Acvr2a (activin A receptor type 2A) - Rat Genome Database

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Gene: Acvr2a (activin A receptor type 2A) Rattus norvegicus
Analyze
Symbol: Acvr2a
Name: activin A receptor type 2A
RGD ID: 70911
Description: Enables activin binding activity and inhibin binding activity. Involved in several processes, including SMAD protein signal transduction; cellular response to oxygen-glucose deprivation; and positive regulation of follicle-stimulating hormone secretion. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Used to study cocaine dependence. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A); PARTICIPATES IN activin signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activin A receptor, type IIA; activin receptor IIA; activin receptor type IIA; activin receptor type-2A; ACTR-IIA; Acvr2; rActR-II; type II activin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,614,143 - 53,701,933 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl353,614,171 - 53,701,941 (+)EnsemblGRCr8
mRatBN7.2333,204,961 - 33,292,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,205,523 - 33,289,968 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx336,594,864 - 36,673,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,179,586 - 45,258,078 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,001,947 - 43,080,473 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0332,947,901 - 33,034,598 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl332,947,378 - 33,034,282 (+)Ensemblrn6Rnor6.0
Rnor_5.0338,113,728 - 38,197,531 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4329,779,827 - 29,808,881 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera331,412,348 - 31,490,813 (+)NCBICelera
RGSC_v3.1329,676,198 - 29,705,253 (+)NCBI
Cytogenetic Map3q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,IEA,ISO)
adrenal gland development  (IEA,IEP)
anterior/posterior pattern specification  (ISO)
autophagy  (IMP)
BMP signaling pathway  (IEA,ISO,ISS)
cell communication  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to oxygen-glucose deprivation  (IMP)
determination of left/right symmetry  (ISO)
embryonic skeletal system development  (ISO)
gastrulation with mouth forming second  (ISO)
male gonad development  (ISO)
mesoderm development  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (IEA,ISO)
pattern specification process  (IBA)
penile erection  (ISO)
positive regulation of activin receptor signaling pathway  (IEA,ISO)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of follicle-stimulating hormone secretion  (IMP)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein phosphorylation  (TAS)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of signal transduction  (ISO)
response to cocaine  (IEP)
Sertoli cell proliferation  (ISO)
signaling  (IEA)
SMAD protein signal transduction  (IMP)
sperm ejaculation  (ISO)
spermatogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors. Chapman SC, etal., Mol Cell Endocrinol. 2002 Oct 31;196(1-2):79-93.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Expression of type II activin receptor genes in the male and female reproductive tissues of the rat. Feng ZM, etal., Endocrinology 1993 Jun;132(6):2593-600.
4. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity. Gancarz AM, etal., Nat Neurosci. 2015 Jul;18(7):959-61. doi: 10.1038/nn.4036. Epub 2015 Jun 1.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis. Gold EJ, etal., Mol Cell Endocrinol. 2003 Mar 28;201(1-2):143-53.
8. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Jung B, etal., Gastroenterology. 2004 Mar;126(3):654-9.
9. Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer. Kleeff J, etal., Int J Cancer. 1998 Sep 11;77(6):860-8.
10. Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo. Leal AM, etal., Endocrinology. 2002 Mar;143(3):964-9.
11. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. Rossi MR, etal., Cancer Genet Cytogenet. 2005 Dec;163(2):123-9.
19. Osteoblasts express types I and II activin receptors during early intramembranous and endochondral bone formation. Shuto T, etal., J Bone Miner Res. 1997 Mar;12(3):403-11.
20. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
21. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
22. Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. Xue LX, etal., Biochem Biophys Res Commun. 2016 Nov 18;480(3):355-361. doi: 10.1016/j.bbrc.2016.10.050. Epub 2016 Oct 18.
23. Downregulation of Activin A Receptor Type 2A Is Associated with Metastatic Potential and Poor Prognosis of Colon Cancer. Zhuo C, etal., J Cancer. 2018 Sep 8;9(19):3626-3633. doi: 10.7150/jca.26790. eCollection 2018.
Additional References at PubMed
PMID:1385212   PMID:1646080   PMID:7885474   PMID:7890768   PMID:8612709   PMID:8622651   PMID:8721982   PMID:9032295   PMID:9872992   PMID:10452853   PMID:10746731   PMID:11416011  
PMID:11459797   PMID:11459935   PMID:12414726   PMID:12665502   PMID:14738881   PMID:14993131   PMID:16093358   PMID:16648306   PMID:16991118   PMID:17472960   PMID:17936261   PMID:18326817  
PMID:18436533   PMID:19366699   PMID:26774823  


Genomics

Comparative Map Data
Acvr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,614,143 - 53,701,933 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl353,614,171 - 53,701,941 (+)EnsemblGRCr8
mRatBN7.2333,204,961 - 33,292,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,205,523 - 33,289,968 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx336,594,864 - 36,673,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,179,586 - 45,258,078 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,001,947 - 43,080,473 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0332,947,901 - 33,034,598 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl332,947,378 - 33,034,282 (+)Ensemblrn6Rnor6.0
Rnor_5.0338,113,728 - 38,197,531 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4329,779,827 - 29,808,881 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera331,412,348 - 31,490,813 (+)NCBICelera
RGSC_v3.1329,676,198 - 29,705,253 (+)NCBI
Cytogenetic Map3q12NCBI
ACVR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382147,844,517 - 147,930,822 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2147,844,378 - 147,930,826 (+)Ensemblhg38GRCh38
GRCh372148,602,086 - 148,688,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,319,040 - 148,404,863 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342148,436,303 - 148,519,242NCBI
Celera2142,316,710 - 142,402,536 (+)NCBICelera
Cytogenetic Map2q22.3-q23.1NCBI
HuRef2140,599,673 - 140,685,765 (+)NCBIHuRef
CHM1_12148,607,725 - 148,694,041 (+)NCBICHM1_1
T2T-CHM13v2.02148,294,972 - 148,381,274 (+)NCBIT2T-CHM13v2.0
Acvr2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,704,121 - 48,793,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,704,121 - 48,793,281 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38248,814,109 - 48,903,264 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,814,109 - 48,903,269 (+)Ensemblmm10GRCm38
MGSCv37248,669,629 - 48,758,784 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36248,636,166 - 48,724,172 (+)NCBIMGSCv36mm8
Celera250,486,791 - 50,575,736 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.38NCBI
Acvr2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,849,926 - 13,931,374 (+)Ensembl
ChiLan1.0NW_00495544013,849,926 - 13,931,374 (+)NCBIChiLan1.0ChiLan1.0
ACVR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21327,001,835 - 27,089,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B27,016,285 - 27,103,522 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,933,683 - 12,020,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,253,843 - 152,288,385 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,253,826 - 152,288,385 (+)EnsemblpanPan2panpan1.1
ACVR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,642,429 - 49,726,720 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1949,641,219 - 49,723,420 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1949,765,961 - 49,850,433 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01951,114,507 - 51,199,229 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,113,374 - 51,198,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11949,760,723 - 49,845,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01949,894,649 - 49,979,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,291,788 - 51,376,557 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acvr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,344,483 - 112,422,388 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646929,194,908 - 29,273,196 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646929,195,329 - 29,273,237 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,173,805 - 4,259,706 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1154,177,333 - 4,259,056 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,828,828 - 3,910,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,223,902 - 33,311,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,224,099 - 33,307,720 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040166,228,513 - 166,314,554 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624866539,894 - 620,302 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624866539,967 - 619,575 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acvr2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1526,678,656 - 26,760,826 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acvr2a
717 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:161
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000007404
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)34542360958601291Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)33779691953640235Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat

Markers in Region
D3Rat82  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8353,640,047 - 53,640,235 (+)Marker Load Pipeline
mRatBN7.2333,230,788 - 33,230,976 (+)MAPPERmRatBN7.2
Rnor_6.0332,972,757 - 32,972,944NCBIRnor6.0
Rnor_5.0338,138,512 - 38,138,699UniSTSRnor5.0
RGSC_v3.4329,749,287 - 29,749,474UniSTSRGSC3.4
RGSC_v3.4329,749,286 - 29,749,474RGDRGSC3.4
Celera331,431,660 - 31,431,829UniSTS
RGSC_v3.1329,645,659 - 29,645,846RGD
RH 3.4 Map3388.0UniSTS
RH 3.4 Map3388.0RGD
SHRSP x BN Map315.1099RGD
SHRSP x BN Map315.1099UniSTS
Cytogenetic Map3q12UniSTS
Acvr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,282,086 - 33,283,655 (+)MAPPERmRatBN7.2
Rnor_6.0333,024,768 - 33,026,336NCBIRnor6.0
Rnor_5.0338,189,650 - 38,191,218UniSTSRnor5.0
RGSC_v3.4329,801,000 - 29,802,568UniSTSRGSC3.4
Celera331,482,932 - 31,484,500UniSTS
Cytogenetic Map3q12UniSTS
MARC_17905-17906:1025019334:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,288,028 - 33,289,310 (+)MAPPERmRatBN7.2
Rnor_6.0333,030,710 - 33,031,991NCBIRnor6.0
Rnor_5.0338,195,592 - 38,196,873UniSTSRnor5.0
RGSC_v3.4329,806,942 - 29,808,223UniSTSRGSC3.4
Celera331,488,874 - 31,490,155UniSTS
Cytogenetic Map3q12UniSTS
MARC_31635-31636:1045776384:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,289,196 - 33,289,547 (+)MAPPERmRatBN7.2
Rnor_6.0333,031,878 - 33,032,228NCBIRnor6.0
Rnor_5.0338,196,760 - 38,197,110UniSTSRnor5.0
RGSC_v3.4329,808,110 - 29,808,460UniSTSRGSC3.4
Celera331,490,042 - 31,490,392UniSTS
Cytogenetic Map3q12UniSTS
ksks388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,289,237 - 33,289,508 (+)MAPPERmRatBN7.2
Rnor_6.0333,031,919 - 33,032,189NCBIRnor6.0
Rnor_5.0338,196,801 - 38,197,071UniSTSRnor5.0
RGSC_v3.4329,808,151 - 29,808,421UniSTSRGSC3.4
Celera331,490,083 - 31,490,353UniSTS
Cytogenetic Map3q12UniSTS
Acvr2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,205,439 - 33,205,581 (+)MAPPERmRatBN7.2
Rnor_6.0332,947,890 - 32,948,031NCBIRnor6.0
Rnor_5.0338,113,645 - 38,113,786UniSTSRnor5.0
RGSC_v3.4329,720,901 - 29,721,042UniSTSRGSC3.4
Celera331,412,265 - 31,412,406UniSTS
Cytogenetic Map3q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007404   ⟹   ENSRNOP00000007404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,205,523 - 33,289,968 (+)Ensembl
Rnor_6.0 Ensembl332,947,378 - 33,034,282 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113342   ⟹   ENSRNOP00000083010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,260,872 - 33,289,968 (+)Ensembl
RefSeq Acc Id: NM_031571   ⟹   NP_113759
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,614,786 - 53,699,228 (+)NCBI
mRatBN7.2333,205,523 - 33,289,968 (+)NCBI
Rnor_6.0332,947,973 - 33,032,649 (+)NCBI
Rnor_5.0338,113,728 - 38,197,531 (+)NCBI
RGSC_v3.4329,779,827 - 29,808,881 (+)RGD
Celera331,412,348 - 31,490,813 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283199   ⟹   XP_063139269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,614,143 - 53,701,933 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113759 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139269 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40674 (Get FASTA)   NCBI Sequence Viewer  
  AAB23958 (Get FASTA)   NCBI Sequence Viewer  
  EDM00469 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007404
  ENSRNOP00000083010
GenBank Protein P38444 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113759   ⟸   NM_031571
- Peptide Label: precursor
- UniProtKB: P38444 (UniProtKB/Swiss-Prot),   A6JEZ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007404   ⟸   ENSRNOT00000007404
Ensembl Acc Id: ENSRNOP00000083010   ⟸   ENSRNOT00000113342
RefSeq Acc Id: XP_063139269   ⟸   XM_063283199
- Peptide Label: isoform X1
- UniProtKB: P38444 (UniProtKB/Swiss-Prot),   F1MA24 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38444-F1-model_v2 AlphaFold P38444 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692067
Promoter ID:EPDNEW_R2592
Type:initiation region
Name:Acvr2a_1
Description:activin A receptor type 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0332,947,381 - 32,947,441EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70911 AgrOrtholog
BioCyc Gene G2FUF-49788 BioCyc
Ensembl Genes ENSRNOG00000005334 Ensembl
  ENSRNOG00000065897 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007404 ENTREZGENE
  ENSRNOT00000113342 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Activin_recp UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:29263 UniProtKB/Swiss-Prot
NCBI Gene 29263 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-2A UniProtKB/Swiss-Prot
  PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Acvr2a PhenoGen
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005334 RatGTEx
  ENSRNOG00000065897 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYE8_RAT UniProtKB/TrEMBL
  A0ABK0L8M1_RAT UniProtKB/TrEMBL
  A6JEZ1 ENTREZGENE, UniProtKB/TrEMBL
  AVR2A_RAT UniProtKB/Swiss-Prot
  F1MA24 ENTREZGENE, UniProtKB/TrEMBL
  P38444 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvr2a  activin A receptor type 2A  Acvr2a  activin A receptor, type IIA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Acvr2a  activin A receptor, type IIA  Acvr2a  activin receptor IIA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Acvr2a  activin receptor IIA      Symbol updated 1299863 APPROVED
2002-07-09 Acvr2  activin receptor IIA      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function receptor for activin A, activin B and inhibin A 724707
gene_process involved in transmembrane signaling 724707