Dlc1 (DLC1 Rho GTPase activating protein) - Rat Genome Database

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Gene: Dlc1 (DLC1 Rho GTPase activating protein) Rattus norvegicus
Analyze
Symbol: Dlc1
Name: DLC1 Rho GTPase activating protein
RGD ID: 68416
Description: Enables enzyme activator activity; phospholipase binding activity; and vinculin binding activity. Involved in cellular response to insulin stimulus. Located in actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Arhgap7; deleted in liver cancer 1; deleted in liver cancer 1 protein homolog; dlc-1; p122-RhoGAP; rho GTPase activating protein 7; rho GTPase-activating protein 7; rho-type GTPase-activating protein 7; RhoGAP; stAR-related lipid transfer protein 12; stARD12; START domain-containing protein 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81661,954,177 - 62,374,819 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1661,995,001 - 62,374,819 (+)EnsemblGRCr8
mRatBN7.21655,246,716 - 55,671,441 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1655,291,584 - 55,671,439 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1660,594,445 - 60,978,366 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01664,013,731 - 64,392,697 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01659,228,426 - 59,612,338 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01658,776,489 - 59,247,752 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1659,077,574 - 59,247,754 (+)Ensemblrn6Rnor6.0
Rnor_5.01658,638,567 - 58,928,425 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41659,312,930 - 59,355,129 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1653,351,212 - 53,453,368 (+)NCBICelera
Celera1653,685,682 - 53,727,187 (+)NCBICelera
RGSC_v3.11659,313,004 - 59,355,204 (+)NCBI
Cytogenetic Map16q12.1-q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cumene  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketoconazole  (EXP)
leflunomide  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IDA)
caveola  (IEA,ISO)
cortical actin cytoskeleton  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
focal adhesion  (IBA,IDA,IEA,ISO)
membrane  (IEA)
membrane raft  (IBA)
nucleus  (IEA,ISO)
ruffle membrane  (IEA,ISO)
stress fiber  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. Hers I, etal., J Biol Chem. 2006 Feb 24;281(8):4762-70. Epub 2005 Dec 6.
4. A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. Homma Y and Emori Y, EMBO J 1995 Jan 16;14(2):286-91.
5. A PLCdelta1-binding protein, p122RhoGAP, is localized in focal adhesions. Kawai K, etal., Biochem Soc Trans. 2004 Dec;32(Pt 6):1107-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Sequence variants of DLC1 in colorectal and ovarian tumours. Wilson PJ, etal., Hum Mutat 2000;15(2):156-65.
13. Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein. Yamaga M, etal., Adv Enzyme Regul. 2008;48:41-54. Epub 2007 Nov 19.
Additional References at PubMed
PMID:10364218   PMID:12545165   PMID:15710412   PMID:16641100   PMID:16951145   PMID:17190795   PMID:17292327   PMID:17888903   PMID:17932950   PMID:19158340   PMID:19692654  


Genomics

Comparative Map Data
Dlc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81661,954,177 - 62,374,819 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1661,995,001 - 62,374,819 (+)EnsemblGRCr8
mRatBN7.21655,246,716 - 55,671,441 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1655,291,584 - 55,671,439 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1660,594,445 - 60,978,366 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01664,013,731 - 64,392,697 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01659,228,426 - 59,612,338 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01658,776,489 - 59,247,752 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1659,077,574 - 59,247,754 (+)Ensemblrn6Rnor6.0
Rnor_5.01658,638,567 - 58,928,425 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41659,312,930 - 59,355,129 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1653,351,212 - 53,453,368 (+)NCBICelera
Celera1653,685,682 - 53,727,187 (+)NCBICelera
RGSC_v3.11659,313,004 - 59,355,204 (+)NCBI
Cytogenetic Map16q12.1-q12.2NCBI
DLC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38813,083,361 - 13,604,620 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl813,083,361 - 13,604,610 (-)Ensemblhg38GRCh38
GRCh37812,940,870 - 13,462,129 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36812,985,243 - 13,416,766 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34812,985,242 - 13,416,766NCBI
Celera811,906,167 - 12,337,728 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef811,483,338 - 11,914,734 (-)NCBIHuRef
CHM1_1813,142,556 - 13,574,157 (-)NCBICHM1_1
T2T-CHM13v2.0813,349,832 - 13,871,204 (-)NCBIT2T-CHM13v2.0
Dlc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39837,034,893 - 37,420,343 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl837,034,905 - 37,420,297 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38836,567,739 - 36,953,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl836,567,751 - 36,953,143 (-)Ensemblmm10GRCm38
MGSCv37837,630,799 - 37,676,928 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36837,630,799 - 37,676,928 (-)NCBIMGSCv36mm8
Celera839,196,115 - 39,243,125 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.05NCBI
Dlc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554633,598,985 - 3,990,849 (+)Ensembl
ChiLan1.0NW_0049554633,599,415 - 3,981,187 (+)NCBIChiLan1.0ChiLan1.0
DLC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2731,519,027 - 32,046,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan187,229,350 - 7,756,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0812,282,190 - 12,809,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.189,037,742 - 9,087,819 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl89,037,742 - 9,460,233 (-)EnsemblpanPan2panpan1.1
DLC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11636,531,754 - 36,943,033 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1636,531,754 - 36,943,033 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1636,996,594 - 37,413,641 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01638,571,399 - 39,066,161 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1638,571,399 - 39,066,142 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11636,670,048 - 37,080,683 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01637,232,627 - 37,643,411 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01637,352,432 - 37,763,946 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dlc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494342,192,682 - 42,649,385 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365732,492,875 - 2,658,714 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365732,493,051 - 2,658,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,170,208 - 1,637,114 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1171,169,709 - 1,637,171 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DLC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1811,211,230 - 11,632,278 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605230,700,864 - 31,128,407 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248393,509,441 - 3,899,162 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248393,495,580 - 3,899,009 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlc1
3526 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:62
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000014924
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
D16Rat62  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81662,044,330 - 62,044,502 (+)Marker Load Pipeline
mRatBN7.21655,340,915 - 55,341,087 (+)MAPPERmRatBN7.2
Rnor_6.01658,825,899 - 58,826,070NCBIRnor6.0
Rnor_5.01658,513,569 - 58,513,740UniSTSRnor5.0
RGSC_v3.41659,025,441 - 59,025,613RGDRGSC3.4
RGSC_v3.41659,025,442 - 59,025,613UniSTSRGSC3.4
Celera1653,399,318 - 53,399,489UniSTS
RGSC_v3.11659,025,516 - 59,025,688RGD
RH 3.4 Map16555.0RGD
RH 3.4 Map16555.0UniSTS
RH 2.0 Map16642.7RGD
Cytogenetic Map16q12.2UniSTS
D16Nkg55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,639,526 - 55,639,662 (+)MAPPERmRatBN7.2
Rnor_6.01659,217,121 - 59,217,256NCBIRnor6.0
Rnor_5.01658,897,792 - 58,897,927UniSTSRnor5.0
RGSC_v3.41659,324,618 - 59,324,753UniSTSRGSC3.4
Celera1653,697,132 - 53,697,267UniSTS
Cytogenetic Map16q12.2UniSTS
D16Nkg54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,636,014 - 55,636,207 (+)MAPPERmRatBN7.2
Rnor_6.01659,213,607 - 59,213,799NCBIRnor6.0
Rnor_5.01658,894,278 - 58,894,470UniSTSRnor5.0
RGSC_v3.41659,321,104 - 59,321,296UniSTSRGSC3.4
Celera1653,693,618 - 53,693,810UniSTS
Cytogenetic Map16q12.2UniSTS
D16Nkg56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,647,980 - 55,648,294 (+)MAPPERmRatBN7.2
Rnor_6.01659,224,295 - 59,224,608NCBIRnor6.0
Rnor_5.01658,904,966 - 58,905,279UniSTSRnor5.0
RGSC_v3.41659,333,437 - 59,333,750UniSTSRGSC3.4
Celera1653,705,495 - 53,705,808UniSTS
Cytogenetic Map16q12.2UniSTS
BE112293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,554,880 - 55,555,051 (+)MAPPERmRatBN7.2
Rnor_6.01659,124,179 - 59,124,349NCBIRnor6.0
Rnor_5.01658,805,475 - 58,805,645UniSTSRnor5.0
RGSC_v3.41659,239,854 - 59,240,024UniSTSRGSC3.4
Celera1653,613,006 - 53,613,176UniSTS
RH 3.4 Map16556.9UniSTS
Cytogenetic Map16q12.2UniSTS
AI176713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,671,074 - 55,671,197 (+)MAPPERmRatBN7.2
Rnor_6.01659,247,388 - 59,247,510NCBIRnor6.0
Rnor_5.01658,928,059 - 58,928,181UniSTSRnor5.0
RGSC_v3.41659,356,530 - 59,356,652UniSTSRGSC3.4
Celera1653,728,588 - 53,728,710UniSTS
RH 3.4 Map16546.3UniSTS
Cytogenetic Map16q12.2UniSTS
AI104472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,494,837 - 55,494,935 (+)MAPPERmRatBN7.2
Rnor_6.01659,064,098 - 59,064,195NCBIRnor6.0
Rnor_5.01658,745,665 - 58,745,762UniSTSRnor5.0
RGSC_v3.41659,178,965 - 59,179,062UniSTSRGSC3.4
Celera1653,553,045 - 53,553,142UniSTS
RH 3.4 Map16545.8UniSTS
Cytogenetic Map16q12.2UniSTS
BF402825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,658,328 - 55,658,453 (+)MAPPERmRatBN7.2
Rnor_6.01659,234,642 - 59,234,766NCBIRnor6.0
Rnor_5.01658,915,313 - 58,915,437UniSTSRnor5.0
RGSC_v3.41659,343,784 - 59,343,908UniSTSRGSC3.4
Celera1653,715,842 - 53,715,966UniSTS
RH 3.4 Map16557.1UniSTS
Cytogenetic Map16q12.2UniSTS
BI302233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,403,364 - 55,403,578 (+)MAPPERmRatBN7.2
Rnor_6.01658,972,708 - 58,972,921NCBIRnor6.0
Rnor_5.01658,654,484 - 58,654,697UniSTSRnor5.0
RGSC_v3.41659,087,542 - 59,087,755UniSTSRGSC3.4
Celera1653,461,600 - 53,461,813UniSTS
RH 3.4 Map16545.5UniSTS
Cytogenetic Map16q12.2UniSTS
BG374117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,450,039 - 55,450,193 (+)MAPPERmRatBN7.2
Rnor_6.01659,019,217 - 59,019,370NCBIRnor6.0
Rnor_5.01658,700,993 - 58,701,146UniSTSRnor5.0
RGSC_v3.41659,134,217 - 59,134,370UniSTSRGSC3.4
Celera1653,508,277 - 53,508,430UniSTS
RH 3.4 Map16558.8UniSTS
Cytogenetic Map16q12.2UniSTS
MARC_21337-21338:1023126946:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21655,667,766 - 55,668,859 (+)MAPPERmRatBN7.2
Rnor_6.01659,244,080 - 59,245,172NCBIRnor6.0
Rnor_5.01658,924,751 - 58,925,843UniSTSRnor5.0
RGSC_v3.41659,353,222 - 59,354,314UniSTSRGSC3.4
Celera1653,725,280 - 53,726,372UniSTS
Cytogenetic Map16q12.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 13 82 186 91 90 59 89 59 6 396 211 18 167 100 121 31 27 27

Sequence


Ensembl Acc Id: ENSRNOT00000014924   ⟹   ENSRNOP00000014923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1662,349,037 - 62,374,819 (+)Ensembl
mRatBN7.2 Ensembl1655,645,655 - 55,671,439 (+)Ensembl
Rnor_6.0 Ensembl1659,197,367 - 59,247,754 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090477   ⟹   ENSRNOP00000075006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1662,331,265 - 62,374,813 (+)Ensembl
mRatBN7.2 Ensembl1655,627,913 - 55,669,674 (+)Ensembl
Rnor_6.0 Ensembl1659,077,574 - 59,246,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1659,240,670 - 59,241,143 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1659,236,443 - 59,236,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1659,242,819 - 59,244,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104961   ⟹   ENSRNOP00000077109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1661,995,001 - 62,374,819 (+)Ensembl
mRatBN7.2 Ensembl1655,291,584 - 55,671,439 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106416   ⟹   ENSRNOP00000097976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1662,212,155 - 62,374,819 (+)Ensembl
mRatBN7.2 Ensembl1655,508,555 - 55,671,439 (+)Ensembl
RefSeq Acc Id: NM_001127446   ⟹   NP_001120918
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,331,300 - 62,373,054 (+)NCBI
mRatBN7.21655,627,913 - 55,669,674 (+)NCBI
Rnor_6.01659,197,367 - 59,245,987 (+)NCBI
Rnor_5.01658,638,567 - 58,928,425 (+)NCBI
RGSC_v3.41659,312,930 - 59,355,129 (+)RGD
Celera1653,685,682 - 53,727,187 (+)RGD
Sequence:
RefSeq Acc Id: NM_001370997   ⟹   NP_001357926
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81661,995,001 - 62,374,819 (+)NCBI
mRatBN7.21655,291,584 - 55,671,439 (+)NCBI
RefSeq Acc Id: XM_017600236   ⟹   XP_017455725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81661,994,547 - 62,374,819 (+)NCBI
mRatBN7.21655,291,153 - 55,671,441 (+)NCBI
Rnor_6.01658,776,489 - 59,247,752 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094797   ⟹   XP_038950725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81661,954,177 - 62,374,819 (+)NCBI
mRatBN7.21655,246,716 - 55,671,441 (+)NCBI
RefSeq Acc Id: XM_039094798   ⟹   XP_038950726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,212,048 - 62,374,819 (+)NCBI
mRatBN7.21655,508,504 - 55,671,439 (+)NCBI
RefSeq Acc Id: XM_039094799   ⟹   XP_038950727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,332,352 - 62,374,819 (+)NCBI
mRatBN7.21655,628,977 - 55,671,441 (+)NCBI
RefSeq Acc Id: XM_063275672   ⟹   XP_063131742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81661,994,502 - 62,285,183 (+)NCBI
RefSeq Acc Id: XM_063275673   ⟹   XP_063131743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81661,994,503 - 62,328,884 (+)NCBI
RefSeq Acc Id: XM_063275674   ⟹   XP_063131744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81661,994,502 - 62,328,884 (+)NCBI
RefSeq Acc Id: NP_001120918   ⟸   NM_001127446
- Peptide Label: isoform 2
- UniProtKB: Q63744 (UniProtKB/Swiss-Prot),   A0A0G2K9I2 (UniProtKB/TrEMBL),   A6IVJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455725   ⟸   XM_017600236
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014923   ⟸   ENSRNOT00000014924
Ensembl Acc Id: ENSRNOP00000075006   ⟸   ENSRNOT00000090477
RefSeq Acc Id: XP_038950725   ⟸   XM_039094797
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357926   ⟸   NM_001370997
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZJE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950726   ⟸   XM_039094798
- Peptide Label: isoform X2
- UniProtKB: Q63744 (UniProtKB/Swiss-Prot),   A0A8I6AX28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950727   ⟸   XM_039094799
- Peptide Label: isoform X3
- UniProtKB: Q63744 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000077109   ⟸   ENSRNOT00000104961
Ensembl Acc Id: ENSRNOP00000097976   ⟸   ENSRNOT00000106416
RefSeq Acc Id: XP_063131744   ⟸   XM_063275674
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063131742   ⟸   XM_063275672
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131743   ⟸   XM_063275673
- Peptide Label: isoform X5
Protein Domains
Rho-GAP   SAM   START

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63744-F1-model_v2 AlphaFold Q63744 1-1091 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700128
Promoter ID:EPDNEW_R10652
Type:initiation region
Name:Dlc1_2
Description:DLC1 Rho GTPase activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10653  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01659,077,809 - 59,077,869EPDNEW
RGD ID:13700129
Promoter ID:EPDNEW_R10653
Type:multiple initiation site
Name:Dlc1_1
Description:DLC1 Rho GTPase activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10652  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01659,197,343 - 59,197,403EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68416 AgrOrtholog
BioCyc Gene G2FUF-11203 BioCyc
Ensembl Genes ENSRNOG00000010780 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014924 ENTREZGENE
  ENSRNOT00000090477 ENTREZGENE
  ENSRNOT00000104961 ENTREZGENE
  ENSRNOT00000106416 ENTREZGENE
Gene3D-CATH 1.10.287.2070 UniProtKB/Swiss-Prot
  1.10.555.10 UniProtKB/Swiss-Prot
  3.30.530.20 UniProtKB/Swiss-Prot
InterPro Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  START-like_dom_sf UniProtKB/Swiss-Prot
  START_lipid-bd_dom UniProtKB/Swiss-Prot
NCBI Gene 58834 ENTREZGENE
PANTHER PTHR12659:SF2 UniProtKB/Swiss-Prot
  RHO-TYPE GTPASE ACTIVATING PROTEIN UniProtKB/Swiss-Prot
Pfam RhoGAP UniProtKB/Swiss-Prot
  SAM_2 UniProtKB/Swiss-Prot
  START UniProtKB/Swiss-Prot
PhenoGen Dlc1 PhenoGen
PROSITE RHOGAP UniProtKB/Swiss-Prot
  START UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010780 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot
  START UniProtKB/Swiss-Prot
Superfamily-SCOP Bet v1-like UniProtKB/Swiss-Prot
  SSF47769 UniProtKB/Swiss-Prot
  SSF48350 UniProtKB/Swiss-Prot
UniProt A0A0G2K9I2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AX28 ENTREZGENE, UniProtKB/TrEMBL
  A6IVJ9 ENTREZGENE, UniProtKB/TrEMBL
  G3V7H1_RAT UniProtKB/TrEMBL
  Q63744 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-25 Dlc1  DLC1 Rho GTPase activating protein  Dlc1  deleted in liver cancer 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-03-05 Dlc1  deleted in liver cancer 1  Arhgap7  rho GTPase activating protein 7  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-06-10 Arhgap7  rho GTPase activating protein 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference