RGD Reference Report - Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. - Rat Genome Database

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Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.

Authors: Smith, DF  Toft, DO 
Citation: Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
RGD ID: 4892102
Pubmed: PMID:18451092   (View Abstract at PubMed)
PMCID: PMC2582531   (View Article at PubMed Central)
DOI: DOI:10.1210/me.2008-0089   (Journal Full-text)

An involvement of molecular chaperones in the action and well-being of steroid receptors was recognized early in the molecular era of hormone research. However, this has continued to be a topic of much enquiry and some confusion. All steroid receptors associate with heat shock protein 90, the main character of a series of multiprotein chaperone complexes generally referred to as the "heat shock protein 90 chaperoning machine." Receptor association with chaperones occurs in an ordered, step-wise fashion and is necessary for the maintenance of unliganded receptor in a state ready to bind and respond to hormone. Chaperones additionally modulate how receptors respond to hormone and activate target genes. Although much is known about the participants in this chaperoning process and the consequences of chaperoning, many key questions remain unanswered, particularly those concerning molecular mechanisms, cellular dynamics, and the functions of an array of cochaperone proteins. Here, we point out several areas in need of investigation to encourage new ideas and participants in this burgeoning field.

Objects Annotated

Genes (Rattus norvegicus)
Dnaja2  (DnaJ heat shock protein family (Hsp40) member A2)
Fkbp4  (FKBP prolyl isomerase 4)
Hsp90aa1  (heat shock protein 90 alpha family class A member 1)
Hsp90ab1  (heat shock protein 90 alpha family class B member 1)
Hspa4  (heat shock protein family A (Hsp70) member 4)
Ppid  (peptidylprolyl isomerase D)
Ptges3  (prostaglandin E synthase 3)
Stip1  (stress-induced phosphoprotein 1)

Genes (Mus musculus)
Dnaja2  (DnaJ heat shock protein family (Hsp40) member A2)
Fkbp4  (FK506 binding protein 4)
Hsp90aa1  (heat shock protein 90, alpha (cytosolic), class A member 1)
Hsp90ab1  (heat shock protein 90 alpha (cytosolic), class B member 1)
Hspa4  (heat shock protein 4)
Ppid  (peptidylprolyl isomerase D (cyclophilin D))
Ptges3  (prostaglandin E synthase 3)
Stip1  (stress-induced phosphoprotein 1)

Genes (Homo sapiens)
DNAJA2  (DnaJ heat shock protein family (Hsp40) member A2)
FKBP4  (FKBP prolyl isomerase 4)
HSP90AA1  (heat shock protein 90 alpha family class A member 1)
HSP90AB1  (heat shock protein 90 alpha family class B member 1)
HSPA4  (heat shock protein family A (Hsp70) member 4)
PPID  (peptidylprolyl isomerase D)
PTGES3  (prostaglandin E synthase 3)
STIP1  (stress induced phosphoprotein 1)


Additional Information