Gene:	Socs1 ( Rattus norvegicus ) suppressor of cytokine signaling 1
Description:	suppressor of cytokine signalling
Synonyms:	Cish1; cytokine inducible SH2-containing protein 1; Socs-1;
ArrayIDs:	6263435; 6744053; A_44_P102369; 1375568_at; 6675321; rc_AA849015_at; 1371252_at; 6105168; 6064379; 5712391; GE1169798; rc_AI029171_at; 6188788;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: SOCS1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Socs1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Socs1 genome assembly 3.1 10 4819970 - 4820609     Rat Celera Assembly 10 3904754 - 3905392     RGSC genome assembly v3.4 10 4819971 - 4820609     Cytogenetic 10 q11 Mus musculus Socs1 Mouse genome assembly build 36.1 16 10783901 - 10785629     Cytogenetic 16 16 A1 Homo sapiens SOCS1 human genome assembly 16 11255774 - 11257540     Human genome assembly build 36.2 16 11255775 - 11257540     Cytogenetic 16 p13.13   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  kinase inhibitor activity,  protein kinase binding ...  (details...)
Biological Process	Gene Ontology response to cytokine stimulus,  regulation of protein amino acid phosphorylation,  modification-dependent protein catabolic process ...  (details...)
Cellular Component	Gene Ontology cellular_component (details...)
Disease	Ontology HIV Infections,  Ovarian Neoplasms,  Insulin Resistance ...  (details...)
Pathway	Ontology Jak-Stat signaling pathway,  insulin signaling pathway (details...)
Product	Note Reference member of a family of negative regulators of cytokine signalling 634751
External Links
Databases	DATABASE ID SOURCE SMART: SOCS IPI SMART: SH2 IPI PROSITE: SH2 IPI PROSITE: SOCS IPI UNIPARC: UPI0000135B62 IPI KEGG Report: rno:252971 ENTREZGENE HomoloGene Group ID: 2776 ENTREZGENE Germonline: 69272 Pfam: SOCS_box IPI Pfam: SH2 IPI KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04120 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE InterPro: SOCS_C. IPI InterPro: SH2. IPI IPI: IPI00212707 IPI Ensembl Protein: ENSRNOP00000003458 IPI Gene3D-CATH: SH2 IPI Entrez Gene: Socs1 ENTREZGENE TIGR: TC217532 UniProt: SOCS1_RAT IPI Ensembl Genes: ENSRNOG00000002568 IPI
Sequences	Nucleotide: NM_145879 Get FASTA Search GEO Profiles Nucleotide: AJ243123 Get FASTA Search GEO Profiles (View all 2 Nucleotide Accessions) Protein: NP_665886 Get FASTA Protein: CAB64204 Get FASTA Protein: Q9QX78 Get FASTA (View all 3 Protein Accessions)
Clusters	UniGene: 82754
References
Curated References	25 references in RGD related to Socs1
Other References	11 other references at PubMed related to Socs1
Database Information
RGD ID	69272
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 22-APR-04: Socs1 suppressor of cytokine signaling 1 Cish1 cytokine inducible SH2-containing protein 1 APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 625702 10-JUN-02: Cish1 cytokine inducible SH2-containing protein 1 APPROVED Name updated 70584