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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | RGD:68616 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DLC1 mRNA | CTD | PMID:19619570 | 17beta-estradiol | affects expression | ISO | RGD:68616 | 6480464 | Estradiol affects the expression of DLC1 mRNA | CTD | PMID:22574217 | 17beta-estradiol | increases expression | ISO | RGD:68616 | 6480464 | Estradiol results in increased expression of DLC1 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:68616 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DLC1 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:68416 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DLC1 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DLC1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:68616 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DLC1 mRNA | CTD | PMID:19619570 | 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:68616 | 6480464 | decitabine affects the methylation of DLC1 promoter | CTD | PMID:17571247 | 5-fluorouracil | multiple interactions | ISO | RGD:68616 | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of DLC1 mRNA] | CTD | PMID:15016801 | all-trans-retinoic acid | increases expression | ISO | RGD:68616 | 6480464 | Tretinoin results in increased expression of DLC1 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | ISO | RGD:68416 | 6480464 | Ammonium Chloride affects the expression of DLC1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of DLC1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of DLC1 mRNA | CTD | PMID:19770486 | chloroprene | increases expression | ISO | RGD:68416 | 6480464 | Chloroprene results in increased expression of DLC1 mRNA | CTD | PMID:23125180 | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of DLC1 mRNA | CTD | PMID:23125180 | ciglitazone | multiple interactions | ISO | RGD:68616 | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of DLC1 mRNA | CTD | PMID:16197558 | cobalt dichloride | decreases expression | ISO | RGD:68616 | 6480464 | cobaltous chloride results in decreased expression of DLC1 mRNA | CTD | PMID:19320972 | copper(2+) sulfate | increases expression | ISO | RGD:68616 | 6480464 | Copper Sulfate results in increased expression of DLC1 mRNA | CTD | PMID:19549813 | cumene | multiple interactions | EXP | | 6480464 | [cumene co-treated with KRAS gene mutant form] results in decreased expression of DLC1 mRNA | CTD | PMID:18648096 | cyclophosphamide | increases expression | ISO | RGD:68616 | 6480464 | Cyclophosphamide results in increased expression of DLC1 mRNA | CTD | PMID:17403535 | cyclosporin A | decreases expression | ISO | RGD:68616 | 6480464 | Cyclosporine results in decreased expression of DLC1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of DLC1 mRNA | CTD | PMID:19770486 | doxorubicin | affects response to substance | ISO | RGD:68616 | 6480464 | DLC1 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | formaldehyde | decreases expression | ISO | RGD:68616 | 6480464 | Formaldehyde results in decreased expression of DLC1 mRNA | CTD | PMID:20655997 | iron atom | increases expression | ISO | RGD:68416 | 6480464 | Iron deficiency results in increased expression of DLC1 mRNA | CTD | PMID:16629162 | methylmercury chloride | affects expression | EXP | | 6480464 | methylmercuric chloride affects the expression of DLC1 mRNA | CTD | PMID:21613230 | mifepristone | multiple interactions | ISO | RGD:68616 | 6480464 | Mifepristone inhibits the reaction [Progesterone results in increased expression of DLC1 mRNA] | CTD | PMID:15674352 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of DLC1 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | affects expression | EXP | | 6480464 | perfluorooctane sulfonic acid affects the expression of DLC1 mRNA | CTD | PMID:19429403 | perfluorooctanoic acid | affects expression | EXP | | 6480464 | perfluorooctanoic acid affects the expression of DLC1 mRNA | CTD | PMID:19429403 | phenobarbital | affects expression | ISO | RGD:68616 | 6480464 | Phenobarbital affects the expression of DLC1 mRNA | CTD | PMID:19159669 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of DLC1 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | RGD:68616 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DLC1 mRNA | CTD | PMID:19710929 | progesterone | multiple interactions | ISO | RGD:68616 | 6480464 | Mifepristone inhibits the reaction [Progesterone results in increased expression of DLC1 mRNA] | CTD | PMID:15674352 | progesterone | increases expression | ISO | RGD:68616 | 6480464 | Progesterone results in increased expression of DLC1 mRNA | CTD | PMID:15674352 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of DLC1 mRNA | CTD | PMID:21278054 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of DLC1 mRNA | CTD | PMID:17484886 | topotecan | affects response to substance | ISO | RGD:68616 | 6480464 | DLC1 protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | ursodeoxycholic acid | multiple interactions | ISO | RGD:68616 | 6480464 | DLC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased activity of RHOA protein] | CTD | PMID:21455586 | ursodeoxycholic acid | increases expression | ISO | RGD:68616 | 6480464 | Ursodeoxycholic Acid results in increased expression of DLC1 protein | CTD | PMID:21455586 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of DLC1 mRNA | CTD | PMID:17963808 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of DLC1 mRNA | CTD | PMID:21427059 | | 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Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Regulation of RhoA activity (PID:200061) |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Regulation of RhoA activity (PID:200061) |
Phenotype Annotations
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References - curated| 1. |
MGD and Homologene mouse data transfer |
| 2. |
MGD data from the GO Consortium |
| 3. |
MGD IEA |
| 4. |
RGD automated import pipeline |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
| 6. |
RGD Automated Pipelines |
References - uncurated| PubMed | 10349636 |
| 10702663 | |
| 11042159 | |
| 11076861 | |
| 11217851 | |
| 12034501 | |
| 12040188 | |
| 12466851 | |
| 12477932 | |
| 12520002 | |
| 12904583 | |
| 14610273 | |
| 15710412 | |
| 16141072 | |
| 16141073 | |
| 16919269 | |
| 17967808 | |
| 18519636 | |
| 18799693 | |
| 20199662 | |
| 21267068 | |
| 21677750 | |
| 22792269 | |
| 23010077 | |
| 8889548 |
RGD Disease Portals| Dlc1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Dlc1 (Mus musculus) |
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| DLC1 (Homo sapiens) |
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| Dlc1 (Rattus norvegicus) |
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Position Markers| AW742331 |
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| AW743025 |
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| BE199599 |
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| D8Mit226 |
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| D8Mit97 |
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| Arhgap7 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001194940 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001194941 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_015802 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01069587 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01069588 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069590 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069591 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069592 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069593 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069594 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069595 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069596 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069597 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069598 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069599 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069600 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069601 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069602 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069603 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069604 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069605 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069606 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069607 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069608 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069609 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069610 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069611 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069612 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069613 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069614 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069615 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069616 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069617 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069618 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069619 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069620 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069621 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069622 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01069623 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC102761 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC103378 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC138593 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC158349 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC168051 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF178078 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411435 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411436 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411437 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411438 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411439 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411441 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF411442 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK040846 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK043205 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK045326 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK053142 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK086364 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK141828 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK147539 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK160715 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK162413 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK166175 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC028562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC048730 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC056230 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC096052 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC150802 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BE199599 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466554 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU169068 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU169069 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GU169070 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HM008381 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_015802 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_056617 | |||||||||||||||||||||||||
| Peptide Label: | isoform 2 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001194940 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001181869 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001194941 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001181870 | ||||||||||||||||||||
| Peptide Label: | isoform 3 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001181869 | (Get FASTA) |
| NP_001181870 | (Get FASTA) | |
| NP_056617 | (Get FASTA) | |
| GenBank Protein | AAD51760 | (Get FASTA) |
| AAI50803 | (Get FASTA) | |
| AAL87620 | (Get FASTA) | |
| ACZ34175 | (Get FASTA) | |
| ACZ34176 | (Get FASTA) | |
| ACZ34177 | (Get FASTA) | |
| ADE60006 | (Get FASTA) | |
| BAC31491 | (Get FASTA) | |
| BAC32310 | (Get FASTA) | |
| BAC35281 | (Get FASTA) | |
| BAE27982 | (Get FASTA) | |
| BAE36903 | (Get FASTA) | |
| EDL35481 | (Get FASTA) | |
| Q9R0Z9 | (Get FASTA) |
Promoters| RGD ID: | 6843032 | ||||||||||
| Promoter ID: | MM_KWN:54183 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day3, 3T3L1_Day4, Kidney, Liver, Lung, MEF_B4, MEF_B6 | ||||||||||
| Transcripts: | OTTMUST00000070716 | ||||||||||
| Position: |
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| RGD ID: | 6843034 | ||||||||||
| Promoter ID: | MM_KWN:54185 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6 | ||||||||||
| Transcripts: | OTTMUST00000070714, OTTMUST00000070715, UC009LLS.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000031523 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000033923 | ENTREZGENE |
| ENSMUSP00000096425 | ENTREZGENE | |
| Ensembl Transcript | ENSMUST00000033923 | ENTREZGENE |
| ENSMUST00000098826 | ENTREZGENE | |
| Entrez Gene | 50768 | ENTREZGENE |
| Gene3D-CATH | G3DSA:3.30.530.20 | UniProtKB/Swiss-Prot |
| RhoGAP | UniProtKB/Swiss-Prot | |
| Germonline | ENSMUSG00000031523 | |
| HomoloGene Group ID | 4442 | ENTREZGENE |
| InterPro | Rho_GTPase_activation_prot | UniProtKB/Swiss-Prot |
| RhoGAP_dom | UniProtKB/Swiss-Prot | |
| SAM_2 | UniProtKB/Swiss-Prot | |
| START-like_dom | UniProtKB/Swiss-Prot | |
| START_lipid-bd | UniProtKB/Swiss-Prot | |
| IPI | IPI00314102 | UniProtKB/Swiss-Prot |
| IPI00404371 | UniProtKB/TrEMBL | |
| IPI00761452 | UniProtKB/TrEMBL | |
| IPI00990565 | UniProtKB/Swiss-Prot | |
| IPI01008162 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:50768 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1354949 | ENTREZGENE |
| Pfam | RhoGAP | UniProtKB/Swiss-Prot |
| SAM_2 | UniProtKB/Swiss-Prot | |
| START | UniProtKB/Swiss-Prot | |
| PROSITE | RHOGAP | UniProtKB/Swiss-Prot |
| SAM_DOMAIN; FALSE_NEG | UniProtKB/Swiss-Prot | |
| START | UniProtKB/Swiss-Prot | |
| SMART | RhoGAP | UniProtKB/Swiss-Prot |
| START | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Rho_GAP | UniProtKB/Swiss-Prot |
| UniGene | Mm.125155 | ENTREZGENE |
| Mm.210875 | ENTREZGENE | |
| UniProt | B9EKA3_MOUSE | UniProtKB/TrEMBL |
| D2JZZ5_MOUSE | UniProtKB/TrEMBL | |
| D2JZZ6_MOUSE | UniProtKB/TrEMBL | |
| D2JZZ7_MOUSE | UniProtKB/TrEMBL | |
| D5M8I5_MOUSE | UniProtKB/TrEMBL | |
| E9PXD2_MOUSE | UniProtKB/TrEMBL | |
| E9QKB1_MOUSE | UniProtKB/TrEMBL | |
| J3QPV2_MOUSE | UniProtKB/TrEMBL | |
| Q8BR96_MOUSE | UniProtKB/TrEMBL | |
| Q8C6U8_MOUSE | UniProtKB/TrEMBL | |
| Q8C920_MOUSE | UniProtKB/TrEMBL | |
| RHG07_MOUSE | UniProtKB/Swiss-Prot |
| More on Dlc1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 68617 |
| Created: | 2001-07-11 |
| Species: | Mus musculus |
| Last Modified: | 2013-03-12 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.