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Gene: Bhlhe41 (basic helix-loop-helix family, member e41) Rattus norvegicus

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Symbol:

Bhlhe41

Name:

basic helix-loop-helix family, member e41

RGD ID:

70900

Description:

Predicted to enable several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein dimerization activity. Involved in circadian rhythm and regulation of neuronal synaptic plasticity. Predicted to be active in nucleus. Orthologous to human BHLHE41 (basic helix-loop-helix family member e41); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

basic helix-loop-helix domain containing class B 3; basic helix-loop-helix domain containing, class B3; Bhlhb3; class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; enhancer-of-split and hairy-related protein 1; SHARP-1; Sharp1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	180,565,003 - 180,569,415 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	180,565,003 - 180,569,355 (-)	Ensembl				GRCr8
mRatBN7.2	4	178,834,264 - 178,838,618 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	178,834,271 - 178,838,468 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	185,117,084 - 185,121,450 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	180,901,598 - 180,905,964 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	179,522,031 - 179,526,399 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	180,230,742 - 180,235,138 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	180,232,382 - 180,234,804 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	244,394,139 - 244,398,535 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	4	167,334,944 - 167,338,512 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

esophageal cancer (ISO)

Familial Natural Short Sleep 1 (ISO)

lung adenocarcinoma (ISO)

Lung Neoplasms (ISO)

oral squamous cell carcinoma (ISO)

sleep disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,3-dinitrobenzene (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiolic acid (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloroprene (EXP)

choline (ISO)

cisplatin (EXP,ISO)

clofibric acid (EXP)

crocidolite asbestos (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

diethyl maleate (EXP)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dimethylarsinic acid (ISO)

dimethylarsinous acid (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fenamidone (ISO)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

gentamycin (EXP)

ketamine (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

methylarsonic acid (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nickel dichloride (EXP)

O-methyleugenol (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

progesterone (EXP,ISO)

propanal (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sevoflurane (EXP)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

topotecan (EXP)

tributylstannane (ISO)

trichloroethene (EXP,ISO)

troglitazone (EXP)

undecane (EXP)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IBA)

circadian regulation of gene expression (IBA,IEA,ISO)

circadian rhythm (IEA,IEP,ISO)

DNA-templated transcription (IEA)

negative regulation of DNA-templated transcription (IEA,ISO,ISS)

negative regulation of myotube differentiation (IEA,ISO)

negative regulation of transcription by competitive promoter binding (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

nervous system development (NAS)

regulation of DNA-templated transcription (IEA)

regulation of neurogenesis (IBA)

regulation of neuronal synaptic plasticity (IEA,IEP,NAS)

rhythmic process (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IBA,IEA)

Molecular Function

bHLH transcription factor binding (IEA,ISO)

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO,ISS)

E-box binding (IEA,ISO)

histone deacetylase binding (IEA,ISO)

MRF binding (IEA,ISO)

protein binding (ISO)

protein dimerization activity (IEA)

protein heterodimerization activity (IEA,ISO)

protein homodimerization activity (IEA,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	BHLHB3: a candidate tumor suppressor in lung cancer.	Falvella FS, etal., Oncogene. 2008 Jun 12;27(26):3761-4. doi: 10.1038/sj.onc.1211038. Epub 2008 Jan 28.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Dec1 and Dec2 are regulators of the mammalian molecular clock.	Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
5.	MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2.	Liang Y, etal., Biomed Pharmacother. 2018 Sep;105:582-589. doi: 10.1016/j.biopha.2018.05.152. Epub 2018 Jun 8.
6.	Gene Data Set	MGD Curation, June 12, 2002
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.	Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
13.	SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.	Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
14.	The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.	Zhao Q, etal., Oncotarget. 2016 Oct 25;7(43):70290-70302. doi: 10.18632/oncotarget.11844.

Additional References at PubMed

PMID:12657651	PMID:14672706	PMID:15038852	PMID:15147242	PMID:15193144	PMID:15560782	PMID:17487425	PMID:18411297	PMID:19786558	PMID:21430201	PMID:24446161	PMID:24736997

Genomics

Comparative Map Data

Bhlhe41
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	180,565,003 - 180,569,415 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	180,565,003 - 180,569,355 (-)	Ensembl				GRCr8
mRatBN7.2	4	178,834,264 - 178,838,618 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	178,834,271 - 178,838,468 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	185,117,084 - 185,121,450 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	180,901,598 - 180,905,964 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	179,522,031 - 179,526,399 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	180,230,742 - 180,235,138 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	180,232,382 - 180,234,804 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	244,394,139 - 244,398,535 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	4	167,334,944 - 167,338,512 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

BHLHE41
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	26,120,030 - 26,125,037 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	26,120,030 - 26,125,037 (-)	Ensembl			hg38	GRCh38
GRCh37	12	26,272,963 - 26,277,970 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	26,164,226 - 26,169,113 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	26,164,227 - 26,169,113	NCBI
Celera	12	31,419,506 - 31,424,550 (-)	NCBI		Celera
Cytogenetic Map	12	p12.1	NCBI
HuRef	12	26,043,295 - 26,047,960 (-)	NCBI		HuRef
CHM1_1	12	26,237,976 - 26,243,020 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	25,992,585 - 25,998,690 (-)	NCBI		T2T-CHM13v2.0

Bhlhe41
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	145,803,969 - 145,811,146 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	145,803,969 - 145,811,284 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	145,858,243 - 145,865,420 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	145,858,243 - 145,865,558 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	145,811,257 - 145,813,860 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	145,819,896 - 145,822,499 (-)	NCBI		MGSCv36	mm8
Celera	6	148,934,952 - 148,937,555 (-)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	77.7	NCBI

Bhlhe41
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	21,100,585 - 21,102,034 (-)	Ensembl
ChiLan1.0	NW_004955413	21,100,021 - 21,103,358 (-)	NCBI	ChiLan1.0	ChiLan1.0

BHLHE41
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	70,697,481 - 70,702,552 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	70,693,542 - 70,698,949 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	60,194,758 - 60,199,344 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	62,806,113 - 62,810,773 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

BHLHE41
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	21,464,302 - 21,469,119 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	24,913,768 - 24,918,529 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	21,659,233 - 21,663,998 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	21,659,186 - 21,663,998 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	21,469,068 - 21,473,810 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	21,491,838 - 21,496,575 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	25,081,155 - 25,085,938 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Bhlhe41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	83,384,039 - 83,391,789 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936548	1,306,939 - 1,314,678 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BHLHE41
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	47,686,404 - 47,692,762 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	47,687,662 - 47,692,761 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	51,429,074 - 51,433,848 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BHLHE41
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	25,872,139 - 25,879,985 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	25,874,108 - 25,876,826 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666069	9,196,174 - 9,200,076 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bhlhe41
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	13,000,525 - 13,003,079 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	13,000,238 - 13,004,777 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Bhlhe41
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	3,593,438 - 3,597,843 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bhlhe41
50 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	80
Interacting mature miRNAs:	85
Transcripts:	ENSRNOT00000070957
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	160623982	184426481	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	176806581	181925369	Rat

Markers in Region

RH143816

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	178,835,730 - 178,835,842 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	180,232,209 - 180,232,320	NCBI	Rnor6.0
Rnor_5.0	4	244,395,606 - 244,395,717	UniSTS	Rnor5.0
RH 3.4 Map	4	1070.3	UniSTS
Cytogenetic Map	4	q43	UniSTS

AI170756

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	178,834,487 - 178,834,688 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	180,230,966 - 180,231,166	NCBI	Rnor6.0
Rnor_5.0	4	244,394,363 - 244,394,563	UniSTS	Rnor5.0
Celera	4	167,334,878 - 167,335,078	UniSTS
RH 3.4 Map	4	1067.7	UniSTS
Cytogenetic Map	4	q43	UniSTS

Bhlhe41

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	178,835,532 - 178,835,812 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	180,232,011 - 180,232,290	NCBI	Rnor6.0
Rnor_5.0	4	244,395,408 - 244,395,687	UniSTS	Rnor5.0
Cytogenetic Map	4	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	88	87	56	87	56	6	348	187	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002729454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF009329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000070957 ⟹ ENSRNOP00000064008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	180,567,609 - 180,569,355 (-)	Ensembl
mRatBN7.2 Ensembl	4	178,836,870 - 178,838,468 (-)	Ensembl
Rnor_6.0 Ensembl	4	180,232,382 - 180,234,804 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094651 ⟹ ENSRNOP00000095943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	180,565,003 - 180,569,355 (-)	Ensembl
mRatBN7.2 Ensembl	4	178,834,271 - 178,838,468 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160326 ⟹ ENSRNOP00000105933

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	180,565,003 - 180,569,355 (-)	Ensembl

RefSeq Acc Id:

NM_133303 ⟹ NP_579837

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	180,565,003 - 180,569,355 (-)	NCBI
mRatBN7.2	4	178,834,264 - 178,838,618 (-)	NCBI

RefSeq Acc Id:

XM_063285422 ⟹ XP_063141492

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	180,565,005 - 180,569,415 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_579837	(Get FASTA)	NCBI Sequence Viewer
	XP_063141492	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB63586	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000095943
	ENSRNOP00000105933
GenBank Protein	O35779	(Get FASTA)	NCBI Sequence Viewer

Ensembl Acc Id:

ENSRNOP00000064008 ⟸ ENSRNOT00000070957

Ensembl Acc Id:

ENSRNOP00000095943 ⟸ ENSRNOT00000094651

RefSeq Acc Id:	NP_579837 ⟸ NM_133303
- UniProtKB:	O35779 (UniProtKB/Swiss-Prot), A0A8I6GLD9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063141492 ⟸ XM_063285422
- Peptide Label:	isoform X1
- UniProtKB:	O35779 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000105933 ⟸ ENSRNOT00000160326

Protein Domains

bHLH Orange

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35779-F1-model_v2	AlphaFold	O35779	1-410	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70900	AgrOrtholog
BioCyc Gene	G2FUF-42448	BioCyc
Ensembl Genes	ENSRNOG00000048961	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000094651	ENTREZGENE
	ENSRNOT00000160326	ENTREZGENE
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot
	6.10.250.980	UniProtKB/Swiss-Prot
InterPro	bHLH_dom	UniProtKB/Swiss-Prot
	HES_HEY	UniProtKB/Swiss-Prot
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot
	Orange_dom	UniProtKB/Swiss-Prot
NCBI Gene	117095	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED	UniProtKB/Swiss-Prot
Pfam	Hairy_orange	UniProtKB/Swiss-Prot
	HLH	UniProtKB/Swiss-Prot
PhenoGen	Bhlhe41	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot
	ORANGE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000048961	RatGTEx
SMART	HLH	UniProtKB/Swiss-Prot
	ORANGE	UniProtKB/Swiss-Prot
Superfamily-SCOP	Orange domain-like	UniProtKB/Swiss-Prot
	SSF47459	UniProtKB/Swiss-Prot
UniProt	A0A8I6GLD9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LW56_RAT	UniProtKB/TrEMBL
	BHE41_RAT	UniProtKB/Swiss-Prot
	M0R3T6_RAT	UniProtKB/TrEMBL
	O35779	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-02-19	Bhlhe41	basic helix-loop-helix family, member e41	Bhlhb3	basic helix-loop-helix domain containing, class B3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Bhlhb3	basic helix-loop-helix domain containing, class B3			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the suprachiasmic nucleus of the hypothalamus (SCN) in a circadian fashion	625726
gene_expression	expressed in the caudate putamen, pineal gland, granular cell layer of the cerebellum, olfactory bulb, piriform cortex, hippocampus and hypothalamic nuclei	625726
gene_process	expression may be associated with neuronal stimulation	728119
gene_product	member of a family of neuronal bHLH proteins	728119

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)