Gipc1 (GIPC PDZ domain containing family, member 1) - Rat Genome Database

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Gene: Gipc1 (GIPC PDZ domain containing family, member 1) Rattus norvegicus
Analyze
Symbol: Gipc1
Name: GIPC PDZ domain containing family, member 1
RGD ID: 68338
Description: Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of melanin biosynthetic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in brush border and endocytic vesicle. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GAIP C-terminus-interacting protein; Gipc; GLUT1 C-terminal-binding protein; GLUT1CBP; PDZ domain-containing protein GIPC1; regulator of G-protein signaling 19; regulator of G-protein signaling 19 interacting protein 1; RGS-GAIP interacting protein C-terminus; RGS-GAIP interacting protein, C-terminus; RGS-GAIP-interacting protein; Rgs19; RGS19-interacting protein 1; Rgs19ip1; synectin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,380,125 - 41,392,078 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,380,125 - 41,391,725 (-)EnsemblGRCr8
mRatBN7.21924,474,291 - 24,487,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,453,123 - 24,486,997 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,296,524 - 31,300,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,950,945 - 31,954,760 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,173,772 - 34,177,589 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,786,604 - 24,798,231 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,765,772 - 35,778,495 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,165,658 - 26,177,206 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,018,366 - 24,029,872 (-)NCBICelera
RGSC_v3.11926,170,483 - 26,174,300 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Bunn RC, etal., Mol Biol Cell 1999 Apr;10(4):819-32.
2. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. Cai H and Reed RR, J Neurosci. 1999 Aug 1;19(15):6519-27.
3. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. De Vries L, etal., Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12340-5.
4. Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. Fischer T, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8270-5. Epub 2003 Jun 25.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Jeanneteau F, etal., Mol Biol Cell. 2004 Feb;15(2):696-705. Epub 2003 Nov 14.
7. Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors. Kato H, etal., FEBS Lett. 2004 Aug 13;572(1-3):123-8.
8. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Liu M and Horowitz A, Mol Biol Cell. 2006 Apr;17(4):1880-7. Epub 2006 Feb 8.
9. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou X, etal., J Am Soc Nephrol. 2002 Apr;13(4):918-27.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Yano H, etal., Nat Neurosci. 2006 Aug;9(8):1009-18. doi: 10.1038/nn1730. Epub 2006 Jul 2.
Additional References at PubMed
PMID:11251075   PMID:11546783   PMID:12857860   PMID:14499480   PMID:15458844   PMID:15459234   PMID:15975910   PMID:16316992   PMID:16908842   PMID:17959809   PMID:19056867   PMID:19581409  
PMID:19946888   PMID:21291857   PMID:22888021   PMID:23376485   PMID:25468996   PMID:29581031  


Genomics

Comparative Map Data
Gipc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,380,125 - 41,392,078 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,380,125 - 41,391,725 (-)EnsemblGRCr8
mRatBN7.21924,474,291 - 24,487,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,453,123 - 24,486,997 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,296,524 - 31,300,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,950,945 - 31,954,760 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,173,772 - 34,177,589 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,786,604 - 24,798,231 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,765,772 - 35,778,495 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,165,658 - 26,177,206 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,018,366 - 24,029,872 (-)NCBICelera
RGSC_v3.11926,170,483 - 26,174,300 (-)NCBI
Cytogenetic Map19q11NCBI
GIPC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,477,762 - 14,496,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,477,759 - 14,496,157 (-)Ensemblhg38GRCh38
GRCh371914,588,574 - 14,606,939 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,449,571 - 14,467,944 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341914,449,571 - 14,467,944NCBI
Celera1914,482,692 - 14,501,043 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,158,686 - 14,177,001 (-)NCBIHuRef
CHM1_11914,588,560 - 14,606,924 (-)NCBICHM1_1
T2T-CHM13v2.01914,604,395 - 14,622,744 (-)NCBIT2T-CHM13v2.0
Gipc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,376,037 - 84,391,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,379,306 - 84,391,323 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38883,649,408 - 83,664,789 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Gipc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,067,689 - 33,074,730 (-)Ensembl
ChiLan1.0NW_00495541533,067,689 - 33,077,749 (-)NCBIChiLan1.0ChiLan1.0
GIPC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,407,561 - 19,425,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,409,821 - 18,428,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,041,192 - 14,059,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,884,529 - 14,897,247 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,885,185 - 14,889,701 (-)EnsemblpanPan2panpan1.1
GIPC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,144,076 - 48,155,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,150,498 - 48,157,191 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2048,020,555 - 48,030,681 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02048,660,996 - 48,673,506 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,661,602 - 48,678,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,874,912 - 47,885,049 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,301,291 - 48,311,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,544,132 - 48,554,244 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gipc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,324,418 - 207,334,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366593,012,012 - 3,026,883 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366593,019,829 - 3,030,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIPC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,780,442 - 64,794,919 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1264,780,447 - 64,794,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,158,635 - 65,174,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GIPC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,136,647 - 13,155,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,136,624 - 13,142,002 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660746,500,986 - 6,519,302 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gipc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11716,608,485 - 16,620,958 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gipc1
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:60
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000005374
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
RH134027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,475,484 - 24,475,676 (-)MAPPERmRatBN7.2
Rnor_6.01924,797,955 - 24,798,146NCBIRnor6.0
Rnor_5.01935,777,110 - 35,777,301UniSTSRnor5.0
RGSC_v3.41926,165,743 - 26,165,934UniSTSRGSC3.4
Celera1924,018,451 - 24,018,642UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005374   ⟹   ENSRNOP00000005374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,380,132 - 41,391,725 (-)Ensembl
mRatBN7.2 Ensembl1924,475,409 - 24,486,997 (-)Ensembl
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105318   ⟹   ENSRNOP00000089319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,380,125 - 41,384,187 (-)Ensembl
mRatBN7.2 Ensembl1924,476,081 - 24,480,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112591   ⟹   ENSRNOP00000082767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,453,123 - 24,481,454 (-)Ensembl
RefSeq Acc Id: NM_053341   ⟹   NP_445793
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,380,125 - 41,383,942 (-)NCBI
mRatBN7.21924,475,400 - 24,479,214 (-)NCBI
Rnor_6.01924,786,683 - 24,798,231 (+)NCBI
Rnor_5.01935,765,772 - 35,778,495 (+)NCBI
RGSC_v3.41926,165,658 - 26,177,206 (-)RGD
Celera1924,018,366 - 24,029,872 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601372   ⟹   XP_017456861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,380,131 - 41,391,713 (-)NCBI
mRatBN7.21924,475,405 - 24,486,988 (-)NCBI
Rnor_6.01924,786,604 - 24,798,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098035   ⟹   XP_038953963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,380,131 - 41,392,078 (-)NCBI
mRatBN7.21924,474,291 - 24,487,082 (-)NCBI
RefSeq Acc Id: NP_445793   ⟸   NM_053341
- UniProtKB: Q9Z254 (UniProtKB/Swiss-Prot),   Q9QUQ4 (UniProtKB/Swiss-Prot),   Q6GR70 (UniProtKB/Swiss-Prot),   A6IYD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456861   ⟸   XM_017601372
- Peptide Label: isoform X1
- UniProtKB: Q9Z254 (UniProtKB/Swiss-Prot),   Q9QUQ4 (UniProtKB/Swiss-Prot),   Q6GR70 (UniProtKB/Swiss-Prot),   A6IYD6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005374   ⟸   ENSRNOT00000005374
RefSeq Acc Id: XP_038953963   ⟸   XM_039098035
- Peptide Label: isoform X1
- UniProtKB: Q9Z254 (UniProtKB/Swiss-Prot),   Q9QUQ4 (UniProtKB/Swiss-Prot),   Q6GR70 (UniProtKB/Swiss-Prot),   A6IYD6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082767   ⟸   ENSRNOT00000112591
Ensembl Acc Id: ENSRNOP00000089319   ⟸   ENSRNOT00000105318
Protein Domains
GIPC1-3 GH1   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z254-F1-model_v2 AlphaFold Q9Z254 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701002
Promoter ID:EPDNEW_R11526
Type:initiation region
Name:Gipc1_1
Description:GIPC PDZ domain containing family, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01924,786,659 - 24,786,719EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68338 AgrOrtholog
BioCyc Gene G2FUF-6020 BioCyc
Ensembl Genes ENSRNOG00000003864 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005374 ENTREZGENE
  ENSRNOT00000005374.6 UniProtKB/Swiss-Prot
  ENSRNOT00000105318 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5620910 IMAGE-MGC_LOAD
  IMAGE:7097697 IMAGE-MGC_LOAD
InterPro GH2_GIPC UniProtKB/Swiss-Prot
  GIPC1-3_GH1 UniProtKB/Swiss-Prot
  GIPC1/2/3 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:83823 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72367 IMAGE-MGC_LOAD
  MGC:91590 IMAGE-MGC_LOAD
NCBI Gene Gipc1 ENTREZGENE
PANTHER PDZ DOMAIN-CONTAINING PROTEIN GIPC1 UniProtKB/Swiss-Prot
  PTHR12259 UniProtKB/Swiss-Prot
Pfam GIPC1_GH1 UniProtKB/Swiss-Prot
  GIPC1_GH2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Gipc1 PhenoGen
PIRSF UCP038083_GIPC UniProtKB/Swiss-Prot
PROSITE PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003864 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
TIGR TC230181
UniProt A0A8I6ABP2_RAT UniProtKB/TrEMBL
  A6IYD6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYD7_RAT UniProtKB/TrEMBL
  GIPC1_RAT UniProtKB/Swiss-Prot
  Q6GR70 ENTREZGENE
  Q9QUQ4 ENTREZGENE
  Q9Z254 ENTREZGENE
UniProt Secondary Q6GR70 UniProtKB/Swiss-Prot
  Q9QUQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Gipc1  GIPC PDZ domain containing family, member 1  Rgs19ip1  regulator of G-protein signaling 19 interacting protein 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Rgs19ip1  regulator of G-protein signaling 19 interacting protein 1       Name updated 70584 APPROVED
2002-02-27 Rgs19ip1  regulator of G-protein signaling 19 interacting protein 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane of transfected HEK293 cells 1299148
gene_domains contains a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain 68252
gene_function exclusively binds RGS-GAIP, RGSZ1, and RGSZ2 1299148