Pawr (pro-apoptotic WT1 regulator) - Rat Genome Database

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Gene: Pawr (pro-apoptotic WT1 regulator) Rattus norvegicus
Analyze
Symbol: Pawr
Name: pro-apoptotic WT1 regulator
RGD ID: 69065
Description: Enables actin binding activity; protein kinase C binding activity; and protein phosphatase 1 binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; positive regulation of apoptotic process; and regulation of cellular extravasation. Located in axon and neuronal cell body. Colocalizes with actin filament. Biomarker of depressive disorder; epilepsy; middle cerebral artery infarction; and transient cerebral ischemia. Orthologous to human PAWR (pro-apoptotic WT1 regulator); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-colchicine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Par-4; par-4 induced by effectors of apoptosis; Par4; PRKC apoptosis WT1 regulator; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; transcriptional repressor Par-4-like protein PAWR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,531,480 - 45,611,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl745,531,637 - 45,611,492 (+)EnsemblGRCr8
mRatBN7.2743,645,028 - 43,725,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,645,084 - 43,725,028 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx745,554,243 - 45,635,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,757,364 - 47,838,790 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,535,105 - 47,616,535 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0751,273,764 - 51,353,700 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl751,273,771 - 51,353,068 (-)Ensemblrn6Rnor6.0
Rnor_5.0751,286,663 - 51,366,383 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4747,040,162 - 47,119,613 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera740,512,247 - 40,591,588 (+)NCBICelera
RGSC_v3.1747,060,432 - 47,139,881 (+)NCBI
Cytogenetic Map7q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-butoxyethanol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alvocidib  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
miglustat  (ISO)
N-nitrosodiethylamine  (ISO)
nimesulide  (ISO)
NS-398  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SC-58125  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament bundle assembly  (IDA)
apoptotic process  (IDA,IEA)
apoptotic signaling pathway  (IBA,ISO)
calcium ion import across plasma membrane  (IDA)
cellular response to estradiol stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to vitamin E  (IEP)
detection of mechanical stimulus involved in sensory perception of pain  (IDA)
detection of temperature stimulus involved in sensory perception of pain  (IDA)
negative regulation of B cell proliferation  (ISO)
negative regulation of calcium ion import  (IDA)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of action potential  (IDA)
positive regulation of amyloid precursor protein biosynthetic process  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cellular senescence  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hindgut contraction  (IDA)
positive regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IMP)
positive regulation of leukocyte tethering or rolling  (IDA)
positive regulation of neuron apoptotic process  (IBA,IMP)
positive regulation of neuronal action potential  (IMP)
positive regulation of neutrophil extravasation  (IDA)
positive regulation of relaxation of smooth muscle  (IDA)
response to estradiol  (IEP)
response to iron(II) ion  (IEP)
response to lipopolysaccharide  (IEP)

Cellular Component
actin filament  (IDA)
axon  (IDA)
chromatin  (ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO)
neuronal cell body  (IDA)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Asfaha S, etal., Br J Pharmacol. 2007 Jan;150(2):176-85. Epub 2006 Dec 18.
2. Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues. Boghaert ER, etal., Cell Growth Differ. 1997 Aug;8(8):881-90.
3. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis. Boosen M, etal., Exp Cell Res. 2005 Dec 10;311(2):177-91. Epub 2005 Oct 14.
4. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Burikhanov R, etal., Cell. 2009 Jul 23;138(2):377-88. doi: 10.1016/j.cell.2009.05.022.
5. Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation. Chan SL, etal., J Neurochem. 1999 Aug;73(2):502-12.
6. Evidence for the involvement of Par-4 in ischemic neuron cell death. Culmsee C, etal., J Cereb Blood Flow Metab. 2001 Apr;21(4):334-43.
7. Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells. de Thonel A, etal., Cell Death Dis. 2014 Jan 23;5:e1016. doi: 10.1038/cddis.2013.532.
8. Regional expression of Par-4 mRNA and protein after fluid percussion brain injury in the rat. Dhillon HS, etal., Exp Neurol. 2001 Jul;170(1):140-8.
9. Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration. Duan W, etal., J Neurochem. 1999 Jun;72(6):2312-22.
10. Long-term melatonin or 17beta-estradiol supplementation alleviates oxidative stress in ovariectomized adult rats. Feng Z and Zhang JT, Free Radic Biol Med. 2005 Jul 15;39(2):195-204. Epub 2005 Mar 25.
11. Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically. Franchitto A, etal., Am J Pathol. 2010 Oct;177(4):1779-90. doi: 10.2353/ajpath.2010.091171. Epub 2010 Aug 19.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression. Glantz LA, etal., Schizophr Res. 2010 May;118(1-3):292-9. doi: 10.1016/j.schres.2009.12.027. Epub 2010 Jan 13.
14. Regulation of the expression of prostate apoptosis response protein 4 (Par-4) in rat granulosa cells. Gonzalez IH, etal., Apoptosis. 2007 Apr;12(4):769-79.
15. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Guo Q, etal., Nat Med. 1998 Aug;4(8):957-62.
16. Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra. Henrich-Noack P, etal., Brain Res. 2006 Jan 27;1070(1):232-41. Epub 2006 Jan 3.
17. Cellular expression pattern of the protease-activated receptor 4 in the hippocampus in naive rats and after global ischaemia. Henrich-Noack P, etal., J Neurosci Res. 2010 Mar;88(4):850-7. doi: 10.1002/jnr.22261.
18. Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Hwang S, etal., Endocr J. 2009;56(4):609-17. Epub 2009 Apr 7.
19. Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury. Jesmin S, etal., Inflammation. 2007 Apr;30(1-2):14-27. Epub 2006 Nov 30.
20. Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1. Kawabata A, etal., Br J Pharmacol. 2000 Oct;131(3):578-84.
21. Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle. MacDonald JA, etal., Arch Biochem Biophys. 2013 Jul 1;535(1):84-90. doi: 10.1016/j.abb.2012.11.009. Epub 2012 Dec 3.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon. Mule F, etal., Gut. 2004 Feb;53(2):229-34.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Page G, etal., Oncogene. 1999 Dec 2;18(51):7265-73.
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. GOA pipeline RGD automated data pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush. Rohatgi T, etal., J Neurosci Res 2003 Jul 15;73(2):246-54.
30. Transient focal ischemia in rat brain differentially regulates mRNA expression of protease-activated receptors 1 to 4. Rohatgi T, etal., J Neurosci Res 2004 Jan 15;75(2):273-9.
31. Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism. Russell FA, etal., J Neurophysiol. 2010 Jan;103(1):155-63. doi: 10.1152/jn.00486.2009. Epub 2009 Nov 4.
32. The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation. Russell FA, etal., Pain. 2011 Feb;152(2):354-60. doi: 10.1016/j.pain.2010.10.038.
33. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Sells SF, etal., Cell Growth Differ 1994 Apr;5(4):457-66.
34. Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. Strande JL, etal., J Pharmacol Exp Ther. 2008 Mar;324(3):1045-54. Epub 2007 Nov 30.
35. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Identification of protease-activated receptor-4 (PAR-4) in puromycin-purified brain capillary endothelial cells cultured on Matrigel. Vajda S, etal., Neurochem Int. 2008 May;52(6):1234-9. doi: 10.1016/j.neuint.2008.01.003. Epub 2008 Jan 12.
38. Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4. Vergnolle N, etal., J Immunol. 2002 Aug 1;169(3):1467-73.
39. Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis. Vetterkind S, etal., Exp Cell Res. 2005 May 1;305(2):392-408.
40. Par-4: a new activator of myosin phosphatase. Vetterkind S, etal., Mol Biol Cell. 2010 Apr 1;21(7):1214-24. doi: 10.1091/mbc.E09-08-0711. Epub 2010 Feb 3.
41. Interleukin-1beta increased the expression of protease-activated receptor 4 mRNA and protein in dorsal root ganglion neurons. Wang Z, etal., Neurochem Res. 2013 Sep;38(9):1895-903. doi: 10.1007/s11064-013-1095-z. Epub 2013 Jun 18.
42. Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum. Zhu X, etal., Behav Brain Res. 2011 Oct 1;223(2):329-35. Epub 2011 May 8.
Additional References at PubMed
PMID:8943350   PMID:10580117   PMID:12897127   PMID:12917339   PMID:12970181   PMID:14627703   PMID:15246161   PMID:15657440   PMID:15671026   PMID:15831492   PMID:18505470   PMID:19490121  
PMID:19625447   PMID:20369315   PMID:25472717   PMID:29854833   PMID:33450132  


Genomics

Comparative Map Data
Pawr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,531,480 - 45,611,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl745,531,637 - 45,611,492 (+)EnsemblGRCr8
mRatBN7.2743,645,028 - 43,725,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,645,084 - 43,725,028 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx745,554,243 - 45,635,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,757,364 - 47,838,790 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,535,105 - 47,616,535 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0751,273,764 - 51,353,700 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl751,273,771 - 51,353,068 (-)Ensemblrn6Rnor6.0
Rnor_5.0751,286,663 - 51,366,383 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4747,040,162 - 47,119,613 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera740,512,247 - 40,591,588 (+)NCBICelera
RGSC_v3.1747,060,432 - 47,139,881 (+)NCBI
Cytogenetic Map7q21NCBI
PAWR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381279,584,879 - 79,690,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1279,574,979 - 79,690,964 (-)Ensemblhg38GRCh38
GRCh371279,978,659 - 80,084,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,509,876 - 78,608,921 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341278,488,214 - 78,587,258NCBI
Celera1279,652,459 - 79,751,312 (-)NCBICelera
Cytogenetic Map12q21.2NCBI
HuRef1277,042,009 - 77,141,117 (-)NCBIHuRef
CHM1_11279,952,168 - 80,051,122 (-)NCBICHM1_1
T2T-CHM13v2.01279,563,553 - 79,669,620 (-)NCBIT2T-CHM13v2.0
Pawr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910108,168,050 - 108,250,708 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10108,167,982 - 108,250,101 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810108,332,189 - 108,414,391 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10108,332,121 - 108,414,240 (+)Ensemblmm10GRCm38
MGSCv3710107,769,245 - 107,851,447 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610107,736,299 - 107,817,863 (+)NCBIMGSCv36mm8
Celera10110,266,638 - 110,348,648 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1056.43NCBI
Pawr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540518,434,711 - 18,540,710 (-)Ensembl
ChiLan1.0NW_00495540518,434,711 - 18,540,710 (-)NCBIChiLan1.0ChiLan1.0
PAWR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21087,634,172 - 87,743,476 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11287,630,560 - 87,739,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01277,114,282 - 77,224,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11279,964,693 - 80,071,088 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1279,969,517 - 80,070,796 (-)EnsemblpanPan2panpan1.1
PAWR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11522,114,014 - 22,159,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1522,543,122 - 22,644,822 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01522,466,453 - 22,568,184 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1522,468,188 - 22,568,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11522,054,871 - 22,156,503 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01522,115,634 - 22,217,474 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01522,355,750 - 22,457,672 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pawr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494538,166,185 - 38,266,605 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936698650,953 - 747,057 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936698650,225 - 746,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAWR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5101,693,246 - 101,797,838 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.15101,693,145 - 101,797,842 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25106,705,487 - 106,742,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAWR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11175,132,547 - 75,219,633 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1175,133,186 - 75,219,072 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037170,232,946 - 170,321,286 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pawr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475018,562,221 - 18,705,540 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475018,562,270 - 18,710,397 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pawr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11186,551,436 - 186,631,083 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pawr
650 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:501
Count of miRNA genes:255
Interacting mature miRNAs:313
Transcripts:ENSRNOT00000008222
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH129154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,724,790 - 43,724,976 (-)MAPPERmRatBN7.2
Rnor_6.0751,273,823 - 51,274,008NCBIRnor6.0
Rnor_5.0751,286,722 - 51,286,907UniSTSRnor5.0
RGSC_v3.4747,119,373 - 47,119,558UniSTSRGSC3.4
Celera740,591,348 - 40,591,533UniSTS
RH 3.4 Map7351.71UniSTS
Cytogenetic Map7q21UniSTS
AU047800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,646,571 - 43,646,802 (-)MAPPERmRatBN7.2
Rnor_6.0751,352,041 - 51,352,271NCBIRnor6.0
Rnor_5.0751,364,748 - 51,364,978UniSTSRnor5.0
RGSC_v3.4747,040,959 - 47,041,189UniSTSRGSC3.4
Celera740,513,044 - 40,513,274UniSTS
Cytogenetic Map7q21UniSTS
AU047769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,646,548 - 43,646,803 (-)MAPPERmRatBN7.2
Rnor_6.0751,352,040 - 51,352,294NCBIRnor6.0
Rnor_5.0751,364,747 - 51,365,001UniSTSRnor5.0
RGSC_v3.4747,040,936 - 47,041,190UniSTSRGSC3.4
Celera740,513,021 - 40,513,275UniSTS
Cytogenetic Map7q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 156 91 90 59 31 59 6 295 131 11 135 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000008222   ⟹   ENSRNOP00000008222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,531,637 - 45,611,489 (+)Ensembl
mRatBN7.2 Ensembl743,645,775 - 43,725,028 (+)Ensembl
Rnor_6.0 Ensembl751,273,771 - 51,353,068 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096379   ⟹   ENSRNOP00000093356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,532,305 - 45,611,492 (+)Ensembl
mRatBN7.2 Ensembl743,645,841 - 43,725,028 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113713   ⟹   ENSRNOP00000085170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,531,637 - 45,611,489 (+)Ensembl
mRatBN7.2 Ensembl743,645,084 - 43,725,028 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167387   ⟹   ENSRNOP00000107478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,531,803 - 45,611,492 (+)Ensembl
RefSeq Acc Id: NM_033485   ⟹   NP_277020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,532,239 - 45,611,492 (+)NCBI
mRatBN7.2743,645,775 - 43,725,031 (+)NCBI
Rnor_6.0751,273,768 - 51,353,068 (-)NCBI
Rnor_5.0751,286,663 - 51,366,383 (-)NCBI
RGSC_v3.4747,040,162 - 47,119,613 (+)RGD
Celera740,512,247 - 40,591,588 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241317   ⟹   XP_006241379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,531,480 - 45,611,492 (+)NCBI
mRatBN7.2743,645,029 - 43,725,033 (+)NCBI
Rnor_6.0751,273,764 - 51,353,700 (-)NCBI
Rnor_5.0751,286,663 - 51,366,383 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079857   ⟹   XP_038935785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,531,480 - 45,611,492 (+)NCBI
mRatBN7.2743,645,028 - 43,725,033 (+)NCBI
RefSeq Acc Id: NP_277020   ⟸   NM_033485
- UniProtKB: Q62627 (UniProtKB/Swiss-Prot),   A6IGE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241379   ⟸   XM_006241317
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000008222   ⟸   ENSRNOT00000008222
RefSeq Acc Id: XP_038935785   ⟸   XM_039079857
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000085170   ⟸   ENSRNOT00000113713
Ensembl Acc Id: ENSRNOP00000093356   ⟸   ENSRNOT00000096379
Ensembl Acc Id: ENSRNOP00000107478   ⟸   ENSRNOT00000167387

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62627-F1-model_v2 AlphaFold Q62627 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695182
Promoter ID:EPDNEW_R5707
Type:single initiation site
Name:Pawr_1
Description:pro-apoptotic WT1 regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0751,353,084 - 51,353,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69065 AgrOrtholog
BioCyc Gene G2FUF-34166 BioCyc
Ensembl Genes ENSRNOG00000005917 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000113713 ENTREZGENE
  ENSRNOT00000167387 ENTREZGENE
InterPro Par-4 UniProtKB/Swiss-Prot
KEGG Report rno:64513 UniProtKB/Swiss-Prot
NCBI Gene 64513 ENTREZGENE
PANTHER PRKC APOPTOSIS WT1 REGULATOR PROTEIN UniProtKB/Swiss-Prot
  PTHR15093 UniProtKB/Swiss-Prot
PhenoGen Pawr PhenoGen
RatGTEx ENSRNOG00000005917 RatGTEx
TIGR TC206563
UniProt A0A8I6A135_RAT UniProtKB/TrEMBL
  A0A8I6GK93_RAT UniProtKB/TrEMBL
  A0ABK0M1Z1_RAT UniProtKB/TrEMBL
  A6IGE0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6S1_RAT UniProtKB/TrEMBL
  PAWR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Pawr  pro-apoptotic WT1 regulator  Pawr  PRKC, apoptosis, WT1, regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pawr  PRKC, apoptosis, WT1, regulator      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in prostate 68876