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Gene: Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Rattus norvegicus

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Symbol:

Atic

Name:

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

RGD ID:

70879

Description:

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including 'de novo' IMP biosynthetic process; brain development; and dihydrofolate metabolic process. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase); PARTICIPATES IN de novo purine biosynthetic pathway; folate mediated one-carbon metabolic pathway; adenine phoshoribosyltransferase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP; AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH; bifunctional purine biosynthesis protein PURH-like; LOC100910688

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	80,614,311 - 80,634,360 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	80,614,283 - 80,635,756 (+)	Ensembl				GRCr8
mRatBN7.2	9	73,164,846 - 73,184,897 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	73,164,846 - 73,184,889 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	81,636,634 - 81,656,672 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	86,765,482 - 86,785,520 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	85,155,750 - 85,175,788 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	78,862,013 - 78,882,061 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	78,862,013 - 78,882,060 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	78,636,339 - 78,656,387 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	70,676,744 - 70,696,865 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	70,582,456 - 70,602,475 (+)	NCBI		Celera
RGSC_v3.1	9	70,823,725 - 70,843,846 (+)	NCBI
Cytogenetic Map	9	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

AICAR Transformylase Inosine Monophosphate Cyclohydrolase Deficiency (ISO)

blindness (ISO)

Experimental Arthritis (IMP)

intellectual disability (ISO)

osteoporosis (ISO)

purine-pyrimidine metabolic disorder (ISO)

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

alachlor (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aniline (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

DDE (ISO)

deguelin (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dioxygen (ISO)

doxorubicin (ISO)

flutamide (EXP)

folic acid (ISO)

furfural (ISO)

genistein (ISO)

gentamycin (EXP)

gold atom (ISO)

gold(0) (ISO)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

ivermectin (ISO)

menadione (ISO)

methimazole (EXP)

methotrexate (ISO)

morphine (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

Nutlin-3 (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (EXP)

rac-lactic acid (ISO)

rotenone (EXP,ISO)

Salinomycin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

T-2 toxin (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' AMP biosynthetic process (IEA,ISO)

'de novo' IMP biosynthetic process (IBA,IDA,IEA,ISO)

'de novo' XMP biosynthetic process (IEA,ISO)

animal organ regeneration (IEP)

brainstem development (IEP)

cellular response to interleukin-7 (ISO)

cerebellum development (IEP)

cerebral cortex development (IEP)

dihydrofolate metabolic process (IDA)

GMP biosynthetic process (IEA,ISO)

purine nucleotide biosynthetic process (IEA)

small molecule metabolic process (IEA)

tetrahydrofolate biosynthetic process (IDA)

Cellular Component

cytosol (IBA,IEA)

Molecular Function

catalytic activity (IEA)

hydrolase activity (IEA)

IMP cyclohydrolase activity (IBA,IDA,IEA,ISO)

phosphoribosylaminoimidazolecarboxamide formyltransferase activity (IBA,IDA,IEA,ISO)

protein binding (IPI)

protein homodimerization activity (IEA,ISO,ISS)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

de novo purine biosynthetic pathway (IDA,ISO)

folate mediated one-carbon metabolic pathway (IDA,IEA,ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Akira T, etal., Gene 1997 Sep 15;197(1-2):289-93.
2.	Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.	Baggott JE and Morgan SL, Eur J Pharm Sci. 2007 Jun;31(2):95-101. Epub 2007 Mar 1.
3.	Cofactor role for 10-formyldihydrofolic acid.	Baggott JE, etal., Biochem J. 1995 Jun 15;308 ( Pt 3):1031-6.
4.	The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.	Boutchueng-Djidjou M, etal., Mol Cell Proteomics. 2015 Apr;14(4):1079-92. doi: 10.1074/mcp.M114.047159. Epub 2015 Feb 16.
5.	Pediatric neurological syndromes and inborn errors of purine metabolism.	Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
6.	Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.	Deacon R, etal., Biochem J. 1985 Apr 1;227(1):67-71.
7.	Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats.	Deacon R, etal., J Clin Pathol. 1985 Dec;38(12):1349-52.
8.	Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain.	Dominguez J and Ordonez LA, J Neurochem. 1982 Mar;38(3):625-30.
9.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
11.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
12.	AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.	Marie S, etal., Am J Hum Genet. 2004 Jun;74(6):1276-81. Epub 2004 Apr 26.
13.	Gene Data Set	MGD Curation, June 12, 2002
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
18.	GOA pipeline	RGD automated data pipeline
19.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
21.	Comprehensive gene review and curation	RGD comprehensive gene curation
22.	Trafficking of intracellular folates.	Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
23.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24.	Pyrazofurin inhibition of purine biosynthesis via 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate formyltransferase.	Worzalla JF and Sweeney MJ, Cancer Res. 1980 May;40(5):1482-5.

Additional References at PubMed

PMID:14756553	PMID:14966129	PMID:15489334	PMID:18614015	PMID:19056867	PMID:19946888	PMID:20458337	PMID:23533145	PMID:25468996	PMID:29476059	PMID:29581031	PMID:31505169
PMID:38181403

Genomics

Comparative Map Data

Atic
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	80,614,311 - 80,634,360 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	80,614,283 - 80,635,756 (+)	Ensembl				GRCr8
mRatBN7.2	9	73,164,846 - 73,184,897 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	73,164,846 - 73,184,889 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	81,636,634 - 81,656,672 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	86,765,482 - 86,785,520 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	85,155,750 - 85,175,788 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	78,862,013 - 78,882,061 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	78,862,013 - 78,882,060 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	78,636,339 - 78,656,387 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	70,676,744 - 70,696,865 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	70,582,456 - 70,602,475 (+)	NCBI		Celera
RGSC_v3.1	9	70,823,725 - 70,843,846 (+)	NCBI
Cytogenetic Map	9	q33	NCBI

ATIC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	215,312,059 - 215,368,592 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	215,311,956 - 215,349,773 (+)	Ensembl			hg38	GRCh38
GRCh37	2	216,176,782 - 216,214,487 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	215,885,081 - 215,922,724 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	216,002,341 - 216,039,983	NCBI
Celera	2	209,946,316 - 209,984,125 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	208,033,447 - 208,071,522 (+)	NCBI		HuRef
CHM1_1	2	216,182,580 - 216,220,395 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	215,797,091 - 215,854,273 (+)	NCBI		T2T-CHM13v2.0

Atic
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	71,596,315 - 71,618,562 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	71,596,309 - 71,618,790 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	71,557,156 - 71,579,403 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	71,557,150 - 71,579,631 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	71,603,730 - 71,625,977 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	71,490,382 - 71,512,612 (+)	NCBI		MGSCv36	mm8
Celera	1	72,112,478 - 72,134,887 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	36.03	NCBI

Atic
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	704,213 - 730,134 (-)	Ensembl
ChiLan1.0	NW_004955457	704,213 - 729,702 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATIC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	117,940,800 - 118,001,222 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	117,955,739 - 118,005,747 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	102,574,700 - 102,612,492 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	221,159,439 - 221,197,360 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	221,159,439 - 221,197,360 (+)	Ensembl			panPan2	panpan1.1

ATIC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	22,420,645 - 22,446,769 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	22,420,603 - 22,446,697 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	23,247,318 - 23,273,326 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	22,443,734 - 22,469,844 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	22,443,400 - 22,469,837 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	22,332,320 - 22,358,260 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	22,283,592 - 22,309,634 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	22,300,293 - 22,326,226 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Atic
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	170,816,360 - 170,843,277 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936586	1,782,528 - 1,810,010 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936586	1,782,581 - 1,809,458 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATIC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	117,617,502 - 117,649,107 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	117,617,584 - 117,649,063 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	130,321,702 - 130,348,801 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATIC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	101,128,583 - 101,166,668 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	98,215,624 - 98,252,491 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atic
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	782,701 - 809,448 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624765	782,703 - 809,461 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Atic
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	145,123,063 - 145,143,390 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Atic
122 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	61
Count of miRNA genes:	57
Interacting mature miRNAs:	58
Transcripts:	ENSRNOT00000021105
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat

Markers in Region

RH128549

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	2	240,831,262 - 240,831,468	NCBI	Rnor5.0
Rnor_5.0	9	78,656,024 - 78,656,230	NCBI	Rnor5.0
RGSC_v3.4	9	70,696,503 - 70,696,708	UniSTS	RGSC3.4
RGSC_v3.4	2	215,906,362 - 215,906,567	UniSTS	RGSC3.4
Celera	9	70,602,113 - 70,602,318	UniSTS
Celera	2	200,019,154 - 200,019,359	UniSTS
Cytogenetic Map	9	q33	UniSTS
Cytogenetic Map	2	q41	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC072496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D89514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021105 ⟹ ENSRNOP00000021105

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	80,614,291 - 80,634,352 (+)	Ensembl
mRatBN7.2 Ensembl	9	73,164,846 - 73,184,889 (+)	Ensembl
Rnor_6.0 Ensembl	9	78,862,013 - 78,882,060 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098789 ⟹ ENSRNOP00000084375

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	73,164,904 - 73,184,824 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116844 ⟹ ENSRNOP00000078278

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	80,614,283 - 80,635,756 (+)	Ensembl
mRatBN7.2 Ensembl	9	73,164,872 - 73,184,824 (+)	Ensembl

RefSeq Acc Id:

NM_031014 ⟹ NP_112276

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	80,614,311 - 80,634,360 (+)	NCBI
mRatBN7.2	9	73,164,846 - 73,184,897 (+)	NCBI
Rnor_6.0	9	78,862,013 - 78,882,061 (+)	NCBI
Rnor_5.0	9	78,636,339 - 78,656,387 (+)	NCBI
RGSC_v3.4	9	70,676,744 - 70,696,865 (+)	RGD
Celera	9	70,582,456 - 70,602,475 (+)	RGD

Sequence:

show sequence

GGCCTGCCAGCCTAGGCACGTGTCCTGTCTGTCTCCAGACTCCGCGACCCGGCGCAGCAGCCAT
GGCTTCCTCCCAGCTTGCCCTGTTCAGTGTGTCTGACAAAACTGGCCTCGTGGAATTTGCCAGA
AACCTCGCGTCTCTTGGTTTGAGTTTGGTCGCTTCTGGAGGCACGGCAAAAGCGATCAGGGATG
CTGGCCTGGCAGTGAGAGATGTGTCTGAGCTAACTGGGTTCCCTGAAATGTTAGGGGGGCGTGT
GAAAACCTTGCATCCTGCAGTCCATGCTGGAATCTTAGCACGCAATATTCCAGAAGATGCTGCT
GACATGGCCAGGCTTGATTTCAACCTCATAAGAGTTGTTGTCTGTAACCTGTACCCGTTCGTGA
AGACTGTGGCTTCTCCAGATGTAACCGTTGAGGCAGCTGTTGAGCAAATTGACATTGGTGGCGT
GACCTTACTGAGAGCTGCAGCCAAAAACCATGCTCGAGTGACAGTTGTGTGTGAGCCAGAGGAC
TATGGTGCGGTGGCTGCAGAGATGCAGGGCTCTGGTAATAAGGACACCTCCCTGGAGACCAGGC
GCCACTTGGCATTGAAGGCATTCACGCATACCGCTCAATATGATGAAGCGATTTCGGATTACTT
CAGGAGACAGTACAGTAAAGGAATTTCTCAGATGCCCTTGAGGTATGGGATGAACCCCCATCAG
ACTCCTGCCCAGCTGTATACACTGAAGCCCAAGCTTCCCATCACAGTTCTCAACGGAGCCCCAG
GATTCATAAACCTCTGCGATGCTTTGAATGCCTGGCAGCTGGTGACAGAGCTGAGAGGAGCAGT
AGACATTCCAGCTGCGGCGTCTTTCAAGCACGTCAGCCCAGCAGGTGCTGCTGTTGGGGTTCCA
CTCAGTGAGGACGAAGCCAGAGTCTGCATGGTCTATGACCTCTATCCGACCCTCACGCCCCTGG
CCATTGCATATGCAAGAGCAAGAGGAGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCATT
ATCTGATGTTTGTGATGTCCCAACTGCAAAAATTATCTCCAGAGAAGTGTCAGATGGTATTGTT
GCCCCAGGATATGAGGAAGAGGCCTTGAAAATACTTTCTAAAAAGAAAAATGGAAGCTACTGTG
TTCTTCAGATGGACCAGTCCTACAAACCGGATGAAAATGAAGTTCGAACGCTCTTTGGTCTTCG
TTTAAGCCAGAAGAGAAATAATGGTGTTGTTGACAAGTCGTTGTTTAGCAATATTGTCACCAAG
AATAAAGATCTGCCGGAATCTGCTCTCCGAGACCTCATTGTCGCCACCATCGCTGTCAAGTATA
CTCAGTCTAATTCGGTGTGCTATGCCAAGGACGGGCAGGTTATTGGCATCGGAGCAGGACAGCA
GTCTCGGATACACTGTACACGCCTTGCAGGTGATAAGGCAAACTCTTGGTGGCTTCGGCACCAT
CCACGAGTGCTTTCCATGAAGTTTAAAGCTGGGGTGAAGAGAGCAGAAGTCTCCAATGCCATCG
ATCAGTATGTGACCGGCACCATTGGTGAGGGTGAAGACCTGGTGAAATGGAAAGCACTGTTTGA
AGAGGTTCCTGAGTTACTCACTGAGGCGGAGAAGAAGGAATGGGTGGACAAGCTGAGTGGCGTG
TCTGTCAGTTCCGATGCTTTCTTTCCTTTCAGGGATAATGTAGACCGAGCGAAAAGGAGTGGTG
TGGCCTACATTGTTGCTCCATCCGGATCTACTGCTGACAAGGTTGTGATCGAGGCGTGTGACGA
GCTGGGGATCGTGTTGGCTCATACAGATCTGCGTCTCTTCCACCACTGACCTTGGCTGACATTG
TTACATTGTTTCCTAGTGGGAGATACTCATGTGTGGGACCCTGAAAGTATCTCTTTTTAAACAG
AGTCATTCTTATCTTAATATTTGGGTCTGTGGTTTTAGATAGTTAGGTCTTACTCACTTGAAAG
GTATAGCCTGAGACACCACGTGGGGAGGCTTGTTTCTGCAAAACCTGAAAGGATCCCTCCCCAT
GGGAGCCAGCTTTCACAAAAAGTCCCTGCAAGACACCTAAGTGCAGGTAACCAAGGAGAAGCCA
AGCTGCCTTATGATGACATCCCACTGAGGACTGCTCTCCCCAGGGCTCCTTTCTCTGTGCCTCT
CAGAACTGGATCCTTAGCAGGATCTAGATAATGGTGATACTGCTCTTCCTTTCTCCAGAACTGC
TTAAAAACCGTGAGCTCCTTAGTGACCTGTTTGGTACAAACCTACAAACTGACCCATAGAGCTT
TTCACCCATAGTGAGCAGACTTGGACTGTGTGTTGGGGGCGGGGGAGGTGACAGGACTGAATCT
GTGTCCCCGTGTTAGTCCTGACTGTTCACACAGGCGATGCCTGGGGTCAACGGTAACCTTTGGT
TAGTTTTGCCTTCTTTCCACTCCTCTAAATAAATTTCAAAAAGTTTTTGTTGAAAAAAAAAAAA
AAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112276	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72496	(Get FASTA)	NCBI Sequence Viewer
	BAA22837	(Get FASTA)	NCBI Sequence Viewer
	EDL75264	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078278
	ENSRNOP00000078278.1
	ENSRNOP00000084375.1
GenBank Protein	O35567	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112276 ⟸ NM_031014

- UniProtKB:

Q6IN16 (UniProtKB/Swiss-Prot), O35567 (UniProtKB/Swiss-Prot), A6KFG3 (UniProtKB/TrEMBL), A0A8L2QB21 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGR
VKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGG
VTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDY
FRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGA
VDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVA
LSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGL
RLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQ
QSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALF
EEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACD
ELGIVLAHTDLRLFHH

hide sequence

Ensembl Acc Id:

ENSRNOP00000021105 ⟸ ENSRNOT00000021105

Ensembl Acc Id:

ENSRNOP00000078278 ⟸ ENSRNOT00000116844

Ensembl Acc Id:

ENSRNOP00000084375 ⟸ ENSRNOT00000098789

Protein Domains

MGS-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35567-F1-model_v2	AlphaFold	O35567	1-592	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696733

Promoter ID:

EPDNEW_R7257

Type:

initiation region

Name:

Atic_1

Description:

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMPcyclohydrolase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	78,862,039 - 78,862,099	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70879	AgrOrtholog
BioCyc Gene	G2FUF-27251	BioCyc
Ensembl Genes	ENSRNOG00000015511	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000098789.1	UniProtKB/Swiss-Prot
	ENSRNOT00000116844	ENTREZGENE
	ENSRNOT00000116844.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.440	UniProtKB/Swiss-Prot
	3.40.140.20	UniProtKB/Swiss-Prot
	3.40.50.1380	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7096880	IMAGE-MGC_LOAD
InterPro	AICAR_Tfase_dup_dom_sf	UniProtKB/Swiss-Prot
	AICAR_Tfase_insert_dom_sf	UniProtKB/Swiss-Prot
	Cytidine_deaminase-like	UniProtKB/Swiss-Prot
	MGS-like_dom	UniProtKB/Swiss-Prot
	MGS-like_dom_sf	UniProtKB/Swiss-Prot
	PurH-like	UniProtKB/Swiss-Prot
KEGG Report	rno:81643	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:91657	IMAGE-MGC_LOAD
NCBI Gene	81643	ENTREZGENE
PANTHER	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC	UniProtKB/Swiss-Prot
	PTHR11692	UniProtKB/Swiss-Prot
Pfam	AICARFT_IMPCHas	UniProtKB/Swiss-Prot
	MGS	UniProtKB/Swiss-Prot
PharmGKB	ATIC	RGD
PhenoGen	Atic	PhenoGen
PIRSF	AICARFT_IMPCHas	UniProtKB/Swiss-Prot
PROSITE	MGS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000015511	RatGTEx
SMART	AICARFT_IMPCHas	UniProtKB/Swiss-Prot
	MGS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52335	UniProtKB/Swiss-Prot
	SSF53927	UniProtKB/Swiss-Prot
UniProt	A0A8L2QB21	ENTREZGENE, UniProtKB/TrEMBL
	A6KFG3	ENTREZGENE, UniProtKB/TrEMBL
	O35567	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6IN16	ENTREZGENE
UniProt Secondary	Q6IN16	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	LOC100910688	bifunctional purine biosynthesis protein PURH-like	Data merged from RGD:6497544	737654	PROVISIONAL
2012-07-05	LOC100910688	bifunctional purine biosynthesis protein PURH-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP	Name updated	1299863	APPROVED
2002-07-09	Atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in liver	70804
gene_homology	84 and 91% identical to human gene at the nucleotide and amino acid sequence level, respectively.	70804
gene_protein	contains 592 amino acids	70804
gene_regulation	expression greatly induced at 24 h after partial (70%) hepatectomy	70804
gene_transcript	mRNA 2.8 kb in size	70804

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)