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Gene: Asic3 (acid sensing ion channel subunit 3) Rattus norvegicus

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Symbol:

Asic3

Name:

acid sensing ion channel subunit 3

RGD ID:

708578

Description:

Enables pH-gated calcium channel activity and pH-gated sodium channel activity. Involved in detection of chemical stimulus involved in sensory perception of pain; membrane depolarization; and monoatomic ion transmembrane transport. Acts upstream of or within response to acidic pH and sodium ion transport. Located in perinuclear region of cytoplasm. Is active in plasma membrane. Orthologous to human ASIC3 (acid sensing ion channel subunit 3); INTERACTS WITH acetylsalicylic acid; ammonium chloride; ATP.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Accn3; acid sensing ion channel 3; acid-sensing (proton-gated) ion channel 3; acid-sensing ion channel 3; amiloride-sensitive cation channel 3; dorsal root ASIC; DRASIC; proton gated cation channel DRASIC

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ASIC3 (acid sensing ion channel subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Asic3 (acid-sensing ion channel 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Asic3 (acid-sensing ion channel 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ASIC3 (acid sensing ion channel subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	asic1c (acid-sensing (proton-gated) ion channel 1c)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	asic1b (acid-sensing (proton-gated) ion channel 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Danio rerio (zebrafish):	asic1b (acid-sensing (proton-gated) ion channel 1b)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acd-1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-4	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-5	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	delm-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	delm-2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	flr-1	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	ppk	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk11	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	ppk13	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk12	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk12	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk28	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk28	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk23	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk24	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	delm-1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	delm-1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	ppk8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk16	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk16	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Nach	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Nach	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	ppk17	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk21	Alliance	DIOPT (OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk29	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk18	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk18	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC116411522	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)

Allele / Splice:

Asic3^em6Mcwi

Genetic Models:

WKY-Asic3^em6Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,652,946 - 11,657,415 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	11,652,946 - 11,657,367 (-)	Ensembl				GRCr8
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	15,906,873 - 15,910,919 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,727,066 - 11,731,112 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	10,078,850 - 10,082,896 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	7,287,868 - 7,293,295 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	7,288,855 - 7,292,901 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	7,300,219 - 7,304,265 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	6,125,614 - 6,129,660 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	6,375,165 - 6,379,211 (-)	NCBI		Celera
RGSC_v3.1	4	6,125,613 - 6,129,660 (-)	NCBI
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Inflammation (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

acetylsalicylic acid (EXP)

acrylamide (ISO)

aldehydo-D-glucose (ISO)

amiloride (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

ATP (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (EXP)

diclofenac (EXP)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

glucose (ISO)

ibuprofen (EXP)

lovastatin (ISO)

methamphetamine (EXP)

methoxychlor (EXP)

Muraglitazar (EXP)

paracetamol (ISO)

paraquat (EXP)

procymidone (EXP)

S-nitrosoglutathione (ISO)

salicylic acid (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

tetramethylpyrazine (ISO)

thiram (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

troglitazone (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

detection of chemical stimulus involved in sensory perception (ISO)

detection of chemical stimulus involved in sensory perception of pain (IDA,ISO)

detection of mechanical stimulus involved in sensory perception (ISO)

detection of mechanical stimulus involved in sensory perception of pain (ISO)

detection of temperature stimulus involved in sensory perception (ISO)

detection of temperature stimulus involved in sensory perception of pain (ISO)

membrane depolarization (IDA,ISO)

monoatomic cation transport (ISO)

monoatomic ion transmembrane transport (IDA,IEA,ISO)

monoatomic ion transport (IEA)

response to acidic pH (IDA,ISO)

response to heat (ISO)

response to mechanical stimulus (ISO)

sensory perception of sour taste (ISO)

sodium ion transmembrane transport (IBA,IEA)

sodium ion transport (IDA,IEA,IMP)

Cellular Component

cytoplasm (IEA)

membrane (IEA)

perinuclear region of cytoplasm (IDA)

plasma membrane (IBA,IDA,IEA,ISO)

Molecular Function

ligand-gated monoatomic ion channel activity (IEA)

ligand-gated sodium channel activity (IDA,IEA,IMP)

monoatomic cation channel activity (ISO)

monoatomic ion-gated channel activity (ISO)

pH-gated calcium channel activity (IDA)

pH-gated monoatomic ion channel activity (ISO)

pH-gated sodium channel activity (IBA,IDA,ISO)

protein binding (IPI,ISO)

sodium channel activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons.	Anzai N, etal., J Biol Chem. 2002 May 10;277(19):16655-61. Epub 2002 Feb 28.
2.	Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+.	Babinski K, etal., J Biol Chem. 2000 Sep 15;275(37):28519-25. doi: 10.1074/jbc.M004114200.
3.	A stomatin dimer modulates the activity of acid-sensing ion channels.	Brand J, etal., EMBO J. 2012 Aug 29;31(17):3635-46. doi: 10.1038/emboj.2012.203. Epub 2012 Jul 31.
4.	Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1.	Deval E, etal., J Biol Chem. 2006 Jan 20;281(3):1796-807. Epub 2005 Oct 17.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons.	Sutherland SP, etal., Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):711-6. doi: 10.1073/pnas.98.2.711. Epub 2000 Dec 19.
10.	Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton.	Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
11.	Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.	Waldmann R, etal., J Biol Chem 1997 Aug 22;272(34):20975-8.
12.	A stomatin-domain protein essential for touch sensation in the mouse.	Wetzel C, etal., Nature. 2007 Jan 11;445(7124):206-9. Epub 2006 Dec 13.

Additional References at PubMed

PMID:9368048	PMID:9707631	PMID:10187795	PMID:11528414	PMID:11587714	PMID:11588175	PMID:11754838	PMID:11842212	PMID:11854527	PMID:12060708	PMID:12486159	PMID:12526774
PMID:12668052	PMID:14522957	PMID:14976185	PMID:15044953	PMID:15317815	PMID:15452199	PMID:16085050	PMID:16305749	PMID:16319075	PMID:16510130	PMID:17389250	PMID:17696763
PMID:17872465	PMID:17936312	PMID:18466073	PMID:18579798	PMID:18923424	PMID:19339181	PMID:19356693	PMID:19590043	PMID:19812697	PMID:20019330	PMID:20206612	PMID:20501405
PMID:20860671	PMID:20924599	PMID:21078372	PMID:21143836	PMID:21508231	PMID:21998313	PMID:22842475	PMID:23135698	PMID:23808707	PMID:24942880	PMID:25006846	PMID:25377529
PMID:26823770	PMID:28765874	PMID:29636447	PMID:29736613	PMID:29802295	PMID:30209688	PMID:31314951	PMID:31347922	PMID:31565832	PMID:32012213	PMID:32302492	PMID:32592826
PMID:32887365	PMID:33280501	PMID:34088898	PMID:34918385	PMID:37604935

Genomics

Comparative Map Data

Asic3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,652,946 - 11,657,415 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	11,652,946 - 11,657,367 (-)	Ensembl				GRCr8
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	15,906,873 - 15,910,919 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,727,066 - 11,731,112 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	10,078,850 - 10,082,896 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	7,287,868 - 7,293,295 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	7,288,855 - 7,292,901 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	7,300,219 - 7,304,265 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	6,125,614 - 6,129,660 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	6,375,165 - 6,379,211 (-)	NCBI		Celera
RGSC_v3.1	4	6,125,613 - 6,129,660 (-)	NCBI
Cytogenetic Map	4	q11	NCBI

ASIC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	151,048,292 - 151,052,756 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	151,048,292 - 151,052,756 (+)	Ensembl			hg38	GRCh38
GRCh37	7	150,745,379 - 150,749,843 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,376,885 - 150,380,774 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	150,183,609 - 150,187,488	NCBI
Celera	7	145,302,914 - 145,307,152 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,557,715 - 144,562,179 (+)	NCBI		HuRef
CHM1_1	7	150,753,727 - 150,758,191 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	152,221,380 - 152,225,844 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	150,074,918 - 150,079,382 (+)	NCBI

Asic3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	24,618,449 - 24,622,836 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	24,618,390 - 24,622,833 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	24,413,451 - 24,417,840 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	24,413,392 - 24,417,835 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	23,919,269 - 23,923,652 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	23,923,516 - 23,927,899 (+)	NCBI		MGSCv36	mm8
Celera	5	21,363,200 - 21,367,641 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	11.72	NCBI

Asic3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,488,249 - 5,491,447 (+)	Ensembl
ChiLan1.0	NW_004955491	5,487,788 - 5,491,562 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASIC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,467,618 - 187,474,669 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,478,716 - 39,485,845 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,633,357 - 142,639,571 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,786,835 - 154,792,289 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	154,786,835 - 154,792,289 (+)	Ensembl			panPan2	panpan1.1

ASIC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	15,099,023 - 15,104,088 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	15,099,883 - 15,104,080 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,706,096 - 15,712,334 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,820,077 - 16,826,314 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	16,822,357 - 16,826,307 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	15,192,516 - 15,198,753 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,775,203 - 15,780,207 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,824,677 - 15,830,914 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Asic3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,424,673 - 6,428,461 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,474,995 - 6,478,711 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,473,305 - 6,478,756 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASIC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,172,471 - 6,180,440 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	6,172,410 - 6,180,440 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,542,445 - 6,547,297 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ASIC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	119,226,940 - 119,234,626 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	119,230,796 - 119,234,696 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666072	15,198,711 - 15,205,127 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Asic3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,567,541 - 5,570,851 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624800	5,567,516 - 5,571,292 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Asic3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	153,606,240 - 153,610,595 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Asic3
20 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	40
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000011300
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	32668025	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	28392287	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	32668025	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	34142783	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	34142783	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	31106810	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	28392287	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	32668025	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	28392287	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	40471598	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	8428551	30449094	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	33538816	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	32668025	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10758701	40490708	Rat

Markers in Region

RH133078

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,766,311 - 10,766,495 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	7,294,570 - 7,294,753	NCBI	Rnor6.0
Rnor_5.0	4	7,305,934 - 7,306,117	UniSTS	Rnor5.0
RGSC_v3.4	4	6,131,329 - 6,131,512	UniSTS	RGSC3.4
Celera	4	6,380,880 - 6,381,063	UniSTS
Cytogenetic Map	4	q11	UniSTS

Genetic Models

This gene Asic3 is modified in the following models/strains:

WKY-Asic3^em6Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	6	33	132	40	39	8	72	8	4	208	131	6	110	53	66	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF013598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF527175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ815093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011300 ⟹ ENSRNOP00000011300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	11,652,946 - 11,657,367 (-)	Ensembl
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl
Rnor_6.0 Ensembl	4	7,288,855 - 7,292,901 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110269 ⟹ ENSRNOP00000080943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	11,652,946 - 11,657,367 (-)	Ensembl
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165465 ⟹ ENSRNOP00000107682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	11,652,979 - 11,657,367 (-)	Ensembl

RefSeq Acc Id:

NM_173135 ⟹ NP_775158

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,367 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,930 (-)	NCBI
Rnor_6.0	4	7,288,855 - 7,292,901 (-)	NCBI
Rnor_5.0	4	7,300,219 - 7,304,265 (-)	NCBI
RGSC_v3.4	4	6,125,614 - 6,129,660 (-)	RGD
Celera	4	6,375,165 - 6,379,211 (-)	RGD

Sequence:

show sequence

ATGAAACCTCGCTCCGGACTGGAGGAGGCCCAGCGGCGACAGGCCTCAGACATCCGGGTGTTTG
CCAGCAGCTGCACAATGCATGGTCTGGGCCACATCTTTGGCCCTGGAGGCCTGACCCTGCGCCG
AGGGCTGTGGGCCACAGCTGTGCTCCTGTCGCTGGCGGCCTTCCTCTACCAGGTGGCTGAGCGG
GTTCGCTACTATGGGGAGTTCCACCATAAGACCACCCTGGATGAGCGTGAGAGCCACCAGCTCA
CCTTCCCAGCTGTGACTCTGTGTAATATCAACCCACTGCGCCGCTCACGCCTCACACCCAATGA
CTTGCACTGGGCTGGAACAGCGCTGCTGGGCCTGGACCCTGCTGAACATGCTGCCTACCTTCGT
GCACTGGGCCAGCCCCCCGCACCACCTGGCTTCATGCCCAGTCCGACCTTTGACATGGCACAAC
TCTACGCCAGAGCCGGCCACTCCCTTGAGGACATGTTGTTGGATTGCCGATACCGTGGCCAGCC
CTGTGGGCCTGAGAACTTCACAGTGATCTTTACTCGAATGGGGCAATGCTACACCTTCAACTCT
GGTGCCCACGGTGCAGAGCTGCTCACCACTCCAAAGGGTGGTGCTGGCAACGGACTGGAGATTA
TGCTAGATGTACAGCAAGAGGAGTATCTGCCCATCTGGAAGGACATGGAAGAGACCCCGTTTGA
GGTGGGGATCCGAGTGCAGATTCACAGCCAGGATGAGCCCCCTGCCATTGACCAGCTGGGCTTC
GGGGCAGCCCCAGGCCATCAGACTTTTGTGTCCTGTCAGCAGCAGCAACTGAGTTTCCTGCCAC
CACCCTGGGGTGACTGCAATACCGCATCTTTGGATCCCGACGACTTTGATCCAGAGCCCTCTGA
TCCCTTGGGTTCCCCCAGACCCAGACCCAGCCCTCCTTATAGTTTAATAGGTTGTCGCCTGGCC
TGTGAGTCTCGCTATGTGGCTCGGAAGTGTGGCTGTCGAATGATGCATATGCCTGGAAACTCCC
CAGTGTGCAGCCCCCAGCAGTACAAGGACTGCGCCAGCCCAGCTCTGGACGCTATGCTGCGAAA
GGACACGTGTGTCTGCCCCAACCCGTGCGCTACTACACGCTATGCCAAGGAGCTCTCCATGGTG
CGGATTCCCAGCCGCGCGTCAGCTCGCTACCTGGCCCGGAAATACAACCGCAGCGAGTCCTACA
TTACGGAGAATGTACTGGTTCTGGATATCTTCTTTGAGGCCCTCAACTATGAAGCGGTGGAACA
AAAGGCGGCCTATGAAGTGTCGGAGCTGCTGGGAGACATTGGGGGACAGATGGGACTGTTTATT
GGAGCAAGCCTGCTTACCATCCTTGAGATCCTCGACTATCTCTGTGAGGTTTTCCAAGACAGAG
TCCTGGGGTATTTCTGGAACAGAAGGAGCGCTCAAAAGCGCTCTGGCAACACTCTGCTCCAGGA
AGAGTTGAATGGCCATCGAACACATGTTCCCCACCTCAGCCTAGGGCCCAGGCCTCCTACCACT
CCCTGTGCTGTCACCAAGACACTCTCTGCCTCCCACCGTACCTGTTACCTCGTCACAAGGCTCT
AG

hide sequence

RefSeq Acc Id:

XM_008762632 ⟹ XP_008760854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI
Rnor_6.0	4	7,287,868 - 7,293,292 (-)	NCBI

Sequence:

show sequence

GACCTTCCCTACCCCCCCAGACTGCTCTGCTGCCCCCCAGCCCCCCTCGTGCTGAAACCTAATC
CTCTGCCGCAGCTCTAGCTCAGTGCTGCTCCGCAGCCCCTGCCTGCTGCTACATCCCGTGCCCT
ACTCGGTCTTCACTGCAGAGACCCAGCCCCACGGAGCCAACGCCTGTTCTGGGGAAGGCAGAAC
TGGACCGAAGTTCAACTCATCCAGTCCTAGCAGGCCAGTACTTTCACCTCTGTCTTGGCTCCTC
CCTTCTCTCCCTTCTTCTCCTTTTCTTTCCTCCCTAGTCCTTGCTACTTGAGTCCCATCTCCAT
CCCCACCACTACCCTGCTAGCCCTACAAAACAGCTTCCCCAGTCAGCAACTCCCCGGTCCCTGG
TCCAGCCATGAAACCTCGCTCCGGACTGGAGGAGGCCCAGCGGCGACAGGCCTCAGACATCCGG
GTGTTTGCCAGCAGCTGCACAATGCATGGTCTGGGCCACATCTTTGGCCCTGGAGGCCTGACCC
TGCGCCGAGGGCTGTGGGCCACAGCTGTGCTCCTGTCGCTGGCGGCCTTCCTCTACCAGGTGGC
TGAGCGGGTTCGCTACTATGGGGAGTTCCACCATAAGACCACCCTGGATGAGCGTGAGAGCCAC
CAGCTCACCTTCCCAGCTGTGACTCTGTGTAATATCAACCCACTGCGCCGCTCACGCCTCACAC
CCAATGACTTGCACTGGGCTGGAACAGCGCTGCTGGGCCTGGACCCTGCTGAACATGCTGCCTA
CCTTCGTGCACTGGGCCAGCCCCCCGCACCACCTGGCTTCATGCCCAGTCCGACCTTTGACATG
GCACAACTCTACGCCAGAGCCGGCCACTCCCTTGAGGACATGTTGTTGGATTGCCGATACCGTG
GCCAGCCCTGTGGGCCTGAGAACTTCACAGTGATCTTTACTCGAATGGGGCAATGCTACACCTT
CAACTCTGGTGCCCACGGTGCAGAGCTGCTCACCACTCCAAAGGGTGGTGCTGGCAACGGACTG
GAGATTATGCTAGATGTACAGCAAGAGGAGTATCTGCCCATCTGGAAGGACATGGAAGAGACCC
CGTTTGAGGTGGGGATCCGAGTGCAGATTCACAGCCAGGATGAGCCCCCTGCCATTGACCAGCT
GGGCTTCGGGGCAGCCCCAGGCCATCAGACTTTTGTGTCCTGTCAGCAGCAGCAACTGAGTTTC
CTGCCACCACCCTGGGGTGACTGCAATACCGCATCTTTGGATCCCGACGACTTTGATCCAGAGC
CCTCTGATCCCTTGGGTTCCCCCAGACCCAGACCCAGCCCTCCTTATAGTTTAATAGGTTGTCG
CCTGGCCTGTGAGTCTCGCTATGTGGCTCGGAAGTGTGGCTGTCGAATGATGCATATGCCTGGA
AACTCCCCAGTGTGCAGCCCCCAGCAGTACAAGGACTGCGCCAGCCCAGCTCTGGACGCTATGC
TGCGAAAGGACACGTGTGTCTGCCCCAACCCGTGCGCTACTACACGCTATGCCAAGGAGCTCTC
CATGGTGCGGATTCCCAGCCGCGCGTCAGCTCGCTACCTGGCCCGGAAATACAACCGCAGCGAG
TCCTACATTACGGAGAATGTACTGGTTCTGGATATCTTCTTTGAGGCCCTCAACTATGAAGCGG
TGGAACAAAAGGCGGCCTATGAAGTGTCGGAGCTGCTGGGAGACATTGGGGGACAGATGGGACT
GTTTATTGGAGCAAGCCTGCTTACCATCCTTGAGATCCTCGACTATCTCTGTGAGGTTTTCCAA
GACAGAGTCCTGGGGTATTTCTGGAACAGAAGGAGCGCTCAAAAGCGCTCTGGCAACACTCTGG
CCTCCTACCACTCCCTGTGCTGTCACCAAGACACTCTCTGCCTCCCACCGTACCTGTTACCTCG
TCACAAGGCTCTAGACCAGCTTGGCTGCACTGTGACATCTTGGACATGTCCAGCCTGTATATCT
TTGCTGTCTCCACCCTAATAAAGCTCTCGTACATGTGCCTCAGATGTCTACCTTACAGATCAGA
CACTACCACAGTCGATGAGAGCCCCCAGCCTCATCCATTCTCCCGCTGGGACCTGGATCCCAGT
TAGACTTAACAACTCATTTGAGGTGTGGGTGGGGCTAATTTTAAGACGAGATCAGTCAGGTGCA
CCCTAGTGTTAGTGAGCTTCTCAAAGATTTTCATTTAATTTTGTGTTTCTTGAGTAATGGGGAC
AGAACCTCGAGTCTGGAGGATGCCCACTGTTTGAATGTTTTCCCATGGAAGGGTATCCCCTTCA
CTCTGGTTCTTCTGAGGCAGGACCTCCAGCTGGGCTTGTACTATGCAGCCAAGGATGATCTTGA
ACTCCTAACCTCCCAAACATTGACATCATAGGCATATAGCACCATGGTTGGCTTCCCTTTTTAT
ATCTTGTTTATTTAGAAACAGTCTCACTAAGTTGTCCAGATTACCTTGAACTCACTCTGAAGCC
CACACTAGCCTTGCAGCACATCTGCCTCAGGCTTCTTGGTAGTTTGGAATACCGGCCAGTACCA
CTAGGCCCACCTCCAACAATGTCTAAGAAGGTAGTCTCTCCATGCCCAGAGCTTAGGTGATGGC
CCACAGGGGGCATGGTCAGGAGGTATTCACTGCACCAACAGTGGAGAGCTGGAACAAAGTTCTA
AGTAGCTCAGTGAGATGGTGGAAGTGGCAGGGTTACCCAAGAAACTAGTCCACGTGTAAGAACA
CCAATCAGCGTCCCGCCTTCAAAGGTTCTTGCCTTCCTGACCTCTCCACAGGAGCTGAGAGTGG
GCGGGAAAGAGCTTTCCCTTCCCCTTCCTGTCAAGAGGGCACCCCTGGAGATCTGCCTCAGCTC
CCCTTCCCTACGCTCACTGTACCCTAAGCCCTGGAAAAGTG

hide sequence

RefSeq Acc Id:

XM_017592496 ⟹ XP_017447985

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,413 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI
Rnor_6.0	4	7,287,868 - 7,293,295 (-)	NCBI

Sequence:

show sequence

AGGGACCTTCCCTACCCCCCCAGACTGCTCTGCTGCCCCCCAGCCCCCCTCGTGCTGAAACCTA
ATCCTCTGCCGCAGCTCTAGCTCAGTGCTGCTCCGCAGCCCCTGCCTGCTGCTACATCCCGTGC
CCTACTCGGTCTTCACTGCAGAGACCCAGCCCCACGGAGCCAACGCCTGTTCTGGGGAAGGCAG
AACTGGACCGAAGTTCAACTCATCCAGTCCTAGCAGGCCAGTACTTTCACCTCTGTCTTGGCTC
CTCCCTTCTCTCCCTTCTTCTCCTTTTCTTTCCTCCCTAGTCCTTGCTACTTGAGTCCCATCTC
CATCCCCACCACTACCCTGCTAGCCCTACAAAACAGCTTCCCCAGTCAGCAACTCCCCGGTCCC
TGGTCCAGCCATGAAACCTCGCTCCGGACTGGAGGAGGCCCAGCGGCGACAGGCCTCAGACATC
CGGGTGTTTGCCAGCAGCTGCACAATGCATGGTCTGGGCCACATCTTTGGCCCTGGAGGCCTGA
CCCTGCGCCGAGGGCTGTGGGCCACAGCTGTGCTCCTGTCGCTGGCGGCCTTCCTCTACCAGGT
GGCTGAGCGGGTTCGCTACTATGGGGAGTTCCACCATAAGACCACCCTGGATGAGCGTGAGAGC
CACCAGCTCACCTTCCCAGCTGTGACTCTGTGTAATATCAACCCACTGCGCCGCTCACGCCTCA
CACCCAATGACTTGCACTGGGCTGGAACAGCGCTGCTGGGCCTGGACCCTGCTGAACATGCTGC
CTACCTTCGTGCACTGGGCCAGCCCCCCGCACCACCTGGCTTCATGCCCAGTCCGACCTTTGAC
ATGGCACAACTCTACGCCAGAGCCGGCCACTCCCTTGAGGACATGTTGTTGGATTGCCGATACC
GTGGCCAGCCCTGTGGGCCTGAGAACTTCACAGTGATCTTTACTCGAATGGGGCAATGCTACAC
CTTCAACTCTGGTGCCCACGGTGCAGAGCTGCTCACCACTCCAAAGGGTGGTGCTGGCAACGGA
CTGGAGATTATGCTAGATGTACAGCAAGAGGAGTATCTGCCCATCTGGAAGGACATGGAAGAGA
CCCCGTTTGAGGTGGGGATCCGAGTGCAGATTCACAGCCAGGATGAGCCCCCTGCCATTGACCA
GCTGGGCTTCGGGGCAGCCCCAGGCCATCAGACTTTTGTGTCCTGTCAGCAGCAGCAACTGAGT
TTCCTGCCACCACCCTGGGGTGACTGCAATACCGCATCTTTGGATCCCGACGACTTTGATCCAG
AGCCCTCTGATCCCTTGGGTTCCCCCAGACCCAGACCCAGCCCTCCTTATAGTTTAATAGGTTG
TCGCCTGGCCTGTGAGTCTCGCTATGTGGCTCGGAAGTGTGGCTGTCGAATGATGCATATGCCT
GGAAACTCCCCAGTGTGCAGCCCCCAGCAGTACAAGGACTGCGCCAGCCCAGCTCTGGACGCTA
TGCTGCGAAAGGACACGTGTGTCTGCCCCAACCCGTGCGCTACTACACGCTATGCCAAGGAGCT
CTCCATGGTGCGGATTCCCAGCCGCGCGTCAGCTCGCTACCTGGCCCGGAAATACAACCGCAGC
GAGTCCTACATTACGGAGAATGTACTGGTTCTGGATATCTTCTTTGAGGCCCTCAACTATGAAG
CGGTGGAACAAAAGGCGGCCTATGAAGTGTCGGAGCTGCTGGGTGTGTACAGAGTGCCGGGGTC
TGCGAGGTGCAGACACGGTTTTCCAAGACAGAGTCCTGGGGTATTTCTGGAACAGAAGGAGCGC
TCAAAAGCGCTCTGGCAACACTCTGCTCCAGGAAGAGTTGAATGGCCATCGAACACATGTTCCC
CACCTCAGCCTAGGGCCCAGGCCTCCTACCACTCCCTGTGCTGTCACCAAGACACTCTCTGCCT
CCCACCGTACCTGTTACCTCGTCACAAGGCTCTAGACCAGCTTGGCTGCACTGTGACATCTTGG
ACATGTCCAGCCTGTATATCTTTGCTGTCTCCACCCTAATAAAGCTCTCGTACATGTGCCTCAG
ATGTCTACCTTACAGATCAGACACTACCACAGTCGATGAGAGCCCCCAGCCTCATCCATTCTCC
CGCTGGGACCTGGATCCCAGTTAGACTTAACAACTCATTTGAGGTGTGGGTGGGGCTAATTTTA
AGACGAGATCAGTCAGGTGCACCCTAGTGTTAGTGAGCTTCTCAAAGATTTTCATTTAATTTTG
TGTTTCTTGAGTAATGGGGACAGAACCTCGAGTCTGGAGGATGCCCACTGTTTGAATGTTTTCC
CATGGAAGGGTATCCCCTTCACTCTGGTTCTTCTGAGGCAGGACCTCCAGCTGGGCTTGTACTA
TGCAGCCAAGGATGATCTTGAACTCCTAACCTCCCAAACATTGACATCATAGGCATATAGCACC
ATGGTTGGCTTCCCTTTTTATATCTTGTTTATTTAGAAACAGTCTCACTAAGTTGTCCAGATTA
CCTTGAACTCACTCTGAAGCCCACACTAGCCTTGCAGCACATCTGCCTCAGGCTTCTTGGTAGT
TTGGAATACCGGCCAGTACCACTAGGCCCACCTCCAACAATGTCTAAGAAGGTAGTCTCTCCAT
GCCCAGAGCTTAGGTGATGGCCCACAGGGGGCATGGTCAGGAGGTATTCACTGCACCAACAGTG
GAGAGCTGGAACAAAGTTCTAAGTAGCTCAGTGAGATGGTGGAAGTGGCAGGGTTACCCAAGAA
ACTAGTCCACGTGTAAGAACACCAATCAGCGTCCCGCCTTCAAAGGTTCTTGCCTTCCTGACCT
CTCCACAGGAGCTGAGAGTGGGCGGGAAAGAGCTTTCCCTTCCCCTTCCTGTCAAGAGGGCACC
CCTGGAGATCTGCCTCAGCTCCCCTTCCCTACGCTCACTGTACCCTAAGCCCTGGAAAAGTG

hide sequence

RefSeq Acc Id:

XM_039107164 ⟹ XP_038963092

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI

RefSeq Acc Id:

XM_063285654 ⟹ XP_063141724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI

RefSeq Acc Id:

XM_063285655 ⟹ XP_063141725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI

RefSeq Acc Id:

XM_063285656 ⟹ XP_063141726

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,653,273 - 11,657,415 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_775158	(Get FASTA)	NCBI Sequence Viewer
	XP_008760854	(Get FASTA)	NCBI Sequence Viewer
	XP_017447985	(Get FASTA)	NCBI Sequence Viewer
	XP_038963092	(Get FASTA)	NCBI Sequence Viewer
	XP_063141724	(Get FASTA)	NCBI Sequence Viewer
	XP_063141725	(Get FASTA)	NCBI Sequence Viewer
	XP_063141726	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB69328	(Get FASTA)	NCBI Sequence Viewer
	AAN77135	(Get FASTA)	NCBI Sequence Viewer
	CAG30027	(Get FASTA)	NCBI Sequence Viewer
	EDL99368	(Get FASTA)	NCBI Sequence Viewer
	EDL99369	(Get FASTA)	NCBI Sequence Viewer
	EDL99370	(Get FASTA)	NCBI Sequence Viewer
	EDL99371	(Get FASTA)	NCBI Sequence Viewer
	EDL99372	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011300
	ENSRNOP00000011300.1
	ENSRNOP00000107682
GenBank Protein	O35240	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_775158 ⟸ NM_173135

- UniProtKB:

O35240 (UniProtKB/Swiss-Prot), A6K560 (UniProtKB/TrEMBL), A6K562 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAER
VRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLR
ALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNS
GAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGF
GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLA
CESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMV
RIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFI
GASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTT
PCAVTKTLSASHRTCYLVTRL

hide sequence

RefSeq Acc Id:	XP_008760854 ⟸ XM_008762632
- Peptide Label:	isoform X4
- UniProtKB:	A6K562 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAER VRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLR ALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNS GAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGF GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLA CESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMV RIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFI GASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLASYHSLCCHQDTLCLPPYLLPRHK ALDQLGCTVTSWTCPACISLLSPP hide sequence

RefSeq Acc Id:	XP_017447985 ⟸ XM_017592496
- Peptide Label:	isoform X3
- UniProtKB:	A6K559 (UniProtKB/TrEMBL), A6K562 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAER VRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLR ALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNS GAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGF GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLA CESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMV RIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGVYRVPGSARC RHGFPRQSPGVFLEQKERSKALWQHSAPGRVEWPSNTCSPPQPRAQASYHSLCCHQDTLCLPPY LLPRHKALDQLGCTVTSWTCPACISLLSPP hide sequence

Ensembl Acc Id:

ENSRNOP00000011300 ⟸ ENSRNOT00000011300

RefSeq Acc Id:	XP_038963092 ⟸ XM_039107164
- Peptide Label:	isoform X1
- UniProtKB:	A6K562 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000080943 ⟸ ENSRNOT00000110269

RefSeq Acc Id:	XP_063141725 ⟸ XM_063285655
- Peptide Label:	isoform X2
- UniProtKB:	A6K562 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063141724 ⟸ XM_063285654
- Peptide Label:	isoform X2
- UniProtKB:	A6K562 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063141726 ⟸ XM_063285656
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZRU8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000107682 ⟸ ENSRNOT00000165465

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35240-F1-model_v2	AlphaFold	O35240	1-533	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692791

Promoter ID:

EPDNEW_R3316

Type:

single initiation site

Name:

Asic3_1

Description:

acid sensing ion channel subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	7,292,964 - 7,293,024	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708578	AgrOrtholog
BioCyc Gene	G2FUF-46041	BioCyc
Ensembl Genes	ENSRNOG00000008380	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000011300	ENTREZGENE
	ENSRNOT00000011300.3	UniProtKB/Swiss-Prot
	ENSRNOT00000165465	ENTREZGENE
Gene3D-CATH	acid-sensing ion channel 1 domain	UniProtKB/Swiss-Prot
	Acid-sensing ion channel domain	UniProtKB/Swiss-Prot
	YojJ-like	UniProtKB/Swiss-Prot
InterPro	ENaC	UniProtKB/Swiss-Prot
	ENaC_chordates	UniProtKB/Swiss-Prot
	ENaC_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:286920	UniProtKB/Swiss-Prot
NCBI Gene	286920	ENTREZGENE
PANTHER	ACID-SENSING ION CHANNEL 3	UniProtKB/Swiss-Prot
	PTHR11690	UniProtKB/Swiss-Prot
Pfam	ASC	UniProtKB/Swiss-Prot
PhenoGen	Asic3	PhenoGen
PRINTS	AMINACHANNEL	UniProtKB/Swiss-Prot
PROSITE	ASC	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008380	RatGTEx
UniProt	A0A8I5ZRU8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LU69_RAT	UniProtKB/TrEMBL
	A6K559	ENTREZGENE, UniProtKB/TrEMBL
	A6K560	ENTREZGENE, UniProtKB/TrEMBL
	A6K562	ENTREZGENE, UniProtKB/TrEMBL
	ASIC3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-23	Asic3	acid sensing ion channel subunit 3	Asic3	acid sensing ion channel 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-12-09	Asic3	acid sensing ion channel 3	Asic3	acid-sensing (proton-gated) ion channel 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-13	Asic3	acid-sensing (proton-gated) ion channel 3	Accn3	amiloride-sensitive cation channel 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Accn3	amiloride-sensitive cation channel 3	Asic3	proton gated cation channel DRASIC	Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed specifically in sensory neurons	1299543

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD