ACVR2A (activin A receptor type 2A)

Gene: ACVR2A (activin A receptor type 2A) Canis lupus familiaris

Analyze

Symbol:

ACVR2A

Name:

activin A receptor type 2A

RGD ID:

12323815

Description:

ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity (ortholog); BMP receptor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 1 (ortholog); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); inhibin-betaglycan-ActRII complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

activin receptor type-2A

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	49,642,429 - 49,726,720 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	49,641,219 - 49,723,420 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	49,765,961 - 49,850,433 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	51,114,507 - 51,199,229 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	51,113,374 - 51,198,144 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	49,760,723 - 49,845,201 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	49,894,649 - 49,979,187 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	51,291,788 - 51,376,557 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 1 (ISO)

colon cancer (ISO)

Experimental Liver Cirrhosis (ISO)

Femoral Fractures (ISO)

genetic disease (ISO)

Lynch syndrome (ISO)

Microsatellite Instability (ISO)

myocardial infarction (ISO)

Neoplasm Metastasis (ISO)

pancreatic cancer (ISO)

Prostatic Neoplasms (ISO)

Weissenbacher-Zweymuller syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (IEA)

adrenal gland development (ISO)

anterior/posterior pattern specification (ISO)

autophagy (ISO)

BMP signaling pathway (ISO)

cell surface receptor protein serine/threonine kinase signaling pathway (IEA)

cellular response to BMP stimulus (ISO)

cellular response to growth factor stimulus (IEA)

cellular response to oxygen-glucose deprivation (ISO)

determination of left/right symmetry (ISO)

embryonic skeletal system development (ISO)

gastrulation with mouth forming second (ISO)

male gonad development (ISO)

mesoderm development (ISO)

odontogenesis of dentin-containing tooth (ISO)

penile erection (ISO)

positive regulation of activin receptor signaling pathway (ISO)

positive regulation of bone mineralization (ISO)

positive regulation of erythrocyte differentiation (ISO)

positive regulation of follicle-stimulating hormone secretion (ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of nitric oxide biosynthetic process (ISO)

regulation of signal transduction (ISO)

Sertoli cell proliferation (ISO)

SMAD protein signal transduction (ISO)

sperm ejaculation (ISO)

spermatogenesis (ISO)

Cellular Component

activin receptor complex (IEA)

cell surface (ISO)

cytoplasm (ISO)

inhibin-betaglycan-ActRII complex (ISO)

membrane (IEA)

plasma membrane (IEA,ISO)

receptor complex (ISO)

Molecular Function

activin binding (IEA,ISO)

activin receptor activity (IEA,ISO)

ATP binding (IEA)

BMP receptor activity (ISO)

coreceptor activity (ISO)

growth factor binding (ISO)

inhibin binding (ISO)

metal ion binding (IEA)

PDZ domain binding (ISO)

protein binding (ISO)

protein serine/threonine kinase activity (IEA)

transmembrane receptor protein serine/threonine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

activin signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ACVR2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	49,642,429 - 49,726,720 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	49,641,219 - 49,723,420 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	49,765,961 - 49,850,433 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	51,114,507 - 51,199,229 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	51,113,374 - 51,198,144 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	49,760,723 - 49,845,201 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	49,894,649 - 49,979,187 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	51,291,788 - 51,376,557 (+)	NCBI		UU_Cfam_GSD_1.0

ACVR2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	147,844,517 - 147,930,822 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	147,844,517 - 147,930,826 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	148,602,086 - 148,688,391 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	148,319,040 - 148,404,863 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	148,436,303 - 148,519,242	NCBI
Celera	2	142,316,710 - 142,402,536 (+)	NCBI		Celera
Cytogenetic Map	2	q22.3-q23.1	NCBI
HuRef	2	140,599,673 - 140,685,765 (+)	NCBI		HuRef
CHM1_1	2	148,607,725 - 148,694,041 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	148,294,972 - 148,381,274 (+)	NCBI		T2T-CHM13v2.0

Acvr2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	48,704,121 - 48,793,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	48,704,121 - 48,793,281 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	48,814,109 - 48,903,264 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	48,814,109 - 48,903,269 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	48,669,629 - 48,758,784 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	48,636,166 - 48,724,172 (+)	NCBI		MGSCv36	mm8
Celera	2	50,486,791 - 50,575,736 (+)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	28.38	NCBI

Acvr2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	53,614,143 - 53,701,933 (+)	NCBI		GRCr8
mRatBN7.2	3	33,204,961 - 33,292,673 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	33,205,523 - 33,289,968 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	36,594,864 - 36,673,345 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	45,179,586 - 45,258,078 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	43,001,947 - 43,080,473 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	32,947,901 - 33,034,598 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	32,947,378 - 33,034,282 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	38,113,728 - 38,197,531 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	29,779,827 - 29,808,881 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	29,676,198 - 29,705,253 (+)	NCBI
Celera	3	31,412,348 - 31,490,813 (+)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

Acvr2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	13,849,926 - 13,931,374 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	13,849,926 - 13,931,374 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACVR2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	27,001,835 - 27,089,040 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	27,016,285 - 27,103,522 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	11,933,683 - 12,020,287 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	152,253,843 - 152,288,385 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	152,253,826 - 152,288,385 (+)	Ensembl	panpan1.1		panPan2

Acvr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	112,344,483 - 112,422,388 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	29,194,908 - 29,273,196 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	29,195,329 - 29,273,237 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACVR2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	4,173,805 - 4,259,706 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	4,177,333 - 4,259,056 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	3,828,828 - 3,910,559 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACVR2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	33,223,902 - 33,311,257 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	33,224,099 - 33,307,720 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	166,228,513 - 166,314,554 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acvr2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624866	539,894 - 620,302 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624866	539,967 - 619,575 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ACVR2A
814 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	1		6				6		10		1	1
Low	4	5	16	6	6	6		6	2	8	9	5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005631965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038426218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038426219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038454689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038502412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038502413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038565135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038565136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038629233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038629235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_852167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000008888 ⟹ ENSCAFP00000008245

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	19	49,641,219 - 49,723,420 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000075724 ⟹ ENSCAFP00000055829

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	19	49,641,219 - 49,723,420 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000081141 ⟹ ENSCAFP00000057487

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	19	49,641,219 - 49,723,420 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845011101 ⟹ ENSCAFP00845008662

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	19	51,113,374 - 51,198,144 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845011151 ⟹ ENSCAFP00845008695

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	19	51,114,780 - 51,197,771 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845011205 ⟹ ENSCAFP00845008741

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	19	51,114,780 - 51,197,771 (+)	Ensembl

RefSeq Acc Id:

XM_038426218 ⟹ XP_038282146

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	19	51,114,507 - 51,199,229 (+)	NCBI

RefSeq Acc Id:

XM_038426219 ⟹ XP_038282147

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	19	51,160,095 - 51,196,017 (+)	NCBI

RefSeq Acc Id:

XM_038454689 ⟹ XP_038310617

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	19	49,811,316 - 49,847,221 (+)	NCBI

RefSeq Acc Id:

XM_038502412 ⟹ XP_038358340

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	19	49,760,723 - 49,845,201 (+)	NCBI

RefSeq Acc Id:

XM_038502413 ⟹ XP_038358341

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	19	49,806,101 - 49,841,988 (+)	NCBI

RefSeq Acc Id:

XM_038565135 ⟹ XP_038421063

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	19	51,291,788 - 51,376,557 (+)	NCBI

RefSeq Acc Id:

XM_038565136 ⟹ XP_038421064

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	19	51,337,381 - 51,373,343 (+)	NCBI

RefSeq Acc Id:

XM_038629233 ⟹ XP_038485161

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	19	49,894,649 - 49,979,187 (+)	NCBI

RefSeq Acc Id:

XM_038629235 ⟹ XP_038485163

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	19	49,940,018 - 49,975,974 (+)	NCBI

RefSeq Acc Id:

XM_852167 ⟹ XP_857260

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	19	49,642,429 - 49,723,507 (+)	NCBI
Dog10K_Boxer_Tasha	19	49,765,961 - 49,850,433 (+)	NCBI

Sequence:

show sequence

TCTTTTATTTTTTCCTTTTTTTTTTTTTCTTAACCCCGTGAACCTTTTTCGTTTTTTATTTTTT
TTTATTTTTCTTTTTGGTCGGGGGCTTCCGAATATGTTTTATGACGGTTGATTTCACACCAGGA
GGTTTGTCTCCGAGGAAGACCAGGGAACGGGCTCTCTAGCGAGAACTTGCTGCGGATCCCCCGG
CGCCTCGGAAAATGGGAGCTGCTGCGAAGTTGGCGTTCGCCGTGTTTCTTATCTCCTGCTCTTC
AGGTGCTATACTTGGTAGATCAGAAACTCAGGAGTGTATTTTCTATAATGCTAATTGGGAGAGA
GATAGAACCAATCGAACTGGTGTTGAACCCTGTTATGGTGACAAAGATAAAAGGCGACATTGTT
TTGCTACCTGGAAGAATATTTCTGGTTCCATTGAAATAGTGAAGCAAGGTTGTTGGCTGGATGA
TATCAACTGTTATGACAGGACTGATTGTATAGAAAAAAAAGACAGCCCTGAAGTGTATTTTTGT
TGCTGTGAGGGCAATATGTGTAACGAAAGGTTTTCTTATTTTCCGGAGATGGAAGTCACACAGC
CTACTTCGAACCCAGTTACACCTAAGCCACCCTATTACAACATATTGCTTTATTCCTTGGTGCC
ACTTATGTTGATTGCGGGGATTGTTATTTGTGCATTTTGGGTGTATAGGCATCATAAGATGGCC
TACCCTCCTGTACTTGTTCCAACTCAAGACCCAGGACCACCCCCACCTTCTCCATTACTAGGTT
TGAAGCCACTGCAGTTATTAGAAGTGAAAGCAAGGGGAAGATTTGGTTGTGTATGGAAAGCGCA
GCTGCTCAATGAGTACGTGGCTGTGAAAATATTTCCAATACAGGACAAACAATCATGGCAAAAT
GAATATGAAGTTTATAGTTTACCTGGAATGAAGCATGAGAACATACTACAGTTCATTGGTGCAG
AAAAACGAGGCACCAGTGTTGATGTGGATCTTTGGCTAATTACAGCATTTCATGAGAAGGGTTC
ACTGTCAGACTTTCTTAAGGCTAATGTGGTCTCTTGGAATGAACTATGTCATATTGCAGAAACC
ATGGCCAGAGGATTGGCTTATTTGCACGAGGATATACCTGGCCTAAAAGATGGCCATAAACCTG
CCATATCTCACAGGGACATCAAAAGTAAAAATGTGCTGTTGAAAAACAATCTGACAGCTTGCAT
TGCTGACTTTGGGTTGGCATTAAAATTCGAGGCTGGCAAGTCTGCAGGTGATACCCATGGACAG
GTTGGTACCCGGAGATATATGGCTCCAGAGGTATTAGAGGGTGCTATAAACTTCCAAAGGGATG
CATTTTTGAGGATAGATATGTACGCCATGGGATTAGTCCTGTGGGAACTGGCTTCTCGCTGTAC
TGCCGCAGATGGACCTGTAGATGAATACATGTTGCCATTTGAGGAGGAAATTGGCCAGCATCCA
TCTCTTGAAGACATGCAGGAAGTTGTTGTGCATAAAAAAAAGCGGCCTGTTTTAAGAGATTATT
GGCAGAAACATGCTGGGATGGCAATGCTCTGTGAAACGATAGAAGAATGTTGGGATCACGATGC
AGAAGCCAGGTTATCAGCTGGATGTGTAGGTGAAAGAATCACTCAGATGCAAAGACTAACAAAT
ATCATTACCACAGAGGACATTGTAACAGTGGTCACGATGGTGACAAATGTTGACTTTCCTCCCA
AAGAATCTAGTCTATGATGGTGGCACCATGTGTACACAGTGAGAAACGGGACTCTGAACTGGAG
CTGCTAAGCTAACGGACCTGCTTACAGTTTATTTTCTGTGAGAAATGAACACGGTGTCTCCTGG
ACAGGTCAGAAAGACGACCCTCGTTTCAAATGTGGCTCTGGGAGACGTCCAGCATTGCCCGCAG
CAGACGCCAAGGACACGAGACTAAGGAAAGCTGCAGACTCTATAAAGAAACTTTTGAAAACGTG
TACATGAAGAACGTAGCCCTCTCCAAATCAAGGATCTTTTGGACCTGGCTAATCAAGTGTTTGA
AAACTGACATCAGATTTCTAAATGTCTGTCGGAAGACACTAATT

hide sequence

Protein Sequences


Protein RefSeqs	XP_038282146	(Get FASTA)	NCBI Sequence Viewer
	XP_038282147	(Get FASTA)	NCBI Sequence Viewer
	XP_038310617	(Get FASTA)	NCBI Sequence Viewer
	XP_038358340	(Get FASTA)	NCBI Sequence Viewer
	XP_038358341	(Get FASTA)	NCBI Sequence Viewer
	XP_038421063	(Get FASTA)	NCBI Sequence Viewer
	XP_038421064	(Get FASTA)	NCBI Sequence Viewer
	XP_038485161	(Get FASTA)	NCBI Sequence Viewer
	XP_038485163	(Get FASTA)	NCBI Sequence Viewer
	XP_857260	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000008245.3
	ENSCAFP00000057487.1
	ENSCAFP00030024557.1
	ENSCAFP00030024647.1
	ENSCAFP00030024712.1
	ENSCAFP00040033921.1
	ENSCAFP00040033985.1
	ENSCAFP00040034043.1
	ENSCAFP00845008662.1
	ENSCAFP00845008695.1
	ENSCAFP00845008741
	ENSCAFP00845008741.1

RefSeq Acc Id:	XP_857260 ⟸ XM_852167
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0Z3E6 (UniProtKB/TrEMBL), A0A8C0R225 (UniProtKB/TrEMBL), A0A8I3MYH0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAAAKLAFAVFLISCSSGAILGRSETQECIFYNANWERDRTNRTGVEPCYGDKDKRRHCFATW KNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNERFSYFPEMEVTQPTSN PVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPL QLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRG TSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISH RDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLR IDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKH AGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESS L hide sequence

RefSeq Acc Id:

ENSCAFP00000008245 ⟸ ENSCAFT00000008888

RefSeq Acc Id:

ENSCAFP00000055829 ⟸ ENSCAFT00000075724

RefSeq Acc Id:

ENSCAFP00000057487 ⟸ ENSCAFT00000081141

RefSeq Acc Id:	XP_038358340 ⟸ XM_038502412
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038358341 ⟸ XM_038502413
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038485161 ⟸ XM_038629233
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038485163 ⟸ XM_038629235
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038282146 ⟸ XM_038426218
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0Z3E6 (UniProtKB/TrEMBL), A0A8C0R225 (UniProtKB/TrEMBL), A0A8I3MYH0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038282147 ⟸ XM_038426219
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038310617 ⟸ XM_038454689
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038421063 ⟸ XM_038565135
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0R225 (UniProtKB/TrEMBL), A0A8C0Z3E6 (UniProtKB/TrEMBL), A0A8I3MYH0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038421064 ⟸ XM_038565136
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSCAFP00845008741 ⟸ ENSCAFT00845011205

RefSeq Acc Id:

ENSCAFP00845008695 ⟸ ENSCAFT00845011151

RefSeq Acc Id:

ENSCAFP00845008662 ⟸ ENSCAFT00845011101

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000005507	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030015234	UniProtKB/TrEMBL
	ENSCAFG00040020986	UniProtKB/TrEMBL
	ENSCAFG00845006266	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000008888.5	UniProtKB/TrEMBL
	ENSCAFT00000081141.2	UniProtKB/TrEMBL
	ENSCAFT00030028138.1	UniProtKB/TrEMBL
	ENSCAFT00030028252.1	UniProtKB/TrEMBL
	ENSCAFT00030028326.1	UniProtKB/TrEMBL
	ENSCAFT00040038896.1	UniProtKB/TrEMBL
	ENSCAFT00040038971.1	UniProtKB/TrEMBL
	ENSCAFT00040039039.1	UniProtKB/TrEMBL
	ENSCAFT00845011101.1	UniProtKB/TrEMBL
	ENSCAFT00845011151.1	UniProtKB/TrEMBL
	ENSCAFT00845011205	ENTREZGENE
	ENSCAFT00845011205.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.60.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Activin_recp	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Snake_toxin-like_sf	UniProtKB/TrEMBL
	TGFB_receptor	UniProtKB/TrEMBL
NCBI Gene	ACVR2A	ENTREZGENE
PANTHER	ACTIVIN RECEPTOR TYPE-2A	UniProtKB/TrEMBL
	PTHR23255	UniProtKB/TrEMBL
Pfam	Activin_recp	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PRINTS	ACTIVIN2R	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
	SSF57302	UniProtKB/TrEMBL
UniProt	A0A8C0NEU5_CANLF	UniProtKB/TrEMBL
	A0A8C0NGY3_CANLF	UniProtKB/TrEMBL
	A0A8C0R225	ENTREZGENE
	A0A8C0TCX8_CANLF	UniProtKB/TrEMBL
	A0A8C0Z3E6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MUB5_CANLF	UniProtKB/TrEMBL
	A0A8I3MYH0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N281_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:37564	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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