Fxyd4 (FXYD domain-containing ion transport regulator 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fxyd4 (FXYD domain-containing ion transport regulator 4) Rattus norvegicus
Analyze
Symbol: Fxyd4
Name: FXYD domain-containing ion transport regulator 4
RGD ID: 70998
Description: Enables potassium channel activity. Involved in inorganic cation transmembrane transport. Part of sodium:potassium-exchanging ATPase complex. Orthologous to human FXYD4 (FXYD domain containing ion transport regulator 4); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: channel-inducing factor; Chif; corticosteroid-induced protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,782,181 - 152,786,118 (-)NCBIGRCr8
mRatBN7.24151,109,779 - 151,113,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,109,779 - 151,113,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,372,062 - 157,375,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,156,020 - 153,159,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,779,036 - 151,782,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04149,984,206 - 149,988,744 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4149,984,206 - 149,988,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04215,913,321 - 215,917,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,233,712 - 154,237,571 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,478,552 - 154,482,412 (-)NCBI
Celera4139,985,246 - 139,989,104 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes. Attali B, etal., Proc Natl Acad Sci U S A 1995 Jun 20;92(13):6092-6.
2. CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit. Béguin P, etal., EMBO J. 2001 Aug 1;20(15):3993-4002. doi: 10.1093/emboj/20.15.3993.
3. Cellular localization and regulation of CHIF in kidney and colon. Capurro C, etal., Am J Physiol 1996 Sep;271(3 Pt 1):C753-62.
4. Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers. Crowell KJ, etal., Biochim Biophys Acta 2003 Jan 31;1645(1):15-21.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Structure-function relations of interactions between Na,K-ATPase, the gamma subunit, and corticosteroid hormone-induced factor. Lindzen M, etal., J Biol Chem. 2003 May 23;278(21):18738-43. Epub 2003 Mar 7.
7. Structural interactions between FXYD proteins and Na+,K+-ATPase: alpha/beta/FXYD subunit stoichiometry and cross-linking. Lindzen M, etal., J Biol Chem. 2006 Mar 3;281(9):5947-55. Epub 2005 Dec 21.
8. Gene Data Set MGD Curation, June 12, 2002
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Membrane topology and immunolocalization of CHIF in kidney and intestine. Shi H, etal., Am J Physiol Renal Physiol. 2001 Mar;280(3):F505-12. doi: 10.1152/ajprenal.2001.280.3.F505.
15. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ and Rael E, Genomics 2000 Aug 15;68(1):41-56.
Additional References at PubMed
PMID:15743908   PMID:16288923   PMID:16476578   PMID:16757733   PMID:18000745   PMID:23651441   PMID:26685865  


Genomics

Comparative Map Data
Fxyd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,782,181 - 152,786,118 (-)NCBIGRCr8
mRatBN7.24151,109,779 - 151,113,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,109,779 - 151,113,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,372,062 - 157,375,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,156,020 - 153,159,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,779,036 - 151,782,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04149,984,206 - 149,988,744 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4149,984,206 - 149,988,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04215,913,321 - 215,917,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,233,712 - 154,237,571 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,478,552 - 154,482,412 (-)NCBI
Celera4139,985,246 - 139,989,104 (-)NCBICelera
Cytogenetic Map4q42NCBI
FXYD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381043,371,636 - 43,376,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1043,371,636 - 43,376,335 (+)EnsemblGRCh38hg38GRCh38
GRCh371043,867,084 - 43,871,783 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361043,187,098 - 43,191,789 (+)NCBINCBI36Build 36hg18NCBI36
Build 341043,187,097 - 43,191,789NCBI
Celera1039,869,483 - 39,874,173 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1040,393,622 - 40,398,313 (+)NCBIHuRef
CHM1_11043,906,432 - 43,911,121 (+)NCBICHM1_1
T2T-CHM13v2.01044,250,626 - 44,255,324 (+)NCBIT2T-CHM13v2.0
Fxyd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396117,910,519 - 117,914,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6117,910,520 - 117,914,653 (-)EnsemblGRCm39 Ensembl
GRCm386117,933,558 - 117,937,714 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6117,933,559 - 117,937,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv376117,883,577 - 117,887,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366117,899,178 - 117,902,954 (-)NCBIMGSCv36mm8
Celera6119,754,104 - 119,757,880 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.7NCBI
Fxyd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,375,907 - 1,379,314 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,375,907 - 1,379,314 (+)NCBIChiLan1.0ChiLan1.0
FXYD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2856,084,293 - 56,098,344 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11056,089,622 - 56,103,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,353,589 - 40,358,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,534,310 - 43,539,001 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,536,179 - 43,539,001 (+)Ensemblpanpan1.1panPan2
FXYD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,685,057 - 3,690,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,685,151 - 3,687,652 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha283,918,301 - 3,927,238 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0283,863,783 - 3,872,721 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl283,863,935 - 3,866,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1283,661,019 - 3,669,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,704,141 - 3,713,073 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,838,068 - 3,847,003 (-)NCBIUU_Cfam_GSD_1.0
Fxyd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,553,093 - 83,560,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366173,226,551 - 3,229,468 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366173,224,968 - 3,229,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXYD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1461,633,588 - 61,637,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11461,633,355 - 61,637,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21466,459,843 - 66,469,119 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fxyd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624922546,044 - 549,057 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fxyd4
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:92
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000019649
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 3
Low 8 21 5 18 5 8 8 10 4 13 11 8
Below cutoff 3 3 6 6 1 6 2 1 2 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001368663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000019649   ⟹   ENSRNOP00000019649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,109,779 - 151,113,637 (-)Ensembl
Rnor_6.0 Ensembl4149,984,206 - 149,988,295 (-)Ensembl
RefSeq Acc Id: NM_001368663   ⟹   NP_001355592
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,782,181 - 152,786,045 (-)NCBI
mRatBN7.24151,109,779 - 151,113,643 (-)NCBI
RefSeq Acc Id: XM_039108308   ⟹   XP_038964236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,782,183 - 152,786,118 (-)NCBI
mRatBN7.24151,109,781 - 151,113,659 (-)NCBI
RefSeq Acc Id: XM_063286657   ⟹   XP_063142727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,782,183 - 152,785,641 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000019649   ⟸   ENSRNOT00000019649
RefSeq Acc Id: NP_001355592   ⟸   NM_001368663
- Peptide Label: precursor
- UniProtKB: Q63113 (UniProtKB/Swiss-Prot),   A6IL54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964236   ⟸   XM_039108308
- Peptide Label: isoform X1
- UniProtKB: Q63113 (UniProtKB/Swiss-Prot),   A6IL54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142727   ⟸   XM_063286657
- Peptide Label: isoform X1
- UniProtKB: Q63113 (UniProtKB/Swiss-Prot),   A6IL54 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63113-F1-model_v2 AlphaFold Q63113 1-87 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693344
Promoter ID:EPDNEW_R3868
Type:single initiation site
Name:Fxyd4_1
Description:FXYD domain-containing ion transport regulator 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04149,988,314 - 149,988,374EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70998 AgrOrtholog
BioCyc Gene G2FUF-43245 BioCyc
Ensembl Genes ENSRNOG00000014578 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055008049 UniProtKB/Swiss-Prot
  ENSRNOG00060027128 UniProtKB/Swiss-Prot
  ENSRNOG00065028596 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019649.4 UniProtKB/Swiss-Prot
  ENSRNOT00055013603 UniProtKB/Swiss-Prot
  ENSRNOT00060047054 UniProtKB/Swiss-Prot
  ENSRNOT00065049292 UniProtKB/Swiss-Prot
Gene3D-CATH Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FXYD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXYD_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion-transport_regulator_FXYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64190 ENTREZGENE
PANTHER FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP1G1_PLM_MAT8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fxyd4 PhenoGen
PROSITE FXYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014578 RatGTEx
  ENSRNOG00055008049 RatGTEx
  ENSRNOG00060027128 RatGTEx
  ENSRNOG00065028596 RatGTEx
UniProt A6IL51_RAT UniProtKB/TrEMBL
  A6IL54 ENTREZGENE, UniProtKB/TrEMBL
  FXYD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Fxyd4  FXYD domain-containing ion transport regulator 4      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the FXYD family of small ion transport regulators or channels 632671