Celsr2 (cadherin, EGF LAG seven-pass G-type receptor 2) - Rat Genome Database

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Gene: Celsr2 (cadherin, EGF LAG seven-pass G-type receptor 2) Rattus norvegicus
Analyze
Symbol: Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
RGD ID: 69237
Description: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dendrite morphogenesis; regulation of cell-cell adhesion; and spermatogenesis. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cadherin EGF LAG seven-pas G-type receptor 2; cadherin EGF LAG seven-pass G-type receptor 2; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); flamingo-like protein celsr2; Flamingo1; Megf3; multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; multiple epidermal growth factor-like domains protein 3; seven-pass transmembrane cadherin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,717,333 - 198,741,689 (-)NCBIGRCr8
mRatBN7.22196,029,206 - 196,053,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2196,029,434 - 196,053,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,673,871 - 203,696,491 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,555,989 - 201,578,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,372,945 - 196,395,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,183,410 - 211,207,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,183,311 - 211,207,465 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,653,341 - 230,677,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,960,513 - 203,983,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,923,277 - 203,943,562 (-)NCBI
Celera2188,676,929 - 188,699,559 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. Beall SA, etal., J Androl. 2005 Jul-Aug;26(4):529-38.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Shima Y, etal., Dev Cell. 2004 Aug;7(2):205-16.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10907856   PMID:12755329   PMID:15744052   PMID:16484285   PMID:17618280   PMID:20473291   PMID:20631168   PMID:21746835   PMID:32988580  


Genomics

Comparative Map Data
Celsr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,717,333 - 198,741,689 (-)NCBIGRCr8
mRatBN7.22196,029,206 - 196,053,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2196,029,434 - 196,053,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,673,871 - 203,696,491 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,555,989 - 201,578,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,372,945 - 196,395,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,183,410 - 211,207,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,183,311 - 211,207,465 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,653,341 - 230,677,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,960,513 - 203,983,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,923,277 - 203,943,562 (-)NCBI
Celera2188,676,929 - 188,699,559 (-)NCBICelera
Cytogenetic Map2q34NCBI
CELSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,249,539 - 109,275,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,249,539 - 109,275,751 (+)EnsemblGRCh38hg38GRCh38
GRCh371109,792,161 - 109,818,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,594,164 - 109,619,901 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,504,682 - 109,530,414NCBI
Celera1108,062,003 - 108,087,743 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1107,685,865 - 107,711,622 (+)NCBIHuRef
CHM1_11109,907,493 - 109,933,231 (+)NCBICHM1_1
T2T-CHM13v2.01109,282,346 - 109,308,548 (+)NCBIT2T-CHM13v2.0
Celsr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,298,164 - 108,323,416 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3108,298,167 - 108,323,383 (-)EnsemblGRCm39 Ensembl
GRCm383108,390,848 - 108,416,069 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,390,851 - 108,415,552 (-)EnsemblGRCm38mm10GRCm38
MGSCv373108,193,766 - 108,218,412 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,520,500 - 108,543,550 (-)NCBIMGSCv36mm8
Celera3110,725,058 - 110,749,705 (-)NCBICelera
Cytogenetic Map3F3NCBI
cM Map347.02NCBI
Celsr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543512,671,759 - 12,695,564 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543512,671,759 - 12,695,070 (+)NCBIChiLan1.0ChiLan1.0
CELSR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,028,278 - 118,054,493 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,188,189 - 117,214,398 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01111,627,551 - 111,653,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,791,720 - 110,817,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,791,682 - 110,815,421 (+)Ensemblpanpan1.1panPan2
CELSR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,547,638 - 42,573,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,548,983 - 42,573,962 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha645,322,198 - 45,348,111 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,878,783 - 42,904,743 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,879,935 - 42,904,724 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,610,137 - 42,636,081 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,568,221 - 42,594,142 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0643,003,504 - 43,029,464 (-)NCBIUU_Cfam_GSD_1.0
Celsr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505819,310,286 - 19,334,616 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936704778,480 - 803,886 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936704779,528 - 803,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CELSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,819,428 - 110,845,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,819,422 - 110,845,354 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24121,290,848 - 121,295,430 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CELSR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12024,270,963 - 24,296,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2024,270,952 - 24,296,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603834,162,262 - 34,190,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Celsr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247724,990,178 - 5,014,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247724,990,185 - 5,014,008 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Celsr2
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:67
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000027263
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat

Markers in Region
RH135417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,031,286 - 196,031,476 (+)MAPPERmRatBN7.2
Rnor_6.02211,185,491 - 211,185,680NCBIRnor6.0
Rnor_5.02230,655,422 - 230,655,611UniSTSRnor5.0
RGSC_v3.42203,961,164 - 203,961,353UniSTSRGSC3.4
Celera2188,677,580 - 188,677,769UniSTS
RH 3.4 Map21397.7UniSTS
Cytogenetic Map2q34UniSTS
Celsr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,031,934 - 196,032,556 (+)MAPPERmRatBN7.2
Rnor_6.02211,186,139 - 211,186,760NCBIRnor6.0
Rnor_5.02230,656,070 - 230,656,691UniSTSRnor5.0
RGSC_v3.42203,961,812 - 203,962,433UniSTSRGSC3.4
Celera2188,678,228 - 188,678,849UniSTS
Cytogenetic Map2q34UniSTS
G16013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,053,050 - 196,053,269 (+)MAPPERmRatBN7.2
Rnor_6.02211,207,254 - 211,207,472NCBIRnor6.0
Rnor_5.02230,677,187 - 230,677,405UniSTSRnor5.0
RGSC_v3.42203,982,929 - 203,983,147UniSTSRGSC3.4
Celera2188,699,355 - 188,699,573UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:495983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,052,960 - 196,053,041 (+)MAPPERmRatBN7.2
Rnor_6.02211,207,164 - 211,207,244NCBIRnor6.0
Rnor_5.02230,677,097 - 230,677,177UniSTSRnor5.0
RGSC_v3.42203,982,839 - 203,982,919UniSTSRGSC3.4
Celera2188,699,265 - 188,699,345UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 74 35 20
Low 3 28 26 14 16 14 8 11 21 11 8
Below cutoff 15 31 27 3 27

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027263   ⟹   ENSRNOP00000027263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2196,029,434 - 196,053,845 (-)Ensembl
Rnor_6.0 Ensembl2211,183,311 - 211,207,465 (-)Ensembl
RefSeq Acc Id: NM_001191110   ⟹   NP_001178039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,718,763 - 198,741,382 (-)NCBI
mRatBN7.22196,030,636 - 196,053,255 (-)NCBI
Rnor_6.02211,184,840 - 211,207,458 (-)NCBI
Rnor_5.02230,653,341 - 230,677,459 (-)NCBI
Celera2188,676,929 - 188,699,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233192   ⟹   XP_006233254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,717,333 - 198,741,689 (-)NCBI
mRatBN7.22196,029,206 - 196,053,845 (-)NCBI
Rnor_6.02211,183,410 - 211,207,458 (-)NCBI
Rnor_5.02230,653,341 - 230,677,459 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591134   ⟹   XP_017446623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,717,333 - 198,741,689 (-)NCBI
mRatBN7.22196,029,206 - 196,053,846 (-)NCBI
Rnor_6.02211,183,410 - 211,207,458 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103241   ⟹   XP_038959169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,717,333 - 198,741,689 (-)NCBI
mRatBN7.22196,029,206 - 196,053,848 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178039   ⟸   NM_001191110
- Peptide Label: precursor
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL),   A6HV01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233254   ⟸   XM_006233192
- Peptide Label: isoform X1
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446623   ⟸   XM_017591134
- Peptide Label: isoform X2
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027263   ⟸   ENSRNOT00000027263
RefSeq Acc Id: XP_038959169   ⟸   XM_039103241
- Peptide Label: isoform X3
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL)
Protein Domains
Cadherin   EGF-like   G-protein coupled receptors family 2 profile   GPS   Laminin EGF-like   Laminin G   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYP2-F1-model_v2 AlphaFold Q9QYP2 1-2144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69237 AgrOrtholog
BioCyc Gene G2FUF-51619 BioCyc
Ensembl Genes ENSRNOG00000020058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027263.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.220.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83465 UniProtKB/TrEMBL
NCBI Gene 83465 ENTREZGENE
PANTHER CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAT ATYPICAL CADHERIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Celsr2 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020058 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Lam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232810
UniProt A6HV01 ENTREZGENE, UniProtKB/TrEMBL
  CELR2_RAT UniProtKB/Swiss-Prot
  G3V8P3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYP2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Celsr2  cadherin, EGF LAG seven-pass G-type receptor 2  Celsr2  cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Celsr2  cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)  Celsr2  cadherin EGF LAG seven-pass G-type receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Celsr2  cadherin EGF LAG seven-pass G-type receptor 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains seven transmembrane-spanning segments 68759
gene_process promotes homophilic cell aggregation 68759