Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Rattus norvegicus
Analyze
Symbol: Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
RGD ID: 70879
Description: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including 'de novo' IMP biosynthetic process; brain development; and folic acid-containing compound metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase); PARTICIPATES IN de novo purine biosynthetic pathway; folate mediated one-carbon metabolic pathway; adenine phoshoribosyltransferase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP; AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH; bifunctional purine biosynthesis protein PURH-like; LOC100910688
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,614,311 - 80,634,360 (+)NCBIGRCr8
mRatBN7.2973,164,846 - 73,184,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,164,846 - 73,184,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,636,634 - 81,656,672 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,765,482 - 86,785,520 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0985,155,750 - 85,175,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,862,013 - 78,882,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,862,013 - 78,882,060 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,636,339 - 78,656,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,676,744 - 70,696,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,823,725 - 70,843,846 (+)NCBI
Celera970,582,456 - 70,602,475 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
ivermectin  (ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
tungsten  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Akira T, etal., Gene 1997 Sep 15;197(1-2):289-93.
2. Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. Baggott JE and Morgan SL, Eur J Pharm Sci. 2007 Jun;31(2):95-101. Epub 2007 Mar 1.
3. Cofactor role for 10-formyldihydrofolic acid. Baggott JE, etal., Biochem J. 1995 Jun 15;308 ( Pt 3):1031-6.
4. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Boutchueng-Djidjou M, etal., Mol Cell Proteomics. 2015 Apr;14(4):1079-92. doi: 10.1074/mcp.M114.047159. Epub 2015 Feb 16.
5. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
6. Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats. Deacon R, etal., Biochem J. 1985 Apr 1;227(1):67-71.
7. Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats. Deacon R, etal., J Clin Pathol. 1985 Dec;38(12):1349-52.
8. Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain. Dominguez J and Ordonez LA, J Neurochem. 1982 Mar;38(3):625-30.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Marie S, etal., Am J Hum Genet. 2004 Jun;74(6):1276-81. Epub 2004 Apr 26.
13. Gene Data Set MGD Curation, June 12, 2002
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Trafficking of intracellular folates. Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Pyrazofurin inhibition of purine biosynthesis via 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate formyltransferase. Worzalla JF and Sweeney MJ, Cancer Res. 1980 May;40(5):1482-5.
Additional References at PubMed
PMID:14756553   PMID:14966129   PMID:15489334   PMID:18614015   PMID:19056867   PMID:19946888   PMID:20458337   PMID:23533145   PMID:25468996   PMID:29476059   PMID:29581031   PMID:31505169  


Genomics

Comparative Map Data
Atic
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,614,311 - 80,634,360 (+)NCBIGRCr8
mRatBN7.2973,164,846 - 73,184,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,164,846 - 73,184,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,636,634 - 81,656,672 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,765,482 - 86,785,520 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0985,155,750 - 85,175,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,862,013 - 78,882,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,862,013 - 78,882,060 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,636,339 - 78,656,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,676,744 - 70,696,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,823,725 - 70,843,846 (+)NCBI
Celera970,582,456 - 70,602,475 (+)NCBICelera
Cytogenetic Map9q33NCBI
ATIC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382215,312,059 - 215,368,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2215,311,956 - 215,349,773 (+)EnsemblGRCh38hg38GRCh38
GRCh372216,176,782 - 216,214,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,885,081 - 215,922,724 (+)NCBINCBI36Build 36hg18NCBI36
Build 342216,002,341 - 216,039,983NCBI
Celera2209,946,316 - 209,984,125 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,033,447 - 208,071,522 (+)NCBIHuRef
CHM1_12216,182,580 - 216,220,395 (+)NCBICHM1_1
T2T-CHM13v2.02215,797,091 - 215,854,273 (+)NCBIT2T-CHM13v2.0
Atic
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,596,315 - 71,618,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,596,309 - 71,618,790 (+)EnsemblGRCm39 Ensembl
GRCm38171,557,156 - 71,579,403 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,557,150 - 71,579,631 (+)EnsemblGRCm38mm10GRCm38
MGSCv37171,603,730 - 71,625,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36171,490,382 - 71,512,612 (+)NCBIMGSCv36mm8
Celera172,112,478 - 72,134,887 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.03NCBI
Atic
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955457704,213 - 730,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955457704,213 - 729,702 (-)NCBIChiLan1.0ChiLan1.0
ATIC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213117,940,800 - 118,001,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B117,955,739 - 118,005,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B102,574,700 - 102,612,492 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B221,159,439 - 221,197,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,159,439 - 221,197,360 (+)Ensemblpanpan1.1panPan2
ATIC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13722,420,645 - 22,446,769 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3722,420,603 - 22,446,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,247,318 - 23,273,326 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03722,443,734 - 22,469,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3722,443,400 - 22,469,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13722,332,320 - 22,358,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03722,283,592 - 22,309,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03722,300,293 - 22,326,226 (+)NCBIUU_Cfam_GSD_1.0
Atic
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,816,360 - 170,843,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365861,782,528 - 1,810,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365861,782,581 - 1,809,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATIC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,617,502 - 117,649,107 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,617,584 - 117,649,063 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,321,702 - 130,348,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATIC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,128,583 - 101,166,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604098,215,624 - 98,252,491 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atic
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624765782,701 - 809,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624765782,703 - 809,461 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atic
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:57
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000021105
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
RH128549  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02240,831,262 - 240,831,468NCBIRnor5.0
Rnor_5.0978,656,024 - 78,656,230NCBIRnor5.0
RGSC_v3.4970,696,503 - 70,696,708UniSTSRGSC3.4
RGSC_v3.42215,906,362 - 215,906,567UniSTSRGSC3.4
Celera970,602,113 - 70,602,318UniSTS
Celera2200,019,154 - 200,019,359UniSTS
Cytogenetic Map9q33UniSTS
Cytogenetic Map2q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021105   ⟹   ENSRNOP00000021105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,164,846 - 73,184,889 (+)Ensembl
Rnor_6.0 Ensembl978,862,013 - 78,882,060 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098789   ⟹   ENSRNOP00000084375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,164,904 - 73,184,824 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116844   ⟹   ENSRNOP00000078278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,164,872 - 73,184,824 (+)Ensembl
RefSeq Acc Id: NM_031014   ⟹   NP_112276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,614,311 - 80,634,360 (+)NCBI
mRatBN7.2973,164,846 - 73,184,897 (+)NCBI
Rnor_6.0978,862,013 - 78,882,061 (+)NCBI
Rnor_5.0978,636,339 - 78,656,387 (+)NCBI
RGSC_v3.4970,676,744 - 70,696,865 (+)RGD
Celera970,582,456 - 70,602,475 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112276   ⟸   NM_031014
- UniProtKB: Q6IN16 (UniProtKB/Swiss-Prot),   O35567 (UniProtKB/Swiss-Prot),   A6KFG3 (UniProtKB/TrEMBL),   A0A8L2QB21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021105   ⟸   ENSRNOT00000021105
RefSeq Acc Id: ENSRNOP00000078278   ⟸   ENSRNOT00000116844
RefSeq Acc Id: ENSRNOP00000084375   ⟸   ENSRNOT00000098789
Protein Domains
MGS-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35567-F1-model_v2 AlphaFold O35567 1-592 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696733
Promoter ID:EPDNEW_R7257
Type:initiation region
Name:Atic_1
Description:5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMPcyclohydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0978,862,039 - 78,862,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70879 AgrOrtholog
BioCyc Gene G2FUF-27251 BioCyc
Ensembl Genes ENSRNOG00000015511 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010094 UniProtKB/Swiss-Prot
  ENSRNOG00060023906 UniProtKB/Swiss-Prot
  ENSRNOG00065008770 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021105.5 UniProtKB/TrEMBL
  ENSRNOT00000098789.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116844 ENTREZGENE
  ENSRNOT00000116844.1 UniProtKB/Swiss-Prot
  ENSRNOT00055017055 UniProtKB/Swiss-Prot
  ENSRNOT00060041758 UniProtKB/Swiss-Prot
  ENSRNOT00065013989 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096880 IMAGE-MGC_LOAD
InterPro AICAR_Tfase_dup_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AICAR_Tfase_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PurH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81643 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91657 IMAGE-MGC_LOAD
NCBI Gene 81643 ENTREZGENE
PANTHER BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11692 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AICARFT_IMPCHas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ATIC RGD
PhenoGen Atic PhenoGen
PIRSF AICARFT_IMPCHas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015511 RatGTEx
  ENSRNOG00055010094 RatGTEx
  ENSRNOG00060023906 RatGTEx
  ENSRNOG00065008770 RatGTEx
SMART AICARFT_IMPCHas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QB21 ENTREZGENE, UniProtKB/TrEMBL
  A6KFG3 ENTREZGENE, UniProtKB/TrEMBL
  O35567 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6IN16 ENTREZGENE
UniProt Secondary Q6IN16 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Atic  5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase  LOC100910688  bifunctional purine biosynthesis protein PURH-like  Data merged from RGD:6497544 737654 PROVISIONAL
2012-07-05 LOC100910688  bifunctional purine biosynthesis protein PURH-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Atic  5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase    5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP  Name updated 1299863 APPROVED
2002-07-09 Atic  5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 70804
gene_homology 84 and 91% identical to human gene at the nucleotide and amino acid sequence level, respectively. 70804
gene_protein contains 592 amino acids 70804
gene_regulation expression greatly induced at 24 h after partial (70%) hepatectomy 70804
gene_transcript mRNA 2.8 kb in size 70804