressed	70722
gene_product	member of the DnaJ-related proteins	70722

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)