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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70513
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gnrhr
Name: gonadotropin releasing hormone receptor
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnrhrdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of GNRHR mRNAPMID:16522720 PMID:16614383
Gnrhrdecreases expressionISOGnrhr (Mus musculus)6480464CTDEstradiol results in decreased expression of GNRHR mRNAPMID:17185802
Gnrhrmultiple interactionsISOGNRHR (Homo sapiens)6480464CTDGNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 protein]]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]PMID:12574206
Gnrhrmultiple interactionsISOGnrhr (Mus musculus)6480464CTD[Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; [Estradiol co-treated with Progesterone] results in decreased expression of GNRHR mRNA; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]PMID:17185802
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