Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | C5AR1 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:25741868 | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | C5AR1 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:25741868 | |
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# | Reference Title | Reference Citation |
1. | cDNA cloning and characterization of rat C5a anaphylatoxin receptor. | Akatsu H, etal., Microbiol Immunol 1997;41(7):575-80. |
2. | Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease. | Andersson CK, etal., Am J Respir Crit Care Med. 2010 Feb 1;181(3):206-17. Epub 2009 Nov 19. |
3. | Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. | Arumugam TV, etal., J Hepatol. 2004 Jun;40(6):934-41. |
4. | Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death. | Benard M, etal., J Biol Chem. 2004 Oct 15;279(42):43487-96. Epub 2004 Aug 2. |
5. | Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum. | Benard M, etal., Mol Immunol. 2008 Aug;45(14):3767-74. Epub 2008 Jul 16. |
6. | Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. | Bhatia M, etal., Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G974-8. |
7. | Amnionitis and T strain mycoplasmemia. | Caspi E, etal., Am J Obstet Gynecol. 1971 Dec 15;111(8):1102-6. |
8. | Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat. | Daveau M, etal., J Immunol. 2004 Sep 1;173(5):3418-24. |
9. | Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease. | Farkas I, etal., J Immunol. 2003 Jun 1;170(11):5764-71. |
10. | The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. | Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560. |
11. | Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma. | Fregonese L, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1148-54. |
12. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
13. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
14. | Neutrophil C5a receptor and the outcome in a rat model of sepsis. | Guo RF, etal., FASEB J. 2003 Oct;17(13):1889-91. Epub 2003 Aug 1. |
15. | Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm. | Harkin DW, etal., J Vasc Surg. 2004 Jan;39(1):196-206. |
16. | Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. | Hillebrandt S, etal., Nat Genet. 2005 Aug;37(8):835-43. Epub 2005 Jul 3. |
17. | Has small-scale audio-visual dental health education a viable future? | Hirsch RS and Clarke NG, Community Dent Oral Epidemiol 1977 Jul;5(4):160-3. |
18. | Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV. | Jiang Y, etal., Viruses. 2019 Jan 9;11(1). pii: v11010039. doi: 10.3390/v11010039. |
19. | Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis. | Jun SW, etal., J Allergy Clin Immunol. 2008 Jul;122(1):119-25. Epub 2008 Jun 5. |
20. | A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. | Kohl J, etal., J Clin Invest. 2006 Mar;116(3):783-96. |
21. | The role of C5a in the development of thrombotic glomerulonephritis in rats. | Kondo C, etal., Clin Exp Immunol. 2001 May;124(2):323-9. |
22. | Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. | Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29. |
23. | C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. | Lim J, etal., FASEB J. 2013 Feb;27(2):822-31. doi: 10.1096/fj.12-220582. Epub 2012 Nov 1. |
24. | Gene Data Set | MGD Curation, June 12, 2002 |
25. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
26. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
27. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
28. | Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. | Proctor LM, etal., Br J Pharmacol. 2004 Jun;142(4):756-64. Epub 2004 May 24. |
29. | Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. | Proctor LM, etal., Int Immunopharmacol. 2006 Aug;6(8):1224-32. Epub 2006 Apr 3. |
30. | GOA pipeline | RGD automated data pipeline |
31. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
32. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
33. | Expression and function of the C5a receptor in rat alveolar epithelial cells. | Riedemann NC, etal., J Immunol 2002 Feb 15;168(4):1919-25. |
34. | Molecular cloning and expression of the functional rat C5a receptor. | Rothermel E, etal., Mol Immunol 1997 Aug-Sep;34(12-13):877-86. |
35. | Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. | Short AJ, etal., Br J Pharmacol. 1999 Oct;128(3):511-4. |
36. | Complement Inhibition Alleviates Paraquat-Induced Acute Lung Injury. | Sun S, etal., Am J Respir Cell Mol Biol. 2011 Mar 18. |
37. | Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. | Tschernig T, etal., Exp Toxicol Pathol. 2007 Aug;58(6):419-25. Epub 2007 Jun 1. |
38. | The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. | Woodruff TM, etal., J Immunol. 2008 Dec 15;181(12):8727-34. |
PMID:1401897 | PMID:1472004 | PMID:10571060 | PMID:12477932 | PMID:15489334 | PMID:16452172 | PMID:17114491 | PMID:17703884 | PMID:19020281 | PMID:19561098 | PMID:19917081 | PMID:21460748 |
PMID:21753735 | PMID:22099750 | PMID:22496247 | PMID:22960554 | PMID:25917954 | PMID:28690033 | PMID:34637270 | PMID:38165570 | PMID:38326494 |
C5ar1 (Rattus norvegicus - Norway rat) |
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C5AR1 (Homo sapiens - human) |
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C5ar1 (Mus musculus - house mouse) |
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C5ar1 (Chinchilla lanigera - long-tailed chinchilla) |
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C5AR1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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C5AR1 (Canis lupus familiaris - dog) |
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C5ar1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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C5AR1 (Sus scrofa - pig) |
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C5AR1 (Chlorocebus sabaeus - green monkey) |
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C5ar1 (Heterocephalus glaber - naked mole-rat) |
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Variants in C5ar1
71 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH144047 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 3 | 7 | ||||||||||
Low | 3 | 33 | 53 | 37 | 16 | 37 | 8 | 11 | 49 | 35 | 31 | 4 | 8 |
Below cutoff | 10 | 4 | 4 | 4 | 21 | 3 |
RefSeq Transcripts | NM_053619 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039105863 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AB003042 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF090996 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC078770 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473979 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ230454 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ235138 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000001 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X65862 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X95990 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
Y09613 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000073034 ⟹ ENSRNOP00000064558 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_053619 ⟹ NP_446071 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039105863 ⟹ XP_038961791 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_446071 | (Get FASTA) | NCBI Sequence Viewer |
XP_038961791 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAG24260 | (Get FASTA) | NCBI Sequence Viewer |
AAH78770 | (Get FASTA) | NCBI Sequence Viewer | |
BAA20263 | (Get FASTA) | NCBI Sequence Viewer | |
CAA46692 | (Get FASTA) | NCBI Sequence Viewer | |
CAA70825 | (Get FASTA) | NCBI Sequence Viewer | |
EDM08332 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00060029603 | ||
GenBank Protein | P97520 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_446071 ⟸ NM_053619 |
- UniProtKB: | O09088 (UniProtKB/Swiss-Prot), P97520 (UniProtKB/Swiss-Prot), A6J8A2 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000064558 ⟸ ENSRNOT00000073034 |
RefSeq Acc Id: | XP_038961791 ⟸ XM_039105863 |
- Peptide Label: | isoform X1 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P97520-F1-model_v2 | AlphaFold | P97520 | 1-352 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:70553 | AgrOrtholog |
BioCyc Gene | G2FUF-60616 | BioCyc |
Ensembl Genes | ENSRNOG00000047800 | Ensembl |
ENSRNOG00060020768 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00060035976 | UniProtKB/Swiss-Prot |
Gene3D-CATH | Rhodopsin 7-helix transmembrane proteins | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMAGE_CLONE | IMAGE:7121456 | IMAGE-MGC_LOAD |
InterPro | Anphylx_rcpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Formyl_rcpt-rel | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_Rhodpsn | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_Rhodpsn_7TM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:113959 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGC_CLONE | MGC:93295 | IMAGE-MGC_LOAD |
NCBI Gene | 113959 | ENTREZGENE |
PANTHER | C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CHEMOTACTIC RECEPTOR | UniProtKB/TrEMBL, UniProtKB/Swiss-Prot | |
Pfam | 7tm_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | C5ar1 | PhenoGen |
PRINTS | ANPHYLATOXNR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
C5ANPHYLTXNR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCRRHODOPSN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000047800 | RatGTEx |
ENSRNOG00060020768 | RatGTEx | |
Superfamily-SCOP | Family A G protein-coupled receptor-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A6J8A2 | ENTREZGENE, UniProtKB/TrEMBL |
C5AR1_RAT | UniProtKB/Swiss-Prot | |
O09088 | ENTREZGENE | |
P97520 | ENTREZGENE | |
UniProt Secondary | O09088 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-08-18 | C5ar1 | complement C5a receptor 1 | C5ar1 | complement component 5a receptor 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-02-18 | C5ar1 | complement component 5a receptor 1 | C5r1 | complement component 5, receptor 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | C5r1 | complement component 5, receptor 1 | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_function | receptor for complement 5 | 70320 |
gene_function | receptor for complement 5 | 70679 |
gene_process | functions in lung inflamatory response | 70320 |
gene_process | functions in lung inflamatory response | 70679 |