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Gene: Sh2b2 (SH2B adaptor protein 2) Rattus norvegicus

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Symbol:

Sh2b2

Name:

SH2B adaptor protein 2

RGD ID:

69284

Description:

Enables identical protein binding activity. Involved in nervous system development and regulation of Ras protein signal transduction. Predicted to be located in actin cytoskeleton; cytoplasm; and ruffle. Predicted to be active in plasma membrane. Orthologous to human SH2B2 (SH2B adaptor protein 2); PARTICIPATES IN insulin signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Aps; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SH2B2 (SH2B adaptor protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sh2b2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sh2b2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100987922 (SH2B adapter protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SH2B2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sh2b2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SH2B2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SH2B2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sh2b2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sh2b2 (SH2B adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Sh2b2 (SH2B adaptor protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SH2B2 (SH2B adaptor protein 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lnk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Lnk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	sh2b2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,063,812 - 26,093,468 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	26,064,486 - 26,093,467 (+)	Ensembl				GRCr8
mRatBN7.2	12	20,427,057 - 20,456,845 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	20,429,043 - 20,456,844 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	21,568,557 - 21,596,621 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	22,181,267 - 22,209,333 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	21,247,079 - 21,274,830 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	23,471,477 - 23,501,043 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	23,473,270 - 23,501,036 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	25,472,225 - 25,501,387 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	21,544,434 - 21,572,232 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	22,198,080 - 22,225,866 (+)	NCBI		Celera
RGSC_v3.1	12	21,534,314 - 21,562,110 (+)	NCBI
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

aripiprazole (ISO)

arsane (ISO)

arsenic atom (ISO)

benzene-1,2,4-triol (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

caffeine (EXP)

carbon nanotube (ISO)

cefaloridine (EXP)

chlorpyrifos (ISO)

dioxygen (EXP)

endosulfan (EXP)

FR900359 (ISO)

furan (EXP)

gentamycin (EXP)

hypochlorous acid (ISO)

ketamine (EXP)

lipopolysaccharide (EXP)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

niclosamide (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

ranitidine (EXP)

sodium arsenate (ISO)

Soman (EXP)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

antigen receptor-mediated signaling pathway (ISO)

B cell receptor signaling pathway (IBA,IEA,ISO)

B-1 B cell homeostasis (ISO)

brown fat cell differentiation (ISO)

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

cytokine-mediated signaling pathway (ISO)

insulin receptor signaling pathway (ISO)

intracellular signal transduction (IBA,IEA,ISO)

nervous system development (IMP)

regulation of immune response (ISO)

regulation of Ras protein signal transduction (IDA)

signal transduction (IEA)

Cellular Component

actin filament (IEA,ISO)

cytoplasm (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

ruffle (IEA,ISO)

stress fiber (IEA,ISO)

Molecular Function

protein binding (ISO)

SH2 domain binding (IEA,ISO)

signaling adaptor activity (IEA,ISO)

transmembrane receptor protein tyrosine kinase adaptor activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin signaling pathway (IEA,ISO)

neurotrophic factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.	Hu J and Hubbard SR, J Mol Biol. 2006 Aug 4;361(1):69-79. Epub 2006 Jun 16.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	Identification and characterization of novel substrates of Trk receptors in developing neurons.	Qian X, etal., Neuron 1998 Nov;21(5):1017-29.
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11.	Regulation of insulin receptor function.	Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.

Additional References at PubMed

PMID:9233773	PMID:9989826	PMID:10196204	PMID:10374881	PMID:10854852	PMID:10872802	PMID:11997497	PMID:14578283	PMID:14690593	PMID:14993264	PMID:15031295	PMID:15231829
PMID:15946664	PMID:16141217	PMID:18492766

Genomics

Comparative Map Data

Sh2b2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,063,812 - 26,093,468 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	26,064,486 - 26,093,467 (+)	Ensembl				GRCr8
mRatBN7.2	12	20,427,057 - 20,456,845 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	20,429,043 - 20,456,844 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	21,568,557 - 21,596,621 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	22,181,267 - 22,209,333 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	21,247,079 - 21,274,830 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	23,471,477 - 23,501,043 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	23,473,270 - 23,501,036 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	25,472,225 - 25,501,387 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	21,544,434 - 21,572,232 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	22,198,080 - 22,225,866 (+)	NCBI		Celera
RGSC_v3.1	12	21,534,314 - 21,562,110 (+)	NCBI
Cytogenetic Map	12	q12	NCBI

SH2B2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	102,285,141 - 102,321,711 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	102,284,995 - 102,321,712 (+)	Ensembl			hg38	GRCh38
GRCh37	7	101,928,432 - 101,962,178 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	101,715,166 - 101,748,898 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	101,521,886 - 101,555,612	NCBI
Celera	7	96,937,415 - 96,974,023 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	96,518,618 - 96,555,244 (+)	NCBI		HuRef
CHM1_1	7	101,856,547 - 101,892,227 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	103,602,545 - 103,639,107 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	101,285,864 - 101,322,461 (+)	NCBI

Sh2b2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	136,247,003 - 136,275,446 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	136,247,001 - 136,275,410 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	136,218,147 - 136,246,595 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	136,218,147 - 136,246,556 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	136,694,019 - 136,720,773 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	136,502,776 - 136,529,530 (-)	NCBI		MGSCv36	mm8
Celera	5	133,234,728 - 133,261,476 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.93	NCBI

Sh2b2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	15,253,856 - 15,265,845 (-)	Ensembl
ChiLan1.0	NW_004955456	15,253,711 - 15,265,874 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100987922
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	88,678,181 - 88,703,893 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	137,006,683 - 137,034,320 (+)	NCBI		NHGRI_mPanPan1

SH2B2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	7,795,756 - 7,820,010 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	7,795,373 - 7,819,843 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	9,490,633 - 9,514,600 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	7,615,994 - 7,639,944 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	7,615,880 - 7,639,946 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	7,584,419 - 7,605,038 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	7,547,911 - 7,571,843 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	7,711,487 - 7,735,478 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sh2b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	132,215,641 - 132,236,929 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	1,799,568 - 1,822,028 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	1,799,610 - 1,820,889 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SH2B2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	9,670,815 - 9,695,629 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	9,670,838 - 9,695,325 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	9,455,164 - 9,467,362 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH2B2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	10,862,922 - 10,900,967 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	10,864,188 - 10,883,437 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	5,502,499 - 5,541,690 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sh2b2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	15,266,653 - 15,278,165 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	15,266,759 - 15,289,420 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sh2b2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	17,773,681 - 17,801,297 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sh2b2
331 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	92
Count of miRNA genes:	65
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000001935
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	20139028	26430640	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

AU046360

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	26,065,998 - 26,066,137 (+)	Marker Load Pipeline
mRatBN7.2	12	20,429,369 - 20,429,506 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	23,473,597 - 23,473,733	NCBI	Rnor6.0
Rnor_5.0	12	25,473,947 - 25,474,083	UniSTS	Rnor5.0
RGSC_v3.4	12	21,544,761 - 21,544,897	UniSTS	RGSC3.4
Celera	12	22,198,407 - 22,198,531	UniSTS
Cytogenetic Map	12	q12	UniSTS

RH142461

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	20,437,961 - 20,438,184 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	23,482,189 - 23,482,411	NCBI	Rnor6.0
Rnor_5.0	12	25,482,539 - 25,482,761	UniSTS	Rnor5.0
RGSC_v3.4	12	21,553,353 - 21,553,575	UniSTS	RGSC3.4
Celera	12	22,206,987 - 22,207,209	UniSTS
RH 3.4 Map	12	299.2	UniSTS
Cytogenetic Map	12	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	351	192	11	144	76	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC091536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF095576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001935 ⟹ ENSRNOP00000001935

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	26,065,620 - 26,093,467 (+)	Ensembl
mRatBN7.2 Ensembl	12	20,429,043 - 20,456,844 (+)	Ensembl
Rnor_6.0 Ensembl	12	23,473,270 - 23,501,036 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093990 ⟹ ENSRNOP00000095058

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	26,065,620 - 26,087,317 (+)	Ensembl
mRatBN7.2 Ensembl	12	20,429,043 - 20,450,694 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102136 ⟹ ENSRNOP00000097265

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	26,064,486 - 26,093,467 (+)	Ensembl
mRatBN7.2 Ensembl	12	20,429,043 - 20,456,349 (+)	Ensembl

RefSeq Acc Id:

NM_053669 ⟹ NP_446121

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,065,672 - 26,093,468 (+)	NCBI
mRatBN7.2	12	20,429,043 - 20,456,845 (+)	NCBI
Rnor_6.0	12	23,473,270 - 23,501,037 (+)	NCBI
Rnor_5.0	12	25,472,225 - 25,501,387 (+)	NCBI
RGSC_v3.4	12	21,544,434 - 21,572,232 (+)	RGD
Celera	12	22,198,080 - 22,225,866 (+)	RGD

Sequence:

show sequence

GGCACGAGCAAAGAGGGAGAGAACCTCAAGGGGCCCGCCCCGGGACTGCTAAGAGCGCACGAGC
CTCGCAGACTGCAGGCCAGGGAAGCGGGAGCCAGCCCCCGCCGCCGCCGCCACCACCGGCCACC
AAGGGCGGAGCTACGGCCCGGAGGGCCATGCGCCACCGGGTCCGAGGATCCCGGCCGCGGTCCG
GGCAGCGCTTCTCCGGCGCCCCGGCCGGCGCGGCCGAAGCTGCGCGCCTGTAGTCCGAGGCTGC
CATGGGACCAAAGCCATGAATGGTGCCACCCCCGGCTCGGCAGCCGCCCCCGCCCCAGTCCCCG
ACTGGAGGCAATTCTGCGAGCTGCACGCTCAGGTAGCTGCTGTGGACTTCGCTCACAAGTTCTG
CCGCTTCCTTCGGGACAACCCGACCTACGACACGCCTGACGCTGGGACCTCGTTCTCCCGCCAC
TTTGCAGCCAACTTCTTGGCAGTCTTCAGCGAGGAAGTGCGCCGCGTGCTGGGGACAGCAGCTG
ACACCATGGAACCCGAGCCTGCGGTGACCTCCGTGACCTCGGCGCTCAAGACTGCAACCTATGG
CCACTCTCGCAGCTCCGAAGATGTGTCTGCTCACGTGGCTACCAAGGCCCGTGTCCGCAAAGGC
TTCTCACTGCGTAACATGAGCCTGTGTGTAGTGGACGGAGTGCGCGACCTATGGCACCGGCGCG
CATCCCCAGAGCCCGAGGGTGGGGCCACCCCGAAAACCACCGAGCCTGTGTCCGAGCCTCGTGA
CAAATGGACGCGACGTCTGCGGCTGGCACGAACCCTGGCAGCCAAAGTGGAGTTAGTGGACATC
CAGCGCGAGGGCGCACTGCGCTTCATGGTGGCAGATGATGCAGCCTCCGGCCCTGGGGGCACGG
CACAGTGGCAGAAATGTCGCCTGCTCCTCCGAAGGGCTGTGGCCGGAGAGCGCTTCCGCCTGGA
GTTCTTCGTGCCACCCAAGGCTTCCAGACCCAAGGTCAGCATCCCCCTGTCGGCCATCATCGAG
GTCCGAACCACCATGCCCCTGGAAATGCCTGAGAAGGACAACACATTTGTGCTCAAGGTGGAGA
ACGGAGCGGAGTACATTCTGGAGACGATAGACTCACTACAGAAGCACTCGTGGGTGGCTGACAT
CCAGGGCTGTGTGGATCCTGGGGACAGTGAGGAAGACACAGGGCTGTCTTGTGCACGGGGAGGC
TGTCTGGCCAGCCGCGTGACCTCCTGCAGCTGTGAGCTCCTGACAGAAGCAGACATGCCCCGGC
CCCCAGAGACGATGACAGCAGTGGGTGCTGTGGTTACAGCTCCACATGGCCGAGCTCGTGACAC
CGTGGGAGAGTCCCTGGCTCACGTTCCCCTGGAGACTTTCCTGCAAACCCTGGAGTCTTCAGGT
GGTGTCAGTGAGAGCAATAACACAGGGGATGAAGGAGCTGAGCTGGACCCCGATGCTGAGGCTG
AGCTGGAACTCTCCGACTACCCCTGGTTCCATGGGACACTGTCCCGGGTGAAGGCCGCCCAGCT
GGTGTTGGCTGGTGGGCCCCGGAGTCACGGCCTCTTTGTGATCCGCCAAAGCGAGACTCGGCCT
GGGGAGTGTGTGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCACCTTCGCCTTTCTCTGAATG
GTCACGGCCAGTGTCATGTCCAACACCTGTGGTTCCAGTCGGTGTTTGACATGCTTCGACACTT
CCACACCCACCCCATTCCCCTGGAGTCAGGAGGATCCGCTGACATCACCCTACGAAGCTACGTG
CGTGCCCAAGGTCCACCTCCTGATCCAGGACCAGCGCCCAACACTGCAGCCCCGGTCCCGGCCT
GCTGGACGGAGCCGGCTGGCCAGCACTACTTCTCCAGCCTGGCCACGGCCACCTGCCCACCCAC
TTCACCCTCCAATGGCGCTGGAGCATCGTCGTCATCCGGTTCATCATCCTCTGCTACGTCCGTG
CCCCCACGCCCAGCCGAGGGGCCACTCAGTGCGCGCAGTCGCAGCAACAGCACAGAGCACCTGC
TAGAGGCTGCATCCGGAGCCACTGAGGAGCCCGCAGATGCCACGCTGGGCCGCGCTCGCGCTGT
GGAGAATCAGTACTCCTTTTACTAGCTGCCATGCCTATTACCCACGGGTGTCACGCACAACACA
GCAGGCCACGAACACCTGCTGTCTGTCCTGCCCACCCACAGCCTGGCTAGCCCATGACGGTCAA
CAACACCTAACAAATGGCTAGACACACCTATCCATGGTCTAGCATGGCCAAGACAGATGGCCAG
CCTAGCCACTTCAAACCCCAGGGGCCCATTATGACCGTGTGTGGCAGGCCAAGGCTAAGTCCAT
GGTCGATCAAACCCATGATAGCCCTCCAATGATTTCACGCCCCGCCCACTGGTGGTTGGCCACG
CCCACCAGCAGCTATTTCTATACAGTCCATCGTATCCACGACAGGCAGCTCACTGACAACTAAC
CACATTTGGTGACTTCAGGCCCTGCCTACTGTTGGTTGGTTACTCCTACAGTGGCATCATGGCC
AACCCACTGGCTGCCTGCTTTGCTCGAGGGTAGCAAGCCACGTCTATCAAGCCCATGAAGGCTT
ACCCACTGATTCCTAACAACCTCAGGCCCTGCCCACCCATGTTGGGTCACATACTCCAATAGCC
CACCAGGCTGTGGTCCGCCTAGCCTAGGACAGCCTGTCACGCCCACCAGCCCCAGCCCAACGCT
GGGGGGAAAAGCCAAGCTCTTCAGTGAAGACAAACATTATTAAAGAGCCTGTTTTAGGGACTAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008769112 ⟹ XP_008767334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,063,819 - 26,093,468 (+)	NCBI
mRatBN7.2	12	20,427,057 - 20,456,845 (+)	NCBI
Rnor_6.0	12	23,471,593 - 23,501,043 (+)	NCBI

Sequence:

show sequence

AATCCTCGCCAGCCGCTGACTGCCCACCATCGAATCAAGCCACAACTTAGAACAGGTCCAGAGA
CAGAGCAGCTGCTAGTCCCTGTGTAGCCGAGAAGAAACAGGTACCCAGGCAGGCCTCAACAGAG
GTATGGCTGGTTTCAGTGGCCCCAAGCAAATTTCCATGTGCTCGGCACACCCCACCTCTCCAGT
GTCAGCCCAGTTCCCCTAGCCCCATGCCACCCCTGCTGCTTCCTGGAAAATAATCAGTGAATCT
GAGTTCCTGTGAGTGAAAGGACTTTACAAAGGTCAGAGGCCACCGTGAGTGGGAGGAGGGCAGC
AGATGGAGACACTCCAGGCAGATCACAGCCAGAGGTCTACACAGACAGAAGAATGACTGCTGAC
CATCCTGGAATGGGAAGCCAGGAAGAGAGGAGAGCAGATCCAAGGGACCATGTCCACTGCAGAA
TCCGAGGCTGCCATGGGACCAAAGCCATGAATGGTGCCACCCCCGGCTCGGCAGCCGCCCCCGC
CCCAGTCCCCGACTGGAGGCAATTCTGCGAGCTGCACGCTCAGGTAGCTGCTGTGGACTTCGCT
CACAAGTTCTGCCGCTTCCTTCGGGACAACCCGACCTACGACACGCCTGACGCTGGGACCTCGT
TCTCCCGCCACTTTGCAGCCAACTTCTTGGCAGTCTTCAGCGAGGAAGTGCGCCGCGTGCTGGG
GACAGCAGCTGACACCATGGAACCCGAGCCTGCGGTGACCTCCGTGACCTCGGCGCTCAAGACT
GCAACCTATGGCCACTCTCGCAGCTCCGAAGATGTGTCTGCTCACGTGGCTACCAAGGCCCGTG
TCCGCAAAGGCTTCTCACTGCGTAACATGAGCCTGTGTGTAGTGGACGGAGTGCGCGACCTATG
GCACCGGCGCGCATCCCCAGAGCCCGAGGGTGGGGCCACCCCGAAAACCACCGAGCCTGTGTCC
GAGCCTCGTGACAAATGGACGCGACGTCTGCGGCTGGCACGAACCCTGGCAGCCAAAGTGGAGT
TAGTGGACATCCAGCGCGAGGGCGCACTGCGCTTCATGGTGGCAGATGATGCAGCCTCCGGCCC
TGGGGGCACGGCACAGTGGCAGAAATGTCGCCTGCTCCTCCGAAGGGCTGTGGCCGGAGAGCGC
TTCCGCCTGGAGTTCTTCGTGCCACCCAAGGCTTCCAGACCCAAGGTCAGCATCCCCCTGTCGG
CCATCATCGAGGTCCGAACCACCATGCCCCTGGAAATGCCTGAGAAGGACAACACATTTGTGCT
CAAGGTGGAGAACGGAGCGGAGTACATTCTGGAGACGATAGACTCACTACAGAAGCACTCGTGG
GTGGCTGACATCCAGGGCTGTGTGGATCCTGGGGACAGTGAGGAAGACACAGGGCTGTCTTGTG
CACGGGGAGGCTGTCTGGCCAGCCGCGTGACCTCCTGCAGCTGTGAGCTCCTGACAGAAGCAGA
CATGCCCCGGCCCCCAGAGACGATGACAGCAGTGGGTGCTGTGGTTACAGCTCCACATGGCCGA
GCTCGTGACACCGTGGGAGAGTCCCTGGCTCACGTTCCCCTGGAGACTTTCCTGCAAACCCTGG
AGTCTTCAGGTGGTGTCAGTGAGAGCAATAACACAGGGGATGAAGGAGCTGAGCTGGACCCCGA
TGCTGAGGCTGAGCTGGAACTCTCCGACTACCCCTGGTTCCATGGGACACTGTCCCGGGTGAAG
GCCGCCCAGCTGGTGTTGGCTGGTGGGCCCCGGAGTCACGGCCTCTTTGTGATCCGCCAAAGCG
AGACTCGGCCTGGGGAGTGTGTGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCACCTTCGCCT
TTCTCTGAATGGTCACGGCCAGTGTCATGTCCAACACCTGTGGTTCCAGTCGGTGTTTGACATG
CTTCGACACTTCCACACCCACCCCATTCCCCTGGAGTCAGGAGGATCCGCTGACATCACCCTAC
GAAGCTACGTGCGTGCCCAAGGTCCACCTCCTGATCCAGGACCAGCGCCCAACACTGCAGCCCC
GGTCCCGGCCTGCTGGACGGAGCCGGCTGGCCAGCACTACTTCTCCAGCCTGGCCACGGCCACC
TGCCCACCCACTTCACCCTCCAATGGCGCTGGAGCATCGTCGTCATCCGGTTCATCATCCTCTG
CTACGTCCGTGCCCCCACGCCCAGCCGAGGGGCCACTCAGTGCGCGCAGTCGCAGCAACAGCAC
AGAGCACCTGCTAGAGGCTGCATCCGGAGCCACTGAGGAGCCCGCAGATGCCACGCTGGGCCGC
GCTCGCGCTGTGGAGAATCAGTACTCCTTTTACTAGCTGCCATGCCTATTACCCACGGGTGTCA
CGCACAACACAGCAGGCCACGAACACCTGCTGTCTGTCCTGCCCACCCACAGCCTGGCTAGCCC
ATGACGGTCAACAACACCTAACAAATGGCTAGACACACCTATCCATGGTCTAGCATGGCCAAGA
CAGATGGCCAGCCTAGCCACTTCAAACCCCAGGGGCCCATTATGACCGTGTGTGGCAGGCCAAG
GCTAAGTCCATGGTCGATCAAACCCATGATAGCCCTCCAATGATTTCACGCCCCGCCCACTGGT
GGTTGGCCACGCCCACCAGCAGCTATTTCTATACAGTCCATCGTATCCACGACAGGCAGCTCAC
TGACAACTAACCACATTTGGTGACTTCAGGCCCTGCCTACTGTTGGTTGGTTACTCCTACAGTG
GCATCATGGCCAACCCACTGGCTGCCTGCTTTGCTCGAGGGTAGCAAGCCACGTCTATCAAGCC
CATGAAGGCTTACCCACTGATTCCTAACAACCTCAGGCCCTGCCCACCCATGTTGGGTCACATA
CTCCAATAGCCCACCAGGCTGTGGTCCGCCTAGCCTAGGACAGCCTGTCACGCCCACCAGCCCC
AGCCCAACGCTGGGGGGAAAAGCCAAGCTCTTCAGTGAAGACAAACATTATTAAAGAGCCTGTT
TTAGGGACTACCCCCT

hide sequence

RefSeq Acc Id:

XM_008769113 ⟹ XP_008767335

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,065,550 - 26,093,468 (+)	NCBI
mRatBN7.2	12	20,433,970 - 20,456,845 (+)	NCBI
Rnor_6.0	12	23,482,109 - 23,501,043 (+)	NCBI

Sequence:

show sequence

CAAGTGCTCTACCACTGAGCTAAATCCCCAACCCCCTGCCTCACCCTCCTAATGCTAAGCTTAC
AGGCACATGCCGCCCAGGCTGGCACAACTGTCTCCTCTAAGACCCTCCACCCTAAAGCTAGGCT
TATAATCAGGTGCCACCACACCCTGCTTCCCCTGTTCTCTGTAGCCTGGGACACAAGACAGCTA
GCTATACTGGCCCATAAGCTCCTGGCCTGCCGGTGGGGTTGGAGAAGAGAGGGCAGGAAAGATC
CAGCCACTCTCCTGCTTAGGACACAATGCACCTCTCAGAATCTTGGCGGAGTCTAATTTCCACC
TGGCTTGGGTGGGGCCCTACATAGGCCCTGTCCTCCGTGATTCTGTTCCTTCTCCATTCAAAGG
CTTTCACAGCCATCAGAAGGGACAAAGGGAAGCCTAAAACCCAGTGCCAGGGCTGACCTCCTAG
CAGCCTCCACACAGGCCCATAATTAGCCTTCCGACCATGCTCACCCATGCCATCACACAGAGTA
GGAGATGCCCTGCTGGGTAAGTGCATGGACTTGGGGCAGGCCCTCCTGGGTTTAGCAGTGAGTC
CTTCCATCCTTCTTGGAGGTCATGGTGGTGGTGGTGGTGGTGGTGGTGGTGACGGCAGTGGCCT
AGCAGGTACAGTCCCTACTTCCAGGGAAAAGAGTGAGTGACAGGAATCTGAGATATGACTCAGG
CCTTCCTTCCGCCCACAAGGACAACCCGTGCCAGCCGGAGAGATAGACTTAAAAGCAGGCACAG
AGCACAGCACAAGTGGTAGCTTGCTAGAGGGACACTCATGGAAGCTTAGAAGAGACACTTGTCG
CGCAAGGCCCTGGGTTCAGTCCCCAGCTCCGAAAAAAAGAAAAAAGAAGACGAAGAAAGAAAAA
AAAAAAAAAAGAGAGAGAGACACTTGTGCCAGCCTGGACAGAGGAAGTCAAGGAAGGCTTCCTA
GAGGAAGAAGTTTCATTATGGAAGGATGACTAGGAGTTGAGAAACAGGGTAGAGTAAGGGTCAG
GCATCCGTGACGCTCATGAGGACCCAGCGCCCACCTCTCTCCACTTCACGGACTTCGCACACTG
CCCTCTGATTTCCAAAAGTCTCACCGCAGTCATTGCTCCTTCCGTGGCGCCACCTTTGTCCTAT
CTATAGTCCGAGGCTGCCATGGGACCAAAGCCATGAATGGTGCCACCCCCGGCTCGGCAGCCGC
CCCCGCCCCAGTCCCCGACTGGAGGCAATTCTGCGAGCTGCACGCTCAGGTAGCTGCTGTGGAC
TTCGCTCACAAGTTCTGCCGCTTCCTTCGGGACAACCCGACCTACGACACGCCTGACGCTGGGA
CCTCGTTCTCCCGCCACTTTGCAGCCAACTTCTTGGCAGTCTTCAGCGAGGAAGTGCGCCGCGT
GCTGGGGACAGCAGCTGACACCATGGAACCCGAGCCTGCGGTGACCTCCGTGACCTCGGCGCTC
AAGACTGCAACCTATGGCCACTCTCGCAGCTCCGAAGATGTGTCTGCTCACGTGGCTACCAAGG
CCCGTGTCCGCAAAGGCTTCTCACTGCGTAACATGAGCCTGTGTGTAGTGGACGGAGTGCGCGA
CCTATGGCACCGGCGCGCATCCCCAGAGCCCGAGGGTGGGGCCACCCCGAAAACCACCGAGCCT
GTGTCCGAGCCTCGTGACAAATGGACGCGACGTCTGCGGCTGGCACGAACCCTGGCAGCCAAAG
TGGAGTTAGTGGACATCCAGCGCGAGGGCGCACTGCGCTTCATGGTGGCAGATGATGCAGCCTC
CGGCCCTGGGGGCACGGCACAGTGGCAGAAATGTCGCCTGCTCCTCCGAAGGGCTGTGGCCGGA
GAGCGCTTCCGCCTGGAGTTCTTCGTGCCACCCAAGGCTTCCAGACCCAAGGTCAGCATCCCCC
TGTCGGCCATCATCGAGGTCCGAACCACCATGCCCCTGGAAATGCCTGAGAAGGACAACACATT
TGTGCTCAAGGTGGAGAACGGAGCGGAGTACATTCTGGAGACGATAGACTCACTACAGAAGCAC
TCGTGGGTGGCTGACATCCAGGGCTGTGTGGATCCTGGGGACAGTGAGGAAGACACAGGGCTGT
CTTGTGCACGGGGAGGCTGTCTGGCCAGCCGCGTGACCTCCTGCAGCTGTGAGCTCCTGACAGA
AGCAGACATGCCCCGGCCCCCAGAGACGATGACAGCAGTGGGTGCTGTGGTTACAGCTCCACAT
GGCCGAGCTCGTGACACCGTGGGAGAGTCCCTGGCTCACGTTCCCCTGGAGACTTTCCTGCAAA
CCCTGGAGTCTTCAGGTGGTGTCAGTGAGAGCAATAACACAGGGGATGAAGGAGCTGAGCTGGA
CCCCGATGCTGAGGCTGAGCTGGAACTCTCCGACTACCCCTGGTTCCATGGGACACTGTCCCGG
GTGAAGGCCGCCCAGCTGGTGTTGGCTGGTGGGCCCCGGAGTCACGGCCTCTTTGTGATCCGCC
AAAGCGAGACTCGGCCTGGGGAGTGTGTGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCACCT
TCGCCTTTCTCTGAATGGTCACGGCCAGTGTCATGTCCAACACCTGTGGTTCCAGTCGGTGTTT
GACATGCTTCGACACTTCCACACCCACCCCATTCCCCTGGAGTCAGGAGGATCCGCTGACATCA
CCCTACGAAGCTACGTGCGTGCCCAAGGTCCACCTCCTGATCCAGGACCAGCGCCCAACACTGC
AGCCCCGGTCCCGGCCTGCTGGACGGAGCCGGCTGGCCAGCACTACTTCTCCAGCCTGGCCACG
GCCACCTGCCCACCCACTTCACCCTCCAATGGCGCTGGAGCATCGTCGTCATCCGGTTCATCAT
CCTCTGCTACGTCCGTGCCCCCACGCCCAGCCGAGGGGCCACTCAGTGCGCGCAGTCGCAGCAA
CAGCACAGAGCACCTGCTAGAGGCTGCATCCGGAGCCACTGAGGAGCCCGCAGATGCCACGCTG
GGCCGCGCTCGCGCTGTGGAGAATCAGTACTCCTTTTACTAGCTGCCATGCCTATTACCCACGG
GTGTCACGCACAACACAGCAGGCCACGAACACCTGCTGTCTGTCCTGCCCACCCACAGCCTGGC
TAGCCCATGACGGTCAACAACACCTAACAAATGGCTAGACACACCTATCCATGGTCTAGCATGG
CCAAGACAGATGGCCAGCCTAGCCACTTCAAACCCCAGGGGCCCATTATGACCGTGTGTGGCAG
GCCAAGGCTAAGTCCATGGTCGATCAAACCCATGATAGCCCTCCAATGATTTCACGCCCCGCCC
ACTGGTGGTTGGCCACGCCCACCAGCAGCTATTTCTATACAGTCCATCGTATCCACGACAGGCA
GCTCACTGACAACTAACCACATTTGGTGACTTCAGGCCCTGCCTACTGTTGGTTGGTTACTCCT
ACAGTGGCATCATGGCCAACCCACTGGCTGCCTGCTTTGCTCGAGGGTAGCAAGCCACGTCTAT
CAAGCCCATGAAGGCTTACCCACTGATTCCTAACAACCTCAGGCCCTGCCCACCCATGTTGGGT
CACATACTCCAATAGCCCACCAGGCTGTGGTCCGCCTAGCCTAGGACAGCCTGTCACGCCCACC
AGCCCCAGCCCAACGCTGGGGGGAAAAGCCAAGCTCTTCAGTGAAGACAAACATTATTAAAGAG
CCTGTTTTAGGGACTACCCCCT

hide sequence

RefSeq Acc Id:

XM_017598238 ⟹ XP_017453727

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,065,550 - 26,093,468 (+)	NCBI
mRatBN7.2	12	20,428,917 - 20,456,845 (+)	NCBI
Rnor_6.0	12	23,473,485 - 23,501,043 (+)	NCBI

Sequence:

show sequence

GGCCGAAGCTGCGCGCCTGTAGGACAACCCGTGCCAGCCGGAGAGATAGACTTAAAAGCAGGCA
CAGAGCACAGCACAAGTGGTAGCTTGCTAGAGGGACACTCATGGAAGCTTAGAAGAGACACTTG
TCGCGCAAGGCCCTGGGTTCAGTCCCCAGCTCCGAAAAAAAGAAAAAAGAAGACGAAGAAAGAA
AAAAAAAAAAAAAGAGAGAGAGACACTTGTGCCAGCCTGGACAGAGGAAGTCAAGGAAGGCTTC
CTAGAGGAAGAAGTTTCATTATGGAAGGATGACTAGGAGTTGAGAAACAGGGTAGAGTAAGGGT
CAGGCATCCGTGACGCTCATGAGGACCCAGCGCCCACCTCTCTCCACTTCACGGACTTCGCACA
CTGCCCTCTGATTTCCAAAAGTCTCACCGCAGTCATTGCTCCTTCCGTGGCGCCACCTTTGTCC
TATCTATAGTCCGAGGCTGCCATGGGACCAAAGCCATGAATGGTGCCACCCCCGGCTCGGCAGC
CGCCCCCGCCCCAGTCCCCGACTGGAGGCAATTCTGCGAGCTGCACGCTCAGGTAGCTGCTGTG
GACTTCGCTCACAAGTTCTGCCGCTTCCTTCGGGACAACCCGACCTACGACACGCCTGACGCTG
GGACCTCGTTCTCCCGCCACTTTGCAGCCAACTTCTTGGCAGTCTTCAGCGAGGAAGTGCGCCG
CGTGCTGGGGACAGCAGCTGACACCATGGAACCCGAGCCTGCGGTGACCTCCGTGACCTCGGCG
CTCAAGACTGCAACCTATGGCCACTCTCGCAGCTCCGAAGATGTGTCTGCTCACGTGGCTACCA
AGGCCCGTGTCCGCAAAGGCTTCTCACTGCGTAACATGAGCCTGTGTGTAGTGGACGGAGTGCG
CGACCTATGGCACCGGCGCGCATCCCCAGAGCCCGAGGGTGGGGCCACCCCGAAAACCACCGAG
CCTGTGTCCGAGCCTCGTGACAAATGGACGCGACGTCTGCGGCTGGCACGAACCCTGGCAGCCA
AAGTGGAGTTAGTGGACATCCAGCGCGAGGGCGCACTGCGCTTCATGGTGGCAGATGATGCAGC
CTCCGGCCCTGGGGGCACGGCACAGTGGCAGAAATGTCGCCTGCTCCTCCGAAGGGCTGTGGCC
GGAGAGCGCTTCCGCCTGGAGTTCTTCGTGCCACCCAAGGCTTCCAGACCCAAGGTCAGCATCC
CCCTGTCGGCCATCATCGAGGTCCGAACCACCATGCCCCTGGAAATGCCTGAGAAGGACAACAC
ATTTGTGCTCAAGGTGGAGAACGGAGCGGAGTACATTCTGGAGACGATAGACTCACTACAGAAG
CACTCGTGGGTGGCTGACATCCAGGGCTGTGTGGATCCTGGGGACAGTGAGGAAGACACAGGGC
TGTCTTGTGCACGGGGAGGCTGTCTGGCCAGCCGCGTGACCTCCTGCAGCTGTGAGCTCCTGAC
AGAAGCAGACATGCCCCGGCCCCCAGAGACGATGACAGCAGTGGGTGCTGTGGTTACAGCTCCA
CATGGCCGAGCTCGTGACACCGTGGGAGAGTCCCTGGCTCACGTTCCCCTGGAGACTTTCCTGC
AAACCCTGGAGTCTTCAGGTGGTGTCAGTGAGAGCAATAACACAGGGGATGAAGGAGCTGAGCT
GGACCCCGATGCTGAGGCTGAGCTGGAACTCTCCGACTACCCCTGGTTCCATGGGACACTGTCC
CGGGTGAAGGCCGCCCAGCTGGTGTTGGCTGGTGGGCCCCGGAGTCACGGCCTCTTTGTGATCC
GCCAAAGCGAGACTCGGCCTGGGGAGTGTGTGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCA
CCTTCGCCTTTCTCTGAATGGTCACGGCCAGTGTCATGTCCAACACCTGTGGTTCCAGTCGGTG
TTTGACATGCTTCGACACTTCCACACCCACCCCATTCCCCTGGAGTCAGGAGGATCCGCTGACA
TCACCCTACGAAGCTACGTGCGTGCCCAAGGTCCACCTCCTGATCCAGGACCAGCGCCCAACAC
TGCAGCCCCGGTCCCGGCCTGCTGGACGGAGCCGGCTGGCCAGCACTACTTCTCCAGCCTGGCC
ACGGCCACCTGCCCACCCACTTCACCCTCCAATGGCGCTGGAGCATCGTCGTCATCCGGTTCAT
CATCCTCTGCTACGTCCGTGCCCCCACGCCCAGCCGAGGGGCCACTCAGTGCGCGCAGTCGCAG
CAACAGCACAGAGCACCTGCTAGAGGCTGCATCCGGAGCCACTGAGGAGCCCGCAGATGCCACG
CTGGGCCGCGCTCGCGCTGTGGAGAATCAGTACTCCTTTTACTAGCTGCCATGCCTATTACCCA
CGGGTGTCACGCACAACACAGCAGGCCACGAACACCTGCTGTCTGTCCTGCCCACCCACAGCCT
GGCTAGCCCATGACGGTCAACAACACCTAACAAATGGCTAGACACACCTATCCATGGTCTAGCA
TGGCCAAGACAGATGGCCAGCCTAGCCACTTCAAACCCCAGGGGCCCATTATGACCGTGTGTGG
CAGGCCAAGGCTAAGTCCATGGTCGATCAAACCCATGATAGCCCTCCAATGATTTCACGCCCCG
CCCACTGGTGGTTGGCCACGCCCACCAGCAGCTATTTCTATACAGTCCATCGTATCCACGACAG
GCAGCTCACTGACAACTAACCACATTTGGTGACTTCAGGCCCTGCCTACTGTTGGTTGGTTACT
CCTACAGTGGCATCATGGCCAACCCACTGGCTGCCTGCTTTGCTCGAGGGTAGCAAGCCACGTC
TATCAAGCCCATGAAGGCTTACCCACTGATTCCTAACAACCTCAGGCCCTGCCCACCCATGTTG
GGTCACATACTCCAATAGCCCACCAGGCTGTGGTCCGCCTAGCCTAGGACAGCCTGTCACGCCC
ACCAGCCCCAGCCCAACGCTGGGGGGAAAAGCCAAGCTCTTCAGTGAAGACAAACATTATTAAA
GAGCCTGTTTTAGGGACTACCCCCT

hide sequence

RefSeq Acc Id:

XM_017598239 ⟹ XP_017453728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,063,820 - 26,093,468 (+)	NCBI
mRatBN7.2	12	20,427,057 - 20,456,845 (+)	NCBI
Rnor_6.0	12	23,471,477 - 23,501,043 (+)	NCBI

Sequence:

show sequence

TCACCGCCACCCTCCTTCTATGTGTCCCGTCAGTTCCTCATGTGGGTCCGACTCACTCCTCACT
TCCTCCTCTGGGGCATCAGAACCATTGTCTGATTCTGGGTTTCCCATCCCAGAATCCTCGCCAG
CCGCTGACTGCCCACCATCGAATCAAGCCACAACTTAGAACAGTCCGAGGCTGCCATGGGACCA
AAGCCATGAATGGTGCCACCCCCGGCTCGGCAGCCGCCCCCGCCCCAGTCCCCGACTGGAGGCA
ATTCTGCGAGCTGCACGCTCAGGTAGCTGCTGTGGACTTCGCTCACAAGTTCTGCCGCTTCCTT
CGGGACAACCCGACCTACGACACGCCTGACGCTGGGACCTCGTTCTCCCGCCACTTTGCAGCCA
ACTTCTTGGCAGTCTTCAGCGAGGAAGTGCGCCGCGTGCTGGGGACAGCAGCTGACACCATGGA
ACCCGAGCCTGCGGTGACCTCCGTGACCTCGGCGCTCAAGACTGCAACCTATGGCCACTCTCGC
AGCTCCGAAGATGTGTCTGCTCACGTGGCTACCAAGGCCCGTGTCCGCAAAGGCTTCTCACTGC
GTAACATGAGCCTGTGTGTAGTGGACGGAGTGCGCGACCTATGGCACCGGCGCGCATCCCCAGA
GCCCGAGGGTGGGGCCACCCCGAAAACCACCGAGCCTGTGTCCGAGCCTCGTGACAAATGGACG
CGACGTCTGCGGCTGGCACGAACCCTGGCAGCCAAAGTGGAGTTAGTGGACATCCAGCGCGAGG
GCGCACTGCGCTTCATGGTGGCAGATGATGCAGCCTCCGGCCCTGGGGGCACGGCACAGTGGCA
GAAATGTCGCCTGCTCCTCCGAAGGGCTGTGGCCGGAGAGCGCTTCCGCCTGGAGTTCTTCGTG
CCACCCAAGGCTTCCAGACCCAAGGTCAGCATCCCCCTGTCGGCCATCATCGAGGTCCGAACCA
CCATGCCCCTGGAAATGCCTGAGAAGGACAACACATTTGTGCTCAAGGTGGAGAACGGAGCGGA
GTACATTCTGGAGACGATAGACTCACTACAGAAGCACTCGTGGGTGGCTGACATCCAGGGCTGT
GTGGATCCTGGGGACAGTGAGGAAGACACAGGGCTGTCTTGTGCACGGGGAGGCTGTCTGGCCA
GCCGCGTGACCTCCTGCAGCTGTGAGCTCCTGACAGAAGCAGACATGCCCCGGCCCCCAGAGAC
GATGACAGCAGTGGGTGCTGTGGTTACAGCTCCACATGGCCGAGCTCGTGACACCGTGGGAGAG
TCCCTGGCTCACGTTCCCCTGGAGACTTTCCTGCAAACCCTGGAGTCTTCAGGTGGTGTCAGTG
AGAGCAATAACACAGGGGATGAAGGAGCTGAGCTGGACCCCGATGCTGAGGCTGAGCTGGAACT
CTCCGACTACCCCTGGTTCCATGGGACACTGTCCCGGGTGAAGGCCGCCCAGCTGGTGTTGGCT
GGTGGGCCCCGGAGTCACGGCCTCTTTGTGATCCGCCAAAGCGAGACTCGGCCTGGGGAGTGTG
TGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCACCTTCGCCTTTCTCTGAATGGTCACGGCCA
GTGTCATGTCCAACACCTGTGGTTCCAGTCGGTGTTTGACATGCTTCGACACTTCCACACCCAC
CCCATTCCCCTGGAGTCAGGAGGATCCGCTGACATCACCCTACGAAGCTACGTGCGTGCCCAAG
GTCCACCTCCTGATCCAGGACCAGCGCCCAACACTGCAGCCCCGGTCCCGGCCTGCTGGACGGA
GCCGGCTGGCCAGCACTACTTCTCCAGCCTGGCCACGGCCACCTGCCCACCCACTTCACCCTCC
AATGGCGCTGGAGCATCGTCGTCATCCGGTTCATCATCCTCTGCTACGTCCGTGCCCCCACGCC
CAGCCGAGGGGCCACTCAGTGCGCGCAGTCGCAGCAACAGCACAGAGCACCTGCTAGAGGCTGC
ATCCGGAGCCACTGAGGAGCCCGCAGATGCCACGCTGGGCCGCGCTCGCGCTGTGGAGAATCAG
TACTCCTTTTACTAGCTGCCATGCCTATTACCCACGGGTGTCACGCACAACACAGCAGGCCACG
AACACCTGCTGTCTGTCCTGCCCACCCACAGCCTGGCTAGCCCATGACGGTCAACAACACCTAA
CAAATGGCTAGACACACCTATCCATGGTCTAGCATGGCCAAGACAGATGGCCAGCCTAGCCACT
TCAAACCCCAGGGGCCCATTATGACCGTGTGTGGCAGGCCAAGGCTAAGTCCATGGTCGATCAA
ACCCATGATAGCCCTCCAATGATTTCACGCCCCGCCCACTGGTGGTTGGCCACGCCCACCAGCA
GCTATTTCTATACAGTCCATCGTATCCACGACAGGCAGCTCACTGACAACTAACCACATTTGGT
GACTTCAGGCCCTGCCTACTGTTGGTTGGTTACTCCTACAGTGGCATCATGGCCAACCCACTGG
CTGCCTGCTTTGCTCGAGGGTAGCAAGCCACGTCTATCAAGCCCATGAAGGCTTACCCACTGAT
TCCTAACAACCTCAGGCCCTGCCCACCCATGTTGGGTCACATACTCCAATAGCCCACCAGGCTG
TGGTCCGCCTAGCCTAGGACAGCCTGTCACGCCCACCAGCCCCAGCCCAACGCTGGGGGGAAAA
GCCAAGCTCTTCAGTGAAGACAAACATTATTAAAGAGCCTGTTTTAGGGACTACCCCCT

hide sequence

RefSeq Acc Id:

XM_039089010 ⟹ XP_038944938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,063,812 - 26,093,468 (+)	NCBI
mRatBN7.2	12	20,427,434 - 20,456,845 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446121	(Get FASTA)	NCBI Sequence Viewer
	XP_008767334	(Get FASTA)	NCBI Sequence Viewer
	XP_008767335	(Get FASTA)	NCBI Sequence Viewer
	XP_017453727	(Get FASTA)	NCBI Sequence Viewer
	XP_017453728	(Get FASTA)	NCBI Sequence Viewer
	XP_038944938	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC64408	(Get FASTA)	NCBI Sequence Viewer
	EDM13315	(Get FASTA)	NCBI Sequence Viewer
	EDM13316	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001935
	ENSRNOP00000001935.5
	ENSRNOP00000097265
GenBank Protein	Q9Z200	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446121 ⟸ NM_053669

- UniProtKB:

Q9Z200 (UniProtKB/Swiss-Prot), A6J076 (UniProtKB/TrEMBL), A0A8I6GLZ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANF
LAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRN
MSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGA
LRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTM
PLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASR
VTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSES
NNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVL
TFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGP
PPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPA
EGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY

hide sequence

RefSeq Acc Id:	XP_008767334 ⟸ XM_008769112
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLZ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTADHPGMGSQEERRADPRDHVHCRIRGCHGTKAMNGATPGSAAAPAPVPDWRQFCELHAQVAA VDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTS ALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTT EPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAV AGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQ KHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTA PHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTL SRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQS VFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSL ATATCPPTSPSNGAGASSSSGSSSSATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADA TLGRARAVENQYSFY hide sequence

RefSeq Acc Id:	XP_008767335 ⟸ XM_008769113
- Peptide Label:	isoform X3
- UniProtKB:	Q9Z200 (UniProtKB/Swiss-Prot), A6J076 (UniProtKB/TrEMBL), A0A8I6GLZ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANF LAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRN MSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGA LRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTM PLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASR VTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSES NNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVL TFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGP PPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPA EGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY hide sequence

RefSeq Acc Id:	XP_017453728 ⟸ XM_017598239
- Peptide Label:	isoform X3
- UniProtKB:	Q9Z200 (UniProtKB/Swiss-Prot), A6J076 (UniProtKB/TrEMBL), A0A8I6GLZ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANF LAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRN MSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGA LRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTM PLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASR VTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSES NNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVL TFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGP PPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPA EGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY hide sequence

RefSeq Acc Id:	XP_017453727 ⟸ XM_017598238
- Peptide Label:	isoform X3
- UniProtKB:	Q9Z200 (UniProtKB/Swiss-Prot), A6J076 (UniProtKB/TrEMBL), A0A8I6GLZ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANF LAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRN MSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGA LRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTM PLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASR VTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSES NNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVL TFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGP PPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPA EGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY hide sequence

Ensembl Acc Id:

ENSRNOP00000001935 ⟸ ENSRNOT00000001935

RefSeq Acc Id:	XP_038944938 ⟸ XM_039089010
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6GLZ7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095058 ⟸ ENSRNOT00000093990

Ensembl Acc Id:

ENSRNOP00000097265 ⟸ ENSRNOT00000102136

Protein Domains

PH SH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z200-F1-model_v2	AlphaFold	Q9Z200	1-621	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698535

Promoter ID:

EPDNEW_R9060

Type:

initiation region

Name:

Sh2b2_1

Description:

SH2B adaptor protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	23,473,218 - 23,473,278	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69284	AgrOrtholog
BioCyc Gene	G2FUF-19658	BioCyc
Ensembl Genes	ENSRNOG00000001425	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001935	ENTREZGENE
	ENSRNOT00000001935.6	UniProtKB/Swiss-Prot
	ENSRNOT00000102136	ENTREZGENE
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
	3.30.505.10	UniProtKB/Swiss-Prot
	6.10.140.110	UniProtKB/Swiss-Prot
InterPro	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	Phe_ZIP	UniProtKB/Swiss-Prot
	Phe_ZIP_sf	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
	SH2_dom_sf	UniProtKB/Swiss-Prot
	SH2B	UniProtKB/Swiss-Prot
	SH2B2_SH2	UniProtKB/Swiss-Prot
KEGG Report	rno:114203	UniProtKB/Swiss-Prot
NCBI Gene	114203	ENTREZGENE
PANTHER	PTHR10872	UniProtKB/Swiss-Prot
	PTHR10872:SF4	UniProtKB/Swiss-Prot
Pfam	PF00169	UniProtKB/Swiss-Prot
	Phe_ZIP	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
PhenoGen	Sh2b2	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001425	RatGTEx
SMART	SH2	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF109805	UniProtKB/Swiss-Prot
	SSF55550	UniProtKB/Swiss-Prot
TIGR	TC224595
UniProt	A0A8I6GLF9_RAT	UniProtKB/TrEMBL
	A0A8I6GLZ7	ENTREZGENE, UniProtKB/TrEMBL
	A6J076	ENTREZGENE, UniProtKB/TrEMBL
	Q9Z200	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-18	Sh2b2	SH2B adaptor protein 2	Aps	adaptor protein with pleckstrin homology and src homology 2 domains	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Aps	adaptor protein with pleckstrin homology and src homology 2 domains			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_pathway	substrate of TrkB and TrkC in cortical neurons; binds to Grb2, leading to NGF induction of Ras, MAP kinase (MAPK), and morphological differentiation	68805

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)