Gnrhr (gonadotropin releasing hormone receptor) - Rat Genome Database

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Gene: Gnrhr (gonadotropin releasing hormone receptor) Rattus norvegicus
Analyze
Symbol: Gnrhr
Name: gonadotropin releasing hormone receptor
RGD ID: 70513
Description: Enables growth hormone-releasing hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor); PARTICIPATES IN gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GH1; gnRH receptor; gnRH-R; gonadotropin-releasing hormone receptor; growth hormone; Lhrhr
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81422,211,666 - 22,229,654 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21421,856,871 - 21,874,861 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,856,871 - 21,874,861 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1422,213,471 - 22,231,501 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,525,897 - 23,543,927 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01422,056,995 - 22,075,025 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1422,502,601 - 22,520,643 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1422,607,664 - 22,625,702 (+)NCBILyon_Normotensive
Lyon_Hypertensive1422,615,614 - 22,633,656 (+)NCBILyon_Hypertensive
F344_StmMcwi1422,592,529 - 22,610,559 (+)NCBIF344_StmMcwi
Rnor_6.01423,480,462 - 23,498,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,480,462 - 23,498,450 (+)Ensemblrn6Rnor6.0
Rnor_5.01423,384,861 - 23,402,815 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,625,135 - 23,656,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1421,327,308 - 21,348,471 (+)NCBICelera
RGSC_v3.11423,625,137 - 23,656,250 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
buserelin  (ISO)
cadmium dichloride  (EXP)
calcidiol  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (EXP)
decabromodiphenyl ether  (EXP)
Deslorelin  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dipentyl phthalate  (EXP)
doxorubicin  (ISO)
equol  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
flutamide  (EXP)
galaxolide  (EXP)
hexamethylene diisocyanate  (ISO)
isoflavones  (EXP)
lipoic acid  (EXP)
maleic acid  (ISO)
melatonin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentobarbital  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
potassium dichromate  (EXP,ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
sophoraflavanone B  (EXP)
T-2 toxin  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thimerosal  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptorelin  (ISO)
tunicamycin  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression. Brothers SP, etal., J Mol Endocrinol. 2006 Dec;37(3):479-88.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor. Kaiser UB, etal., Biochem Biophys Res Commun 1992 Dec 30;189(3):1645-52.
5. Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats. Kovacs M and Schally AV, Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12197-202.
6. Isolation of rat GnRH receptor cDNA having different 5'-noncoding sequence. Kudo A, etal., Zoolog Sci 1993 Oct;10(5):863-7.
7. Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b. Kyritsi K, etal., Am J Pathol. 2017 Jul;187(7):1551-1565. doi: 10.1016/j.ajpath.2017.03.013. Epub 2017 May 12.
8. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. Liu F, etal., J Biol Chem 2002 Aug 30;277(35):32099-108.
9. Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue. Marian J and Conn PM, Endocrinology. 1983 Jan;112(1):104-12.
10. Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. Matagne V, etal., J Neuroendocrinol. 2012 Jun;24(6):916-29. doi: 10.1111/j.1365-2826.2012.02302.x.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Gonadotropin-releasing hormone receptor-mediated growth suppression of immortalized LbetaT2 gonadotrope and stable HEK293 cell lines. Miles LE, etal., Endocrinology. 2004 Jan;145(1):194-204. Epub 2003 Oct 9.
13. Nucleotide sequence analysis of mRNAs predicts that rat pituitary and gonadal gonadotropin-releasing hormone receptor proteins have identical primary structure. Moumni M, etal., Biochem Biophys Res Commun 1994 May 16;200(3):1359-66.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
17. DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element. Page GS, etal., Nucleic Acids Res 1981 May 11;9(9):2087-104.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. Pitteloud N, etal., J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA. Rohn WM and Weigent DA, Neuroimmunomodulation 1995 Mar-Apr;2(2):108-14.
24. Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Seeburg PH, etal., Nature 1977 Dec 8;270(5637):486-94.
Additional References at PubMed
PMID:1338727   PMID:7916600   PMID:9220016   PMID:11278883   PMID:11897706   PMID:11997175   PMID:12062898   PMID:12479044   PMID:12697272   PMID:14525953   PMID:14561652   PMID:15188505  
PMID:15563546   PMID:15886197   PMID:15908340   PMID:16613990   PMID:16672174   PMID:17674129   PMID:17875654   PMID:17935160   PMID:18024297   PMID:18319619   PMID:19228890   PMID:19539704  
PMID:21123436   PMID:22414758   PMID:23211524   PMID:23233674   PMID:23906992   PMID:25048263   PMID:25556311   PMID:27349532   PMID:27569529   PMID:28032117   PMID:33576068  


Genomics

Comparative Map Data
Gnrhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81422,211,666 - 22,229,654 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21421,856,871 - 21,874,861 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,856,871 - 21,874,861 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1422,213,471 - 22,231,501 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,525,897 - 23,543,927 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01422,056,995 - 22,075,025 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1422,502,601 - 22,520,643 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1422,607,664 - 22,625,702 (+)NCBILyon_Normotensive
Lyon_Hypertensive1422,615,614 - 22,633,656 (+)NCBILyon_Hypertensive
F344_StmMcwi1422,592,529 - 22,610,559 (+)NCBIF344_StmMcwi
Rnor_6.01423,480,462 - 23,498,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,480,462 - 23,498,450 (+)Ensemblrn6Rnor6.0
Rnor_5.01423,384,861 - 23,402,815 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,625,135 - 23,656,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1421,327,308 - 21,348,471 (+)NCBICelera
RGSC_v3.11423,625,137 - 23,656,250 (+)NCBI
Cytogenetic Map14p21NCBI
GNRHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38467,737,118 - 67,754,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl467,737,118 - 67,754,388 (-)Ensemblhg38GRCh38
GRCh37468,602,836 - 68,620,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,285,688 - 68,304,399 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34468,434,963 - 68,450,570NCBI
Celera466,065,459 - 66,084,171 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef464,516,278 - 64,534,988 (-)NCBIHuRef
CHM1_1468,640,204 - 68,658,910 (-)NCBICHM1_1
T2T-CHM13v2.0471,180,228 - 71,197,499 (-)NCBIT2T-CHM13v2.0
Gnrhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,328,613 - 86,345,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,328,613 - 86,345,760 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38586,180,754 - 86,197,901 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,180,754 - 86,197,901 (-)Ensemblmm10GRCm38
MGSCv37586,611,019 - 86,626,895 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36587,256,555 - 87,272,431 (-)NCBIMGSCv36mm8
Celera583,413,347 - 83,430,921 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
GNRHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2362,141,365 - 62,155,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1462,351,392 - 62,367,764 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0456,295,425 - 56,314,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1462,687,474 - 62,706,179 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,687,474 - 62,706,167 (+)EnsemblpanPan2panpan1.1
GNRHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,253,112 - 58,266,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1358,253,027 - 58,266,705 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1358,168,278 - 58,181,765 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01358,865,514 - 58,878,973 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1358,865,514 - 58,878,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11358,590,137 - 58,603,620 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01358,080,483 - 58,093,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01359,090,982 - 59,104,477 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gnrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528518,185,844 - 18,202,017 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936582749,016 - 765,189 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936582749,016 - 765,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNRHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.171,205,294 - 1,225,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660661,294,292 - 1,311,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnrhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247611,216,556 - 1,225,994 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247611,216,501 - 1,231,229 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gnrhr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v111559,545 - 579,065 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gnrhr
169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:220
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000002755
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
RH142317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,855,292 - 21,855,446 (+)MAPPERmRatBN7.2
Rnor_6.01423,478,884 - 23,479,037NCBIRnor6.0
Rnor_5.01423,383,283 - 23,383,436UniSTSRnor5.0
RGSC_v3.41423,623,557 - 23,623,710UniSTSRGSC3.4
Celera1421,325,726 - 21,325,879UniSTS
Cytogenetic Map14p21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 9 23 71 53 51 21 55 21 6 159 106 9 44 16 60 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000002755   ⟹   ENSRNOP00000002755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,856,871 - 21,874,861 (+)Ensembl
Rnor_6.0 Ensembl1423,480,462 - 23,498,450 (+)Ensembl
RefSeq Acc Id: NM_031038   ⟹   NP_112300
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81422,211,666 - 22,229,654 (+)NCBI
mRatBN7.21421,856,871 - 21,874,861 (+)NCBI
Dahl_SR_JrHsd1422,502,601 - 22,520,643 (+)NCBI
Lyon_Normotensive1422,607,664 - 22,625,702 (+)NCBI
Lyon_Hypertensive1422,615,614 - 22,633,656 (+)NCBI
F344_StmMcwi1422,592,529 - 22,610,559 (+)NCBI
Rnor_6.01423,480,462 - 23,498,450 (+)NCBI
Rnor_5.01423,384,861 - 23,402,815 (+)NCBI
RGSC_v3.41423,625,135 - 23,656,583 (+)RGD
Celera1421,327,308 - 21,348,471 (+)RGD
Sequence:
RefSeq Acc Id: NP_112300   ⟸   NM_031038
- UniProtKB: P30969 (UniProtKB/Swiss-Prot),   A6JCR6 (UniProtKB/TrEMBL),   G3V693 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002755   ⟸   ENSRNOT00000002755
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30969-F1-model_v2 AlphaFold P30969 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70513 AgrOrtholog
BioCyc Gene G2FUF-16066 BioCyc
Ensembl Genes ENSRNOG00000002011 Ensembl
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  GphnRH_fam_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:81668 UniProtKB/Swiss-Prot
NCBI Gene 81668 ENTREZGENE
PANTHER GONADOTROPIN-RELEASING HORMONE RECEPTOR UniProtKB/Swiss-Prot
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gnrhr PhenoGen
PRINTS GNADOTRPHINR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002011 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6JCR6 ENTREZGENE, UniProtKB/TrEMBL
  A6JCR7_RAT UniProtKB/TrEMBL
  G3V693 ENTREZGENE
  GNRHR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Gnrhr  gonadotropin releasing hormone receptor    gonadotropin-releasing hormone receptor  Name updated 1299863 APPROVED
2002-06-10 Gnrhr  gonadotropin-releasing hormone receptor      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA level increased by exposure of pituitary cells in vitro to GNRH or triptorelin 69669
gene_function high-affinity, G protein-coupled receptor 69669
gene_regulation pituitary expression inhibited by cetrorelix, a GNRH antagonist, by counteracting GNHR stimulatory effect 69669