Strain Report - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Strain: WI-CitfhJjlo/Rrrc

Symbol: WI-CitfhJjlo/Rrrc
Strain: WI-Citfh
Substrain: JjloRrrc
Full Name: flathead rat
RGD ID: 6482243
Citation ID: RRID:RRRC_00322
Ontology ID: RS:0003222
Alleles: CitfhJjlo
Also Known As: WI-CitfhJjloRrrc; WI-Citfh/JjloRrrc; WI-Cit^[fhJjlo]/Rrrc
Type: mutant
Available Source: Rat Resource and Research Center
Origination: Department of Physiology and Neurobiology, University of Connecticut
Description: Flathead rat was discovered at University of Connecticut in an inbred colony of Wistar rats. Spontaneous single G deletion in exon 1 of citron kinase (Cit) confers a premature stop codon and lack of citron kinase protein.
Coat Color: Albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2017-07-21)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,763,699 - 40,763,699RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01246,493,042 - 46,493,042RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01248,136,329 - 48,295,119RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41241,858,134 - 42,019,601RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
epilepsy  (IAGP)
microcephaly  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A gene essential to brain growth and development maps to the distal arm of rat chromosome 12. Cogswell CA, etal., Neurosci Lett. 1998 Jul 17;251(1):5-8.
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. Sarkisian MR, etal., Epilepsia. 1999 Apr;40(4):394-400.
5. Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat. Sarkisian MR, etal., J Neurosci. 2002 Apr 15;22(8):RC217. Epub 2002 Apr 2.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
CitfhJjlo-var1 chr12 40763699 40763699 C - deletion mRatBN7.2
CitfhJjlo-var1 chr12 46493042 46493042 C - deletion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Heterozygotes are phenotypically normal. Homozygotes have severe microcephaly and spontaneous seizures and die by post-natal day 25. 2292495
strain_other Spontaneous single G deletion in exon 1 of citron kinase (Cit). Confers a premature stop codon and lack of citron kinase protein. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-30 WI-CitfhJjlo/Rrrc  flathead rat  WI-Citfh/JjloRrrc  flathead rat  Symbol updated 68687 APPROVED
2018-07-30 WI-Citfh/JjloRrrc  flathead rat  WI-CitfhJjloRrrc  flathead rat  Symbol updated 68687 APPROVED
2018-05-01 WI-CitfhJjloRrrc  flathead rat  WI-CitfhJjlo/Rrrc  flathead rat  Symbol updated 68687 APPROVED
2017-07-21 WI-CitfhJjlo/Rrrc  flathead rat  WI-CitfhJjlo/Rrrc  flathead rat  Symbol updated 68687 APPROVED
2017-07-21 WI-CitfhJjlo/Rrrc  flathead rat  WI-CitfhJjloRrrc  flathead rat  Symbol updated 68687 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00322 RGD