Cyp3a9 (cytochrome P450, family 3, subfamily a, polypeptide 9) - Rat Genome Database

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Gene: Cyp3a9 (cytochrome P450, family 3, subfamily a, polypeptide 9) Rattus norvegicus
Analyze
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
RGD ID: 708392
Description: Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; carbamazepine pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3AH15; Cyp3a13; CYPIIIA9; cytochrome P450 3A9; cytochrome P450 olfactive 3; cytochrome P450, family 3, subfamily a, polypeptide 13; cytochrome P450-OLF3; MGC93139; olfactive; olfactory cytochrome P450olf3; P450-OLF3; P450olf3
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,919,955 - 21,960,160 (-)NCBIGRCr8
mRatBN7.21216,806,222 - 16,846,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,636,912 - 17,677,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,260,644 - 18,300,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,314,042 - 17,354,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,074,288 - 19,114,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,132,926 - 21,173,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,164,384 - 17,204,589 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,153,354 - 17,193,208 (+)NCBI
Celera1218,744,706 - 18,784,438 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Cyp3a9Ratacute lymphoblastic leukemia disease_progressionISOCYP3A5 (Homo sapiens)11353796 RGD 
Cyp3a9Ratacute lymphoblastic leukemia susceptibilityISOCYP3A5 (Homo sapiens)11353805DNA:polymorphism: :RGD 
Cyp3a9RatB-lymphoblastic leukemia/lymphoma treatmentISOCYP3A5 (Homo sapiens)11353807DNA:polymorphisms: :RGD 
Cyp3a9RatChemotherapy-Induced Febrile Neutropenia susceptibilityISOCYP3A5 (Homo sapiens)11353804associated with breast neoplasm and DNA:polymorphism:splice junction:6986A>G (human)RGD 
Cyp3a9Ratchronic myeloid leukemia susceptibilityISOCYP3A5 (Homo sapiens)11353798DNA:polymorphism:intron :6986A>G (human)RGD 
Cyp3a9Ratchronic myeloid leukemia treatmentISOCYP3A5 (Homo sapiens)11353810DNA:SNP:: (rs776746) (human)RGD 
Cyp3a9RatDrug-Induced Leukopenia susceptibilityISOCYP3A5 (Homo sapiens)11353800associated with Ovarian Neoplasms: DNA:polymorphism: :RGD 
Cyp3a9RatDrug-induced Neutropenia susceptibilityISOCYP3A5 (Homo sapiens)11353800associated with Ovarian Neoplasms: DNA:polymorphism: :RGD 
Cyp3a9RatDrug-induced Neutropenia susceptibilityISOCYP3A5 (Homo sapiens)11353804associated with breast neoplasm and DNA:polymorphism:splice junction:6986A>G (human)RGD 
Cyp3a9Ratliver cirrhosis  IEP 405820211mRNA:increased expression:liver (rat)RGD 
Cyp3a9RatMyeloid Leukemia, Chronic-Phase treatmentISOCYP3A5 (Homo sapiens)11353797DNA:polymorphism:intron :6986A>G (human)RGD 
Cyp3a9Ratoral submucous fibrosis  ISOCYP3A5 (Homo sapiens)405847407mRNA:decreased expression:buccal mucosaRGD 
Cyp3a9RatPediatric Crohn's Disease  ISOCYP3A5 (Homo sapiens)9068941mRNA:increased expression:duodenum:non-inflamed tissueRGDPMID:16917230 and REF_RGD_ID:5685614
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Cyp3a9Ratessential hypertension  ISOCYP3A5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11279519 more ...
Cyp3a9Ratmyasthenia gravis  ISOCYP3A5 (Homo sapiens)8554872ClinVar Annotator: match by term: refractory myasthenia gravisClinVarPMID:11279519 more ...
Cyp3a9Ratpleomorphic xanthoastrocytoma  ISOCYP3A5 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
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Cyp3a9Ratautism spectrum disorder  ISOCYP3A5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Cyp3a9Ratessential hypertension  ISOCYP3A5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cyp3a9RatExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Cyp3a9RatExperimental Liver Cirrhosis  ISOCyp3a13 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980
Cyp3a9Ratkidney disease  ISOCYP3A5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18408564 and PMID:20526235
Cyp3a9Ratnephrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18725544
Cyp3a9RatProstatic Neoplasms  ISOCYP3A5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18306354
Cyp3a9RatReperfusion Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22749977
Cyp3a9Ratthrombosis  ISOCYP3A5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16754899
Cyp3a9Rattoxic encephalopathy  ISOCYP3A5 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:21225912
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Cyp3a9Ratessential hypertension susceptibilityISOCYP3A5 (Homo sapiens)7240710 OMIM 

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Cyp3a9Rat(+)-catechin multiple interactionsISOCyp3a13 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP3A13 mRNACTDPMID:25663641
Cyp3a9Rat(+)-epicatechin-3-O-gallate multiple interactionsISOCyp3a13 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP3A13 mRNACTDPMID:25663641
Cyp3a9Rat(+)-Tetrandrine increases glutathionylationISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased glutathionylation of tetrandrineCTDPMID:21992520
Cyp3a9Rat(+)-Tetrandrine multiple interactionsISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] more ...CTDPMID:26302866
Cyp3a9Rat(+)-Tetrandrine increases response to substanceISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased susceptibility to tetrandrineCTDPMID:26302866
Cyp3a9Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCyp3a13 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP3A13 mRNACTDPMID:25663641
Cyp3a9Rat(1->4)-beta-D-glucan multiple interactionsISOCyp3a13 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP3A13 mRNACTDPMID:36331819
Cyp3a9Rat(R,R,R)-alpha-tocopherol increases expressionISOCyp3a13 (Mus musculus)6480464alpha-Tocopherol results in increased expression of CYP3A13 mRNA and alpha-Tocopherol results in increased expression of CYP3A13 proteinCTDPMID:26102010
Cyp3a9Rat(R,R,R)-alpha-tocopherol multiple interactionsISOCYP3A5 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]CTDPMID:31102695
Cyp3a9Rat1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases hydroxylationISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased hydroxylation of 1 more ...CTDPMID:12167570
Cyp3a9Rat1,2-dichloroethane increases expressionISOCyp3a13 (Mus musculus)6480464ethylene dichloride results in increased expression of CYP3A13 mRNACTDPMID:28960355
Cyp3a9Rat1,2-dimethylhydrazine decreases expressionISOCyp3a13 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CYP3A13 mRNACTDPMID:22206623
Cyp3a9Rat1,4-naphthoquinone increases abundanceISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased abundance of 1 and 4-naphthoquinoneCTDPMID:16243959
Cyp3a9Rat1,8-cineole increases hydroxylationISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased hydroxylation of EucalyptolCTDPMID:15715982
Cyp3a9Rat1-aminobenzotriazole multiple interactionsISOCYP3A5 (Homo sapiens)64804641-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]CTDPMID:24555085
Cyp3a9Rat1-hydroxymidazolam increases chemical synthesisISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolamCTDPMID:18191104 and PMID:26958860
Cyp3a9Rat1-hydroxymidazolam multiple interactionsISOCYP3A5 (Homo sapiens)6480464[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]CTDPMID:34189909
Cyp3a9Rat1-naphthol increases abundanceISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased abundance of 1-naphtholCTDPMID:16243959
Cyp3a9Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of CYP3A9 mRNACTDPMID:25380136 and PMID:30723492
Cyp3a9Rat17alpha-ethynylestradiol increases hydroxylationISOCYP3A5 (Homo sapiens)6480464CYP3A5 protein results in increased hydroxylation of Ethinyl EstradiolCTDPMID:15304426

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Biological Process
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Cyp3a9Ratalkaloid catabolic process involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:15039299RGDPMID:15039299
Cyp3a9Ratestrogen metabolic process involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:12865317RGDPMID:12865317
Cyp3a9Ratfemale pregnancy  IEP 1299416 RGD 
Cyp3a9Ratlipid hydroxylation involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:14559847RGDPMID:14559847
Cyp3a9Ratoxidative demethylation involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:15039299RGDPMID:15039299
Cyp3a9Ratoxidative demethylation involved_inIBAPANTHER:PTN001548724 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp3a9Ratpositive regulation of gene expression acts_upstream_of_or_withinISOCyp3a13 (Mus musculus)1624291MGI:3764486 PMID:18794335RGDPMID:18794335
Cyp3a9Ratpositive regulation of gene expression acts_upstream_of_or_withinIEAUniProtKB:Q64464 and ensembl:ENSMUSP000000317411600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp3a9Ratresponse to dexamethasone  IEP 11353812 RGD 
Cyp3a9Ratresponse to estradiol  IEP 11353816 RGD 
Cyp3a9Ratresponse to estrogen  IEP 11353813 RGD 
Cyp3a9Ratresponse to ethanol  IEP 11353817 RGD 
Cyp3a9Ratresponse to zinc ion  IEP 11353814 RGD 
Cyp3a9Ratretinoic acid metabolic process involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:11093772RGDPMID:11093772
Cyp3a9Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a9Ratsteroid metabolic process involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:14559847RGDPMID:14559847
Cyp3a9Ratsteroid metabolic process involved_inIBAPANTHER:PTN001548724 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp3a9Ratxenobiotic catabolic process involved_inISOCYP3A5 (Homo sapiens)1624291 PMID:15039299RGDPMID:15039299
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Cellular Component

  
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Cyp3a9Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a9Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp3a9Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0015287611600115GO_REF:0000104UniProtGO_REF:0000104
Cyp3a9Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a9Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
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Cyp3a9Ratestrogen 16-alpha-hydroxylase activity enablesISOCYP3A5 (Homo sapiens)1624291 PMID:14559847RGDPMID:14559847
Cyp3a9Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a9Ratheme binding enablesIEAUniRule:UR0015287611600115GO_REF:0000104UniProtGO_REF:0000104
Cyp3a9Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a9Ratiron ion binding enablesIEAUniRule:UR0015287611600115GO_REF:0000104UniProtGO_REF:0000104
Cyp3a9Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a9Ratmonooxygenase activity enablesISSUniProtKB:Q86SK31600115GO_REF:0000024UniProtGO_REF:0000024
Cyp3a9Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a9Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a9Ratoxidoreductase activity enablesISOCYP3A5 (Homo sapiens)1624291 PMID:15039299RGDPMID:15039299
Cyp3a9Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a9Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a9Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAInterPro:IPR0080721600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a9Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEARHEA:171491600115GO_REF:0000116RHEAGO_REF:0000116
Cyp3a9Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAEC:1.14.14.11600115GO_REF:0000003UniProtGO_REF:0000003
Cyp3a9Ratprotein binding enablesISOCYP3A5 (Homo sapiens)1624291UniProtKB:P42858 and PMID:32814053RGDPMID:32814053
Cyp3a9Ratretinoic acid 4-hydroxylase activity enablesISOCYP3A5 (Homo sapiens)1624291 PMID:11093772RGDPMID:11093772
Cyp3a9Ratsteroid hydroxylase activity  TAS 1299417 RGD 
Cyp3a9Rattestosterone 6-beta-hydroxylase activity enablesIBAPANTHER:PTN001548724 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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Cyp3a9Ratartemether pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00651
Cyp3a9Ratcarbamazepine pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00634
Cyp3a9Ratclopidogrel pharmacodynamics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00260
Cyp3a9Ratclopidogrel pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00610
Cyp3a9Ratetoposide pharmacodynamics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00442
Cyp3a9Ratetoposide pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00601
Cyp3a9Ratfluoxetine pharmacodynamics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00426
Cyp3a9Ratfluoxetine pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00646
Cyp3a9Ratifosfamide pharmacodynamics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00448
Cyp3a9Ratifosfamide pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00605
Cyp3a9Ratirinotecan pharmacodynamics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00433
Cyp3a9Ratirinotecan pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00600
Cyp3a9Ratmycophenolic acid pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00652
Cyp3a9Ratneviparine pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00642
Cyp3a9Ratretinol metabolic pathway   ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00074
Cyp3a9Rattamoxifen pharmacodynamics pathway   ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00471
Cyp3a9Rattamoxifen pharmacokinetics pathway   ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00606
Cyp3a9Ratteniposide pharmacodynamics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00443
Cyp3a9Ratteniposide pharmacokinetics pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00602
Cyp3a9Ratvitamin A deficiency pathway  ISOCYP3A5 (Homo sapiens)10402751 SMPDBSMP:00336
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Imported Annotations - KEGG (archival)

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Cyp3a9Ratlinoleic acid metabolic pathway  IEA 6907045 KEGGrno:00591
Cyp3a9Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Cyp3a9Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982
Cyp3a9Ratretinol metabolic pathway   IEA 6907045 KEGGrno:00830
Cyp3a9Ratsteroid hormone biosynthetic pathway   IEA 6907045 KEGGrno:00140

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Reference Title
Reference Citation
1. Insights into gender bias: rat cytochrome P450 3A9. Anakk S, etal., J Pharmacol Exp Ther 2003 May;305(2):703-9. Epub 2003 Feb 11.
2. Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy? Bedewy AM and El-Maghraby SM, Hematology. 2013 Jul;18(4):211-6. doi: 10.1179/1607845412Y.0000000067. Epub 2013 Jan 31.
3. Effects of liver fibrosis on verapamil pharmacokinetics in rats. Chen M, etal., Clin Exp Pharmacol Physiol. 2008 Mar;35(3):287-94. doi: 10.1111/j.1440-1681.2007.04826.x. Epub 2007 Oct 31.
4. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Egbelakin A, etal., Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11.
5. Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. Fakhoury M, etal., Inflamm Bowel Dis. 2006 Aug;12(8):745-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Impact of CYP3A5*3 and CYP2C8-HapC on paclitaxel/carboplatin-induced myelosuppression in patients with ovarian cancer. Green H, etal., J Pharm Sci. 2011 Oct;100(10):4205-9. doi: 10.1002/jps.22680. Epub 2011 Jun 23.
8. [Expression of CYP3A5 mRNA in children with acute leukemia]. Huang Z, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):549-54.
9. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Jager W, etal., Drug Metab Dispos. 1999 Dec;27(12):1505-11.
10. Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia. Kim DH, etal., Clin Cancer Res. 2009 Jul 15;15(14):4750-8. doi: 10.1158/1078-0432.CCR-09-0145. Epub 2009 Jul 7.
11. Do CYP3A and ABCB1 genotypes influence the plasma concentration and clinical outcome of donepezil treatment? Magliulo L, etal., Eur J Clin Pharmacol. 2011 Jan;67(1):47-54. Epub 2010 Oct 8.
12. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Mahnke A, etal., Arch Biochem Biophys. 1997 Jan 1;337(1):62-8.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Chronic intragastric infusion of ethanol-containing diets induces CYP3A9 while decreasing CYP3A2 in male rats. Rowlands JC, etal., J Pharmacol Exp Ther. 2000 Nov;295(2):747-52.
20. Analysis of CYP3A5*3 and CYP3A5*6 gene polymorphisms in Indian chronic myeloid leukemia patients. Sailaja K, etal., Asian Pac J Cancer Prev. 2010;11(3):781-4.
1 to 20 of 27 rows
PMID:11093772   PMID:12477932   PMID:12865317   PMID:14559847   PMID:15039299   PMID:15684490   PMID:16484501   PMID:17520307   PMID:18794335   PMID:24525126   PMID:30361391  



Cyp3a9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,919,955 - 21,960,160 (-)NCBIGRCr8
mRatBN7.21216,806,222 - 16,846,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,636,912 - 17,677,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,260,644 - 18,300,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,314,042 - 17,354,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,074,288 - 19,114,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,132,926 - 21,173,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,164,384 - 17,204,589 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,153,354 - 17,193,208 (+)NCBI
Celera1218,744,706 - 18,784,438 (-)NCBICelera
Cytogenetic Map12q11NCBI
CYP3A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,648,194 - 99,679,996 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,245,817 - 99,277,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,907 - 99,207,720 (-)NCBICHM1_1
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
Cyp3a13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,891,195 - 137,923,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,891,194 - 137,919,881 (-)EnsemblGRCm39 Ensembl
GRCm385137,892,933 - 137,925,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,892,932 - 137,921,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,334,161 - 138,362,847 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,122,721 - 138,151,405 (-)NCBIMGSCv36mm8
Celera5134,879,058 - 134,907,700 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.89NCBI
CYP3A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,505,661 - 117,538,312 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,770,036 - 165,802,947 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,621,561 - 91,654,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,123,437 - 105,155,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,123,437 - 105,155,322 (-)Ensemblpanpan1.1panPan2
CYP3A22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,615,343 - 6,822,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,617,256 - 6,665,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP3A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,473,649 - 13,517,905 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,491,483 - 13,519,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,792,815 - 2,818,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Cyp3a9
216 total Variants

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:73
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000073099
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat

1 to 10 of 49 rows
RH132022  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,806,279 - 16,806,487 (+)MAPPERmRatBN7.2
Rnor_6.01219,074,346 - 19,074,553NCBIRnor6.0
Rnor_5.01221,132,984 - 21,133,191UniSTSRnor5.0
RGSC_v3.41217,204,324 - 17,204,531UniSTSRGSC3.4
Celera1218,744,764 - 18,744,971UniSTS
RH 3.4 Map12256.0UniSTS
Cytogenetic Map12q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 15 64 70 70 39 21 39 6 127 56 45 15 34 31



Ensembl Acc Id: ENSRNOT00000073099   ⟹   ENSRNOP00000067681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)Ensembl
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104591   ⟹   ENSRNOP00000091598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,806,207 - 16,844,348 (-)Ensembl
RefSeq Acc Id: NM_147206   ⟹   NP_671739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81221,919,955 - 21,960,160 (-)NCBI
mRatBN7.21216,806,222 - 16,846,428 (-)NCBI
Rnor_6.01219,074,288 - 19,114,491 (-)NCBI
Rnor_5.01221,132,926 - 21,173,248 (-)NCBI
RGSC_v3.41217,164,384 - 17,204,589 (+)RGD
Celera1218,744,706 - 18,784,438 (-)RGD
Sequence:
Protein RefSeqs NP_671739 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03662 (Get FASTA)   NCBI Sequence Viewer  
  AAH86985 (Get FASTA)   NCBI Sequence Viewer  
  BAC98808 (Get FASTA)   NCBI Sequence Viewer  
  EDL83884 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067681
GenBank Protein P51538 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_671739   ⟸   NM_147206
- UniProtKB: Q64631 (UniProtKB/Swiss-Prot),   Q64557 (UniProtKB/Swiss-Prot),   P51538 (UniProtKB/Swiss-Prot),   Q5PQX2 (UniProtKB/TrEMBL),   M0RDI0 (UniProtKB/TrEMBL),   A0A9K3Y7I1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067681   ⟸   ENSRNOT00000073099
Ensembl Acc Id: ENSRNOP00000091598   ⟸   ENSRNOT00000104591

Name Modeler Protein Id AA Range Protein Structure
AF-P51538-F1-model_v2 AlphaFold P51538 1-503 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19834 BioCyc
Ensembl Genes ENSRNOG00000046643 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000073099 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125835 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
MGC_CLONE MGC:93139 IMAGE-MGC_LOAD
NCBI Gene 171352 ENTREZGENE
PANTHER CYTOCHROME P450 3A7 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A5 RGD
  CYP3A7 RGD
PhenoGen Cyp3a9 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046643 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I6AFH9_RAT UniProtKB/TrEMBL
  A0A9K3Y7I1 ENTREZGENE, UniProtKB/TrEMBL
  CP3A9_RAT UniProtKB/Swiss-Prot
  M0RDI0 ENTREZGENE
  P51538 ENTREZGENE
  Q5PQX2 ENTREZGENE, UniProtKB/TrEMBL
  Q64557 ENTREZGENE
  Q64631 ENTREZGENE
UniProt Secondary Q64557 UniProtKB/Swiss-Prot
  Q64631 UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp3a9  cytochrome P450, family 3, subfamily a, polypeptide 9  Cyp3a13  cytochrome P450, family 3, subfamily a, polypeptide 13  Name updated 1299863 APPROVED
2004-09-10 Cyp3a13  cytochrome P450, family 3, subfamily a, polypeptide 13  Cyp3a9  cytochrome P450 3A9  Symbol and Name updated 1299863 APPROVED

Note Type Note Reference
gene_expression females display higher mRNA levels in liver and lung compared to males 1299416
gene_regulation expression is induced by estrogen 1299416