SOCS2 (suppressor of cytokine signaling 2)

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Keyword

Gene: SOCS2 (suppressor of cytokine signaling 2) Homo sapiens

Symbol:

SOCS2

Name:

suppressor of cytokine signaling 2

Description:

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CIS-2; CIS2; Cish2; cytokine-inducible SH2 protein 2; OTTHUMP00000243097; SOCS-2; SSI-2; SSI2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; STATI2; suppressor of cytokine signaling 2; suppressor of cytokine signaling-2

Orthologs:

Mus musculus : Socs2 (suppressor of cytokine signaling 2) MGI
Rattus norvegicus : Socs2 (suppressor of cytokine signaling 2)

Related Pseudogenes:

SOCS2P1 SOCS2P2

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	12	93,805,811 - 93,812,734	+	NCBI
Human Genome Assembly HuRef	12	91,011,433 - 91,037,277	+	NCBI
Human Genome Assembly GRCh37	12	93,963,598 - 93,970,521	+	NCBI
Human Genome Assembly Build 36	12	92,487,729 - 92,494,109	+	NCBI
Human Cytogenetic Map	12	q		NCBI
Human Genome Assembly	12	92,466,065 - 92,472,446		NCBI