Cyp3a9 (cytochrome P450, family 3, subfamily a, polypeptide 9) - Rat Genome Database

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Gene: Cyp3a9 (cytochrome P450, family 3, subfamily a, polypeptide 9) Rattus norvegicus
Analyze
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
RGD ID: 708392
Description: Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; carbamazepine pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3AH15; Cyp3a13; CYPIIIA9; cytochrome P450 3A9; cytochrome P450 olfactive 3; cytochrome P450, family 3, subfamily a, polypeptide 13; cytochrome P450-OLF3; MGC93139; olfactive; olfactory cytochrome P450olf3; P450-OLF3; P450olf3
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,919,955 - 21,960,160 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1221,919,940 - 21,960,154 (-)EnsemblGRCr8
mRatBN7.21216,806,222 - 16,846,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1217,636,912 - 17,677,023 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,260,644 - 18,300,755 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,314,042 - 17,354,154 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,074,288 - 19,114,491 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,132,926 - 21,173,248 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41217,164,384 - 17,204,589 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1218,744,706 - 18,784,438 (-)NCBICelera
RGSC_v3.11217,153,354 - 17,193,208 (+)NCBI
Cytogenetic Map12q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-naphthoquinone  (ISO)
1,8-cineole  (ISO)
1-aminobenzotriazole  (ISO)
1-hydroxymidazolam  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxymidazolam  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-hydroxydiclofenac  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6beta-hydroxytestosterone  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aconitine  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (ISO)
alfentanil  (ISO)
all-trans-retinoic acid  (EXP)
alpha-tocotrienol  (ISO)
alprazolam  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
beclomethasone  (ISO)
Benoxacor  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brequinar  (ISO)
bromobenzene  (EXP)
bromuconazole  (EXP)
budesonide  (EXP,ISO)
Bufotalin  (ISO)
bupivacaine  (EXP)
buspirone  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbosulfan  (ISO)
carfentanil  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloroethene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (EXP)
cisplatin  (ISO)
citral  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clothianidin  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cyazofamid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
dabrafenib  (ISO)
decabromodiphenyl ether  (EXP)
Dechloroethylcyclophosphamide  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
dextrorphan  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diltiazem  (ISO)
dimethyl sulfoxide  (ISO)
diosmetin  (ISO)
disodium selenite  (ISO)
Droloxifene  (ISO)
drometrizole  (ISO)
dronedarone  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
eplerenone  (ISO)
Erdafitinib  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fenthion  (ISO)
fimasartan  (ISO)
fipronil  (EXP,ISO)
flavonol  (ISO)
fluconazole  (EXP)
flunisolide  (ISO)
flunitrazepam  (ISO)
fluoxetine  (ISO)
fluticasone  (ISO)
fluvoxamine  (ISO)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
gallocatechin  (ISO)
gefitinib  (ISO)
Gelsemine  (ISO)
genistein  (EXP,ISO)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
haloperidol  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydroquinone  (ISO)
Hypaconitine  (ISO)
hyperforin  (ISO)
Icaritin  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
irinotecan  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (EXP)
lansoprazole  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
luteolin  (ISO)
lycopene  (ISO)
malathion  (ISO)
Meclizine  (ISO)
mercury dichloride  (ISO)
methoxychlor  (EXP)
midazolam  (EXP,ISO)
mifepristone  (ISO)
Moniliformin  (ISO)
monosodium L-glutamate  (EXP,ISO)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
naphthalene  (ISO)
nefazodone  (EXP,ISO)
nelfinavir  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
Norfluoxetine  (ISO)
nortriptyline  (ISO)
norverapamil  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP,ISO)
osthole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phencyclidine  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
physostigmine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
progesterone  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quinacrine  (ISO)
rabeprazole  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
risperidone  (ISO)
ritonavir  (ISO)
rivaroxaban  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
sulfaphenazole  (ISO)
tacrolimus hydrate  (ISO)
tamarixetin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tartrazine  (ISO)
tebufenpyrad  (ISO)
teniposide  (ISO)
Terfenadine  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetrodotoxin  (EXP)
thalidomide  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
trabectedin  (EXP)
trazodone  (ISO)
triadimefon  (ISO)
triamcinolone acetonide  (ISO)
triclosan  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
Tris(1-aziridinyl)phosphine oxide  (ISO)
troglitazone  (ISO)
troleandomycin  (ISO)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
verapamil  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)
VX nerve agent  (ISO)
warfarin  (ISO)
XAV939  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Insights into gender bias: rat cytochrome P450 3A9. Anakk S, etal., J Pharmacol Exp Ther 2003 May;305(2):703-9. Epub 2003 Feb 11.
2. Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy? Bedewy AM and El-Maghraby SM, Hematology. 2013 Jul;18(4):211-6. doi: 10.1179/1607845412Y.0000000067. Epub 2013 Jan 31.
3. Effects of liver fibrosis on verapamil pharmacokinetics in rats. Chen M, etal., Clin Exp Pharmacol Physiol. 2008 Mar;35(3):287-94. doi: 10.1111/j.1440-1681.2007.04826.x. Epub 2007 Oct 31.
4. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Egbelakin A, etal., Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11.
5. Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. Fakhoury M, etal., Inflamm Bowel Dis. 2006 Aug;12(8):745-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Impact of CYP3A5*3 and CYP2C8-HapC on paclitaxel/carboplatin-induced myelosuppression in patients with ovarian cancer. Green H, etal., J Pharm Sci. 2011 Oct;100(10):4205-9. doi: 10.1002/jps.22680. Epub 2011 Jun 23.
8. [Expression of CYP3A5 mRNA in children with acute leukemia]. Huang Z, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):549-54.
9. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Jager W, etal., Drug Metab Dispos. 1999 Dec;27(12):1505-11.
10. Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia. Kim DH, etal., Clin Cancer Res. 2009 Jul 15;15(14):4750-8. doi: 10.1158/1078-0432.CCR-09-0145. Epub 2009 Jul 7.
11. Do CYP3A and ABCB1 genotypes influence the plasma concentration and clinical outcome of donepezil treatment? Magliulo L, etal., Eur J Clin Pharmacol. 2011 Jan;67(1):47-54. Epub 2010 Oct 8.
12. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Mahnke A, etal., Arch Biochem Biophys. 1997 Jan 1;337(1):62-8.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Chronic intragastric infusion of ethanol-containing diets induces CYP3A9 while decreasing CYP3A2 in male rats. Rowlands JC, etal., J Pharmacol Exp Ther. 2000 Nov;295(2):747-52.
20. Analysis of CYP3A5*3 and CYP3A5*6 gene polymorphisms in Indian chronic myeloid leukemia patients. Sailaja K, etal., Asian Pac J Cancer Prev. 2010;11(3):781-4.
21. CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome. Silveira VS, etal., Mol Cell Biochem. 2012 May;364(1-2):217-23. doi: 10.1007/s11010-011-1220-8. Epub 2012 Jan 4.
22. Side effects after docetaxel treatment in Taiwanese breast cancer patients with CYP3A4, CYP3A5, and ABCB1 gene polymorphisms. Tsai SM, etal., Clin Chim Acta. 2009 Jun 27;404(2):160-5. doi: 10.1016/j.cca.2009.03.038. Epub 2009 Mar 28.
23. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Wang H and Strobel HW, Arch Biochem Biophys. 1997 Aug 15;344(2):365-72.
24. cDNA cloning of a novel CYP3A from rat brain. Wang H, etal., Biochem Biophys Res Commun 1996 Apr 5;221(1):157-62.
25. [Expression of cytochrome P450 related genes in oral submucous fibrosis tissue]. Xie H, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2012 Dec;47(12):743-7. doi: 10.3760/cma.j.issn.1002-0098.2012.12.012.
26. Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats. Xu Z, etal., Biochem Pharmacol. 2001 Nov 1;62(9):1283-91.
27. Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase. Xue L, etal., Arch Biochem Biophys 2003 Jan 1;409(1):113-26.
Additional References at PubMed
PMID:11093772   PMID:12477932   PMID:12865317   PMID:14559847   PMID:15039299   PMID:15684490   PMID:16484501   PMID:17520307   PMID:18794335   PMID:24525126   PMID:30361391  


Genomics

Comparative Map Data
Cyp3a9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,919,955 - 21,960,160 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1221,919,940 - 21,960,154 (-)EnsemblGRCr8
mRatBN7.21216,806,222 - 16,846,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1217,636,912 - 17,677,023 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,260,644 - 18,300,755 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,314,042 - 17,354,154 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,074,288 - 19,114,491 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,132,926 - 21,173,248 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41217,164,384 - 17,204,589 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1218,744,706 - 18,784,438 (-)NCBICelera
RGSC_v3.11217,153,354 - 17,193,208 (+)NCBI
Cytogenetic Map12q11NCBI
CYP3A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,648,194 - 99,679,997 (-)Ensemblhg38GRCh38
GRCh37799,245,817 - 99,277,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,907 - 99,207,720 (-)NCBICHM1_1
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
Cyp3a13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,891,195 - 137,923,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,891,194 - 137,919,881 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385137,892,933 - 137,925,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,892,932 - 137,921,619 (-)Ensemblmm10GRCm38
MGSCv375138,334,161 - 138,362,847 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365138,122,721 - 138,151,405 (-)NCBIMGSCv36mm8
Celera5134,879,058 - 134,907,700 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.89NCBI
CYP3A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,505,661 - 117,538,312 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,770,036 - 165,802,947 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,621,561 - 91,654,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,123,437 - 105,155,322 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,123,437 - 105,155,322 (-)EnsemblpanPan2panpan1.1
CYP3A22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,615,343 - 6,822,817 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.136,617,256 - 6,665,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP3A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,473,649 - 13,517,905 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,491,483 - 13,519,507 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660702,792,815 - 2,818,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp3a9
275 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:73
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000073099
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH132022  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,806,279 - 16,806,487 (+)MAPPERmRatBN7.2
Rnor_6.01219,074,346 - 19,074,553NCBIRnor6.0
Rnor_5.01221,132,984 - 21,133,191UniSTSRnor5.0
RGSC_v3.41217,204,324 - 17,204,531UniSTSRGSC3.4
Celera1218,744,764 - 18,744,971UniSTS
RH 3.4 Map12256.0UniSTS
Cytogenetic Map12q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 19 77 70 70 39 25 39 6 153 66 2 64 24 63 31 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000073099   ⟹   ENSRNOP00000067681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1221,919,940 - 21,960,154 (-)Ensembl
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)Ensembl
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104591   ⟹   ENSRNOP00000091598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1221,919,940 - 21,958,080 (-)Ensembl
mRatBN7.2 Ensembl1216,806,207 - 16,844,348 (-)Ensembl
RefSeq Acc Id: NM_147206   ⟹   NP_671739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81221,919,955 - 21,960,160 (-)NCBI
mRatBN7.21216,806,222 - 16,846,428 (-)NCBI
Rnor_6.01219,074,288 - 19,114,491 (-)NCBI
Rnor_5.01221,132,926 - 21,173,248 (-)NCBI
RGSC_v3.41217,164,384 - 17,204,589 (+)RGD
Celera1218,744,706 - 18,784,438 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_671739 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03662 (Get FASTA)   NCBI Sequence Viewer  
  AAH86985 (Get FASTA)   NCBI Sequence Viewer  
  BAC98808 (Get FASTA)   NCBI Sequence Viewer  
  EDL83884 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067681
GenBank Protein P51538 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_671739   ⟸   NM_147206
- UniProtKB: Q64631 (UniProtKB/Swiss-Prot),   Q64557 (UniProtKB/Swiss-Prot),   P51538 (UniProtKB/Swiss-Prot),   Q5PQX2 (UniProtKB/TrEMBL),   M0RDI0 (UniProtKB/TrEMBL),   A0A9K3Y7I1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067681   ⟸   ENSRNOT00000073099
Ensembl Acc Id: ENSRNOP00000091598   ⟸   ENSRNOT00000104591

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51538-F1-model_v2 AlphaFold P51538 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708392 AgrOrtholog
BioCyc Gene G2FUF-19834 BioCyc
Ensembl Genes ENSRNOG00000046643 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000073099 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125835 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
MGC_CLONE MGC:93139 IMAGE-MGC_LOAD
NCBI Gene 171352 ENTREZGENE
PANTHER CYTOCHROME P450 3A7 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A5 RGD
  CYP3A7 RGD
PhenoGen Cyp3a9 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046643 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I6AFH9_RAT UniProtKB/TrEMBL
  A0A9K3Y7I1 ENTREZGENE, UniProtKB/TrEMBL
  CP3A9_RAT UniProtKB/Swiss-Prot
  M0RDI0 ENTREZGENE
  P51538 ENTREZGENE
  Q5PQX2 ENTREZGENE, UniProtKB/TrEMBL
  Q64557 ENTREZGENE
  Q64631 ENTREZGENE
UniProt Secondary Q64557 UniProtKB/Swiss-Prot
  Q64631 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp3a9  cytochrome P450, family 3, subfamily a, polypeptide 9  Cyp3a13  cytochrome P450, family 3, subfamily a, polypeptide 13  Name updated 1299863 APPROVED
2004-09-10 Cyp3a13  cytochrome P450, family 3, subfamily a, polypeptide 13  Cyp3a9  cytochrome P450 3A9  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression females display higher mRNA levels in liver and lung compared to males 1299416
gene_regulation expression is induced by estrogen 1299416