GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gnrhr | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of GNRHR mRNA | PMID:16522720 PMID:16614383 | Gnrhr | decreases expression | ISO | Gnrhr (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of GNRHR mRNA | PMID:17185802 | Gnrhr | multiple interactions | ISO | GNRHR (Homo sapiens) | 6480464 | CTD | GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of CXCL8 protein]]; GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]] | PMID:12574206 | Gnrhr | multiple interactions | ISO | Gnrhr (Mus musculus) | 6480464 | CTD | [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; [Estradiol co-treated with Progesterone] results in decreased expression of GNRHR mRNA; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA] | PMID:17185802 | |
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