RGD Reference Report - Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. - Rat Genome Database

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Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.

Authors: Hillebrandt, S  Wasmuth, HE  Weiskirchen, R  Hellerbrand, C  Keppeler, H  Werth, A  Schirin-Sokhan, R  Wilkens, G  Geier, A  Lorenzen, J  Kohl, J  Gressner, AM  Matern, S  Lammert, F 
Citation: Hillebrandt S, etal., Nat Genet. 2005 Aug;37(8):835-43. Epub 2005 Jul 3.
RGD ID: 1600592
Pubmed: PMID:15995705   (View Abstract at PubMed)
DOI: DOI:10.1038/ng1599   (Journal Full-text)

Fibrogenesis or scarring of the liver is a common consequence of all chronic liver diseases. Here we refine a quantitative trait locus that confers susceptibility to hepatic fibrosis by in silico mapping and show, using congenic mice and transgenesis with recombined artificial chromosomes, that the gene Hc (encoding complement factor C5) underlies this locus. Small molecule inhibitors of the C5a receptor had antifibrotic effects in vivo, and common haplotype-tagging polymorphisms of the human gene C5 were associated with advanced fibrosis in chronic hepatitis C virus infection. Thus, the mouse quantitative trait gene led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that C5 has a causal role in fibrogenesis across species.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Liver Cirrhosis treatmentISOC5ar1 (Mus musculus)1600592; 1600592 RGD 
Experimental Liver Cirrhosis treatmentIMP 1600592 RGD 
liver cirrhosis disease_progressionISOC5 (Homo sapiens)1600592; 1600592associated with Hepatitis C more ...RGD 
liver cirrhosis disease_progressionIAGP 1600592associated with Hepatitis C more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
C5  (complement C5)
C5ar1  (complement C5a receptor 1)

Genes (Mus musculus)
C5ar1  (complement component 5a receptor 1)
Hc  (hemolytic complement)

Genes (Homo sapiens)
C5  (complement C5)
C5AR1  (complement C5a receptor 1)


Additional Information