Pdk1 (pyruvate dehydrogenase kinase 1) - Rat Genome Database

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Gene: Pdk1 (pyruvate dehydrogenase kinase 1) Rattus norvegicus
Analyze
Symbol: Pdk1
Name: pyruvate dehydrogenase kinase 1
RGD ID: 69427
Description: Enables ATP binding activity; identical protein binding activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in cell surface receptor signaling pathway and peptidyl-serine phosphorylation. Part of pyruvate dehydrogenase complex. Orthologous to human PDK1 (pyruvate dehydrogenase kinase 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; pyruvate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; MGC108625; PDH kinase 1; PDK p48; pyruvate dehydrogenase kinase isoenzyme 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,113,464 - 77,144,145 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl377,113,473 - 77,144,145 (+)EnsemblGRCr8
mRatBN7.2356,705,824 - 56,733,040 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx360,101,009 - 60,128,030 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,684,633 - 68,711,654 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,449,705 - 66,476,726 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,530,870 - 58,561,494 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,530,870 - 58,558,027 (+)Ensemblrn6Rnor6.0
Rnor_5.0365,019,116 - 65,049,739 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4354,292,076 - 54,319,242 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera356,248,990 - 56,275,768 (+)NCBICelera
RGSC_v3.1354,188,447 - 54,215,612 (+)NCBI
Cytogenetic Map3q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
avobenzone  (ISO)
baicalin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
EHT 1864  (ISO)
endosulfan  (EXP)
Erionite  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fipronil  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP)
Fusaric acid  (ISO)
galactose  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
meldonium  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
minocycline  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
morphine  (EXP)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
Pf-06840003  (ISO)
phenobarbital  (EXP)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phosphane  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thenoyltrifluoroacetone  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tubastatin A  (ISO)
Tungsten carbide  (ISO)
ubiquinone-0  (ISO)
undecane  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase. Boulatnikov I and Popov KM, Biochim Biophys Acta. 2003 Feb 21;1645(2):183-92.
2. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Bowker-Kinley MM, etal., Biochem J 1998 Jan 1;329 ( Pt 1):191-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. Korotchkina LG and Patel MS, J Biol Chem. 2001 Oct 5;276(40):37223-9. Epub 2001 Aug 2.
6. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. McConkey M, etal., J Biol Chem. 2004 May 14;279(20):20882-8. Epub 2004 Mar 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. Popov KM, etal., J Biol Chem 1993 Dec 15;268(35):26602-6.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7499431   PMID:11485553   PMID:12477932   PMID:14651853   PMID:17683942   PMID:18541534   PMID:18614015   PMID:21763680   PMID:22195962   PMID:22575885   PMID:24466133   PMID:25436986  
PMID:27748901   PMID:27988334   PMID:30053369   PMID:32216531   PMID:34133802   PMID:34800366   PMID:39080182  


Genomics

Comparative Map Data
Pdk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,113,464 - 77,144,145 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl377,113,473 - 77,144,145 (+)EnsemblGRCr8
mRatBN7.2356,705,824 - 56,733,040 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx360,101,009 - 60,128,030 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,684,633 - 68,711,654 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,449,705 - 66,476,726 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,530,870 - 58,561,494 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,530,870 - 58,558,027 (+)Ensemblrn6Rnor6.0
Rnor_5.0365,019,116 - 65,049,739 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4354,292,076 - 54,319,242 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera356,248,990 - 56,275,768 (+)NCBICelera
RGSC_v3.1354,188,447 - 54,215,612 (+)NCBI
Cytogenetic Map3q23NCBI
PDK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382172,555,373 - 172,724,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2172,555,373 - 172,608,669 (+)Ensemblhg38GRCh38
GRCh372173,420,101 - 173,490,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,129,025 - 173,172,108 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342173,246,285 - 173,289,369NCBI
Celera2167,033,973 - 167,077,058 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2165,298,299 - 165,368,581 (+)NCBIHuRef
CHM1_12173,427,271 - 173,497,479 (+)NCBICHM1_1
T2T-CHM13v2.02173,041,625 - 173,210,788 (+)NCBIT2T-CHM13v2.0
Pdk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,703,398 - 71,734,202 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,703,568 - 71,734,202 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38271,873,215 - 71,903,858 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,873,224 - 71,903,858 (+)Ensemblmm10GRCm38
MGSCv37271,711,329 - 71,741,915 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36271,674,063 - 71,702,840 (+)NCBIMGSCv36mm8
Celera273,545,537 - 73,582,860 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map242.84NCBI
Pdk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554492,549,139 - 2,582,243 (-)Ensembl
ChiLan1.0NW_0049554492,546,790 - 2,582,402 (-)NCBIChiLan1.0ChiLan1.0
PDK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21375,229,457 - 75,391,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B75,244,422 - 75,361,852 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B59,841,840 - 59,958,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B177,297,840 - 177,412,691 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B177,297,840 - 177,341,113 (+)EnsemblpanPan2panpan1.1
PDK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13616,918,329 - 16,944,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3616,918,058 - 16,944,620 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3616,924,778 - 16,954,215 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03617,044,728 - 17,074,152 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3617,044,626 - 17,074,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13617,126,078 - 17,155,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03617,126,377 - 17,155,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03617,229,734 - 17,259,496 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303134,043,765 - 134,079,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365092,597,452 - 2,633,780 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365092,597,593 - 2,633,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1578,608,432 - 78,652,962 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11578,608,394 - 78,650,958 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21587,917,870 - 87,949,472 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11058,055,508 - 58,168,505 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1058,055,511 - 58,096,774 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040141,395,556 - 141,502,606 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247879,917,309 - 9,959,875 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247879,917,366 - 9,956,393 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1549,170,502 - 49,199,496 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdk1
124 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir375rno-miR-375-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18591395

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:32
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000002072
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002072   ⟹   ENSRNOP00000002072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl377,113,473 - 77,144,145 (+)Ensembl
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)Ensembl
Rnor_6.0 Ensembl358,530,870 - 58,558,027 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115755   ⟹   ENSRNOP00000097986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl377,113,473 - 77,144,145 (+)Ensembl
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)Ensembl
RefSeq Acc Id: NM_053826   ⟹   NP_446278
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,113,514 - 77,140,680 (+)NCBI
mRatBN7.2356,705,871 - 56,733,040 (+)NCBI
Rnor_6.0358,530,870 - 58,558,029 (+)NCBI
Rnor_5.0365,019,116 - 65,049,739 (+)NCBI
RGSC_v3.4354,292,076 - 54,319,242 (+)RGD
Celera356,248,990 - 56,275,768 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234352   ⟹   XP_006234414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,113,778 - 77,144,145 (+)NCBI
mRatBN7.2356,706,137 - 56,733,027 (+)NCBI
Rnor_6.0358,531,192 - 58,561,494 (+)NCBI
Rnor_5.0365,019,116 - 65,049,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104113   ⟹   XP_038960041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,123,541 - 77,144,145 (+)NCBI
mRatBN7.2356,715,960 - 56,733,027 (+)NCBI
RefSeq Acc Id: XR_010064554
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,113,464 - 77,137,934 (+)NCBI
RefSeq Acc Id: NP_446278   ⟸   NM_053826
- Peptide Label: precursor
- UniProtKB: Q5FVT5 (UniProtKB/TrEMBL),   F1MA54 (UniProtKB/TrEMBL),   A0A8I6GMB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234414   ⟸   XM_006234352
- Peptide Label: isoform X1
- UniProtKB: A6HM61 (UniProtKB/TrEMBL),   A6HM58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002072   ⟸   ENSRNOT00000002072
RefSeq Acc Id: XP_038960041   ⟸   XM_039104113
- Peptide Label: isoform X2
- UniProtKB: A6HM65 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097986   ⟸   ENSRNOT00000115755
Protein Domains
Branched-chain alpha-ketoacid dehydrogenase   Histidine kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63065-F1-model_v2 AlphaFold Q63065 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692139
Promoter ID:EPDNEW_R2663
Type:initiation region
Name:Pdk1_1
Description:pyruvate dehydrogenase kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0358,530,922 - 58,530,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69427 AgrOrtholog
BioCyc Gene G2FUF-49445 BioCyc
Ensembl Genes ENSRNOG00000001517 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002072 ENTREZGENE
Gene3D-CATH 1.20.140.20 UniProtKB/Swiss-Prot
  3.30.565.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7321326 IMAGE-MGC_LOAD
InterPro AK/P_DHK_N_sf UniProtKB/Swiss-Prot
  BCDHK/PDK_N UniProtKB/Swiss-Prot
  BCKD/PDK UniProtKB/Swiss-Prot
  HATPase_C_sf UniProtKB/Swiss-Prot
  His_kinase_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:108625 IMAGE-MGC_LOAD
NCBI Gene 116551 ENTREZGENE
PANTHER [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11947 UniProtKB/Swiss-Prot
Pfam BCDHK_Adom3 UniProtKB/Swiss-Prot
  HATPase_c UniProtKB/Swiss-Prot
PharmGKB PDK1 RGD
PhenoGen Pdk1 PhenoGen
PROSITE HIS_KIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001517 RatGTEx
SMART HATPase_c UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot
  SSF69012 UniProtKB/Swiss-Prot
TIGR TC206538
UniProt A0A8I6GMB0 ENTREZGENE, UniProtKB/TrEMBL
  A6HM58 ENTREZGENE, UniProtKB/TrEMBL
  A6HM59_RAT UniProtKB/TrEMBL
  A6HM60_RAT UniProtKB/TrEMBL
  A6HM61 ENTREZGENE, UniProtKB/TrEMBL
  A6HM62_RAT UniProtKB/TrEMBL
  A6HM63_RAT UniProtKB/TrEMBL
  A6HM64_RAT UniProtKB/TrEMBL
  A6HM65 ENTREZGENE, UniProtKB/TrEMBL
  A6HM67_RAT UniProtKB/TrEMBL
  F1MA54 ENTREZGENE
  PDK1_RAT UniProtKB/Swiss-Prot
  Q5FVT5 ENTREZGENE, UniProtKB/TrEMBL
  Q63065 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Pdk1  pyruvate dehydrogenase kinase 1  Pdk1  pyruvate dehydrogenase kinase, isozyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Pdk1  pyruvate dehydrogenase kinase, isozyme 1  Pdk1  pyruvate dehydrogenase kinase, isoenzyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pdk1  pyruvate dehydrogenase kinase, isoenzyme 1    pyruvate dehydrogenase kinase 1  Name updated 1299863 APPROVED
2002-06-10 Pdk1  pyruvate dehydrogenase kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product related to prokaryotic family of protein kinases 68684
gene_protein predicted 434 amino acid protein 68684