Nol3 (nucleolar protein 3) - Rat Genome Database

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Gene: Nol3 (nucleolar protein 3) Rattus norvegicus
Analyze
Symbol: Nol3
Name: nucleolar protein 3
RGD ID: 708558
Description: Enables cysteine-type endopeptidase inhibitor activity; death effector domain binding activity; and enzyme binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of apoptotic signaling pathway; and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrion and sarcoplasmic reticulum. Orthologous to human NOL3 (nucleolar protein 3); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis repressor with CARD; Arc; nucleolar protein 3 (apoptosis repressor with CARD domain); unknown Glu-Pro dipeptide repeat protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,066,493 - 50,068,175 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,063,986 - 50,068,722 (+)EnsemblGRCr8
mRatBN7.21933,154,061 - 33,158,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,154,062 - 33,158,250 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1939,972,172 - 39,973,839 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,625,491 - 40,627,158 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,914,430 - 42,916,067 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,232,567 - 37,236,668 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,098,203 - 48,102,390 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,094,345 - 35,096,012 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1932,585,344 - 32,587,011 (+)NCBICelera
RGSC_v3.11935,099,225 - 35,100,893 (+)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brevetoxin B  (ISO)
butanal  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lead(0)  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
PF-3758309  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
razoxane  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IDA)
intrinsic apoptotic signaling pathway  (ISO)
mRNA processing  (IEA)
mRNA splice site recognition  (ISO,ISS)
myoblast differentiation  (IDA)
negative regulation of apoptotic process  (IDA,IEA,IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of death-inducing signaling complex assembly  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IMP)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (IDA)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,IMP)
negative regulation of mitochondrial calcium ion concentration  (IDA)
negative regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of programmed necrotic cell death  (ISO)
negative regulation of protein targeting to mitochondrion  (IDA)
negative regulation of release of cytochrome c from mitochondria  (IBA,IDA,ISO)
negative regulation of signal transduction  (IEA)
negative regulation of striated muscle cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein complex oligomerization  (ISO,ISS)
regulation of apoptotic process  (IEA,TAS)
regulation of gene expression  (ISO)
regulation of intracellular signal transduction  (IEA)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IMP)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
response to hypoxia  (IEP,ISO)
response to injury involved in regulation of muscle adaptation  (ISO)
response to ischemia  (ISO)
smooth muscle cell proliferation  (IMP)

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (ISO)
membrane  (IEA)
mitochondrion  (IBA,IDA,IEA,ISO)
nucleolus  (ISO,ISS)
nucleoplasm  (ISO)
sarcoplasm  (IEA,ISO)
sarcoplasmic reticulum  (IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Ekhterae D, etal., Circ Res. 1999 Dec 9;85(12):e70-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats. Geertman R, etal., Biochim Biophys Acta 1996 May 2;1306(2-3):147-52.
4. Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia. Hong YM, etal., FEBS Lett 2003 May 22;543(1-3):170-3.
5. Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation. Hunter AL, etal., FEBS Lett. 2007 Mar 6;581(5):879-84. Epub 2007 Feb 2.
6. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. Irie Y, etal., J Biol Chem 2000 Jan 28;275(4):2647-53.
7. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Li PF, etal., Mol Cell 2002 Aug;10(2):247-58.
8. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Li YZ, etal., Mol Cell Biol. 2008 Jan;28(2):564-74. Epub 2007 Nov 12.
9. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. Lu D, etal., J Biol Chem. 2013 Mar 22;288(12):8491-504. doi: 10.1074/jbc.M112.442061. Epub 2013 Feb 4.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Nam YJ, etal., Mol Cell. 2004 Sep 24;15(6):901-12.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Tan WQ, etal., Circulation. 2008 Nov 25;118(22):2268-76. doi: 10.1161/CIRCULATIONAHA.107.750869. Epub 2008 Nov 10.
17. Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis. Yaniv G, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):740-6. doi: 10.1016/j.bbrc.2005.08.167.
18. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Zaiman AL, etal., Circulation. 2011 Dec 6;124(23):2533-42. doi: 10.1161/CIRCULATIONAHA.111.034512. Epub 2011 Nov 14.
19. ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway. Zhang YQ and Herman B, J Cell Biochem. 2006 Oct 1;99(2):575-88.
Additional References at PubMed
PMID:9560245   PMID:10196175   PMID:14645204   PMID:14732288   PMID:15004034   PMID:15509781   PMID:15774698   PMID:15848180   PMID:16189514   PMID:16505176   PMID:17594520   PMID:18171680  
PMID:18782777   PMID:19130235   PMID:19139834   PMID:20026055   PMID:21233493   PMID:22508833   PMID:24312627   PMID:24440909   PMID:28731195   PMID:31257698   PMID:31505169   PMID:31587299  


Genomics

Comparative Map Data
Nol3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,066,493 - 50,068,175 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,063,986 - 50,068,722 (+)EnsemblGRCr8
mRatBN7.21933,154,061 - 33,158,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,154,062 - 33,158,250 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1939,972,172 - 39,973,839 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,625,491 - 40,627,158 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,914,430 - 42,916,067 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,232,567 - 37,236,668 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,098,203 - 48,102,390 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,094,345 - 35,096,012 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1932,585,344 - 32,587,011 (+)NCBICelera
RGSC_v3.11935,099,225 - 35,100,893 (+)NCBI
Cytogenetic Map19q11NCBI
NOL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,170,538 - 67,175,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,170,154 - 67,176,189 (+)Ensemblhg38GRCh38
GRCh371667,204,441 - 67,209,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,765,371 - 65,767,127 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341665,765,370 - 65,767,125NCBI
Celera1651,712,649 - 51,717,887 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,077,589 - 53,082,828 (+)NCBIHuRef
CHM1_11668,611,732 - 68,616,967 (+)NCBICHM1_1
T2T-CHM13v2.01672,964,831 - 72,970,031 (+)NCBIT2T-CHM13v2.0
Nol3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,002,777 - 106,008,571 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,002,772 - 106,008,571 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388105,276,145 - 105,281,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,276,140 - 105,281,939 (+)Ensemblmm10GRCm38
MGSCv378107,800,347 - 107,805,839 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368108,165,576 - 108,171,068 (+)NCBIMGSCv36mm8
Celera8109,499,596 - 109,505,088 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Nol3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,443,090 - 9,447,095 (-)Ensembl
ChiLan1.0NW_0049554849,443,090 - 9,447,142 (-)NCBIChiLan1.0ChiLan1.0
NOL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,700,244 - 76,705,501 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,612,801 - 82,618,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,516,156 - 47,521,441 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11666,904,738 - 66,909,956 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,904,738 - 66,909,956 (+)EnsemblpanPan2panpan1.1
Nol3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,940,899 - 41,944,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,644,653 - 17,648,211 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,644,299 - 17,648,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,281,492 - 60,286,865 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604723,033,169 - 23,039,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nol3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11725,003,375 - 25,007,662 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nol3
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:78
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000020908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat

Markers in Region
RH127522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,157,893 - 33,158,093 (+)MAPPERmRatBN7.2
Rnor_6.01937,236,327 - 37,236,526NCBIRnor6.0
Rnor_5.01948,102,049 - 48,102,248UniSTSRnor5.0
RGSC_v3.41935,095,671 - 35,095,870UniSTSRGSC3.4
Celera1932,586,670 - 32,586,869UniSTS
RH 3.4 Map19359.82UniSTS
Cytogenetic Map19q11UniSTS
RH143966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,158,071 - 33,158,215 (+)MAPPERmRatBN7.2
Rnor_6.01937,236,505 - 37,236,648NCBIRnor6.0
Rnor_5.01948,102,227 - 48,102,370UniSTSRnor5.0
RGSC_v3.41935,095,849 - 35,095,992UniSTSRGSC3.4
Celera1932,586,848 - 32,586,991UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 61 59 6 314 161 11 139 70 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020908   ⟹   ENSRNOP00000020908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,063,986 - 50,067,463 (+)Ensembl
mRatBN7.2 Ensembl1933,154,062 - 33,158,191 (+)Ensembl
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107741   ⟹   ENSRNOP00000088560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,064,028 - 50,068,722 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115672   ⟹   ENSRNOP00000097088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,064,028 - 50,068,122 (+)Ensembl
mRatBN7.2 Ensembl1933,154,105 - 33,158,250 (+)Ensembl
RefSeq Acc Id: NM_053516   ⟹   NP_445968
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,066,493 - 50,068,160 (+)NCBI
mRatBN7.21933,156,568 - 33,158,235 (+)NCBI
Rnor_6.01937,235,001 - 37,236,668 (+)NCBI
Rnor_5.01948,098,203 - 48,102,390 (+)NCBI
RGSC_v3.41935,094,345 - 35,096,012 (+)RGD
Celera1932,585,344 - 32,587,011 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255542   ⟹   XP_006255604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,066,578 - 50,068,175 (+)NCBI
mRatBN7.21933,154,095 - 33,158,250 (+)NCBI
Rnor_6.01937,232,567 - 37,236,627 (+)NCBI
Rnor_5.01948,098,203 - 48,102,390 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001426123 (Get FASTA)   NCBI Sequence Viewer  
  NP_445968 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255604 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB05667 (Get FASTA)   NCBI Sequence Viewer  
  EDL92358 (Get FASTA)   NCBI Sequence Viewer  
  EDL92359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020908
  ENSRNOP00000097088
GenBank Protein Q62881 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445968   ⟸   NM_053516
- UniProtKB: Q62881 (UniProtKB/Swiss-Prot),   G3V7Z3 (UniProtKB/TrEMBL),   A6IYN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255604   ⟸   XM_006255542
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000020908   ⟸   ENSRNOT00000020908
Ensembl Acc Id: ENSRNOP00000097088   ⟸   ENSRNOT00000115672
Ensembl Acc Id: ENSRNOP00000088560   ⟸   ENSRNOT00000107741
Protein Domains
CARD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62881-F1-model_v2 AlphaFold Q62881 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708558 AgrOrtholog
BioCyc Gene G2FUF-5847 BioCyc
Ensembl Genes ENSRNOG00000015588 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020908 ENTREZGENE
  ENSRNOT00000115672 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
InterPro Apoptosis_Repressor_CARD UniProtKB/Swiss-Prot
  CARD UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:85383 UniProtKB/Swiss-Prot
NCBI Gene 85383 ENTREZGENE
PANTHER CARD6/NUCLEOLAR PROTEIN 3 UniProtKB/Swiss-Prot
  NUCLEOLAR PROTEIN 3 UniProtKB/Swiss-Prot
Pfam CARD UniProtKB/Swiss-Prot
PhenoGen Nol3 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015588 RatGTEx
SMART CARD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
UniProt A0A8I6AN50_RAT UniProtKB/TrEMBL
  A6IYN0 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Z3 ENTREZGENE, UniProtKB/TrEMBL
  NOL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Nol3  nucleolar protein 3  Nol3  nucleolar protein 3 (apoptosis repressor with CARD domain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nol3  nucleolar protein 3 (apoptosis repressor with CARD domain)      Symbol and Name status set to approved 1299863 APPROVED