Cit (citron rho-interacting serine/threonine kinase) - Rat Genome Database

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Gene: Cit (citron rho-interacting serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Cit
Name: citron rho-interacting serine/threonine kinase
RGD ID: 70878
Description: Enables scaffold protein binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; gamma-aminobutyric acid signaling pathway; and postsynapse organization. Located in several cellular components, including GABA-ergic synapse; cleavage furrow; and postsynaptic density. Used to study epilepsy and microcephaly. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: citron; citron (rho-interacting, serine/threonine kinase 21); citron kinase; citron Rho-interacting kinase; citron-K; citron-K kinase; CRIK; LOC288698; postsynaptic density protein (citron); rho-interacting, serine/threonine-protein kinase 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: CitfhJjlo
Genetic Models: WI-CitfhJjlo/Rrrc
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,263,881 - 46,425,642 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,266,369 - 46,424,656 (-)EnsemblGRCr8
mRatBN7.21240,603,073 - 40,764,846 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,605,563 - 40,763,860 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1241,778,820 - 41,938,342 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,392,543 - 42,552,063 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,453,005 - 41,612,527 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,334,669 - 46,494,152 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,334,665 - 46,494,174 (-)Ensemblrn6Rnor6.0
Rnor_5.01248,136,329 - 48,295,119 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,858,134 - 42,019,601 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,234,665 - 42,392,523 (-)NCBICelera
RGSC_v3.11241,721,050 - 41,801,648 (-)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lucanthone  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly. Basit S, etal., Hum Genet. 2016 Oct;135(10):1199-207. doi: 10.1007/s00439-016-1724-0. Epub 2016 Aug 12.
2. Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. Camera P, etal., Nat Cell Biol 2003 Dec;5(12):1071-8. Epub 2003 Nov 2.
3. Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Di Cunto F, etal., Neuron 2000 Oct;28(1):115-27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Citron Kinase Is a Cell Cycle-dependent, Nuclear Protein Required for G2/M Transition of Hepatocytes. Liu H, etal., J Biol Chem 2003 Jan 24;278(4):2541-2548.
6. Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes. Liu H, etal., J Biol Chem 2003 Jan 24;278(4):2541-8.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. ASPM and citron kinase co-localize to the midbody ring during cytokinesis. Paramasivam M, etal., Cell Cycle. 2007 Jul 1;6(13):1605-12. Epub 2007 Apr 27.
11. Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis. Raghavendra Rao VL, etal., J Neurosci Res. 2003 Jan 15;71(2):208-19.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Information Derived from GenBank Report RGD, Sept. 2003
16. Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. Sarkisian MR, etal., Epilepsia. 1999 Apr;40(4):394-400.
17. Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat. Sarkisian MR, etal., J Neurosci. 2002 Apr 15;22(8):RC217. Epub 2002 Apr 2.
18. Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans. Shaheen R, etal., Hum Genet. 2016 Oct;135(10):1191-7. doi: 10.1007/s00439-016-1722-2. Epub 2016 Aug 8.
19. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. Zhang W, etal., J Neurosci 1999 Jan 1;19(1):96-108.
Additional References at PubMed
PMID:9697773   PMID:9792683   PMID:12432070   PMID:12764032   PMID:12781320   PMID:16202622   PMID:16236794   PMID:16431929   PMID:17148954   PMID:17474715   PMID:17488780   PMID:18309323  
PMID:19790105   PMID:19946888   PMID:20525772   PMID:20971191   PMID:25593024   PMID:27453578  


Genomics

Comparative Map Data
Cit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,263,881 - 46,425,642 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,266,369 - 46,424,656 (-)EnsemblGRCr8
mRatBN7.21240,603,073 - 40,764,846 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,605,563 - 40,763,860 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1241,778,820 - 41,938,342 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,392,543 - 42,552,063 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,453,005 - 41,612,527 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,334,669 - 46,494,152 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,334,665 - 46,494,174 (-)Ensemblrn6Rnor6.0
Rnor_5.01248,136,329 - 48,295,119 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,858,134 - 42,019,601 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,234,665 - 42,392,523 (-)NCBICelera
RGSC_v3.11241,721,050 - 41,801,648 (-)NCBI
Cytogenetic Map12q16NCBI
CIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812119,685,791 - 119,877,320 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12119,685,791 - 119,877,332 (-)Ensemblhg38GRCh38
GRCh3712120,123,596 - 120,315,124 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612118,607,981 - 118,799,475 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3412118,586,317 - 118,777,812NCBI
Celera12119,756,651 - 119,948,207 (-)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12117,131,727 - 117,325,161 (-)NCBIHuRef
CHM1_112120,091,103 - 120,282,752 (-)NCBICHM1_1
T2T-CHM13v2.012119,673,075 - 119,864,647 (-)NCBIT2T-CHM13v2.0
Cit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,983,284 - 116,147,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,983,337 - 116,147,006 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385115,845,224 - 116,008,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,845,278 - 116,008,947 (+)Ensemblmm10GRCm38
MGSCv375116,295,665 - 116,456,352 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365116,106,655 - 116,267,342 (+)NCBIMGSCv36mm8
Celera5112,946,512 - 113,107,010 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
Cit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,704,964 - 11,872,419 (+)Ensembl
ChiLan1.0NW_00495545511,705,015 - 11,871,762 (+)NCBIChiLan1.0ChiLan1.0
CIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210127,751,423 - 127,942,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112127,747,802 - 127,939,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012117,264,627 - 117,456,069 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112120,641,747 - 120,832,511 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12120,641,747 - 120,832,511 (-)EnsemblpanPan2panpan1.1
CIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12615,721,500 - 15,885,133 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2615,723,690 - 15,884,343 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2615,726,097 - 15,891,228 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02615,988,829 - 16,154,093 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2615,989,170 - 16,153,050 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12615,958,883 - 16,123,644 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,027,058 - 16,192,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,068,008 - 16,233,213 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,492,141 - 146,649,860 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936668991,036 - 1,146,294 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936668991,043 - 1,146,578 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1433,009,877 - 33,196,286 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11433,009,828 - 33,195,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21434,987,299 - 35,141,860 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,026,809 - 115,220,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,025,045 - 115,219,356 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037129,885,578 - 130,080,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,750,283 - 13,915,715 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474713,749,126 - 13,918,222 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cit
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11637,825,537 - 37,983,944 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cit
549 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:113
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000041281, ENSRNOT00000057036
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
D12Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,684,742 - 40,684,904 (+)MAPPERmRatBN7.2
Rnor_6.01246,413,872 - 46,414,033NCBIRnor6.0
Rnor_5.01248,215,043 - 48,215,204UniSTSRnor5.0
RGSC_v3.41241,937,698 - 41,937,859UniSTSRGSC3.4
Celera1242,313,353 - 42,313,514UniSTS
Cytogenetic Map12q16UniSTS
RH131289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,684,880 - 40,685,083 (+)MAPPERmRatBN7.2
Rnor_6.01246,414,010 - 46,414,212NCBIRnor6.0
Rnor_5.01248,215,181 - 48,215,383UniSTSRnor5.0
RGSC_v3.41241,937,836 - 41,938,038UniSTSRGSC3.4
Celera1242,313,491 - 42,313,693UniSTS
Cytogenetic Map12q16UniSTS
G29083  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,641,796 - 40,641,911 (+)MAPPERmRatBN7.2
Rnor_6.01246,370,930 - 46,371,044NCBIRnor6.0
Rnor_5.01248,172,101 - 48,172,215UniSTSRnor5.0
RGSC_v3.41241,894,755 - 41,894,869UniSTSRGSC3.4
Celera1242,270,857 - 42,270,971UniSTS
Cytogenetic Map12q16UniSTS


Genetic Models
This gene Cit is modified in the following models/strains:
WI-CitfhJjlo/Rrrc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001029911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF039218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041281   ⟹   ENSRNOP00000043901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,266,369 - 46,424,656 (-)Ensembl
mRatBN7.2 Ensembl1240,605,563 - 40,763,860 (-)Ensembl
Rnor_6.0 Ensembl1246,334,688 - 46,414,434 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000057036   ⟹   ENSRNOP00000053869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,266,369 - 46,424,656 (-)Ensembl
mRatBN7.2 Ensembl1240,605,563 - 40,763,860 (-)Ensembl
Rnor_6.0 Ensembl1246,335,160 - 46,493,203 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086716   ⟹   ENSRNOP00000069808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,266,369 - 46,424,656 (-)Ensembl
mRatBN7.2 Ensembl1240,605,563 - 40,763,860 (-)Ensembl
Rnor_6.0 Ensembl1246,334,665 - 46,494,174 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118447   ⟹   ENSRNOP00000077575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,266,369 - 46,424,656 (-)Ensembl
mRatBN7.2 Ensembl1240,605,563 - 40,763,860 (-)Ensembl
RefSeq Acc Id: NM_001029911   ⟹   NP_001025082
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,266,369 - 46,424,656 (-)NCBI
mRatBN7.21240,605,563 - 40,763,860 (-)NCBI
Rnor_6.01246,335,160 - 46,493,203 (-)NCBI
Rnor_5.01248,136,329 - 48,295,119 (-)NCBI
RGSC_v3.41241,858,134 - 42,019,601 (-)RGD
Celera1242,234,665 - 42,392,523 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249469   ⟹   XP_006249531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
Rnor_6.01246,334,669 - 46,494,152 (-)NCBI
Rnor_5.01248,136,329 - 48,295,119 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249471   ⟹   XP_006249533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
Rnor_6.01246,334,669 - 46,494,152 (-)NCBI
Rnor_5.01248,136,329 - 48,295,119 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249472   ⟹   XP_006249534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
Rnor_6.01246,334,669 - 46,494,152 (-)NCBI
Rnor_5.01248,136,329 - 48,295,119 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769269   ⟹   XP_008767491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
Rnor_6.01246,334,669 - 46,494,152 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089818   ⟹   XP_038945746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089819   ⟹   XP_038945747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,570 (-)NCBI
mRatBN7.21240,603,073 - 40,764,805 (-)NCBI
RefSeq Acc Id: XM_039089820   ⟹   XP_038945748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089821   ⟹   XP_038945749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089822   ⟹   XP_038945750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089823   ⟹   XP_038945751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089824   ⟹   XP_038945752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089825   ⟹   XP_038945753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089826   ⟹   XP_038945754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
mRatBN7.21240,603,073 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089829   ⟹   XP_038945757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,363,223 (-)NCBI
mRatBN7.21240,603,073 - 40,702,541 (-)NCBI
RefSeq Acc Id: XM_039089830   ⟹   XP_038945758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,383,983 (-)NCBI
mRatBN7.21240,603,073 - 40,723,296 (-)NCBI
RefSeq Acc Id: XM_039089831   ⟹   XP_038945759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,345,638 (-)NCBI
mRatBN7.21240,603,073 - 40,684,840 (-)NCBI
RefSeq Acc Id: XM_039089832   ⟹   XP_038945760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,345,575 (-)NCBI
mRatBN7.21240,603,073 - 40,684,774 (-)NCBI
RefSeq Acc Id: XM_039089834   ⟹   XP_038945762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,285,111 - 46,425,642 (-)NCBI
mRatBN7.21240,624,947 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_039089835   ⟹   XP_038945763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,328,704 (-)NCBI
mRatBN7.21240,603,073 - 40,667,924 (-)NCBI
RefSeq Acc Id: XM_039089836   ⟹   XP_038945764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,293,206 - 46,425,642 (-)NCBI
mRatBN7.21240,633,778 - 40,764,846 (-)NCBI
RefSeq Acc Id: XM_063271705   ⟹   XP_063127775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
RefSeq Acc Id: XM_063271706   ⟹   XP_063127776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
RefSeq Acc Id: XM_063271707   ⟹   XP_063127777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,425,642 (-)NCBI
RefSeq Acc Id: XM_063271709   ⟹   XP_063127779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,345,595 (-)NCBI
RefSeq Acc Id: XM_063271711   ⟹   XP_063127781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,345,638 (-)NCBI
RefSeq Acc Id: XM_063271712   ⟹   XP_063127782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,263,881 - 46,318,945 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001025082 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249531 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249533 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249534 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767491 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945746 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945747 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945748 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945749 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945750 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945751 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945752 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945753 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945754 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945757 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945758 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945759 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945760 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945762 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945763 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945764 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127775 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127776 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127777 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127779 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127781 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127782 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC25483 (Get FASTA)   NCBI Sequence Viewer  
  AAC27932 (Get FASTA)   NCBI Sequence Viewer  
  E9PSL7 (Get FASTA)   NCBI Sequence Viewer  
  EDM13856 (Get FASTA)   NCBI Sequence Viewer  
  EDM13857 (Get FASTA)   NCBI Sequence Viewer  
  EDM13858 (Get FASTA)   NCBI Sequence Viewer  
  EDM13859 (Get FASTA)   NCBI Sequence Viewer  
  EDM13860 (Get FASTA)   NCBI Sequence Viewer  
  EDM13861 (Get FASTA)   NCBI Sequence Viewer  
  EDM13862 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053869
  ENSRNOP00000069808
  ENSRNOP00000069808.1
  ENSRNOP00000077575
RefSeq Acc Id: NP_001025082   ⟸   NM_001029911
- UniProtKB: A0A0G2JWA9 (UniProtKB/Swiss-Prot),   Q9QX19 (UniProtKB/Swiss-Prot),   E9PSL7 (UniProtKB/TrEMBL),   A0A8L2QNW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249534   ⟸   XM_006249472
- Peptide Label: isoform X12
- UniProtKB: A0A0G2JWA9 (UniProtKB/Swiss-Prot),   Q9QX19 (UniProtKB/Swiss-Prot),   E9PSL7 (UniProtKB/TrEMBL),   A0A8L2QNW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249533   ⟸   XM_006249471
- Peptide Label: isoform X11
- UniProtKB: A0A8L2QQI1 (UniProtKB/TrEMBL),   A0A8L2QNW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249531   ⟸   XM_006249469
- Peptide Label: isoform X7
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767491   ⟸   XM_008769269
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043901   ⟸   ENSRNOT00000041281
Ensembl Acc Id: ENSRNOP00000053869   ⟸   ENSRNOT00000057036
Ensembl Acc Id: ENSRNOP00000069808   ⟸   ENSRNOT00000086716
RefSeq Acc Id: XP_038945754   ⟸   XM_039089826
- Peptide Label: isoform X15
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945753   ⟸   XM_039089825
- Peptide Label: isoform X14
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945752   ⟸   XM_039089824
- Peptide Label: isoform X13
- UniProtKB: A0A8I5YCF2 (UniProtKB/TrEMBL),   A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945751   ⟸   XM_039089823
- Peptide Label: isoform X10
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945749   ⟸   XM_039089821
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945750   ⟸   XM_039089822
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945748   ⟸   XM_039089820
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945746   ⟸   XM_039089818
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945747   ⟸   XM_039089819
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945758   ⟸   XM_039089830
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038945757   ⟸   XM_039089829
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038945759   ⟸   XM_039089831
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038945760   ⟸   XM_039089832
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038945763   ⟸   XM_039089835
- Peptide Label: isoform X21
RefSeq Acc Id: XP_038945762   ⟸   XM_039089834
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038945764   ⟸   XM_039089836
- Peptide Label: isoform X22
Ensembl Acc Id: ENSRNOP00000077575   ⟸   ENSRNOT00000118447
RefSeq Acc Id: XP_063127777   ⟸   XM_063271707
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127776   ⟸   XM_063271706
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127775   ⟸   XM_063271705
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QNW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127781   ⟸   XM_063271711
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063127779   ⟸   XM_063271709
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063127782   ⟸   XM_063271712
- Peptide Label: isoform X23
- UniProtKB: A6J1R9 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   CNH   PH   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSL7-F1-model_v2 AlphaFold E9PSL7 1-2055 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698691
Promoter ID:EPDNEW_R9208
Type:multiple initiation site
Name:Cit_1
Description:citron rho-interacting serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01246,494,132 - 46,494,192EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70878 AgrOrtholog
BioCyc Gene G2FUF-19025 BioCyc
Ensembl Genes ENSRNOG00000001143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057036 ENTREZGENE
  ENSRNOT00000086716 ENTREZGENE
  ENSRNOT00000086716.2 UniProtKB/Swiss-Prot
  ENSRNOT00000118447 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  1.20.5.340 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  Citron_Rho-interacting_kinase UniProtKB/Swiss-Prot
  CNH_dom UniProtKB/Swiss-Prot
  CRIK_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Rho-assoc_Ser/Thr_Kinase UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:83620 UniProtKB/Swiss-Prot
NCBI Gene 83620 ENTREZGENE
PANTHER CITRON RHO-INTERACTING KINASE UniProtKB/Swiss-Prot
  MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/Swiss-Prot
Pfam CNH UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Cit PhenoGen
PIRSF Citron_Rho-interacting_kinase UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  CNH UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001143 RatGTEx
SMART CNH UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt A0A0G2JWA9 ENTREZGENE
  A0A8I5YCF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QNW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QQI1 ENTREZGENE, UniProtKB/TrEMBL
  A6J1R9 ENTREZGENE, UniProtKB/TrEMBL
  A6J1S2_RAT UniProtKB/TrEMBL
  CTRO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QX19 ENTREZGENE
UniProt Secondary A0A0G2JWA9 UniProtKB/Swiss-Prot
  Q9QX19 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-01 Cit  citron rho-interacting serine/threonine kinase  Cit  citron  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-04-30 Cit  citron  Cit  citron (rho-interacting, serine/threonine kinase 21)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Cit  citron (rho-interacting, serine/threonine kinase 21)  LOC288698  Citron-K kinase  Data merged from RGD:735091 737654 PROVISIONAL
2012-01-09 Cit  citron (rho-interacting, serine/threonine kinase 21)  Cit  citron  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Cit  citron  Cit  citron (rho-interacting, serine/threonine kinase 21)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Cit  citron (rho-interacting, serine/threonine kinase 21)  Cit  citron  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cit  citron      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to interphase nuclei and the cytoplasm 632407
gene_cellular_localization present in interphase nuclei dispersing into cytoplasm at prophase 628497
gene_expression expression starts at late S and/or early G2 phase; high expression in embryonic liver and gradually decreases after birth 628497
gene_function serine/thronine kinase 628497
gene_function phosphorylates regultory myosin light chain (RMLC) 628497
gene_mutations_overexpression loss of protein results in increase of G2 tetraploid nuclei in one week old rat 628497
gene_process cell cycle dependent protein regulating G2/M transition in hepatocytes 628497
gene_process participates in cytokinesis control as a downstream target of Rho-GTPase and may function in regulation of G2/M transition 628497