Gene:	Pdk1 ( Rattus norvegicus ) pyruvate dehydrogenase kinase, isozyme 1
Description:	catalyzes the phosphorylation and inactivation of the pyruvate dehydrogenase complex
Synonyms:	pyruvate dehydrogenase kinase 1; MGC108625; pyruvate dehydrogenase kinase isoenzyme 1; pyruvate dehydrogenase kinase, isoenzyme 1;  (details...)
ArrayIDs:	rc_AI101596_at; 1368079_at; 6475750; 5645224; 6069333; 6416137; 5656127; 6698517; 6422860; 6070560; 1378314_at; 6616326; A_43_P12946; L22294_at; 1389075_at; 6352693; 6537420; GE19639; 6390980; 5620674; 5738067; A_44_P139718; 6437111; rc_AI103261_at; 6300183; 5743338;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PDK1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pdk1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Pdk1 genome assembly 3.1 3 54188447 - 54215612     Rat Celera Assembly 3 56249021 - 56275755     RGSC genome assembly v3.4 3 54292076 - 54319242     Cytogenetic 3 q22 Mus musculus Pdk1 Mouse genome assembly build 36.1 2 71711329 - 71740731     Cytogenetic 2 2 C3 Homo sapiens PDK1 human genome assembly 2 173246285 - 173289369     Human genome assembly build 36.2 2 173129025 - 173172108     Cytogenetic 2 q31.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology nucleotide binding,  protein homodimerization activity,  kinase activity ...  (details...)
Biological Process	Gene Ontology peptidyl-histidine phosphorylation,  protein amino acid phosphorylation,  glucose metabolic process ...  (details...)
Cellular Component	Gene Ontology pyruvate dehydrogenase complex,  mitochondrion,  mitochondrial matrix (details...)
Pathway	Ontology epidermal growth factor/neuregulin signaling pathway,  pyruvate metabolic pathway (details...)
Product	Note Reference related to prokaryotic family of protein kinases 68684
Protein	Note Reference predicted 434 amino acid protein 68684
External Links
Databases	DATABASE ID SOURCE SMART: HATPase_c IPI PROSITE: HIS_KIN IPI UNIPARC: UPI00001314C4 IPI UNIPARC: UPI00004C9665 IPI KEGG Report: rno:116551 ENTREZGENE HomoloGene Group ID: 20576 ENTREZGENE Germonline: 69427 Pfam: HATPase_c IPI Pfam: BCDHK_Adom3 IPI KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE InterPro: BCDHK/PDK_mit. IPI InterPro: ATP_bd_ATPase. IPI InterPro: Sig_transdc_His_kinase_core. IPI Ensembl Protein: ENSRNOP00000002072 IPI IPI: IPI00554328 IPI IPI: IPI00204957 IPI Gene3D-CATH: ATP_bd_ATPase IPI Entrez Gene: Pdk1 ENTREZGENE IMAGE_CLONE: IMAGE:7321326 IMAGE-MGC_LOAD MGC_CLONE: MGC:108625 IMAGE-MGC_LOAD TIGR: TC206538 UniProt: PDK1_RAT IPI UniProt: Q5FVT5_RAT IPI Ensembl Genes: ENSRNOG00000001517 IPI Superfamily-SCOP: ATP_bd_ATPase IPI
Sequences	Nucleotide: XM_001059645 Get FASTA Search GEO Profiles Nucleotide: L22294 Get FASTA Search GEO Profiles Nucleotide: BC089783 Get FASTA Search GEO Profiles Nucleotide: CH473949 Get FASTA Search GEO Profiles Nucleotide: XM_001059583 Get FASTA Search GEO Profiles Nucleotide: NM_053826 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: NP_446278 Get FASTA Protein: XP_001059645 Get FASTA Protein: XP_001059583 Get FASTA Protein: EDL79109 Get FASTA Protein: EDL79111 Get FASTA Protein: EDL79112 Get FASTA Protein: EDL79113 Get FASTA Protein: EDL79114 Get FASTA Protein: EDL79115 Get FASTA Protein: EDL79116 Get FASTA Protein: EDL79117 Get FASTA Protein: EDL79118 Get FASTA Protein: AAH89783 Get FASTA Protein: AAA62851 Get FASTA Protein: Q5FVT5 Get FASTA Protein: Q63065 Get FASTA Protein: EDL79110 Get FASTA (View all 17 Protein Accessions)
Clusters	UniGene: 11185
References
Curated References	11 references in RGD related to Pdk1
Other References	6 other references at PubMed related to Pdk1
Database Information
RGD ID	69427
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-OCT-08: Pdk1 pyruvate dehydrogenase kinase, isozyme 1 Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 30-MAR-06: Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 pyruvate dehydrogenase kinase 1 APPROVED Name updated 1299863 10-JUN-02: Pdk1 pyruvate dehydrogenase kinase 1 APPROVED Symbol and Name status set to approved 70586