Orm1 (orosomucoid 1) - Rat Genome Database

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Gene: Orm1 (orosomucoid 1) Rattus norvegicus
Analyze
Symbol: Orm1
Name: orosomucoid 1
RGD ID: 67390
Description: Enables small molecule binding activity. Involved in several processes, including cellular response to growth hormone stimulus; cellular response to retinoic acid; and inflammatory response to antigenic stimulus. Located in extracellular space. Orthologous to several human genes including ORM1 (orosomucoid 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AAG; AGP; Agpa1; alpha-1-acid glycoprotein; OMD; Orm; orosomucoid
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,788,509 - 81,791,661 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl581,788,395 - 81,791,667 (+)EnsemblGRCr8
mRatBN7.2576,766,637 - 76,776,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,772,941 - 76,776,154 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx579,172,063 - 79,175,233 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,989,208 - 80,992,378 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,964,702 - 80,967,872 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,179,668 - 79,182,820 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,179,417 - 79,182,820 (+)Ensemblrn6Rnor6.0
Rnor_5.0583,293,902 - 83,297,054 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4580,325,042 - 80,328,194 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera575,706,909 - 75,710,061 (+)NCBICelera
RGSC_v3.1580,330,154 - 80,333,307 (+)NCBI
RH 3.4 Map5578.8RGD
Cytogenetic Map5q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
7,12-dimethyltetraphene  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
atrazine  (ISO)
azathioprine  (EXP)
Benoxacor  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (EXP)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
cholic acid  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DAUDA  (ISO)
DDE  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (EXP,ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
diethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dipyridamole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
drometrizole  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythrosin B  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
graphite  (EXP)
hexachlorobenzene  (EXP)
icariin  (ISO)
indometacin  (ISO)
inulin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
mercaptopurine  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
Mezerein  (ISO)
naphthalene  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
palytoxin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
parathion  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorone  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propionic acid  (ISO)
propranolol  (EXP)
prostaglandin E2  (EXP)
purine-6-thiol  (EXP)
quartz  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
saccharin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
styrene oxide  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tin(II) chloride (anhydrous)  (ISO)
tioguanine  (EXP)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vitamin K  (EXP)
warfarin  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Alpha-1-acid glycoprotein concentrations and protein binding of propranolol in Sprague-Dawley and Dark Agouti rat strains treated by phenobarbital. Chauvelot-Moachon L, etal., J Pharmacol Exp Ther. 1988 Mar;244(3):1103-8.
2. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Fischer A, etal., Biochem Biophys Res Commun. 2001 Jul 13;285(2):470-5.
3. Inducible expression and regulation of the alpha 1-acid glycoprotein gene by alveolar macrophages: prostaglandin E2 and cyclic AMP act as new positive stimuli. Fournier T, etal., J Immunol. 1999 Sep 1;163(5):2883-90.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation. Hung DY, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G343-51. Epub 2005 Sep 15.
6. Liver gene regulation in rats following both 70 or 90% hepatectomy and endotoxin treatment. Jensen SA J Gastroenterol Hepatol. 2001 May;16(5):525-30.
7. Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses. Kondraganti SR, etal., Chem Res Toxicol. 2005 Nov;18(11):1634-41.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. NF-kappaB is involved in the induction of the rat hepatic alpha1-acid glycoprotein gene by phenobarbital. Mejdoubi N, etal., Biochem Biophys Res Commun. 1999 Jan 8;254(1):93-9.
10. Growth hormone inhibits rat liver alpha-1-acid glycoprotein gene expression in vivo and in vitro. Mejdoubi N, etal., Hepatology. 1999 Jan;29(1):186-94.
11. Retinoids increase alpha-1 acid glycoprotein expression at the transcriptional level through two distinct DR1 retinoic acid responsive elements. Mouthiers A, etal., Biochim Biophys Acta. 2004 May 25;1678(2-3):135-44.
12. Selective downregulation of hepatic cytochrome P450 expression and activity in a rat model of inflammatory pain. Projean D, etal., Pharm Res. 2005 Jan;22(1):62-70.
13. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Nucleotide sequence of rat alpha 1-acid glycoprotein messenger RNA. Ricca GA and Taylor JM, J Biol Chem 1981 Nov 10;256(21):11199-202.
18. Kinetics of induction of alpha 1-acid glycoprotein. Ricca GA, etal., Ann N Y Acad Sci 1982;389:88-105.
19. Rat alpha 1-acid glycoprotein mRNA. Cloning of double-stranded cDNA and kinetics of induction of mRNA levels following acute inflammation. Ricca GA, etal., J Biol Chem 1981 Oct 25;256(20):10362-8.
20. FK506 (tacrolimus) increases rat alpha1-acid glycoprotein expression in liver and primary cultured hepatocytes. Shimoishi K, etal., Eur J Pharmacol. 2001 May 25;420(2-3):91-5.
21. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
Additional References at PubMed
PMID:2943986   PMID:3838547   PMID:8774350   PMID:15502707   PMID:16502470   PMID:17234708   PMID:21669904   PMID:22516433   PMID:22916107   PMID:23376485   PMID:23533145   PMID:23973664  
PMID:26740279   PMID:27068509   PMID:27559042   PMID:30707086   PMID:33134382  


Genomics

Comparative Map Data
Orm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,788,509 - 81,791,661 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl581,788,395 - 81,791,667 (+)EnsemblGRCr8
mRatBN7.2576,766,637 - 76,776,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,772,941 - 76,776,154 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx579,172,063 - 79,175,233 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,989,208 - 80,992,378 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,964,702 - 80,967,872 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,179,668 - 79,182,820 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,179,417 - 79,182,820 (+)Ensemblrn6Rnor6.0
Rnor_5.0583,293,902 - 83,297,054 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4580,325,042 - 80,328,194 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera575,706,909 - 75,710,061 (+)NCBICelera
RGSC_v3.1580,330,154 - 80,333,307 (+)NCBI
RH 3.4 Map5578.8RGD
Cytogenetic Map5q24NCBI
ORM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,323,098 - 114,326,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,323,025 - 114,326,479 (+)Ensemblhg38GRCh38
GRCh379117,085,378 - 117,088,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369116,125,157 - 116,128,578 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349114,164,889 - 114,168,311NCBI
Celera987,732,978 - 87,736,434 (+)NCBICelera
Cytogenetic Map9q32NCBI
HuRef986,691,053 - 86,694,374 (+)NCBIHuRef
CHM1_19117,232,023 - 117,235,479 (+)NCBICHM1_1
T2T-CHM13v2.09126,522,292 - 126,525,673 (+)NCBIT2T-CHM13v2.0
Orm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39463,262,793 - 63,266,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl463,262,797 - 63,266,400 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38463,344,556 - 63,348,163 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl463,344,560 - 63,348,163 (+)Ensemblmm10GRCm38
MGSCv37463,005,600 - 63,009,196 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36462,830,927 - 62,834,523 (+)NCBIMGSCv36mm8
Celera462,001,528 - 62,005,125 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.96NCBI
Orm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541913,262,119 - 13,264,986 (-)Ensembl
ChiLan1.0NW_00495541913,262,119 - 13,264,986 (-)NCBIChiLan1.0ChiLan1.0
ORM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,050,683 - 25,055,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,053,044 - 25,058,777 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0985,421,254 - 85,424,659 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19113,793,293 - 113,796,639 (+)NCBIPanPan1.1PanPan1.1panPan2
ORM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11254,939,154 - 254,943,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21286,190,518 - 286,194,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q210-q212NCBI
ORM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,257,002 - 25,261,255 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,256,969 - 25,260,446 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603517,564,284 - 17,568,317 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Orm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1190,224,498 - 90,227,643 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Orm1
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:71
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000010454
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D5Arb8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,775,487 - 76,775,749 (+)MAPPERmRatBN7.2
Rnor_6.0579,182,160 - 79,182,421NCBIRnor6.0
Rnor_5.0583,296,394 - 83,296,655UniSTSRnor5.0
RGSC_v3.4580,327,533 - 80,327,795RGDRGSC3.4
RGSC_v3.4580,327,534 - 80,327,795UniSTSRGSC3.4
Celera575,709,401 - 75,709,662UniSTS
RGSC_v3.1580,332,646 - 80,332,908RGD
Cytogenetic Map5q24UniSTS
RH94673  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8581,791,715 - 81,791,887 (+)Marker Load Pipeline
mRatBN7.2576,776,202 - 76,776,374 (+)MAPPERmRatBN7.2
Rnor_6.0579,182,875 - 79,183,046NCBIRnor6.0
Rnor_5.0583,297,109 - 83,297,280UniSTSRnor5.0
RGSC_v3.4580,328,249 - 80,328,420UniSTSRGSC3.4
Celera575,710,116 - 75,710,287UniSTS
RH 3.4 Map5578.8UniSTS
Cytogenetic Map5q24UniSTS
RH94674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,772,592 - 76,772,772 (+)MAPPERmRatBN7.2
Rnor_6.0579,179,265 - 79,179,444NCBIRnor6.0
Rnor_5.0583,293,499 - 83,293,678UniSTSRnor5.0
RGSC_v3.4580,324,639 - 80,324,818UniSTSRGSC3.4
Celera575,706,506 - 75,706,685UniSTS
Cytogenetic Map5q24UniSTS
RH138430  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,774,739 - 76,776,114 (+)MAPPERmRatBN7.2
Rnor_6.0579,181,412 - 79,182,786NCBIRnor6.0
Rnor_5.0583,295,646 - 83,297,020UniSTSRnor5.0
RGSC_v3.4580,326,786 - 80,328,160UniSTSRGSC3.4
Celera575,708,653 - 75,710,027UniSTS
RH 3.4 Map11655.2UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 9 48 89 91 90 59 51 59 6 236 128 11 60 36 77 31 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010454   ⟹   ENSRNOP00000010454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,788,395 - 81,791,667 (+)Ensembl
mRatBN7.2 Ensembl576,772,941 - 76,776,154 (+)Ensembl
Rnor_6.0 Ensembl579,179,417 - 79,182,820 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107594   ⟹   ENSRNOP00000081272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl576,772,989 - 76,776,154 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112746   ⟹   ENSRNOP00000081825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl581,788,395 - 81,791,062 (+)Ensembl
mRatBN7.2 Ensembl576,772,941 - 76,775,549 (+)Ensembl
RefSeq Acc Id: NM_053288   ⟹   NP_445740
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8581,788,509 - 81,791,661 (+)NCBI
mRatBN7.2576,772,996 - 76,776,148 (+)NCBI
Rnor_6.0579,179,668 - 79,182,820 (+)NCBI
Rnor_5.0583,293,902 - 83,297,054 (+)NCBI
RGSC_v3.4580,325,042 - 80,328,194 (+)RGD
Celera575,706,909 - 75,710,061 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445740 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40699 (Get FASTA)   NCBI Sequence Viewer  
  AAA40700 (Get FASTA)   NCBI Sequence Viewer  
  AAA40701 (Get FASTA)   NCBI Sequence Viewer  
  CAA24527 (Get FASTA)   NCBI Sequence Viewer  
  EDM10527 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010454
GenBank Protein P02764 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445740   ⟸   NM_053288
- Peptide Label: precursor
- UniProtKB: P02764 (UniProtKB/Swiss-Prot),   A0A0H2UHF8 (UniProtKB/TrEMBL),   A6J7Y0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010454   ⟸   ENSRNOT00000010454
Ensembl Acc Id: ENSRNOP00000081825   ⟸   ENSRNOT00000112746
Ensembl Acc Id: ENSRNOP00000081272   ⟸   ENSRNOT00000107594
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02764-F1-model_v2 AlphaFold P02764 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67390 AgrOrtholog
BioCyc Gene G2FUF-41070 BioCyc
Ensembl Genes ENSRNOG00000007886 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010454 ENTREZGENE
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro A1A_glycop UniProtKB/Swiss-Prot
  Calycin UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:24614 UniProtKB/Swiss-Prot
NCBI Gene Orm1 ENTREZGENE
PANTHER ALPHA-1-ACID GLYCOPROTEIN UniProtKB/Swiss-Prot
  ALPHA-1-ACID GLYCOPROTEIN 1 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PharmGKB ORM1 RGD
PhenoGen Orm1 PhenoGen
PIRSF AGP UniProtKB/Swiss-Prot
PRINTS A1AGLPROTEIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007886 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
UniProt A0A0H2UHF8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVI6_RAT UniProtKB/TrEMBL
  A1AG_RAT UniProtKB/Swiss-Prot
  A6J7Y0 ENTREZGENE, UniProtKB/TrEMBL
  P02764 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-28 Orm1  orosomucoid 1  Orm  Orosomucoid 1  Data merged from RGD:3235 628472 APPROVED
2003-04-09 Orm1  orosomucoid 1      Symbol and Name updated 629477 APPROVED
2003-03-06 Orm1  orosomucoid 1  Agpa1  alpha-1-acid glycoprotein  Data merged from RGD:68956 628472 PROVISIONAL
2002-06-10 Orm1        Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Orm  Orosomucoid 1      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Agpa1  alpha-1-acid glycoprotein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression maybe induced during regeneration of hepatocytes after liver damage 61515
gene_expression maybe induced during regeneration of hepatocytes after liver damage 70249
gene_regulation induction regulated by glucocorticoids 729158