Gnrhr (gonadotropin releasing hormone receptor)

Gene: Gnrhr (gonadotropin releasing hormone receptor) Ictidomys tridecemlineatus

Analyze

Symbol:

Gnrhr

Name:

gonadotropin releasing hormone receptor

RGD ID:

12554825

Description:

ENCODES a protein that exhibits growth hormone-releasing hormone receptor activity (ortholog); INVOLVED IN circadian rhythm (ortholog); G protein-coupled receptor signaling pathway (ortholog); negative regulation of cell population proliferation (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); amenorrhea (ortholog); Delayed Puberty (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

gonadotropin-releasing hormone receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	18,185,844 - 18,202,017 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936582	749,016 - 765,189 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936582	749,016 - 765,189 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adrenal Gland Neoplasms (ISO)

amenorrhea (ISO)

Delayed Puberty (ISO)

genetic disease (ISO)

hypogonadism (ISO)

hypogonadotropic hypogonadism (ISO)

hypogonadotropic hypogonadism 12 with or without anosmia (ISO)

hypogonadotropic hypogonadism 7 with or without anosmia (ISO)

infertility (ISO)

Klinefelter syndrome (ISO)

Neurodevelopmental Disorders (ISO)

primary sclerosing cholangitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to gonadotropin-releasing hormone (IEA)

cellular response to hormone stimulus (IEA)

circadian rhythm (ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

negative regulation of cell population proliferation (ISO)

neuropeptide signaling pathway (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

corazonin receptor activity (IEA)

G protein-coupled receptor activity (IEA)

gonadotropin-releasing hormone receptor activity (IEA)

growth hormone-releasing hormone receptor activity (ISO)

peptide binding (IEA)

protein binding (ISO)

protein-hormone receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gnrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	18,185,844 - 18,202,017 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936582	749,016 - 765,189 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936582	749,016 - 765,189 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNRHR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	67,737,118 - 67,754,388 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	67,737,118 - 67,754,388 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	68,602,836 - 68,620,106 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	68,285,688 - 68,304,399 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	68,434,963 - 68,450,570	NCBI
Celera	4	66,065,459 - 66,084,171 (-)	NCBI		Celera
Cytogenetic Map	4	q13.2	NCBI
HuRef	4	64,516,278 - 64,534,988 (-)	NCBI		HuRef
CHM1_1	4	68,640,204 - 68,658,910 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	71,180,228 - 71,197,499 (-)	NCBI		T2T-CHM13v2.0

Gnrhr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	86,328,613 - 86,345,760 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	86,328,613 - 86,345,760 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	86,180,754 - 86,197,901 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	86,180,754 - 86,197,901 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	86,611,019 - 86,626,895 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	87,256,555 - 87,272,431 (-)	NCBI		MGSCv36	mm8
Celera	5	83,413,347 - 83,430,921 (-)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	43.56	NCBI

Gnrhr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	22,211,666 - 22,229,654 (+)	NCBI		GRCr8
mRatBN7.2	14	21,856,871 - 21,874,861 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,856,871 - 21,874,861 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	22,213,471 - 22,231,501 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,525,897 - 23,543,927 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	22,056,995 - 22,075,025 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	23,480,462 - 23,498,450 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	23,480,462 - 23,498,450 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	23,384,861 - 23,402,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	23,625,135 - 23,656,583 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	23,625,137 - 23,656,250 (+)	NCBI
Celera	14	21,327,308 - 21,348,471 (+)	NCBI		Celera
Cytogenetic Map	14	p21	NCBI

GNRHR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	62,141,365 - 62,155,225 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	62,351,392 - 62,367,764 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	56,295,425 - 56,314,962 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	62,687,474 - 62,706,179 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	62,687,474 - 62,706,167 (+)	Ensembl	panpan1.1		panPan2

GNRHR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	58,253,112 - 58,266,600 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	58,253,027 - 58,266,705 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	58,168,278 - 58,181,765 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	58,865,514 - 58,878,973 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	58,865,514 - 58,878,973 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	58,590,137 - 58,603,620 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	58,080,483 - 58,093,952 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	59,090,982 - 59,104,477 (-)	NCBI		UU_Cfam_GSD_1.0

GNRHR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	1,205,294 - 1,225,105 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666066	1,294,292 - 1,311,901 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gnrhr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	1,216,556 - 1,225,994 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	1,216,501 - 1,231,229 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005331712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000029581 ⟹ ENSSTOP00000015911

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936582	749,016 - 765,189 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000037754 ⟹ ENSSTOP00000025002

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936582	749,035 - 762,016 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000040688 ⟹ ENSSTOP00000027918

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936582	749,035 - 764,789 (+)	Ensembl

RefSeq Acc Id:

XM_005331712 ⟹ XP_005331769

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	18,185,844 - 18,202,017 (+)	NCBI
SpeTri2.0	NW_004936582	749,016 - 765,189 (+)	NCBI

Sequence:

show sequence

GCTTTATCATTGGGGAAGTATGGCAAACAATGCCTCTCCTGAACAGAATCAGAATCACTGTTCA
GCCATCAACAACAGCATCTCACTGATGCAGGAAAACCTCCCCACCCTGACCTTATCTGGAAAGA
TTCGAGTGACAGTGACTTTCTGCCTTTTTCTACTCTCCACTACCTTTAATGCTTCTTTCTTATT
GAAACTTCAGAAGTGGACTCAGAAGAAAGAAAAAGGGAAAAAACTCTCCAGAATGAAGGTGCTT
TTAAAACATTTGACATTAGCCAACTTGTTGGAGACTCTGATTGTCATGCCACTGGATGGTATGT
GGAATATTACAGTCCAATGGTATGCAGGAGAGTTCCTCTGCAAAGTCCTCAGCTACCTGAAGCT
TTTTTCCATGTATGCCCCAGCTTTCATGATGGTGGTGATAAGCCTGGATCGTTCCCTGGCTATC
ACCAGACCACTAGCTGTGCAAAACAACCGAAAGCTTGAACAGTCCATGACCAGCCTGGCCTGGA
TTCTCAGTAGTATTTTTGCTGGACCACAGTTATATATATTCAGGATGATCCACCTAACAGATGG
TTCTGGACAAACAGAAATTTTCTCTCAATGTGTAACACACTGCAGTTTTCCACAATGGTGGCAT
CAAGCCTTTTATAACTTCTTCACTTTCAGCTGCCTCTTCATTATCCCTCTTCTCATCATGTTGA
TCTGCAATGCAAAAATTATCTTCACCCTGACACGGGTCCTTCATCATGATCCCCACAAACTACA
ATTGAATCAATCCAAGAACAATATACCAAGAGCACGGCTGAAGACCTTGAAGATGACAGTTGCA
TTTGCCACTTCATTTATTGTCTGCTGGACTCCCTACTATGTCCTTGGAATTTGGTATTGGTTTG
ATCCTGAAATGTTAAACAGGGTCTCAGACCCAGTAAATCATTTCTTCTTTCTCTTTGCTTTTTT
GAACCCATGCTTTGATCCACTTATATATGGATATTTCTCTCTGTAATTGACAGATACACATGAA
ATAATATGAAGAATTATACAGCAAGGTAATGAATTTATCCACTTGGGAACGACAAGAACAAAGT
TGCAACATATTACATATAAAAAAAGCAGGATTTAAGTTTCAGTTATCATTCTTCTTCTTTTTAG
AAATCATATTGTCAAAGTCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005331769	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015911.1
	ENSSTOP00000025002.1
	ENSSTOP00000027918.1
GenBank Protein	KAG3276541	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005331769 ⟸ XM_005331712

- UniProtKB:

I3MUW6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANNASPEQNQNHCSAINNSISLMQENLPTLTLSGKIRVTVTFCLFLLSTTFNASFLLKLQKWT
QKKEKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAP
AFMMVVISLDRSLAITRPLAVQNNRKLEQSMTSLAWILSSIFAGPQLYIFRMIHLTDGSGQTEI
FSQCVTHCSFPQWWHQAFYNFFTFSCLFIIPLLIMLICNAKIIFTLTRVLHHDPHKLQLNQSKN
NIPRARLKTLKMTVAFATSFIVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFAFLNPCFDP
LIYGYFSL

hide sequence

RefSeq Acc Id:

ENSSTOP00000027918 ⟸ ENSSTOT00000040688

RefSeq Acc Id:

ENSSTOP00000025002 ⟸ ENSSTOT00000037754

RefSeq Acc Id:

ENSSTOP00000015911 ⟸ ENSSTOT00000029581

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023714	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029581.2	UniProtKB/TrEMBL
	ENSSTOT00000037754.1	UniProtKB/TrEMBL
	ENSSTOT00000040688.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	GphnRH_fam_rcpt	UniProtKB/TrEMBL
NCBI Gene	Gnrhr	ENTREZGENE
PANTHER	CORAZONIN RECEPTOR, ISOFORM B	UniProtKB/TrEMBL
	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	GONADOTROPIN-RELEASING HORMONE RECEPTOR	UniProtKB/TrEMBL
	NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GNADOTRPHINR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A287CUM5_ICTTR	UniProtKB/TrEMBL
	A0A287D2Y6_ICTTR	UniProtKB/TrEMBL
	I3MUW6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM