Gene:	Socs2 ( Rattus norvegicus ) suppressor of cytokine signaling 2
Description:	suppressor of cytokine signalling
Synonyms:	Socs-2; cytokine inducible SH2-containing protein 2; Cish2;
ArrayIDs:	6161015; 6474104; 6456316; rc_AA900326_at; 6693740; 1372727_at; 1369577_at; AF075382_at; A_42_P543004; rc_AA851185_at; 6458182; 5705324; GE13292; 6193765;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: SOCS2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Socs2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Socs2 genome assembly 3.1 7 32625999 - 32628594     Rat Celera Assembly 7 27114252 - 27116861     RGSC genome assembly v3.4 7 32605714 - 32608323     Cytogenetic 7 q13 Mus musculus Socs2 Mouse genome assembly build 36.1 10 94874676 - 94879455     Cytogenetic 10 10 C2 Homo sapiens SOCS2 human genome assembly 12 92466065 - 92472446     Human genome assembly build 36.2 12 92487729 - 92494109     Cytogenetic 12 12q   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  insulin-like growth factor receptor binding,  growth hormone receptor binding ...  (details...)
Biological Process	Note Reference negative regulator of growth hormone (GH) signaling that regulates body growth postnatally and neuronal differentiation during development 1302348 Gene Ontology mammary gland alveolus development,  regulation of multicellular organism growth,  lactation ...  (details...)
Cellular Component	Gene Ontology cellular_component (details...)
Disease	Ontology Endometrial Neoplasms,  Sepsis,  Breast Neoplasms ...  (details...)
Pathway	Ontology Jak-Stat signaling pathway (details...)
Product	Note Reference member of a family of negative regulators of cytokine signalling 634752
External Links
Databases	DATABASE ID SOURCE SMART: SOCS IPI SMART: SH2 IPI PROSITE: SH2 IPI PROSITE: SOCS IPI UNIPARC: UPI0000135B64 IPI KEGG Report: rno:84607 ENTREZGENE Germonline: 69273 Pfam: SH2 IPI Pfam: SOCS_box IPI KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: SH2. IPI InterPro: SOCS_C. IPI IPI: IPI00210795 IPI Ensembl Protein: ENSRNOP00000011948 IPI Gene3D-CATH: SH2 IPI Entrez Gene: Socs2 ENTREZGENE TIGR: TC225712 UniProt: SOCS2_RAT IPI UniProt: Q9QX77_RAT IPI Ensembl Genes: ENSRNOG00000008965 IPI PRINTS: SH2DOMAIN. IPI
Sequences	Nucleotide: CH473960 Get FASTA Search GEO Profiles Nucleotide: AJ243124 Get FASTA Search GEO Profiles Nucleotide: AF075382 Get FASTA Search GEO Profiles Nucleotide: NM_058208 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: EDM16866 Get FASTA Protein: EDM16862 Get FASTA Protein: EDM16863 Get FASTA Protein: Q9QX77 Get FASTA Protein: O88582 Get FASTA Protein: AAC26222 Get FASTA Protein: NP_478115 Get FASTA Protein: EDM16867 Get FASTA Protein: CAB64205 Get FASTA Protein: EDM16865 Get FASTA Protein: EDM16864 Get FASTA (View all 11 Protein Accessions)
Clusters	UniGene: 205056
References
Curated References	16 references in RGD related to Socs2
Other References	11 other references at PubMed related to Socs2
Database Information
RGD ID	69273
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Socs2 suppressor of cytokine signaling 2 Cish2 cytokine inducible SH2-containing protein 2 APPROVED Symbol and Name updated 1299863 10-JUN-02: Cish2 cytokine inducible SH2-containing protein 2 APPROVED Name updated 70584